BRPI0412447A - método para a preparação de mirtazapina enantiomericamente pura, e, método para a seleção de um ácido ou uma combinação ácido/solvente apropriada para uma reação de fechamento de anel estereoespecìfica de composto enantiomericamente puro - Google Patents
método para a preparação de mirtazapina enantiomericamente pura, e, método para a seleção de um ácido ou uma combinação ácido/solvente apropriada para uma reação de fechamento de anel estereoespecìfica de composto enantiomericamente puroInfo
- Publication number
- BRPI0412447A BRPI0412447A BRPI0412447-2A BRPI0412447A BRPI0412447A BR PI0412447 A BRPI0412447 A BR PI0412447A BR PI0412447 A BRPI0412447 A BR PI0412447A BR PI0412447 A BRPI0412447 A BR PI0412447A
- Authority
- BR
- Brazil
- Prior art keywords
- enantiomerically pure
- acid
- solvent
- ring
- mirtazapine
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 5
- RONZAEMNMFQXRA-UHFFFAOYSA-N mirtazapine Chemical compound C1C2=CC=CN=C2N2CCN(C)CC2C2=CC=CC=C21 RONZAEMNMFQXRA-UHFFFAOYSA-N 0.000 title abstract 4
- 229960001785 mirtazapine Drugs 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000002904 solvent Substances 0.000 title abstract 3
- 238000007363 ring formation reaction Methods 0.000 title abstract 2
- -1 COMPOUND COMPOUND Chemical group 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
"MéTODO PARA A PREPARAçãO DE MIRTAZAPINA ENANTIOMERICAMENTE PURA, E, MéTODO PARA A SELEçãO DE UM ACIDO OU UMA COMBINAçãO áCIDO/SOLVENTE APROPRIADA PARA UMA REAçãO DE FECHAMENTO DE ANEL ESTEREOESPECìFICA DE COMPOSTO ENANTIOMERICAMENTE PURO". A invenção provê um método para a preparação de mirtazapina enantiomericamente pura, compreendendo uma etapa de fechamento de anel de um composto de fórmula (II) em que X é um grupo de saída, cuja a etapa compreende o tratamento com um ácido, pelo que mirtazapina com excesso enantiomérico é formada pelo fechamento de anel do composto de fórmula (II) com excesso enantiomérico por tratamento com um ácido apropriado na ausência de um solvente ou uma combinação apropriada de um ácido e um solvente orgânico.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03102095 | 2003-07-10 | ||
| PCT/EP2004/051357 WO2005005410A1 (en) | 2003-07-10 | 2004-07-05 | A method for the preparation of enantiomerically pure mirtazapine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0412447A true BRPI0412447A (pt) | 2006-09-19 |
Family
ID=34042934
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0412447-2A BRPI0412447A (pt) | 2003-07-10 | 2004-07-05 | método para a preparação de mirtazapina enantiomericamente pura, e, método para a seleção de um ácido ou uma combinação ácido/solvente apropriada para uma reação de fechamento de anel estereoespecìfica de composto enantiomericamente puro |
Country Status (36)
| Country | Link |
|---|---|
| US (2) | US8058436B2 (pt) |
| EP (1) | EP1656365B1 (pt) |
| JP (1) | JP4668184B2 (pt) |
| KR (1) | KR20060056315A (pt) |
| CN (1) | CN100558722C (pt) |
| AR (1) | AR046494A1 (pt) |
| AT (1) | ATE433965T1 (pt) |
| AU (1) | AU2004255874B2 (pt) |
| BR (1) | BRPI0412447A (pt) |
| CA (1) | CA2531165C (pt) |
| CO (1) | CO5640123A2 (pt) |
| CY (1) | CY1109327T1 (pt) |
| DE (1) | DE602004021605D1 (pt) |
| DK (1) | DK1656365T3 (pt) |
