[go: up one dir, main page]

IL145641A0 - C7 ester substituted taxanes as antitumor agents - Google Patents

C7 ester substituted taxanes as antitumor agents

Info

Publication number
IL145641A0
IL145641A0 IL14564101A IL14564101A IL145641A0 IL 145641 A0 IL145641 A0 IL 145641A0 IL 14564101 A IL14564101 A IL 14564101A IL 14564101 A IL14564101 A IL 14564101A IL 145641 A0 IL145641 A0 IL 145641A0
Authority
IL
Israel
Prior art keywords
antitumor agents
ester substituted
substituted taxanes
taxanes
ester
Prior art date
Application number
IL14564101A
Other languages
English (en)
Original Assignee
Univ Florida State Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida State Res Found filed Critical Univ Florida State Res Found
Publication of IL145641A0 publication Critical patent/IL145641A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D305/00Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL14564101A 2000-02-02 2001-02-02 C7 ester substituted taxanes as antitumor agents IL145641A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17979400P 2000-02-02 2000-02-02
PCT/US2001/003385 WO2001057027A1 (fr) 2000-02-02 2001-02-02 Taxanes substitues par ester en c7 utilises comme agents anticancereux

Publications (1)

Publication Number Publication Date
IL145641A0 true IL145641A0 (en) 2002-06-30

Family

ID=22658029

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14564101A IL145641A0 (en) 2000-02-02 2001-02-02 C7 ester substituted taxanes as antitumor agents

Country Status (35)

