[go: up one dir, main page]

IL312114A - תרכובות קינולין כמעכבות קראס - Google Patents

תרכובות קינולין כמעכבות קראס

Info

Publication number
IL312114A
IL312114A IL312114A IL31211424A IL312114A IL 312114 A IL312114 A IL 312114A IL 312114 A IL312114 A IL 312114A IL 31211424 A IL31211424 A IL 31211424A IL 312114 A IL312114 A IL 312114A
Authority
IL
Israel
Prior art keywords
alkyl
independently selected
haloalkyl
membered heterocycloalkyl
membered heteroaryl
Prior art date
Application number
IL312114A
Other languages
English (en)
Inventor
Peter Carlsen
Gia Hoang
Bin Hu
Gencheng Li
Matthew Mccammant
Padmaja Polam
Rocco Policarpo
Chao Qi
Jeremy Roach
Artem Shvartsbart
Alexander Sokolsky
Robert Susick
xiaozhao Wang
Wenqing Yao
Qinda Ye
Haolin Yin
Fenglei Zhang
Le Zhao
Wenyu Zhu
Original Assignee
Incyte Corp
Peter Carlsen
Gia Hoang
Bin Hu
Gencheng Li
Matthew Mccammant
Padmaja Polam
Rocco Policarpo
Chao Qi
Jeremy Roach
Artem Shvartsbart
Alexander Sokolsky
Robert Susick
xiaozhao Wang
Wenqing Yao
Qinda Ye
Haolin Yin
Fenglei Zhang
Le Zhao
Wenyu Zhu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp, Peter Carlsen, Gia Hoang, Bin Hu, Gencheng Li, Matthew Mccammant, Padmaja Polam, Rocco Policarpo, Chao Qi, Jeremy Roach, Artem Shvartsbart, Alexander Sokolsky, Robert Susick, xiaozhao Wang, Wenqing Yao, Qinda Ye, Haolin Yin, Fenglei Zhang, Le Zhao, Wenyu Zhu filed Critical Incyte Corp
Publication of IL312114A publication Critical patent/IL312114A/he

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL312114A 2021-10-14 2022-10-13 תרכובות קינולין כמעכבות קראס IL312114A (he)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163255610P 2021-10-14 2021-10-14
US202163279464P 2021-11-15 2021-11-15
US202263363270P 2022-04-20 2022-04-20
US202263368563P 2022-07-15 2022-07-15
PCT/US2022/078048 WO2023064857A1 (en) 2021-10-14 2022-10-13 Quinoline compounds as inhibitors of kras

Publications (1)

Publication Number Publication Date
IL312114A true IL312114A (he) 2024-06-01

Family

ID=84330780

Family Applications (1)

Application Number Title Priority Date Filing Date
IL312114A IL312114A (he) 2021-10-14 2022-10-13 תרכובות קינולין כמעכבות קראס

Country Status (16)

Country Link
US (2) US11939328B2 (he)
EP (1) EP4415824A1 (he)
JP (1) JP2024539651A (he)
KR (1) KR20240101561A (he)
AU (1) AU2022367432A1 (he)
CA (1) CA3235146A1 (he)
CL (1) CL2024001070A1 (he)
CO (1) CO2024006030A2 (he)
CR (1) CR20240197A (he)
DO (1) DOP2024000069A (he)
EC (1) ECSP24035717A (he)
IL (1) IL312114A (he)
MX (1) MX2024004444A (he)
PE (1) PE20242113A1 (he)
TW (1) TW202322810A (he)
WO (1) WO2023064857A1 (he)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2023218370B2 (en) 2022-02-09 2024-11-28 Quanta Therapeutics, Inc. Kras modulators and uses thereof
IL317601A (he) 2022-05-25 2025-02-01 Quanta Therapeutics Inc מאפננים מבוססי פירימידין ושימושים שלהם
WO2024015731A1 (en) * 2022-07-11 2024-01-18 Incyte Corporation Fused tricyclic compounds as inhibitors of kras g12v mutants
WO2024206858A1 (en) 2023-03-30 2024-10-03 Revolution Medicines, Inc. Compositions for inducing ras gtp hydrolysis and uses thereof
WO2024220645A1 (en) * 2023-04-18 2024-10-24 Incyte Corporation 2-azabicyclo[2.2.1]heptane kras inhibitors
WO2024229406A1 (en) 2023-05-04 2024-11-07 Revolution Medicines, Inc. Combination therapy for a ras related disease or disorder
WO2025008012A1 (en) * 2023-07-01 2025-01-09 Univerzita Palackeho V Olomouci Pyrroloquinolines and their use as tubuline assembly inhibitors
US20250049810A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder

