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IT1248934B - Membrane forate biocompatibili,processi per la loro preparazione,loro impiego come supporto per la crescita in vitro di cellule epiteliali, pelli artificiali cosi' ottenute e loro impiego nei trapianti di pelle - Google Patents

Membrane forate biocompatibili,processi per la loro preparazione,loro impiego come supporto per la crescita in vitro di cellule epiteliali, pelli artificiali cosi' ottenute e loro impiego nei trapianti di pelle

Info

Publication number
IT1248934B
IT1248934B IT02051390A IT2051390A IT1248934B IT 1248934 B IT1248934 B IT 1248934B IT 02051390 A IT02051390 A IT 02051390A IT 2051390 A IT2051390 A IT 2051390A IT 1248934 B IT1248934 B IT 1248934B
Authority
IT
Italy
Prior art keywords
leather
transplants
processes
preparation
support
Prior art date
Application number
IT02051390A
Other languages
English (en)
Other versions
IT9020513A0 (it
IT9020513A1 (it
Inventor
Valle Francesco Della
Gabriella Calderini
Alessandro Rastrelli
Romeo Aurelio
Original Assignee
Fidia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia Spa filed Critical Fidia Spa
Publication of IT9020513A0 publication Critical patent/IT9020513A0/it
Priority to IT02051390A priority Critical patent/IT1248934B/it
Priority to IL98255A priority patent/IL98255A/xx
Priority to ES91108654T priority patent/ES2108019T3/es
Priority to AT91108654T priority patent/ATE156689T1/de
Priority to DK91108654.4T priority patent/DK0462426T3/da
Priority to IE182591A priority patent/IE911825A1/en
Priority to DE69127235T priority patent/DE69127235T2/de
Priority to SG1996005810A priority patent/SG52545A1/en
Priority to EP91108654A priority patent/EP0462426B1/en
Priority to NO912058A priority patent/NO303562B1/no
Priority to BR919102225A priority patent/BR9102225A/pt
Priority to ZA914098A priority patent/ZA914098B/xx
Priority to AR91319818A priority patent/AR244354A1/es
Priority to AU78066/91A priority patent/AU637235B2/en
Priority to CA002043527A priority patent/CA2043527C/en
Priority to FI912591A priority patent/FI108918B/fi
Priority to TW080104245A priority patent/TW208652B/zh
Priority to HU911834A priority patent/HU215534B/hu
Priority to KR1019910008999A priority patent/KR100195574B1/ko
Priority to PT97832A priority patent/PT97832B/pt
Priority to JP12924591A priority patent/JP3202257B2/ja
Priority to UY23231A priority patent/UY23231A1/es
Publication of IT9020513A1 publication Critical patent/IT9020513A1/it
Priority to US08/019,818 priority patent/US5326356A/en
Priority to US08/209,626 priority patent/US5650164A/en
Application granted granted Critical
Publication of IT1248934B publication Critical patent/IT1248934B/it
Priority to US08/478,541 priority patent/US5658331A/en
Priority to GR970402714T priority patent/GR3025075T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • C12N5/0629—Keratinocytes; Whole skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/10—Hair or skin implants
    • A61F2/105—Skin implants, e.g. artificial skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60—Materials for use in artificial skin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0062—General methods for three-dimensional culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/80—Hyaluronan
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2539/00—Supports and/or coatings for cell culture characterised by properties
    • C12N2539/10—Coating allowing for selective detachment of cells, e.g. thermoreactive coating
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/24—Structurally defined web or sheet [e.g., overall dimension, etc.]
    • Y10T428/24273—Structurally defined web or sheet [e.g., overall dimension, etc.] including aperture

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Transplantation (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Cell Biology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IT02051390A 1990-06-01 1990-06-01 Membrane forate biocompatibili,processi per la loro preparazione,loro impiego come supporto per la crescita in vitro di cellule epiteliali, pelli artificiali cosi' ottenute e loro impiego nei trapianti di pelle IT1248934B (it)

Priority Applications (26)