Country Link
US (3) US6610860B2 (fr)
EP (1) EP1183253B8 (fr)
JP (1) JP2003522167A (fr)
KR (1) KR100784161B1 (fr)
CN (1) CN1362955A (fr)
AR (1) AR030188A1 (fr)
AT (1) ATE396188T1 (fr)
AU (1) AU776051B2 (fr)
BG (1) BG65279B1 (fr)
BR (1) BR0104749A (fr)
CA (1) CA2368993C (fr)
CO (1) CO5280224A1 (fr)
CZ (1) CZ298484B6 (fr)
DE (1) DE60134094D1 (fr)
DK (1) DK1183253T3 (fr)
ES (1) ES2307588T3 (fr)
GE (1) GEP20043322B (fr)
HK (1) HK1047938A1 (fr)
HU (1) HUP0200917A3 (fr)
IL (1) IL145641A0 (fr)
MX (1) MXPA01009901A (fr)
MY (1) MY137637A (fr)
NO (1) NO327982B1 (fr)
NZ (1) NZ514409A (fr)
PL (1) PL202668B1 (fr)
PT (1) PT1183253E (fr)
RO (1) RO121777B1 (fr)
RU (1) RU2265017C2 (fr)
SA (1) SA01220045B1 (fr)
SK (1) SK13712001A3 (fr)
TR (1) TR200102856T1 (fr)
TW (1) TWI291873B (fr)
UA (1) UA75573C2 (fr)
WO (1) WO2001057027A1 (fr)
ZA (1) ZA200108060B (fr)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CO5280224A1 (es) 2000-02-02 2003-05-30 Univ Florida State Res Found Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen
PL350075A1 (en) * 2000-02-02 2002-11-04 Univ Florida State Res Found Taxane formulations having improved solubility
CA2354486A1 (fr) * 2001-07-31 2003-01-31 Florida State University Research Foundation, Inc. Taxanes substitues avec un ester en c7
KR100819578B1 (ko) * 2001-08-01 2008-04-04 플로리다 스테이트 유니버시티 리서치 파운데이션, 인크 C7 에스테르 치환된 탁산
SG125889A1 (en) * 2001-08-01 2006-10-30 Univ Florida State Res Found C7 ester subsituted taxanes
US20030082229A1 (en) * 2001-11-01 2003-05-01 Board Of Regents, The University Of Texas Systems Parenteral chlorambucil for treatment of malignant and autoimmune disease and methods of use
US8012950B2 (en) * 2003-08-29 2011-09-06 Wisconsin Alumni Research Foundation Method to diagnose and treat degenerative joint disease
SI1664033T1 (sl) * 2003-09-25 2008-04-30 Tapestry Pharmaceuticals Inc Analogi 9,10-alfa,alfa-oh-taksana in postopki za proizvodnjo le-teh
EP1785416A3 (fr) 2003-09-25 2007-05-30 Tapestry Pharmaceuticals, Inc. Analogues de 9, 10-alpha, alpha-OH-Taxane et méthodes pour leur production
CN1960721A (zh) 2004-03-05 2007-05-09 佛罗里达州立大学研究基金有限公司 C7乳酰氧基取代的紫杉烷类
TW200533339A (en) * 2004-03-16 2005-10-16 Bristol Myers Squibb Co Therapeutic synergy of anti-cancer compounds
EP1812864A2 (fr) * 2004-10-07 2007-08-01 Emory University Conjugues multifonctionnels de nanoparticules et utilisation de ceux-ci
WO2006047575A2 (fr) 2004-10-25 2006-05-04 Dekk-Tec Inc. Sels d'yperite d'isophosphoramide et analogues de ceux-ci utilises en tant qu'agents anti-tumoraux
US20060216767A1 (en) * 2005-03-22 2006-09-28 Saladax Biomedical Inc. Docetaxel immunoassay
PL217731B1 (pl) 2006-06-01 2014-08-29 Tomasz Byrski Sposób wykrywania genetycznie uwarunkowanej obniżonej odpowiedzi na chemioterapię cytostatykiem taksanowym, zastosowanie mutacji założycielskiej oraz zestawu do wykrywania takiej odpowiedzi
US11786504B2 (en) 2006-09-28 2023-10-17 Tapestry Pharmaceuticals, Inc. Taxane analogs for the treatment of brain cancer
WO2008106621A1 (fr) 2007-02-28 2008-09-04 Tapestry Pharmaceuticals, Inc Analogues de taxane destinés à traiter un cancer du cerveau
