IS2674B - Aðferð við framleiðslu á handhverfulega hreinu mírtasapíni - Google Patents

Aðferð við framleiðslu á handhverfulega hreinu mírtasapíni

Info

Publication number: IS2674B
Authority: IS; Iceland
Prior art keywords: myrtasapine; production; enantiomerically pure; enantiomerically; pure
Prior art date: 2003-07-10

Application number

IS8184A

Other languages

English (en)

Other versions

IS8184A (is

Inventor

Johannes Hubertus Wieringa

Adrianus Antonius Martinus Van De Ven

Gerardus Johannes Kamperman

Original Assignee

Organon Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-07-10

Filing date

2005-12-15

Publication date

2010-09-15

2005-12-15 Application filed by Organon Nv filed Critical Organon Nv

2005-12-15 Publication of IS8184A publication Critical patent/IS8184A/is

2010-09-15 Publication of IS2674B publication Critical patent/IS2674B/is

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

IS8184A 2003-07-10 2005-12-15 Aðferð við framleiðslu á handhverfulega hreinu mírtasapíni IS2674B (is)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP03102095		2003-07-10
PCT/EP2004/051357 WO2005005410A1 (en)	2003-07-10	2004-07-05	A method for the preparation of enantiomerically pure mirtazapine

Publications (2)

Publication Number	Publication Date
IS8184A IS8184A (is)	2005-12-15
IS2674B true IS2674B (is)	2010-09-15

Family

ID=34042934

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS8184A IS2674B (is)	2003-07-10	2005-12-15	Aðferð við framleiðslu á handhverfulega hreinu mírtasapíni

Country Status (36)

Country	Link
US (2)	US8058436B2 (is)
EP (1)	EP1656365B1 (is)
JP (1)	JP4668184B2 (is)
KR (1)	KR20060056315A (is)
CN (1)	CN100558722C (is)
AR (1)	AR046494A1 (is)
AT (1)	ATE433965T1 (is)
AU (1)	AU2004255874B2 (is)
BR (1)	BRPI0412447A (is)
CA (1)	CA2531165C (is)
CO (1)	CO5640123A2 (is)
CY (1)	CY1109327T1 (is)
DE (1)	DE602004021605D1 (is)
DK (1)	DK1656365T3 (is)
EC (1)	ECSP066271A (is)
ES (1)	ES2327123T3 (is)
HK (1)	HK1086841A1 (is)
HR (1)	HRP20051019A2 (is)
IL (1)	IL172549A0 (is)
IS (1)	IS2674B (is)
LT (1)	LT5382B (is)
LV (1)	LV13441B (is)
MX (1)	MXPA06000325A (is)
NO (1)	NO20056175L (is)
NZ (1)	NZ544360A (is)
PE (1)	PE20050323A1 (is)
PL (1)	PL1656365T3 (is)
PT (1)	PT1656365E (is)
RS (1)	RS20050972A (is)
RU (1)	RU2352566C2 (is)
SG (1)	SG144914A1 (is)
SI (1)	SI1656365T1 (is)
TW (1)	TWI335915B (is)
UA (1)	UA83666C2 (is)
WO (1)	WO2005005410A1 (is)
ZA (1)	ZA200600019B (is)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20090275749A1 (en) *	2005-09-26	2009-11-05	Hiroshi Maeda	Production method of optically active piperazine compound
JP5080050B2 (ja) *	2005-09-26	2012-11-21	住友化学株式会社	光学活性なピペラジン化合物の製造方法
TW200808804A (en) *	2006-05-22	2008-02-16	Organon Nv	Mirtazapine for the treatment of neuropathic pain
TW200815370A (en) *	2006-06-16	2008-04-01	Organon Nv	Stereoselective synthesis of (S)-1-methyl-3-phenylpiperazine
US8273883B2 (en)	2007-02-09	2012-09-25	Kaneka Corporation	Method for producing optically active 2-arylpiperazine derivative
JP5192707B2 (ja) *	2007-03-22	2013-05-08	住友化学株式会社	ミルタザピンの製造方法
US7994314B2 (en)	2007-04-11	2011-08-09	N.V. Organon	Method for the preparation of an enantiomerically pure benzazepine
JP5635905B2 (ja) *	2007-04-11	2014-12-03	メルク・シャープ・エンド・ドーム・ベー・フェー	ミルタザピンの調製方法
KR101485418B1 (ko) *	2013-05-29	2015-01-26	주식회사 메디켐코리아	고순도 미르타자핀의 제조방법
PT3261645T (pt)	2015-02-27	2021-06-17	Dechra Ltd	Estimulação do apetite, gestão da perda de peso, e tratamento da anorexia em cães e gatos
KR102540021B1 (ko) *	2020-12-02	2023-06-07	(주)유케이케미팜	대량 생산에 적합한 미르타자핀의 제조방법