Application Number Priority Date Filing Date Title
IT02051390A IT1248934B (it) 1990-06-01 1990-06-01 Membrane forate biocompatibili,processi per la loro preparazione,loro impiego come supporto per la crescita in vitro di cellule epiteliali, pelli artificiali cosi' ottenute e loro impiego nei trapianti di pelle
IL98255A IL98255A (en) 1990-06-01 1991-05-24 Biocompatible perforated membranes, processes for their preparation, their use as a support in the in vitro growth of epithelial cells, the artificial skin obtained in this manner, and its use in skin grafts
ES91108654T ES2108019T3 (es) 1990-06-01 1991-05-28 Membranas perforadas biocompatibles y su uso como piel artificial.
AT91108654T ATE156689T1 (de) 1990-06-01 1991-05-28 Biologisch verträgliche perforierte membranen und ihre verwendung als kunsthaut
DK91108654.4T DK0462426T3 (da) 1990-06-01 1991-05-28 Biokompatible, perforerede membraner og deres anvendelse som kunstig hud
IE182591A IE911825A1 (en) 1990-06-01 1991-05-28 Biocompatible perforated membranes, processes for their¹preparation, their use as a support in the in vitro growth¹of epithelial cells, the artificial skin obtained in this¹manner, and its use in skin grafts
DE69127235T DE69127235T2 (de) 1990-06-01 1991-05-28 Biologisch verträgliche perforierte Membranen und ihre Verwendung als Kunsthaut
SG1996005810A SG52545A1 (en) 1990-06-01 1991-05-28 Biocompatible perforated membranes process for their preparation their use as a support in the in vitro growth of epithelial cells the artificial skin
EP91108654A EP0462426B1 (en) 1990-06-01 1991-05-28 Biocompatible perforated membranes and their use as artificial skin
NO912058A NO303562B1 (no) 1990-06-01 1991-05-29 Bioforlikelige membraner og fremgangsmÕte for fremstilling derav, samt fremgangsmÕte for fremstilling av kunstig hud
BR919102225A BR9102225A (pt) 1990-06-01 1991-05-29 Membranas biocompativeis,processo para sua preparacao e pele artificial
ZA914098A ZA914098B (en) 1990-06-01 1991-05-29 Biocompatible perforated membranes,processes for their preparation,their use as a support in the in vitro growth of epithelial cells,the artificial skin obtained in this manner,and its use in skin grafts
AR91319818A AR244354A1 (es) 1990-06-01 1991-05-30 Membranas perforadas biocompatibles, procedimientos para su preparacion y piel artificial obtenida a partir de las mismas.
AU78066/91A AU637235B2 (en) 1990-06-01 1991-05-30 Biocompatible perforated membranes, process for their preparation , their use as a support in the in vitro growth of epithelial cells, the artificial skin obtained in this manner, and its use in skin grafts
CA002043527A CA2043527C (en) 1990-06-01 1991-05-30 Biocompatible perforated membranes, processes for their preparation, and uses thereof
FI912591A FI108918B (fi) 1990-06-01 1991-05-30 Biologisesti yhteen sopivat membraanit
TW080104245A TW208652B (it) 1990-06-01 1991-05-30
UY23231A UY23231A1 (es) 1990-06-01 1991-05-31 Membranas biocompatibles perforadas, procedimiento para su preparación, su uso como soporte para el desarrollo in vitro de células epiteliales y la piel artificial obtenida de ese modo.-
KR1019910008999A KR100195574B1 (ko) 1990-06-01 1991-05-31 생체 적합성 천공막 및 이의 제조방법
PT97832A PT97832B (pt) 1990-06-01 1991-05-31 Processo para a preparacao de membranas biocompativeis perfuradas e de pele artificial
JP12924591A JP3202257B2 (ja) 1990-06-01 1991-05-31 生物適合性の被穿孔膜
HU911834A HU215534B (hu) 1990-06-01 1991-05-31 Biokompatíbilis, perforált membránok, eljárás előállításukra, hámszövet sejtek in vitro növekedésének elősegítésére való alkalmazásuk és az így kapott mesterséges bőr
US08/019,818 US5326356A (en) 1990-06-01 1993-02-16 Biocompatible perforated membranes, processes for their preparation, their use as a support in the in vitro growth of epithelial cells, the artificial skin obtained in this manner, and its use in skin grafts
US08/209,626 US5650164A (en) 1990-06-01 1994-03-14 Process for preparing artificial skin with biocompatible perforated membranes
US08/478,541 US5658331A (en) 1990-06-01 1995-06-07 Biocompatible perforated membranes, processes for their preparation, their use as a support in the in vitro growth of epithelial cells, the artificial skin obtained in this manner, and its use in skin grafts
GR970402714T GR3025075T3 (en) 1990-06-01 1997-10-16 Biocompatible perforated membranes and their use as artificial skin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT02051390A IT1248934B (it) 1990-06-01 1990-06-01 Membrane forate biocompatibili,processi per la loro preparazione,loro impiego come supporto per la crescita in vitro di cellule epiteliali, pelli artificiali cosi' ottenute e loro impiego nei trapianti di pelle

Publications (3)

Publication Number Publication Date
IT9020513A0 IT9020513A0 (it) 1990-06-01
IT9020513A1 IT9020513A1 (it) 1991-12-01
IT1248934B true IT1248934B (it) 1995-02-11

Family

ID=11168072

Family Applications (1)

Application Number Title Priority Date Filing Date
IT02051390A IT1248934B (it) 1990-06-01 1990-06-01 Membrane forate biocompatibili,processi per la loro preparazione,loro impiego come supporto per la crescita in vitro di cellule epiteliali, pelli artificiali cosi' ottenute e loro impiego nei trapianti di pelle

Country Status (24)

Country Link
US (3) US5326356A (it)
EP (1) EP0462426B1 (it)
JP (1) JP3202257B2 (it)
KR (1) KR100195574B1 (it)
AR (1) AR244354A1 (it)
AT (1) ATE156689T1 (it)
AU (1) AU637235B2 (it)
BR (1) BR9102225A (it)
CA (1) CA2043527C (it)
DE (1) DE69127235T2 (it)
DK (1) DK0462426T3 (it)
ES (1) ES2108019T3 (it)
FI (1) FI108918B (it)
GR (1) GR3025075T3 (it)
HU (1) HU215534B (it)
IE (1) IE911825A1 (it)
IL (1) IL98255A (it)
IT (1) IT1248934B (it)
NO (1) NO303562B1 (it)
PT (1) PT97832B (it)
SG (1) SG52545A1 (it)
TW (1) TW208652B (it)
UY (1) UY23231A1 (it)
ZA (1) ZA914098B (it)

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US5326356A (en) 1994-07-05
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