IL145772A0 - Prodrugs of thrombin inhibitors - Google Patents

Prodrugs of thrombin inhibitors

Info

Publication number: IL145772A0
Authority: IL; Israel
Prior art keywords: prodrugs; thrombin inhibitors; thrombin; inhibitors
Prior art date: 1999-04-09

Application number

IL14577200A

Other languages

English (en)

Original Assignee

Basf Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-04-09

Filing date

2000-04-05

Publication date

2002-07-25

2000-04-05 Application filed by Basf Ag filed Critical Basf Ag

2002-07-25 Publication of IL145772A0 publication Critical patent/IL145772A0/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B43/00—Formation or introduction of functional groups containing nitrogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Hematology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Oncology (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

IL14577200A 1999-04-09 2000-04-05 Prodrugs of thrombin inhibitors IL145772A0 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
DE19915930		1999-04-09
DE19934123		1999-07-23
DE19947920		1999-10-06
PCT/EP2000/003009 WO2000061609A2 (de)	1999-04-09	2000-04-05	Prodrugs von thrombininhibitoren

Publications (1)

Publication Number	Publication Date
IL145772A0 true IL145772A0 (en)	2002-07-25

Family

ID=27219075

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL14577200A IL145772A0 (en)	1999-04-09	2000-04-05	Prodrugs of thrombin inhibitors

Country Status (18)

Country	Link
US (1)	US7144902B1 (pt)
EP (1)	EP1165601A2 (pt)
JP (1)	JP2002542165A (pt)
KR (1)	KR20010108481A (pt)
CN (1)	CN1355810A (pt)
AU (1)	AU765244B2 (pt)
BG (1)	BG105986A (pt)
BR (1)	BR0009674A (pt)
CA (1)	CA2370267A1 (pt)
HK (1)	HK1046289A1 (pt)
HU (1)	HUP0202401A3 (pt)
IL (1)	IL145772A0 (pt)
NO (1)	NO20014875L (pt)
NZ (1)	NZ515026A (pt)
PL (1)	PL352824A1 (pt)
SK (1)	SK14222001A3 (pt)
TR (1)	TR200102912T2 (pt)
WO (1)	WO2000061609A2 (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10064797A1 (de) *	2000-12-22	2002-06-27	Knoll Ag	Orale und parenterale pharmazeutische Formulierung, umfassend eine niedermolekulare Thrombininhibitor-Pro-Pharmakon
WO2004002985A1 (en) *	2002-06-27	2004-01-08	Lg Life Sciences Ltd.	Peptidic thrombin inhibitor compound
WO2004102202A1 (en)	2003-05-16	2004-11-25	National Institute For Biological Standards And Control (Nibsc)	Activation mixture
US7939629B2 (en)	2004-10-19	2011-05-10	Lonza Ag	Method for solid phase peptide synthesis
MX2007013257A (es) *	2005-05-05	2008-01-21	Chroma Therapeutics Ltd	Conjugados de ester de alfa-aminoacido-farmaco hidrolizables por carboxilesterasa.
HUE029214T2 (en)	2005-05-10	2017-02-28	Incyte Holdings Corp	Indolamine-2,3-dioxygenase modulators and methods for their use
JP5294874B2 (ja)	2005-12-20	2013-09-18	インサイト・コーポレイション	インドールアミン２，３−ジオキシゲナーゼのモジュレーターとしてのｎ−ヒドロキシアミジノヘテロ環
CL2007002650A1 (es) *	2006-09-19	2008-02-08	Incyte Corp	Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras.
US20080125470A1 (en)	2006-09-19	2008-05-29	Incyte Corporation	N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
PE20110308A1 (es)	2008-07-08	2011-06-10	Incyte Corp	1,2,5-oxadiazoles como inhibidores de indolamina 2,3-dioxigenasa
KR20120120237A (ko)	2009-12-18	2012-11-01	액티브사이트 파마슈티칼즈, 인크.	혈장 칼리크레인 억제제의 전구약물
US9206123B2 (en)	2009-12-18	2015-12-08	Activesite Pharmaceuticals, Inc.	Prodrugs of inhibitors of plasma kallikrein
EP2697196A1 (en)	2011-04-13	2014-02-19	Activesite Pharmaceuticals, Inc.	Prodrugs of inhibitors of plasma kallikrein
DK3066085T3 (da)	2013-11-08	2020-06-02	Incyte Holdings Corp	Fremgangsmåde til syntesen af en indolamin-2,3-dioxygenaseinhibitor
JP6556146B2 (ja) *	2014-08-26	2019-08-07	武田薬品工業株式会社	複素環化合物
CN106674190B (zh) *	2016-12-13	2019-05-10	台州市创源工业技术有限公司	一种2-噻吩甲胺的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA951617B (en)	1994-03-04	1997-02-27	Lilly Co Eli	Antithrombotic agents.
TW541316B (en)	1995-12-21	2003-07-11	Astrazeneca Ab	Prodrugs of thrombin inhibitors
TW523513B (en)	1996-03-01	2003-03-11	Akzo Nobel Nv	Serine protease inhibitors
DE19632773A1 (de)	1996-08-14	1998-02-19	Basf Ag	Neue Thrombininhibitoren
AU751111B2 (en) *	1998-01-26	2002-08-08	Basf Aktiengesellschaft	Thrombin inhibitors
EP1049673A1 (de)	1998-01-26	2000-11-08	Basf Aktiengesellschaft	Heterocyclische amidine als kallikrein protease inhibitoren
KR20000047461A (ko) *	1998-12-29	2000-07-25	성재갑	트롬빈 억제제
CA2369378A1 (en) *	1999-04-09	2000-10-19	Basf Aktiengesellschaft	Low-molecular inhibitors of complement proteases