Family Cites Families (184)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8717644D0 (en) 1987-07-24 1987-09-03 Smithkline Beckman Intercredit Compounds
GB8928281D0 (en) 1989-12-14 1990-02-21 Smith Kline French Lab Compounds
US5521184A (en) 1992-04-03 1996-05-28 Ciba-Geigy Corporation Pyrimidine derivatives and processes for the preparation thereof
FR2695126B1 (fr) 1992-08-27 1994-11-10 Sanofi Elf Dérivés d'acide thiényl ou pyrrolyl carboxyliques, leur préparation et médicaments les contenant.
US5281608A (en) 1992-08-28 1994-01-25 American Home Products Corporation Substituted tetrahydropyrido[3',4':4,5]-pyrrolo[3,2-c]quinolines
DE69309670T2 (de) 1992-12-28 1997-11-20 Eisai Co Ltd Heterocyclische carbonsäure-derivate, die an rar rezeptoren binden können
EP0632102B1 (de) 1993-06-28 1997-04-02 Bayer Ag Massefärben von Kunststoffen
US5547975A (en) 1994-09-20 1996-08-20 Talley; John J. Benzopyranopyrazolyl derivatives for the treatment of inflammation
AU4583599A (en) 1998-06-25 2000-01-10 Sepracor, Inc. Di- and tetra-hydroquinoline-indole antimicrobial agents, uses and compositions related thereto
WO2000009495A1 (en) 1998-08-11 2000-02-24 Novartis Ag Isoquinoline derivatives with angiogenesis inhibiting activity
US6133031A (en) 1999-08-19 2000-10-17 Isis Pharmaceuticals Inc. Antisense inhibition of focal adhesion kinase expression
EP1147113B1 (en) 1999-01-19 2006-06-07 Neurosearch A/S Fused heterocyclic compounds and their use in the treatment of neurodegenerative diseases
GB9905075D0 (en) 1999-03-06 1999-04-28 Zeneca Ltd Chemical compounds
TWI271406B (en) 1999-12-13 2007-01-21 Eisai Co Ltd Tricyclic condensed heterocyclic compounds, preparation method of the same and pharmaceuticals comprising the same
GB0004890D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
EP1142889A1 (en) 2000-04-03 2001-10-10 Pfizer Products Inc. Pyrazole derivatives as anti-inflammatory/analgesic agents
AU2002215608B2 (en) 2000-06-28 2004-12-09 Smithkline Beecham P.L.C. Wet milling process
US7169922B2 (en) 2000-08-04 2007-01-30 Invitrogen Corporation Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings
US6576644B2 (en) 2000-09-06 2003-06-10 Bristol-Myers Squibb Co. Quinoline inhibitors of cGMP phosphodiesterase
BR0212760A (pt) 2001-09-19 2004-12-07 Aventis Pharma Sa Compostos quìmicos
US7250423B2 (en) 2001-09-24 2007-07-31 Chao-Jun Li Methods for synthesizing heterocycles and therapeutic use of the heterocycles for cancers
KR20090087139A (ko) 2001-10-30 2009-08-14 노파르티스 아게 Flt3 수용체 티로신 키나아제 활성의 억제제로서의 스타우로스포린 유도체
EP1456652A4 (en) 2001-11-13 2005-11-02 Dana Farber Cancer Inst Inc IMMUNOCELL ACTIVATION MODULATING SUBSTANCES AND USE METHOD THEREFOR
EA007395B3 (ru) 2002-01-22 2018-02-28 Уорнер-Ламберт Компани Ллс 2-(ПИРИДИН-2-ИЛАМИНО)ПИРИДО[2,3-d]ПИРИМИДИН-7-ОНЫ
AR037647A1 (es) 2002-05-29 2004-12-01 Novartis Ag Derivados de diarilurea utiles para el tratamiento de enfermedades dependientes de la cinasa de proteina
GB0215676D0 (en) 2002-07-05 2002-08-14 Novartis Ag Organic compounds
CL2003002353A1 (es) 2002-11-15 2005-02-04 Vertex Pharma Compuestos derivados de diaminotriazoles, inhibidores d ela proteina quinasa; composicion farmaceutica; procedimiento de preparacion; y su uso del compuesto en el tratamiento de enfermedades de desordenes alergicos, proliferacion, autoinmunes, condic
UA80767C2 (en) 2002-12-20 2007-10-25 Pfizer Prod Inc Pyrimidine derivatives for the treatment of abnormal cell growth
ATE514713T1 (de) 2002-12-23 2011-07-15 Wyeth Llc Antikörper gegen pd-1 und ihre verwendung