US11873308B2 (en) 2006-11-06 2024-01-16 Tapestry Pharmaceuticals, Inc. Biologically active taxane analogs and methods of treatment by oral administration
WO2008121476A1 (fr) 2007-03-28 2008-10-09 Tapestry Pharmaceuticals, Inc. Analogues de taxane biologiquement actifs, et procédés de traitement par administration orale
WO2008098138A1 (fr) 2007-02-07 2008-08-14 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Composés macrocycliques de synthèse
PL2155682T3 (pl) 2007-04-06 2015-12-31 Ziopharm Oncology Inc Sole iperytu izofosforamidowego i ich analogi
WO2010014841A1 (fr) 2008-07-31 2010-02-04 Ziopharm Oncology, Inc. Synthèse et formulations de sels de moutarde d'isophosphoramide et de leurs analogues
AU2010218109B2 (en) 2009-02-24 2015-04-09 Dekk-Tec, Inc. Complexes of 4-hydroperoxy ifosfamide as anti-tumor agents
WO2010138686A1 (fr) 2009-05-29 2010-12-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Agents s'opposant au gène mdr1
CA2791702C (fr) 2010-03-10 2018-05-29 Sri International Utilisation du fenoterol et de ses analogues dans le traitement de glioblastomes et d'astrocytomes
WO2012033601A1 (fr) 2010-08-20 2012-03-15 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Thiosemicarbazones à activité anti-mdr1
CN107929733A (zh) 2011-07-11 2018-04-20 美国政府(由卫生和人类服务部的部长所代表) 光敏抗体‑荧光团缀合物
AU2013266235B2 (en) 2012-05-25 2017-06-08 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of regulating cannabinoid receptor activity-related disorders and diseases
EP3054987B1 (fr) 2013-10-11 2019-10-09 The United States of America, represented by the Secretary, Department of Health and Human Services Anticorps tem8 et leur utilisation
CA2954463C (fr) 2014-08-08 2023-11-07 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Elimination photo-controlee de cibles in vitro et in vivo
CN111556757A (zh) 2017-10-31 2020-08-18 西方溶瘤细胞有限公司 用于全身递送的平台溶瘤载体
WO2019099615A1 (fr) 2017-11-17 2019-05-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Utilisation de copeptine pour moduler la réponse immunitaire et l'hématopoïèse et stimuler la croissance osseuse
US20210079112A1 (en) 2018-04-10 2021-03-18 The United States of America, as represented by the Secretary, Department of Health and Human Ser Combination of near infrared photoimmunotherapy targeting cancer cells and host-immune activation
EP3994173A1 (fr) 2019-07-02 2022-05-11 The United States of America, as represented by the Secretary, Department of Health and Human Services Anticorps monoclonaux se liant à egfrviii et leurs utilisations
WO2021154705A1 (fr) 2020-01-27 2021-08-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Oligonucléotides antisens rab13 et net1 pour traiter le cancer métastatique
AU2022213415A1 (en) 2021-01-29 2023-08-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Near infrared photoimmunotherapy (nir-pit) combination therapy to treat cancer
TW202305125A (zh) 2021-04-30 2023-02-01 美商凱立凡爾免疫治療股份有限公司 用於經修飾mhc表現之溶瘤病毒
WO2024006965A1 (fr) 2022-06-30 2024-01-04 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps spécifiques de cd25 et leurs utilisations
WO2025014896A1 (fr) 2023-07-07 2025-01-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps 40h3 humanisé

