IL145641A0 - C7 ester substituted taxanes as antitumor agents - Google Patents
C7 ester substituted taxanes as antitumor agentsInfo
- Publication number
- IL145641A0 IL145641A0 IL14564101A IL14564101A IL145641A0 IL 145641 A0 IL145641 A0 IL 145641A0 IL 14564101 A IL14564101 A IL 14564101A IL 14564101 A IL14564101 A IL 14564101A IL 145641 A0 IL145641 A0 IL 145641A0
- Authority
- IL
- Israel
- Prior art keywords
- antitumor agents
- ester substituted
- substituted taxanes
- taxanes
- ester
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17979400P | 2000-02-02 | 2000-02-02 | |
PCT/US2001/003385 WO2001057027A1 (fr) | 2000-02-02 | 2001-02-02 | Taxanes substitues par ester en c7 utilises comme agents anticancereux |
Publications (1)
Publication Number | Publication Date |
---|---|
IL145641A0 true IL145641A0 (en) | 2002-06-30 |
Family
ID=22658029
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14564101A IL145641A0 (en) | 2000-02-02 | 2001-02-02 | C7 ester substituted taxanes as antitumor agents |
Country Status (35)
Country | Link |
---|---|
US (3) | US6610860B2 (fr) |
EP (1) | EP1183253B8 (fr) |
JP (1) | JP2003522167A (fr) |
KR (1) | KR100784161B1 (fr) |
CN (1) | CN1362955A (fr) |
AR (1) | AR030188A1 (fr) |
AT (1) | ATE396188T1 (fr) |
AU (1) | AU776051B2 (fr) |
BG (1) | BG65279B1 (fr) |
BR (1) | BR0104749A (fr) |
CA (1) | CA2368993C (fr) |
CO (1) | CO5280224A1 (fr) |
CZ (1) | CZ298484B6 (fr) |
DE (1) | DE60134094D1 (fr) |
DK (1) | DK1183253T3 (fr) |
ES (1) | ES2307588T3 (fr) |
GE (1) | GEP20043322B (fr) |
HK (1) | HK1047938A1 (fr) |
HU (1) | HUP0200917A3 (fr) |
IL (1) | IL145641A0 (fr) |
MX (1) | MXPA01009901A (fr) |
MY (1) | MY137637A (fr) |
NO (1) | NO327982B1 (fr) |
NZ (1) | NZ514409A (fr) |
PL (1) | PL202668B1 (fr) |
PT (1) | PT1183253E (fr) |
RO (1) | RO121777B1 (fr) |
RU (1) | RU2265017C2 (fr) |
SA (1) | SA01220045B1 (fr) |
SK (1) | SK13712001A3 (fr) |
TR (1) | TR200102856T1 (fr) |
TW (1) | TWI291873B (fr) |
UA (1) | UA75573C2 (fr) |
WO (1) | WO2001057027A1 (fr) |
ZA (1) | ZA200108060B (fr) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CO5280224A1 (es) | 2000-02-02 | 2003-05-30 | Univ Florida State Res Found | Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen |
PL350075A1 (en) * | 2000-02-02 | 2002-11-04 | Univ Florida State Res Found | Taxane formulations having improved solubility |
CA2354486A1 (fr) * | 2001-07-31 | 2003-01-31 | Florida State University Research Foundation, Inc. | Taxanes substitues avec un ester en c7 |
KR100819578B1 (ko) * | 2001-08-01 | 2008-04-04 | 플로리다 스테이트 유니버시티 리서치 파운데이션, 인크 | C7 에스테르 치환된 탁산 |
SG125889A1 (en) * | 2001-08-01 | 2006-10-30 | Univ Florida State Res Found | C7 ester subsituted taxanes |
US20030082229A1 (en) * | 2001-11-01 | 2003-05-01 | Board Of Regents, The University Of Texas Systems | Parenteral chlorambucil for treatment of malignant and autoimmune disease and methods of use |
US8012950B2 (en) * | 2003-08-29 | 2011-09-06 | Wisconsin Alumni Research Foundation | Method to diagnose and treat degenerative joint disease |
SI1664033T1 (sl) * | 2003-09-25 | 2008-04-30 | Tapestry Pharmaceuticals Inc | Analogi 9,10-alfa,alfa-oh-taksana in postopki za proizvodnjo le-teh |
EP1785416A3 (fr) | 2003-09-25 | 2007-05-30 | Tapestry Pharmaceuticals, Inc. | Analogues de 9, 10-alpha, alpha-OH-Taxane et méthodes pour leur production |
CN1960721A (zh) | 2004-03-05 | 2007-05-09 | 佛罗里达州立大学研究基金有限公司 | C7乳酰氧基取代的紫杉烷类 |
TW200533339A (en) * | 2004-03-16 | 2005-10-16 | Bristol Myers Squibb Co | Therapeutic synergy of anti-cancer compounds |
EP1812864A2 (fr) * | 2004-10-07 | 2007-08-01 | Emory University | Conjugues multifonctionnels de nanoparticules et utilisation de ceux-ci |