WO2004067513A1 (en) 2003-01-27 2004-08-12 Oy Juvantia Pharma Ltd Antagonists for alpha-2 adrenoceptors
GB0305929D0 (en) 2003-03-14 2003-04-23 Novartis Ag Organic compounds
US20050096256A1 (en) 2003-07-01 2005-05-05 President And Fellows Of Harvard College Compositions for manipulating the lifespan and stress response of cells and organisms
US20060025337A1 (en) 2003-07-01 2006-02-02 President And Fellows Of Harvard College Sirtuin related therapeutics and diagnostics for neurodegenerative diseases
ES2342069T4 (es) 2003-09-05 2011-01-26 Anadys Pharmaceuticals, Inc. Ligandos de tlr7 para el tratamiento de la hepatitis c.
PE20050952A1 (es) 2003-09-24 2005-12-19 Novartis Ag Derivados de isoquinolina como inhibidores de b-raf
RU2384571C2 (ru) 2004-04-28 2010-03-20 Такеда Фармасьютикал Компани Лимитед Конденсированное хинолиновое производное и его применение
US7897609B2 (en) 2004-06-18 2011-03-01 3M Innovative Properties Company Aryl substituted imidazonaphthyridines
JP2008511683A (ja) 2004-09-02 2008-04-17 スリーエム イノベイティブ プロパティズ カンパニー 2−アミノ1h−イミダゾ環構造および方法
EP1885352A2 (en) 2004-11-24 2008-02-13 Novartis AG Combinations comprising jak inhibitors and at least one of bcr-abl, flt-3, fak or raf kinase inhibitors
WO2006076681A2 (en) 2005-01-13 2006-07-20 Sirtris Pharmaceuticals, Inc. Novel compositions for preventing and treating neurodegenerative and blood coagulation disorders
JP2008528510A (ja) 2005-01-20 2008-07-31 サートリス ファーマシューティカルズ, インコーポレイテッド 紅潮および/または薬物誘発性体重増加を処置するためのサーチュイン活性化化合物の使用
US8658666B2 (en) 2005-02-11 2014-02-25 3M Innovative Properties Company Substituted imidazoquinolines and imidazonaphthyridines
US8158794B2 (en) 2005-02-23 2012-04-17 3M Innovative Properties Company Hydroxyalkyl substituted imidazoquinoline compounds and methods
CA2598437A1 (en) 2005-02-23 2006-08-31 Coley Pharmaceutical Group, Inc. Method of preferentially inducing the biosynthesis of interferon
EP2439272A3 (en) 2005-05-09 2013-07-31 Ono Pharmaceutical Co., Ltd. Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics
US7423045B2 (en) 2005-06-28 2008-09-09 Cv Therapeutics, Inc. ABCA1 elevating compounds
KR101411165B1 (ko) 2005-07-01 2014-06-25 메다렉스, 엘.엘.시. 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날항체
US20070149466A1 (en) 2005-07-07 2007-06-28 Michael Milburn Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders
GB0522715D0 (en) 2005-11-08 2005-12-14 Helperby Therapeutics Ltd New use
AU2007283595A1 (en) 2006-08-07 2008-02-14 Basf Se Substituted azolin-2-yl-amino compounds
WO2008035356A2 (en) 2006-09-20 2008-03-27 Glenmark Pharmaceuticals Limited Novel cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation
US7755533B2 (en) 2006-11-01 2010-07-13 Imsar Llc Interferometric switched beam radar apparatus and method
GB0709513D0 (en) 2007-05-17 2007-06-27 Helperby Therapeutics Ltd Topical formulations
JP2010514761A (ja) 2006-12-27 2010-05-06 ギリアード・パロ・アルト・インコーポレイテッド Abca1を上昇させる化合物
DE102007013856A1 (de) 2007-03-20 2008-09-25 Merck Patent Gmbh Substituierte Tetrahydropyrrolochinoline
EP1972629A1 (en) 2007-03-23 2008-09-24 Mutabilis SA New imidazolo-heteroaryl derivatives with antibacterial properties
US8354509B2 (en) 2007-06-18 2013-01-15 Msd Oss B.V. Antibodies to human programmed death receptor PD-1
FR2918061B1 (fr) 2007-06-28 2010-10-22 Sanofi Aventis Derives de 6-cycloamino-3-(pyridin-4-yl)imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique.
WO2009010824A1 (en) 2007-07-13 2009-01-22 Glenmark Pharmaceuticals, S.A. Dihydrochromenopyrazole derivatives as vanilloid receptor ligands