| EC (1) | ECSP066271A (pt) |
| ES (1) | ES2327123T3 (pt) |
| HK (1) | HK1086841A1 (pt) |
| HR (1) | HRP20051019A2 (pt) |
| IL (1) | IL172549A0 (pt) |
| IS (1) | IS2674B (pt) |
| LT (1) | LT5382B (pt) |
| LV (1) | LV13441B (pt) |
| MX (1) | MXPA06000325A (pt) |
| NO (1) | NO20056175L (pt) |
| NZ (1) | NZ544360A (pt) |
| PE (1) | PE20050323A1 (pt) |
| PL (1) | PL1656365T3 (pt) |
| PT (1) | PT1656365E (pt) |
| RS (1) | RS20050972A (pt) |
| RU (1) | RU2352566C2 (pt) |
| SG (1) | SG144914A1 (pt) |
| SI (1) | SI1656365T1 (pt) |
| TW (1) | TWI335915B (pt) |
| UA (1) | UA83666C2 (pt) |
| WO (1) | WO2005005410A1 (pt) |
| ZA (1) | ZA200600019B (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090275749A1 (en) * | 2005-09-26 | 2009-11-05 | Hiroshi Maeda | Production method of optically active piperazine compound |
| JP5080050B2 (ja) * | 2005-09-26 | 2012-11-21 | 住友化学株式会社 | 光学活性なピペラジン化合物の製造方法 |
| TW200808804A (en) * | 2006-05-22 | 2008-02-16 | Organon Nv | Mirtazapine for the treatment of neuropathic pain |
| TW200815370A (en) * | 2006-06-16 | 2008-04-01 | Organon Nv | Stereoselective synthesis of (S)-1-methyl-3-phenylpiperazine |
| US8273883B2 (en) | 2007-02-09 | 2012-09-25 | Kaneka Corporation | Method for producing optically active 2-arylpiperazine derivative |
| JP5192707B2 (ja) * | 2007-03-22 | 2013-05-08 | 住友化学株式会社 | ミルタザピンの製造方法 |
| US7994314B2 (en) | 2007-04-11 | 2011-08-09 | N.V. Organon | Method for the preparation of an enantiomerically pure benzazepine |
| JP5635905B2 (ja) * | 2007-04-11 | 2014-12-03 | メルク・シャープ・エンド・ドーム・ベー・フェー | ミルタザピンの調製方法 |
| KR101485418B1 (ko) * | 2013-05-29 | 2015-01-26 | 주식회사 메디켐코리아 | 고순도 미르타자핀의 제조방법 |
| PT3261645T (pt) | 2015-02-27 | 2021-06-17 | Dechra Ltd | Estimulação do apetite, gestão da perda de peso, e tratamento da anorexia em cães e gatos |
| KR102540021B1 (ko) * | 2020-12-02 | 2023-06-07 | (주)유케이케미팜 | 대량 생산에 적합한 미르타자핀의 제조방법 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3959470A (en) * | 1972-11-28 | 1976-05-25 | Mikhail Davidovich Mashkovsky | Psychotropic medicinal preparation |
| NL189199C (nl) * | 1975-04-05 | 1993-02-01 | Akzo Nv | Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten. |
| NO175781C (no) * | 1989-10-05 | 1994-12-07 | Sankyo Co | Analogifremgangsmåte for fremstilling av terapeutisk aktive tetracykliske forbindelser |
| CZ296282B6 (cs) | 1997-11-14 | 2006-02-15 | Akzo Nobel N. V. | Farmaceutický prostredek |
| JPH11222407A (ja) * | 1997-11-14 | 1999-08-17 | Sankyo Co Ltd | 新規殺菌剤 |
| SK14672001A3 (sk) * | 1999-04-19 | 2002-11-06 | Teva Pharmaceutical Industries Ltd. | Spôsob syntézy a kryštalizácie zlúčenín obsahujúcich piperazínový kruh |
| US20030069417A1 (en) * | 1999-04-19 | 2003-04-10 | Claude Singer | Novel synthesis and crystallization of piperazine ring-containing compounds |
| US6068695A (en) * | 1999-07-13 | 2000-05-30 | Bayer Corporation | Process for the continuous preparation of quinacridones |
| AU6476300A (en) | 1999-09-30 | 2001-05-10 | Sumika Fine Chemicals Co., Ltd. | Process for the preparation of a piperazine derivative |
| AU6474200A (en) | 1999-12-13 | 2001-06-18 | Sumika Fine Chemicals Co., Ltd. | Process for the preparation of a pyridinemethanol compound |
| DE60117122T2 (de) | 2000-02-11 | 2006-07-27 | Akzo Nobel N.V. | Verwendung von mirtazapin zur behandlung von schlafstörungen |