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3959470A (en) *	1972-11-28	1976-05-25	Mikhail Davidovich Mashkovsky	Psychotropic medicinal preparation
NL189199C (nl) *	1975-04-05	1993-02-01	Akzo Nv	Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten.
NO175781C (no) *	1989-10-05	1994-12-07	Sankyo Co	Analogifremgangsmåte for fremstilling av terapeutisk aktive tetracykliske forbindelser
CZ296282B6 (cs)	1997-11-14	2006-02-15	Akzo Nobel N. V.	Farmaceutický prostredek
JPH11222407A (ja) *	1997-11-14	1999-08-17	Sankyo Co Ltd	新規殺菌剤
SK14672001A3 (sk) *	1999-04-19	2002-11-06	Teva Pharmaceutical Industries Ltd.	Spôsob syntézy a kryštalizácie zlúčenín obsahujúcich piperazínový kruh
US20030069417A1 (en) *	1999-04-19	2003-04-10	Claude Singer	Novel synthesis and crystallization of piperazine ring-containing compounds
US6068695A (en) *	1999-07-13	2000-05-30	Bayer Corporation	Process for the continuous preparation of quinacridones
AU6476300A (en)	1999-09-30	2001-05-10	Sumika Fine Chemicals Co., Ltd.	Process for the preparation of a piperazine derivative
AU6474200A (en)	1999-12-13	2001-06-18	Sumika Fine Chemicals Co., Ltd.	Process for the preparation of a pyridinemethanol compound
DE60117122T2 (de)	2000-02-11	2006-07-27	Akzo Nobel N.V.	Verwendung von mirtazapin zur behandlung von schlafstörungen
JP2001342188A (ja) *	2000-03-27	2001-12-11	Takeda Chem Ind Ltd	縮合ピラゾール誘導体、その製造法および用途
TW200538100A (en) *	2004-04-21	2005-12-01	Akzo Nobel Nv	Mirtazapine salts