FR2918986B1 (fr) 2007-07-19 2009-09-04 Sanofi Aventis Sa Derives de 6-cycloamino-3-(pyridazin-4-yl)imidazo[1,2-b]- pyridazine, leur preparation et leur application en therapeutique
EP2231656A1 (en) 2007-12-19 2010-09-29 Amgen Inc. Fused pyridine, pyrimidine and triazine compounds as cell cycle inhibitors
US8168757B2 (en) 2008-03-12 2012-05-01 Merck Sharp & Dohme Corp. PD-1 binding proteins
US8436005B2 (en) 2008-04-03 2013-05-07 Abbott Laboratories Macrocyclic pyrimidine derivatives
FR2934994B1 (fr) 2008-08-12 2010-09-17 Sanofi Aventis Derives de 2-alkyl-6cycloamino-3-(pyridin-4-yl)imidaz°1,2-b! pyridazine, leur preparation et leur application en therapeutique
EP2324029A4 (en) 2008-09-10 2011-09-14 Kalypsys Inc HETEROCYCLIC HEMMER OF HISTAMINE RECEPTORS FOR DISEASE TREATMENT
PL2342226T3 (pl) 2008-09-26 2017-01-31 Dana-Farber Cancer Institute, Inc. Ludzkie przeciwciała anty-PD-1, PD-L1 i PD-L2 oraz ich zastosowania
US20110263588A1 (en) 2008-10-27 2011-10-27 Glaxo Group Limited Tricyclic compounds as glutamate receptor modulators
FR2939134A1 (fr) 2008-12-01 2010-06-04 Sanofi Aventis Derives de 6-cycloamino-3-(1h-pyrrolo°2,3-b!pyridin-4-yl) imidazo°1,2-b!-pyridazine, leur preparation et leur application en therapeutique
MX342591B (es) 2008-12-09 2016-10-05 Genentech Inc * Anticuerpos anti-pd-l1 y su uso para mejorar la función de células t.
FR2940285A1 (fr) 2008-12-19 2010-06-25 Sanofi Aventis Derives de 6-cycloamino-2-thienyl-3-(pyridin-4-yl)imidazo °1,2-b!-pyridazine et 6-cycloamino-2-furanyl-3- (pyridin-4-yl)imidazo°1,2-b!-pyridazine, leur preparation et leur application en therapeutique
FR2940284B1 (fr) 2008-12-19 2011-02-18 Sanofi Aventis Derives de 6-cycloamino-2,3-di-pyridinyl-imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique
PA8852901A1 (es) 2008-12-22 2010-07-27 Lilly Co Eli Inhibidores de proteina cinasa
GB0900404D0 (en) 2009-01-12 2009-02-11 Addex Pharmaceuticals Sa New compounds 4
ES2629337T3 (es) 2009-02-09 2017-08-08 Inserm - Institut National De La Santé Et De La Recherche Médicale Anticuerpos contra PD-1 y anticuerpos contra PD-L1 y usos de los mismos
FR2945289A1 (fr) 2009-05-11 2010-11-12 Sanofi Aventis Derives de 2-cycloamino-5-(pyridin-4-yl)imidazo°2,1-b! °1,3,4!thiadiazole, leur preparation et leur application en therapeutique
US20100298302A1 (en) 2009-05-20 2010-11-25 Fabrice Pierre Novel protein kinase modulators
US20110003776A1 (en) 2009-06-03 2011-01-06 Trustees Of Boston University Tetrahydropyranonaphthyridines derivatives, pharmaceutical compositions and therapeutic treatment thereof
JP2012532187A (ja) 2009-06-30 2012-12-13 ピラマル・ライフ・サイエンシーズ・リミテッド イミダゾ[4,5−c]キノリン誘導体ならびに腫瘍および/または炎症の治療におけるそれらの使用
KR101108154B1 (ko) 2009-08-10 2012-02-08 삼성모바일디스플레이주식회사 축합환 화합물 및 이를 포함한 유기층을 구비한 유기 발광 소자
CN102625708A (zh) 2009-09-09 2012-08-01 阿维拉制药公司 Pi3激酶抑制剂及其用途
GB0919423D0 (en) 2009-11-05 2009-12-23 Glaxosmithkline Llc Novel compounds
EP2504028A4 (en) 2009-11-24 2014-04-09 Amplimmune Inc SIMULTANEOUS INHIBITION OF PD-L1 / PD-L2
CN102115026A (zh) 2009-12-31 2011-07-06 清华大学 一维纳米结构、其制备方法及一维纳米结构作标记的方法
US20130022629A1 (en) 2010-01-04 2013-01-24 Sharpe Arlene H Modulators of Immunoinhibitory Receptor PD-1, and Methods of Use Thereof
UY33227A (es) 2010-02-19 2011-09-30 Novartis Ag Compuestos de pirrolopirimidina como inhibidores de la cdk4/6
WO2011103557A1 (en) 2010-02-22 2011-08-25 Advanced Cancer Therapeutics, Llc Small molecule inhibitors of pfkfb3 and glycolytic flux and their methods of use as anti-cancer therapeutics
EP2571877B1 (en) 2010-05-17 2018-08-15 Boehringer Ingelheim International GmbH 1h-imidazo[4,5-c]quinolines