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US5321128A (en) * 1988-09-06 1994-06-14 Kabi Pharmacia Ab Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
US4960790A (en) 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
SE463189B (sv) 1989-03-13 1990-10-22 Eston Joensson Preparat avsett att tillfoeras amalgamfyllningar i taender foer att daerigenom hindra eller minska avgaang av kvicksilver eller kvicksilveraanga
US5175315A (en) 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
FR2679230B1 (fr) 1991-07-16 1993-11-19 Rhone Poulenc Rorer Sa Nouveaux derives d'analogues du taxol, leur preparation et les compositions qui les contiennent.
US5283253A (en) 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
US5430160A (en) 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
US5721268A (en) 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
US5350866A (en) 1991-09-23 1994-09-27 Bristol-Myers Squibb Company 10-desacetoxytaxol derivatives
US5489601A (en) * 1991-09-23 1996-02-06 Florida State University Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
US5714513A (en) 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
US5227400A (en) 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US5243045A (en) 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
PT1001036E (pt) 1992-01-15 2005-01-31 Squibb & Sons Inc Processos enzimaticos para o desdobramento de misturas enantiomericas de compostos uteis como intermediarios na preparacao de taxanos
US5272171A (en) 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
US5200534A (en) 1992-03-13 1993-04-06 University Of Florida Process for the preparation of taxol and 10-deacetyltaxol
WO1993021173A1 (fr) 1992-04-17 1993-10-28 Abbott Laboratories Derives de taxol
US5248796A (en) 1992-06-18 1993-09-28 Bristol-Myers Squibb Company Taxol derivatives
US5319112A (en) 1992-08-18 1994-06-07 Virgnia Tech Intellectual Properties, Inc. Method for the conversion of cephalomannine to taxol and for the preparation of N-acyl analogs of taxol
WO1994005282A1 (fr) 1992-09-04 1994-03-17 The Scripps Research Institute Derives de taxol hydrosolubles
CA2100808A1 (fr) 1992-10-01 1994-04-02 Vittorio Farina Desoxytaxols
NZ261070A (en) 1992-12-23 1997-10-24 Bristol Myers Squibb Co Oxazoline-substituted taxane derivatives and their preparation; intermediates
IL108443A0 (en) * 1993-01-29 1994-04-12 Univ Florida State C7 taxane derivatives and pharmaceutical compositions containing them
US5703247A (en) 1993-03-11 1997-12-30 Virginia Tech Intellectual Properties, Inc. 2-Debenzoyl-2-acyl taxol derivatives and methods for making same
IL109051A0 (en) * 1993-03-22 1994-06-24 Univ Florida State Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them
DE69429253T2 (de) * 1993-03-22 2002-06-13 Florida State University, Tallahassee Taxane mit pyridyl-substituierter seitenkette
EP1227093B1 (fr) * 1993-03-22 2005-05-11 Florida State University Béta-lactames utiles pour la préparation de taxanes ayant une chaíne latérale substituée par furyl ou thiényl
EP0982301B1 (fr) 1993-06-11 2003-09-10 PHARMACIA & UPJOHN COMPANY Delta 6,7-taxols usage antineoplastique et compositions neoplastiques les contenant
IL109926A (en) 1993-06-15 2000-02-29 Bristol Myers Squibb Co Methods for the preparation of taxanes and microorganisms and enzymes utilized therein
TW397866B (en) 1993-07-14 2000-07-11 Bristol Myers Squibb Co Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes
FR2711369B1 (fr) 1993-10-20 1995-11-17 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions qui les contiennent.
US5415869A (en) 1993-11-12 1995-05-16 The Research Foundation Of State University Of New York Taxol formulation
US5414869A (en) * 1993-11-26 1995-05-16 Thomson; Margaret I. Knotless scarf and method of making same
JPH10508022A (ja) * 1994-10-28 1998-08-04 ザ リサーチ ファウンデーション オブ ステート ユニバーシティ オブ ニューヨーク タキソイド誘導体、それらの製造、およびそれらの抗腫瘍薬としての使用
TW354293B (en) 1995-06-06 1999-03-11 Bristol Myers Squibb Co Prodrugs of paclitaxel derivatives
US5780653A (en) 1995-06-07 1998-07-14 Vivorx Pharmaceuticals, Inc. Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers
WO1997009979A1 (fr) 1995-09-13 1997-03-20 Florida State University Taxanes a effet radiosensibilisant et leurs preparations pharmaceutiques
US5767297A (en) 1997-02-05 1998-06-16 Ensuiko Sugar Refining Co., Ltd. Taxoid derivative and method of producing thereof
FR2745814B1 (fr) * 1996-03-06 1998-04-03 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
AU724499B2 (en) 1996-05-06 2000-09-21 Florida State University 1-deoxy baccatin III, 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof
WO1997044027A1 (fr) * 1996-05-17 1997-11-27 Merck & Co., Inc. Compositions de traitement journalier monodose de maladies a mediation cyclooxygenase-2
WO1997044026A1 (fr) * 1996-05-22 1997-11-27 Neuromedica, Inc. Compositions contenant des conjugues d'acide cis-docosahexanoique et de taxotere
US5795909A (en) * 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
US6576636B2 (en) 1996-05-22 2003-06-10 Protarga, Inc. Method of treating a liver disorder with fatty acid-antiviral agent conjugates
US5811452A (en) 1997-01-08 1998-09-22 The Research Foundation Of State University Of New York Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
US5912264A (en) 1997-03-03 1999-06-15 Bristol-Myers Squibb Company 6-halo-or nitrate-substituted paclitaxels
US7288665B1 (en) 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
WO1999018113A1 (fr) * 1997-10-08 1999-04-15 Bio Research Corporation Of Yokohama Derives taxoides et leur procede de production
US6136988A (en) 1998-04-10 2000-10-24 Hauser, Inc. 7-hexanoyltaxol and methods for preparing the same
US5964739A (en) * 1998-06-18 1999-10-12 Champ; Raynido A. Safety disposable needle structure
US6146659A (en) 1998-07-01 2000-11-14 Neopharm, Inc. Method of administering liposomal encapsulated taxane
CA2375343A1 (fr) 1999-06-21 2000-12-28 Napro Biotherapeutics, Inc. Esters actives de c-2 hydroxyl protege-n-acyl(2r,3s)-3-phenylisoserine et methodes de production de ces derniers
US6348215B1 (en) 1999-10-06 2002-02-19 The Research Foundation Of State University Of New York Stabilization of taxane-containing dispersed systems
CO5280224A1 (es) 2000-02-02 2003-05-30 Univ Florida State Res Found Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen
HUP0200995A3 (en) 2000-02-02 2005-02-28 Univ Florida State Res Found Taxane formulations having improved solubility
PL350075A1 (en) * 2000-02-02 2002-11-04 Univ Florida State Res Found Taxane formulations having improved solubility
IT1319168B1 (it) 2000-03-17 2003-09-26 Indena Spa Derivati di condensazione ad attivita' antitumorale, loro metodo dipreparazione e formulazioni che li contengono.