2000
- 2000-04-05 SK SK1422-2001A patent/SK14222001A3/sk not_active Application Discontinuation
- 2000-04-05 US US09/958,349 patent/US7144902B1/en not_active Expired - Fee Related
- 2000-04-05 BR BR0009674-1A patent/BR0009674A/pt not_active IP Right Cessation
- 2000-04-05 TR TR2001/02912T patent/TR200102912T2/xx unknown
- 2000-04-05 HU HU0202401A patent/HUP0202401A3/hu unknown
- 2000-04-05 JP JP2000611551A patent/JP2002542165A/ja active Pending
- 2000-04-05 EP EP00920661A patent/EP1165601A2/de not_active Withdrawn
- 2000-04-05 NZ NZ515026A patent/NZ515026A/en unknown
- 2000-04-05 KR KR1020017012870A patent/KR20010108481A/ko not_active Application Discontinuation
- 2000-04-05 CA CA002370267A patent/CA2370267A1/en not_active Abandoned
- 2000-04-05 PL PL00352824A patent/PL352824A1/xx unknown
- 2000-04-05 WO PCT/EP2000/003009 patent/WO2000061609A2/de not_active Application Discontinuation
- 2000-04-05 CN CN00807958A patent/CN1355810A/zh active Pending
- 2000-04-05 AU AU41156/00A patent/AU765244B2/en not_active Ceased
- 2000-04-05 IL IL14577200A patent/IL145772A0/xx unknown
2001
- 2001-10-05 BG BG105986A patent/BG105986A/bg unknown
- 2001-10-08 NO NO20014875A patent/NO20014875L/no not_active Application Discontinuation
2002
- 2002-10-30 HK HK02107849.6A patent/HK1046289A1/zh unknown

Also Published As

Publication number	Publication date
BR0009674A (pt)	2002-01-15
SK14222001A3 (sk)	2002-07-02
JP2002542165A (ja)	2002-12-10
WO2000061609A2 (de)	2000-10-19
CA2370267A1 (en)	2000-10-19
AU4115600A (en)	2000-11-14
BG105986A (bg)	2002-06-28
PL352824A1 (en)	2003-09-08
HUP0202401A2 (en)	2002-10-28
WO2000061609A3 (de)	2001-03-15
NO20014875D0 (no)	2001-10-08
EP1165601A2 (de)	2002-01-02
US7144902B1 (en)	2006-12-05
TR200102912T2 (tr)	2002-03-21
HK1046289A1 (zh)	2003-01-03
HUP0202401A3 (en)	2003-11-28
NZ515026A (en)	2003-10-31
CN1355810A (zh)	2002-06-26
WO2000061609B1 (de)	2001-04-26
AU765244B2 (en)	2003-09-11
NO20014875L (no)	2001-11-13
KR20010108481A (ko)	2001-12-07

Publication	Publication Date	Title
IL146518A0 (en)	2002-07-25	Metalloprotease inhibitors
IL149118A0 (en)	2002-11-10	Inhibitors of neuraminidases
EP1124822A4 (en)	2002-04-03	THROMBIN INHIBITORS
GB9900416D0 (en)	1999-02-24	Inhibitors
GB9930659D0 (en)	2000-02-16	Inhibitors of complement activation
IL145772A0 (en)	2002-07-25	Prodrugs of thrombin inhibitors
IL145085A0 (en)	2002-06-30	Dihetero-substituted metalloprotease inhibitors
EP1117660A4 (en)	2002-01-09	THROMBIN INHIBITORS
IL136139A0 (en)	2001-05-20	Thrombin inhibitors
EP1153022A4 (en)	2002-03-27	PROTEASE INHIBITORS
GB0030284D0 (en)	2001-01-24	Enzyme inhibitors
EP1232155A4 (en)	2002-11-20	PROTEASE INHIBITORS
EP1229915A4 (en)	2003-05-14	PROTEASE INHIBITORS
EP1229914A4 (en)	2004-06-23	PROTEASE INHIBITORS
EP1231921A4 (en)	2004-06-23	PROTEASE INHIBITORS
EP1229912A4 (en)	2003-05-07	PROTEASE INHIBITORS
EP1233771A4 (en)	2003-05-14	PROTEASE INHIBITORS
EP1229911A4 (en)	2003-05-07	PROTEASE INHIBITORS
EP1173429A4 (en)	2002-06-19	PROTEASE INHIBITORS
EP1161237A4 (en)	2002-03-27	PROTEASE INHIBITORS
EP1231923A4 (en)	2003-05-14	PROTEASE INHIBITORS
IL145670A0 (en)	2002-06-30	Prodrugs of thrombin inhibitors
EP1189618A4 (en)	2002-06-19	thrombin
IL142301A0 (en)	2002-03-10	Benzamide derivatives as thrombin inhibitors
EP1232154A4 (en)	2004-06-23	PROTEASE INHIBITORS

Legal Events

Date	Code	Title	Description
2003-05-29	HP	Change in proprietorship