DE102010024335A1 (de) 2010-06-18 2011-12-22 Merck Patent Gmbh Verbindungen für elektronische Vorrichtungen
US9163087B2 (en) 2010-06-18 2015-10-20 The Brigham And Women's Hospital, Inc. Bi-specific antibodies against TIM-3 and PD-1 for immunotherapy in chronic immune conditions
US8907053B2 (en) 2010-06-25 2014-12-09 Aurigene Discovery Technologies Limited Immunosuppression modulating compounds
JP5750158B2 (ja) 2010-07-16 2015-07-15 ピラマル エンタープライジーズ リミテッド キナーゼ阻害剤としての置換イミダゾキノリン誘導体
TW201206936A (en) 2010-07-19 2012-02-16 Alcon Res Ltd Methods and compositions for the treatment of allergy
WO2012011642A1 (ko) 2010-07-23 2012-01-26 고려대학교 산학협력단 염료감응 태양전지용 준고체 고분자 전해질, 그에 포함되는 정공수송물질, 및 그 전해질을 포함하는 염료감응 태양전지
ES2583528T3 (es) 2010-09-07 2016-09-21 Astellas Pharma Inc. Compuesto de pirazoloquinolina
CN102399218A (zh) 2010-09-16 2012-04-04 和记黄埔医药(上海)有限公司 一类并合三杂环及其作为pi3k抑制剂的用途
WO2012040924A1 (en) 2010-09-29 2012-04-05 Merck Sharp & Dohme Corp. Fused tetracyclic heterocycle compounds and methods of use thereof for treatment of viral diseases
WO2012041227A1 (en) 2010-09-29 2012-04-05 Merck Sharp & Dohme Corp. Tetracyclic heterocycle compounds for treating hepatitis c viral infection
EP3381920B1 (en) 2010-10-25 2019-03-27 G1 Therapeutics, Inc. Cdk inhibitors
CN102655637A (zh) 2011-03-01 2012-09-05 中兴通讯股份有限公司 一种移动通信系统和组网方法
DK2937349T3 (en) 2011-03-23 2017-02-20 Amgen Inc CONDENSED TRICYCLIC DUAL INHIBITORS OF CDK 4/6 AND FLT3
WO2012154731A1 (en) 2011-05-08 2012-11-15 Vanderbilt University Substituted 1h-pyrrolo[3,2-c]quinolin-4(5h)-one analogs as positive allosteric modulators of the muscarinic acetylcholine receptor m4
JP5742494B2 (ja) 2011-06-10 2015-07-01 住友化学株式会社 高分子化合物及びそれを用いた電子素子
JP5753027B2 (ja) 2011-08-22 2015-07-22 ユー・ディー・シー アイルランド リミテッド 有機電界発光素子、化合物、並びに該素子を用いた発光装置、表示装置及び照明装置
WO2013033268A2 (en) 2011-08-29 2013-03-07 Coferon, Inc. Bivalent bromodomain ligands, and methods of using same
WO2013033269A1 (en) 2011-08-29 2013-03-07 Coferon, Inc. Bioorthogonal monomers capable of dimerizing and targeting bromodomains and methods of using same
ES2527188T3 (es) 2011-09-26 2015-01-21 Sanofi Derivados de pirazolquinolinona, su preparación y su uso terapéutico
CN103012397B (zh) 2011-09-26 2017-03-01 赛诺菲 吡唑并喹啉酮衍生物、其制备方法及其治疗用途
US9169246B2 (en) 2011-09-26 2015-10-27 Sanofi Pyrazoloquinolinone derivatives, preparation thereof and therapeutic use thereof
WO2013052550A2 (en) 2011-10-04 2013-04-11 Janus Biotherapeutics, Inc. Novel imidazole quinoline-based immune system modulators
US8563565B2 (en) 2011-10-07 2013-10-22 Eisai R&D Management Co., Ltd. Pyrazoloquinoline derivatives
EA201490610A1 (ru) 2011-10-21 2014-09-30 ГЛАКСОСМИТКЛАЙН ЭлЭлСи Соединения и способы усиления врожденных иммунных ответов
WO2013147431A1 (ko) 2012-03-28 2013-10-03 주식회사 두산 신규 화합물 및 이를 포함하는 유기 전계 발광 소자
KR101788943B1 (ko) 2012-09-25 2017-10-20 코니카 미놀타 가부시키가이샤 유기 일렉트로루미네센스 소자, 조명 장치 및 표시 장치
WO2014097866A1 (ja) 2012-12-18 2014-06-26 コニカミノルタ株式会社 有機エレクトロルミネッセンス素子、表示装置および照明装置
KR101822827B1 (ko) 2013-03-11 2018-01-29 덕산네오룩스 주식회사 유기전기 소자용 화합물, 이를 이용한 유기전기소자 및 그 전자 장치
EP2968285A4 (en) 2013-03-13 2016-12-21 Flatley Discovery Lab COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS
RU2655171C2 (ru) 2013-04-05 2018-05-24 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Соль производного пиразолохинолина и ее кристалл
WO2014163146A1 (ja) 2013-04-05 2014-10-09 エーザイ・アール・アンド・ディー・マネジメント株式会社 ピリジニルピラゾロキノリン化合物
KR20140142088A (ko) 2013-06-03 2014-12-11 삼성디스플레이 주식회사 아릴 아민계 화합물 및 이를 포함한 유기 발광 소자
ES2849434T3 (es) 2013-06-24 2021-08-18 Merck Patent Gmbh Compuestos de pirazol como moduladores del FRSH y usos de los mismos