WO2006047575A2 (fr) | 2004-10-25 | 2006-05-04 | Dekk-Tec Inc. | Sels d'yperite d'isophosphoramide et analogues de ceux-ci utilises en tant qu'agents anti-tumoraux |
US20060216767A1 (en) * | 2005-03-22 | 2006-09-28 | Saladax Biomedical Inc. | Docetaxel immunoassay |
PL217731B1 (pl) | 2006-06-01 | 2014-08-29 | Tomasz Byrski | Sposób wykrywania genetycznie uwarunkowanej obniżonej odpowiedzi na chemioterapię cytostatykiem taksanowym, zastosowanie mutacji założycielskiej oraz zestawu do wykrywania takiej odpowiedzi |
US11786504B2 (en) | 2006-09-28 | 2023-10-17 | Tapestry Pharmaceuticals, Inc. | Taxane analogs for the treatment of brain cancer |
WO2008106621A1 (fr) | 2007-02-28 | 2008-09-04 | Tapestry Pharmaceuticals, Inc | Analogues de taxane destinés à traiter un cancer du cerveau |
US11873308B2 (en) | 2006-11-06 | 2024-01-16 | Tapestry Pharmaceuticals, Inc. | Biologically active taxane analogs and methods of treatment by oral administration |
WO2008121476A1 (fr) | 2007-03-28 | 2008-10-09 | Tapestry Pharmaceuticals, Inc. | Analogues de taxane biologiquement actifs, et procédés de traitement par administration orale |
WO2008098138A1 (fr) | 2007-02-07 | 2008-08-14 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Composés macrocycliques de synthèse |
PL2155682T3 (pl) | 2007-04-06 | 2015-12-31 | Ziopharm Oncology Inc | Sole iperytu izofosforamidowego i ich analogi |
WO2010014841A1 (fr) | 2008-07-31 | 2010-02-04 | Ziopharm Oncology, Inc. | Synthèse et formulations de sels de moutarde d'isophosphoramide et de leurs analogues |
AU2010218109B2 (en) | 2009-02-24 | 2015-04-09 | Dekk-Tec, Inc. | Complexes of 4-hydroperoxy ifosfamide as anti-tumor agents |
WO2010138686A1 (fr) | 2009-05-29 | 2010-12-02 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Agents s'opposant au gène mdr1 |
CA2791702C (fr) | 2010-03-10 | 2018-05-29 | Sri International | Utilisation du fenoterol et de ses analogues dans le traitement de glioblastomes et d'astrocytomes |
WO2012033601A1 (fr) | 2010-08-20 | 2012-03-15 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Thiosemicarbazones à activité anti-mdr1 |
CN107929733A (zh) | 2011-07-11 | 2018-04-20 | 美国政府(由卫生和人类服务部的部长所代表) | 光敏抗体‑荧光团缀合物 |
AU2013266235B2 (en) | 2012-05-25 | 2017-06-08 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of regulating cannabinoid receptor activity-related disorders and diseases |
EP3054987B1 (fr) | 2013-10-11 | 2019-10-09 | The United States of America, represented by the Secretary, Department of Health and Human Services | Anticorps tem8 et leur utilisation |
CA2954463C (fr) | 2014-08-08 | 2023-11-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Elimination photo-controlee de cibles in vitro et in vivo |
CN111556757A (zh) | 2017-10-31 | 2020-08-18 | 西方溶瘤细胞有限公司 | 用于全身递送的平台溶瘤载体 |
WO2019099615A1 (fr) | 2017-11-17 | 2019-05-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Utilisation de copeptine pour moduler la réponse immunitaire et l'hématopoïèse et stimuler la croissance osseuse |
US20210079112A1 (en) | 2018-04-10 | 2021-03-18 | The United States of America, as represented by the Secretary, Department of Health and Human Ser | Combination of near infrared photoimmunotherapy targeting cancer cells and host-immune activation |
EP3994173A1 (fr) | 2019-07-02 | 2022-05-11 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Anticorps monoclonaux se liant à egfrviii et leurs utilisations |
WO2021154705A1 (fr) | 2020-01-27 | 2021-08-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Oligonucléotides antisens rab13 et net1 pour traiter le cancer métastatique |