Also Published As

Publication number Publication date
BG65279B1 (bg) 2007-11-30
HU0200917D0 (en) 2002-04-29
RU2265017C2 (ru) 2005-11-27
BG105967A (en) 2002-08-30
EP1183253A1 (fr) 2002-03-06
CO5280224A1 (es) 2003-05-30
BR0104749A (pt) 2001-12-26
MXPA01009901A (es) 2003-07-28
HK1047938A1 (zh) 2003-03-14
NO20014759L (no) 2001-11-29
KR20010111583A (ko) 2001-12-19
TR200102856T1 (tr) 2002-06-21
NO20014759D0 (no) 2001-10-01
HUP0200917A2 (en) 2002-08-28
RO121777B1 (ro) 2008-04-30
US20070249708A1 (en) 2007-10-25
PL350026A1 (en) 2002-10-21
JP2003522167A (ja) 2003-07-22
CA2368993A1 (fr) 2001-08-09
GEP20043322B (en) 2003-12-10
ES2307588T3 (es) 2008-12-01
EP1183253B1 (fr) 2008-05-21
DK1183253T3 (da) 2008-09-22
US7186849B2 (en) 2007-03-06
CA2368993C (fr) 2009-10-20
WO2001057027A1 (fr) 2001-08-09
AR030188A1 (es) 2003-08-13
TWI291873B (en) 2008-01-01
SA01220045B1 (ar) 2008-06-07
US20020013346A1 (en) 2002-01-31
CZ20013503A3 (cs) 2002-03-13
ATE396188T1 (de) 2008-06-15
KR100784161B1 (ko) 2007-12-12
CN1362955A (zh) 2002-08-07
NZ514409A (en) 2004-03-26
SK13712001A3 (sk) 2002-05-09
CZ298484B6 (cs) 2007-10-17
AU776051B2 (en) 2004-08-26
EP1183253B8 (fr) 2009-01-07
MY137637A (en) 2009-02-27
ZA200108060B (en) 2003-12-01
US20040014979A1 (en) 2004-01-22
DE60134094D1 (de) 2008-07-03
PT1183253E (pt) 2008-08-04
UA75573C2 (en) 2006-05-15
HUP0200917A3 (en) 2004-07-28
PL202668B1 (pl) 2009-07-31
NO327982B1 (no) 2009-11-02
US6610860B2 (en) 2003-08-26
AU3323901A (en) 2001-08-14

Similar Documents

Publication Publication Date Title
HU0200917D0 (en) C7 ester substituted taxanes as antitumor agents
AU1046802A (en) Polyarylcarboxamides useful as lipid lowering agents
GC0000312A (en) Biphenylcarboxamides useful as lipid lowering agents
PL350075A1 (en) Taxane formulations having improved solubility
HUP0200995A3 (en) Taxane formulations having improved solubility
GB0025437D0 (en) Esters
NZ514074A (en) C10 carbonate substituted taxanes as antitumor agents
PL350315A1 (en) C7 carbonate substituted taxanes as antitumor agents
HUP0600302A2 (en) C10 ester substituted taxanes as antitumor agents
HUP0200752A2 (en) C7 carbamoyloxy substituted taxanes as antitumor agents
HK1061978A1 (en) Lipid peroxide-lowering compositions
GB0025438D0 (en) Esters
HU0103247D0 (en) C7 ester substituted taxanes
ZA200106335B (en) C7 ester substituted taxanes.
TW479555U (en) Vertical moving stage
GB0015865D0 (en) Lipid compositions
GB0017074D0 (en) Ester synthesis
HU0103245D0 (en) C10 ester substituted taxanes
SG129990A1 (en) C10 ester substituted taxanes
HK1047933A1 (zh) 具有改善的溶解度的紫杉烷製劑