US20160264570A1 (en) 2013-11-15 2016-09-15 The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv Method of blocking transmission of malarial parasite
JP6378106B2 (ja) 2014-04-16 2018-08-22 出光興産株式会社 化合物、有機エレクトロルミネッセンス素子および電子機器
WO2015196335A1 (en) 2014-06-23 2015-12-30 Tocopherx, Inc. Pyrazole compounds as modulators of fshr and uses thereof
CA2975277A1 (en) 2015-03-04 2016-09-09 Dana-Farber Cancer Institute, Inc. Tricyclic kinase inhibitors of melk and methods of use
WO2016144647A1 (en) 2015-03-06 2016-09-15 Stc.Unm Method for treating obesity, diabetes, cardiovascular and kidney diseases by regulating gpr30/gper activity
US10487078B2 (en) 2015-04-03 2019-11-26 Nantbio, Inc. Compositions and methods of targeting mutant K-RAS
MX2017013275A (es) 2015-04-15 2018-01-26 Araxes Pharma Llc Inhibidores triciclicos fusionados de kras y metodos de uso de los mismos.
WO2016199943A1 (en) 2015-06-11 2016-12-15 Takeda Pharmaceutical Company Limited Heterocyclic compounds
DK3328419T3 (da) 2015-07-30 2021-10-11 Macrogenics Inc Pd-1-bindingsmolekyler og fremgangsmåder til anvendelse deraf
CN108137586B (zh) 2015-09-14 2021-04-13 辉瑞大药厂 作为LRRK2抑制剂的新颖咪唑并[4,5-c]喹啉和咪唑并[4,5-c][1,5]萘啶衍生物
US10730867B2 (en) 2015-09-28 2020-08-04 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
MA52119A (fr) 2015-10-19 2018-08-29 Ncyte Corp Composés hétérocycliques utilisés comme immunomodulateurs
WO2017070293A1 (en) 2015-10-20 2017-04-27 Ironwood Pharmaceuticals, Inc. Phosphodiesterase 9 inhibitor and levodopa therapy
AU2016355433C1 (en) * 2015-11-16 2021-12-16 Araxes Pharma Llc 2-substituted quinazoline compounds comprising a substituted heterocyclic group and methods of use thereof
MX2018006207A (es) 2015-11-19 2018-09-05 Incyte Corp Compuestos heterociclicos como inmunomoduladores.
CN113912648A (zh) 2015-12-02 2022-01-11 深圳市塔吉瑞生物医药有限公司 一种二氨基嘧啶化合物及包含该化合物的组合物
ES2916874T3 (es) 2015-12-17 2022-07-06 Incyte Corp Derivados de N-fenil-piridina-2-carboxamida y su uso como moduladores de la interacción proteína/proteína PD-1/PD-L1
RS61350B1 (sr) 2015-12-22 2021-02-26 Incyte Corp Heterociklična jedinjenja kao imunomodulatori
US10730871B2 (en) 2016-01-28 2020-08-04 Regents Of The University Of Minnesota Immunomodulators and immunomodulator conjugates
KR102606277B1 (ko) 2016-04-06 2023-11-27 삼성디스플레이 주식회사 유기 발광 소자
WO2017192961A1 (en) 2016-05-06 2017-11-09 Incyte Corporation Heterocyclic compounds as immunomodulators
WO2017205464A1 (en) 2016-05-26 2017-11-30 Incyte Corporation Heterocyclic compounds as immunomodulators
JP7000357B2 (ja) 2016-06-20 2022-01-19 インサイト・コーポレイション 免疫調節剤としての複素環化合物
MA45669A (fr) 2016-07-14 2019-05-22 Incyte Corp Composés hétérocycliques utilisés comme immunomodulateurs
US20180057486A1 (en) 2016-08-29 2018-03-01 Incyte Corporation Heterocyclic compounds as immunomodulators
US20180179201A1 (en) 2016-12-22 2018-06-28 Incyte Corporation Heterocyclic compounds as immunomodulators
PT3558955T (pt) 2016-12-22 2021-10-19 Amgen Inc Derivados de benzisotiazol, isotiazolo[3,4-b]piridina, quinazolina, ftalazina, pirido[2,3-d]piridazima e pirido[2,3-d]pirimidina como inibidores de kras g12c para tratamento de cancro de pulmão, pancreático ou colorretal
US20180177784A1 (en) 2016-12-22 2018-06-28 Incyte Corporation Heterocyclic compounds as immunomodulators
LT3558990T (lt) 2016-12-22 2022-12-27 Incyte Corporation Tetrahidroimidazo[4,5-c]piridino dariniai kaip pd-l1 internalizavimo induktoriai
AU2017382870B2 (en) 2016-12-22 2022-03-24 Incyte Corporation Benzooxazole derivatives as immunomodulators
JP7303108B2 (ja) 2016-12-22 2023-07-04 インサイト・コーポレイション 免疫調節剤としての二環式複素芳香環化合物