AU2022213415A1 (en) | 2021-01-29 | 2023-08-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Near infrared photoimmunotherapy (nir-pit) combination therapy to treat cancer |
TW202305125A (zh) | 2021-04-30 | 2023-02-01 | 美商凱立凡爾免疫治療股份有限公司 | 用於經修飾mhc表現之溶瘤病毒 |
WO2024006965A1 (fr) | 2022-06-30 | 2024-01-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anticorps spécifiques de cd25 et leurs utilisations |
WO2025014896A1 (fr) | 2023-07-07 | 2025-01-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anticorps 40h3 humanisé |
Family Cites Families (58)
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FR2601675B1 (fr) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent |
US5321128A (en) * | 1988-09-06 | 1994-06-14 | Kabi Pharmacia Ab | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
US4960790A (en) | 1989-03-09 | 1990-10-02 | University Of Kansas | Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof |
SE463189B (sv) | 1989-03-13 | 1990-10-22 | Eston Joensson | Preparat avsett att tillfoeras amalgamfyllningar i taender foer att daerigenom hindra eller minska avgaang av kvicksilver eller kvicksilveraanga |
US5175315A (en) | 1989-05-31 | 1992-12-29 | Florida State University | Method for preparation of taxol using β-lactam |
FR2679230B1 (fr) | 1991-07-16 | 1993-11-19 | Rhone Poulenc Rorer Sa | Nouveaux derives d'analogues du taxol, leur preparation et les compositions qui les contiennent. |
US5283253A (en) | 1991-09-23 | 1994-02-01 | Florida State University | Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them |
US5430160A (en) | 1991-09-23 | 1995-07-04 | Florida State University | Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides |
US5721268A (en) | 1991-09-23 | 1998-02-24 | Florida State University | C7 taxane derivatives and pharmaceutical compositions containing them |
US5350866A (en) | 1991-09-23 | 1994-09-27 | Bristol-Myers Squibb Company | 10-desacetoxytaxol derivatives |
US5489601A (en) * | 1991-09-23 | 1996-02-06 | Florida State University | Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them |
US5714513A (en) | 1991-09-23 | 1998-02-03 | Florida State University | C10 taxane derivatives and pharmaceutical compositions |
US5227400A (en) | 1991-09-23 | 1993-07-13 | Florida State University | Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them |
US5243045A (en) | 1991-09-23 | 1993-09-07 | Florida State University | Certain alkoxy substituted taxanes and pharmaceutical compositions containing them |
PT1001036E (pt) | 1992-01-15 | 2005-01-31 | Squibb & Sons Inc | Processos enzimaticos para o desdobramento de misturas enantiomericas de compostos uteis como intermediarios na preparacao de taxanos |
US5272171A (en) | 1992-02-13 | 1993-12-21 | Bristol-Myers Squibb Company | Phosphonooxy and carbonate derivatives of taxol |
US5200534A (en) | 1992-03-13 | 1993-04-06 | University Of Florida | Process for the preparation of taxol and 10-deacetyltaxol |
WO1993021173A1 (fr) | 1992-04-17 | 1993-10-28 | Abbott Laboratories | Derives de taxol |
US5248796A (en) | 1992-06-18 | 1993-09-28 | Bristol-Myers Squibb Company | Taxol derivatives |
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CA2100808A1 (fr) | 1992-10-01 | 1994-04-02 | Vittorio Farina | Desoxytaxols |
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IL109051A0 (en) * | 1993-03-22 | 1994-06-24 | Univ Florida State | Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them |
DE69429253T2 (de) * | 1993-03-22 | 2002-06-13 | Florida State University, Tallahassee | Taxane mit pyridyl-substituierter seitenkette |
EP1227093B1 (fr) * | 1993-03-22 | 2005-05-11 | Florida State University | Béta-lactames utiles pour la préparation de taxanes ayant une chaíne latérale substituée par furyl ou thiényl |