2004
- 2004-05-07 UA UAA200600274A patent/UA83666C2/ru unknown
- 2004-06-28 TW TW093118845A patent/TWI335915B/zh not_active IP Right Cessation
- 2004-07-05 BR BRPI0412447-2A patent/BRPI0412447A/pt not_active IP Right Cessation
- 2004-07-05 US US10/564,193 patent/US8058436B2/en not_active Expired - Fee Related
- 2004-07-05 AT AT04741958T patent/ATE433965T1/de active
- 2004-07-05 DE DE602004021605T patent/DE602004021605D1/de not_active Expired - Lifetime
- 2004-07-05 ES ES04741958T patent/ES2327123T3/es not_active Expired - Lifetime
- 2004-07-05 NZ NZ544360A patent/NZ544360A/en not_active IP Right Cessation
- 2004-07-05 CA CA2531165A patent/CA2531165C/en not_active Expired - Fee Related
- 2004-07-05 CN CNB2004800194891A patent/CN100558722C/zh not_active Expired - Lifetime
- 2004-07-05 RU RU2006103992/04A patent/RU2352566C2/ru not_active IP Right Cessation
- 2004-07-05 WO PCT/EP2004/051357 patent/WO2005005410A1/en active IP Right Grant
- 2004-07-05 SG SG200805127-8A patent/SG144914A1/en unknown
- 2004-07-05 AU AU2004255874A patent/AU2004255874B2/en not_active Expired
- 2004-07-05 KR KR1020067000511A patent/KR20060056315A/ko active IP Right Grant
- 2004-07-05 JP JP2006518216A patent/JP4668184B2/ja not_active Expired - Lifetime
- 2004-07-05 RS YUP-2005/0972A patent/RS20050972A/sr unknown
- 2004-07-05 MX MXPA06000325A patent/MXPA06000325A/es active IP Right Grant
- 2004-07-05 EP EP04741958A patent/EP1656365B1/en not_active Expired - Lifetime
- 2004-07-05 SI SI200431183T patent/SI1656365T1/sl unknown
- 2004-07-05 PT PT04741958T patent/PT1656365E/pt unknown
- 2004-07-05 DK DK04741958T patent/DK1656365T3/da active
- 2004-07-05 PL PL04741958T patent/PL1656365T3/pl unknown
- 2004-07-07 PE PE2004000653A patent/PE20050323A1/es not_active Application Discontinuation
- 2004-07-08 AR ARP040102412A patent/AR046494A1/es not_active Application Discontinuation
2005
- 2005-12-12 LT LT2005107A patent/LT5382B/lt not_active IP Right Cessation
- 2005-12-13 IL IL172549A patent/IL172549A0/en not_active IP Right Cessation
- 2005-12-15 IS IS8184A patent/IS2674B/is unknown
- 2005-12-22 HR HR20051019A patent/HRP20051019A2/xx not_active Application Discontinuation
- 2005-12-23 NO NO20056175A patent/NO20056175L/no not_active Application Discontinuation
2006
- 2006-01-03 ZA ZA200600019A patent/ZA200600019B/en unknown
- 2006-01-09 EC EC2006006271A patent/ECSP066271A/es unknown
- 2006-01-10 CO CO06001617A patent/CO5640123A2/es not_active Application Discontinuation
- 2006-02-10 LV LVP-06-21A patent/LV13441B/en unknown
- 2006-08-17 HK HK06109133.3A patent/HK1086841A1/xx not_active IP Right Cessation
2008
- 2008-07-02 US US12/667,969 patent/US20100179319A1/en not_active Abandoned
2009
- 2009-08-25 CY CY20091100894T patent/CY1109327T1/el unknown

Also Published As

Publication number	Publication date
HK1086841A1 (en)	2006-09-29
TW200510426A (en)	2005-03-16
BRPI0412447A (pt)	2006-09-19
SI1656365T1 (sl)	2009-10-31
ECSP066271A (es)	2006-07-28
RU2352566C2 (ru)	2009-04-20
ES2327123T3 (es)	2009-10-26
CN100558722C (zh)	2009-11-11
US8058436B2 (en)	2011-11-15
CY1109327T1 (el)	2014-07-02
EP1656365A1 (en)	2006-05-17
PE20050323A1 (es)	2005-05-16
AU2004255874A1 (en)	2005-01-20
MXPA06000325A (es)	2006-03-30
US20060229300A1 (en)	2006-10-12
RU2006103992A (ru)	2006-06-27
JP4668184B2 (ja)	2011-04-13
SG144914A1 (en)	2008-08-28
CA2531165A1 (en)	2005-01-20
EP1656365B1 (en)	2009-06-17
LT5382B (lt)	2006-11-27
PT1656365E (pt)	2009-09-01
LV13441B (en)	2006-08-20
ZA200600019B (en)	2007-01-31
LT2005107A (en)	2006-06-27
DE602004021605D1 (de)	2009-07-30
JP2009513537A (ja)	2009-04-02
CO5640123A2 (es)	2006-05-31
ATE433965T1 (de)	2009-07-15
PL1656365T3 (pl)	2009-10-30
RS20050972A (en)	2008-06-05
IL172549A0 (en)	2006-04-10
KR20060056315A (ko)	2006-05-24
NZ544360A (en)	2008-05-30
CA2531165C (en)	2011-08-30
TWI335915B (en)	2011-01-11
UA83666C2 (ru)	2008-08-11
AR046494A1 (es)	2005-12-14
DK1656365T3 (da)	2009-09-14
HRP20051019A2 (en)	2006-02-28
NO20056175L (no)	2006-01-23
US20100179319A1 (en)	2010-07-15
CN1820000A (zh)	2006-08-16
WO2005005410A1 (en)	2005-01-20
AU2004255874B2 (en)	2010-10-28
IS8184A (is)	2005-12-15

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