EP3558973B1 (en) 2016-12-22 2021-09-15 Incyte Corporation Pyridine derivatives as immunomodulators
CN118515666A (zh) 2017-04-27 2024-08-20 博笛生物科技有限公司 2-氨基-喹啉衍生物
JOP20190272A1 (ar) 2017-05-22 2019-11-21 Amgen Inc مثبطات kras g12c وطرق لاستخدامها
US11484502B2 (en) 2017-06-01 2022-11-01 Eisai R&D Management Co., Ltd. Pharmaceutical composition comprising PDE9 inhibitor
EP3632439B1 (en) 2017-06-01 2024-03-27 Eisai R&D Management Co., Ltd. Dementia therapeutic agent combining pyrazoloquinoline derivative and donepezil
CA3061884A1 (en) 2017-06-01 2019-10-29 Eisai R&D Management Co., Ltd. Lewy body disease therapeutic agent containing pyrazoloquinoline derivative
CA3060183A1 (en) 2017-06-01 2018-12-06 Eisai R&D Management Co., Ltd. Dementia therapeutic agent combining pyrazoloquinoline derivative and memantine
IT201700100116A1 (it) 2017-09-07 2019-03-07 Univ Pisa Composti a struttura benzo[a]carbazolica e loro usi
US11778897B2 (en) 2017-09-20 2023-10-03 Universal Display Corporation Organic electroluminescent materials and devices
KR102552271B1 (ko) 2017-10-27 2023-07-07 삼성디스플레이 주식회사 축합환 화합물 및 이를 포함한 유기 발광 소자
CN108003153B (zh) 2017-11-24 2021-04-30 中国医学科学院肿瘤医院 含氮五元杂环并喹啉类化合物及其盐、制法、药物组合物和用途
WO2019110751A1 (en) 2017-12-08 2019-06-13 Astrazeneca Ab Tetracyclic compounds as inhibitors of g12c mutant ras protein, for use as anti-cancer agents
TW201942115A (zh) 2018-02-01 2019-11-01 美商輝瑞股份有限公司 作為抗癌藥之經取代的喹唑啉和吡啶並嘧啶衍生物
WO2019177971A1 (en) 2018-03-12 2019-09-19 Mavupharma, Inc. Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1) inhibitors and uses thereof
EP3774791B1 (en) 2018-03-30 2022-12-21 Incyte Corporation Heterocyclic compounds as immunomodulators
WO2019194481A1 (en) 2018-04-02 2019-10-10 Rohm And Haas Electronic Materials Korea Ltd. Organic electroluminescent compound and organic electroluminescent device comprising the same
WO2019201283A1 (en) 2018-04-20 2019-10-24 Xrad Therapeutics, Inc. Dual atm and dna-pk inhibitors for use in anti-tumor therapy
EP4353235A3 (en) 2018-04-25 2024-07-31 Innate Tumor Immunity, Inc. Nlrp3 modulators
MX2020010836A (es) 2018-05-04 2021-01-08 Amgen Inc Inhibidores de kras g12c y métodos para su uso.
SG11202011165TA (en) 2018-05-11 2020-12-30 Incyte Corp Tetrahydro-imidazo[4,5-c]pyridine derivatives as pd-l1 immunomodulators
JP7433291B2 (ja) 2018-08-16 2024-02-19 イネイト・テューマー・イミュニティ・インコーポレイテッド イミダゾ[4,5-c]キノリン誘導体のNLRP3モジュレーター
EP3837014B1 (en) 2018-08-16 2022-10-19 Innate Tumor Immunity, Inc. Imidazo[4,5-c]quinoline derived nlrp3-modulators
US20210220408A1 (en) 2018-09-04 2021-07-22 Magenta Therapeutics Inc. Aryl hydrocarbon receptor antagonists and methods of use
CN112574224A (zh) 2019-09-30 2021-03-30 上海迪诺医药科技有限公司 Kras g12c抑制剂及其应用
KR20220125287A (ko) 2020-01-10 2022-09-14 인사이트 코포레이션 Kras 억제제로서 트리사이클릭 화합물
US11530218B2 (en) 2020-01-20 2022-12-20 Incyte Corporation Spiro compounds as inhibitors of KRAS
PH12022552739A1 (en) 2020-04-16 2024-03-25 Incyte Corp Fused tricyclic kras inhibitors
WO2021231526A1 (en) 2020-05-13 2021-11-18 Incyte Corporation Fused pyrimidine compounds as kras inhibitors
WO2022037631A1 (zh) 2020-08-21 2022-02-24 浙江海正药业股份有限公司 杂环类衍生物及其制备方法和用途
WO2022047093A1 (en) 2020-08-28 2022-03-03 Incyte Corporation Vinyl imidazole compounds as inhibitors of kras
US11767320B2 (en) 2020-10-02 2023-09-26 Incyte Corporation Bicyclic dione compounds as inhibitors of KRAS
US12077539B2 (en) 2021-03-22 2024-09-03 Incyte Corporation Imidazole and triazole KRAS inhibitors
US20220389033A1 (en) 2021-04-29 2022-12-08 Incyte Corporation Hetero-bicyclic inhibitors of kras