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AU724499B2 (en) | 1996-05-06 | 2000-09-21 | Florida State University | 1-deoxy baccatin III, 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof |
WO1997044027A1 (fr) * | 1996-05-17 | 1997-11-27 | Merck & Co., Inc. | Compositions de traitement journalier monodose de maladies a mediation cyclooxygenase-2 |
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CO5280224A1 (es) | 2000-02-02 | 2003-05-30 | Univ Florida State Res Found | Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen |
HUP0200995A3 (en) | 2000-02-02 | 2005-02-28 | Univ Florida State Res Found | Taxane formulations having improved solubility |
PL350075A1 (en) * | 2000-02-02 | 2002-11-04 | Univ Florida State Res Found | Taxane formulations having improved solubility |
IT1319168B1 (it) | 2000-03-17 | 2003-09-26 | Indena Spa | Derivati di condensazione ad attivita' antitumorale, loro metodo dipreparazione e formulazioni che li contengono. |
-
2001
- 2001-01-31 CO CO01007075A patent/CO5280224A1/es not_active Application Discontinuation
- 2001-01-31 AR ARP010100463A patent/AR030188A1/es not_active Application Discontinuation
- 2001-02-02 EP EP01905349A patent/EP1183253B8/fr not_active Expired - Lifetime
- 2001-02-02 HU HU0200917A patent/HUP0200917A3/hu unknown
- 2001-02-02 SK SK1371-2001A patent/SK13712001A3/sk unknown
- 2001-02-02 CZ CZ20013503A patent/CZ298484B6/cs not_active IP Right Cessation
- 2001-02-02 TR TR2001/02856T patent/TR200102856T1/xx unknown
- 2001-02-02 NZ NZ514409A patent/NZ514409A/xx unknown
- 2001-02-02 UA UA2001106734A patent/UA75573C2/uk unknown
- 2001-02-02 MY MYPI20010481A patent/MY137637A/en unknown
- 2001-02-02 AT AT01905349T patent/ATE396188T1/de not_active IP Right Cessation
- 2001-02-02 WO PCT/US2001/003385 patent/WO2001057027A1/fr active IP Right Grant
- 2001-02-02 MX MXPA01009901A patent/MXPA01009901A/es active IP Right Grant
- 2001-02-02 PT PT01905349T patent/PT1183253E/pt unknown
- 2001-02-02 BR BR0104749-3A patent/BR0104749A/pt not_active IP Right Cessation
- 2001-02-02 ES ES01905349T patent/ES2307588T3/es not_active Expired - Lifetime
- 2001-02-02 RU RU2001129507/04A patent/RU2265017C2/ru not_active IP Right Cessation
- 2001-02-02 US US09/775,851 patent/US6610860B2/en not_active Expired - Fee Related
- 2001-02-02 RO ROA200101085A patent/RO121777B1/ro unknown
- 2001-02-02 JP JP2001557859A patent/JP2003522167A/ja active Pending
- 2001-02-02 DK DK01905349T patent/DK1183253T3/da active
- 2001-02-02 IL IL14564101A patent/IL145641A0/xx unknown
- 2001-02-02 AU AU33239/01A patent/AU776051B2/en not_active Ceased
- 2001-02-02 CA CA002368993A patent/CA2368993C/fr not_active Expired - Fee Related
- 2001-02-02 GE GE4514A patent/GEP20043322B/en unknown
- 2001-02-02 KR KR1020017012600A patent/KR100784161B1/ko not_active IP Right Cessation
- 2001-02-02 CN CN01800306A patent/CN1362955A/zh active Pending
- 2001-02-02 PL PL350026A patent/PL202668B1/pl not_active IP Right Cessation
- 2001-02-02 DE DE60134094T patent/DE60134094D1/de not_active Expired - Fee Related
- 2001-03-06 TW TW090102237A patent/TWI291873B/zh active
- 2001-04-11 SA SA1220045A patent/SA01220045B1/ar unknown
- 2001-10-01 NO NO20014759A patent/NO327982B1/no not_active IP Right Cessation
- 2001-10-01 BG BG105967A patent/BG65279B1/bg unknown
- 2001-10-01 ZA ZA200108060A patent/ZA200108060B/en unknown
-
2003
- 2003-01-07 HK HK03100173.6A patent/HK1047938A1/zh unknown
- 2003-06-25 US US10/606,027 patent/US7186849B2/en not_active Expired - Fee Related
-
2007
- 2007-01-09 US US11/621,321 patent/US20070249708A1/en not_active Abandoned
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