| JP2001342188A (ja) * | 2000-03-27 | 2001-12-11 | Takeda Chem Ind Ltd | 縮合ピラゾール誘導体、その製造法および用途 |
| TW200538100A (en) * | 2004-04-21 | 2005-12-01 | Akzo Nobel Nv | Mirtazapine salts |
-
2004
- 2004-05-07 UA UAA200600274A patent/UA83666C2/ru unknown
- 2004-06-28 TW TW093118845A patent/TWI335915B/zh not_active IP Right Cessation
- 2004-07-05 BR BRPI0412447-2A patent/BRPI0412447A/pt not_active IP Right Cessation
- 2004-07-05 US US10/564,193 patent/US8058436B2/en not_active Expired - Fee Related
- 2004-07-05 AT AT04741958T patent/ATE433965T1/de active
- 2004-07-05 DE DE602004021605T patent/DE602004021605D1/de not_active Expired - Lifetime
- 2004-07-05 ES ES04741958T patent/ES2327123T3/es not_active Expired - Lifetime
- 2004-07-05 NZ NZ544360A patent/NZ544360A/en not_active IP Right Cessation
- 2004-07-05 CA CA2531165A patent/CA2531165C/en not_active Expired - Fee Related
- 2004-07-05 CN CNB2004800194891A patent/CN100558722C/zh not_active Expired - Lifetime
- 2004-07-05 RU RU2006103992/04A patent/RU2352566C2/ru not_active IP Right Cessation
- 2004-07-05 WO PCT/EP2004/051357 patent/WO2005005410A1/en active IP Right Grant
- 2004-07-05 SG SG200805127-8A patent/SG144914A1/en unknown
- 2004-07-05 AU AU2004255874A patent/AU2004255874B2/en not_active Expired
- 2004-07-05 KR KR1020067000511A patent/KR20060056315A/ko active IP Right Grant
- 2004-07-05 JP JP2006518216A patent/JP4668184B2/ja not_active Expired - Lifetime
- 2004-07-05 RS YUP-2005/0972A patent/RS20050972A/sr unknown
- 2004-07-05 MX MXPA06000325A patent/MXPA06000325A/es active IP Right Grant
- 2004-07-05 EP EP04741958A patent/EP1656365B1/en not_active Expired - Lifetime
- 2004-07-05 SI SI200431183T patent/SI1656365T1/sl unknown
- 2004-07-05 PT PT04741958T patent/PT1656365E/pt unknown
- 2004-07-05 DK DK04741958T patent/DK1656365T3/da active
- 2004-07-05 PL PL04741958T patent/PL1656365T3/pl unknown
- 2004-07-07 PE PE2004000653A patent/PE20050323A1/es not_active Application Discontinuation
- 2004-07-08 AR ARP040102412A patent/AR046494A1/es not_active Application Discontinuation
-
2005
- 2005-12-12 LT LT2005107A patent/LT5382B/lt not_active IP Right Cessation
- 2005-12-13 IL IL172549A patent/IL172549A0/en not_active IP Right Cessation
- 2005-12-15 IS IS8184A patent/IS2674B/is unknown
- 2005-12-22 HR HR20051019A patent/HRP20051019A2/xx not_active Application Discontinuation
- 2005-12-23 NO NO20056175A patent/NO20056175L/no not_active Application Discontinuation
-
2006
- 2006-01-03 ZA ZA200600019A patent/ZA200600019B/en unknown
- 2006-01-09 EC EC2006006271A patent/ECSP066271A/es unknown
- 2006-01-10 CO CO06001617A patent/CO5640123A2/es not_active Application Discontinuation
- 2006-02-10 LV LVP-06-21A patent/LV13441B/en unknown
- 2006-08-17 HK HK06109133.3A patent/HK1086841A1/xx not_active IP Right Cessation
-
2008
- 2008-07-02 US US12/667,969 patent/US20100179319A1/en not_active Abandoned
-
2009
- 2009-08-25 CY CY20091100894T patent/CY1109327T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: PARA: INT. CL. C07D 401/04, 471/14; A61P 25/24 Ipc: C07D 401/04 (2011.01), C07D 471/14 (2011.01), A61P |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 9A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2259 DE 22/04/2014. |