Also Published As

Publication number Publication date
CO2024006030A2 (es) 2024-06-17
PE20242113A1 (es) 2024-10-28
EP4415824A1 (en) 2024-08-21
MX2024004444A (es) 2024-05-08
TW202322810A (zh) 2023-06-16
JP2024539651A (ja) 2024-10-29
AU2022367432A1 (en) 2024-05-02
CA3235146A1 (en) 2023-04-20
DOP2024000069A (es) 2024-07-15
US11939328B2 (en) 2024-03-26
CR20240197A (es) 2024-08-07
US20240368152A1 (en) 2024-11-07
US20230144051A1 (en) 2023-05-11
WO2023064857A1 (en) 2023-04-20
CL2024001070A1 (es) 2024-10-04
KR20240101561A (ko) 2024-07-02
ECSP24035717A (es) 2024-07-31

Similar Documents

Publication Publication Date Title
US11530218B2 (en) Spiro compounds as inhibitors of KRAS
IL297165A (he) מעכבי קראס טריציקלי מסוגסג
US11999752B2 (en) Vinyl imidazole compounds as inhibitors of KRAS
US11939328B2 (en) Quinoline compounds as inhibitors of KRAS
US20230174555A1 (en) Naphthyridine compounds as inhibitors of kras
WO2023283213A1 (en) Tricyclic compounds as inhibitors of kras
EP4370515A1 (en) Tricyclic compounds as inhibitors of kras
US12030883B2 (en) Hetero-tricyclic compounds as inhibitors of KRAS
US12030884B2 (en) Pyrazoloquinoline KRAS inhibitors
WO2024015731A1 (en) Fused tricyclic compounds as inhibitors of kras g12v mutants