CO5280224A1 - Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen - Google Patents
Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienenInfo
- Publication number
- CO5280224A1 CO5280224A1 CO01007075A CO01007075A CO5280224A1 CO 5280224 A1 CO5280224 A1 CO 5280224A1 CO 01007075 A CO01007075 A CO 01007075A CO 01007075 A CO01007075 A CO 01007075A CO 5280224 A1 CO5280224 A1 CO 5280224A1
- Authority
- CO
- Colombia
- Prior art keywords
- substituted
- taxans
- ester
- useful
- pharmaceutical compositions
- Prior art date
Links
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 4
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 229940123237 Taxane Drugs 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000004426 substituted alkynyl group Chemical group 0.000 abstract 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Un taxano que tiene la fórmula:<EMI FILE="01007075_1" ID="1" IMF=JPEG >Ac es acetilo;Bz es benzoilo;R7 es RaCOO-;R10 es hidroxi;X3 es alquilo, alquenilo, alquinilo sustituido o no sustituido, o heterociclo;X5 es -COX10, -COOX10 ó CONHX10;X10 es hidrocarbilo, hidrocarbilo sustituido, o heterociclo en donde dicho hidrocarbilo o hidrocarbilo sustituido contiene átomos de carbono en las posiciones alfa y beta relativos al carbono del cual Ra es sustituyente.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17979400P | 2000-02-02 | 2000-02-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5280224A1 true CO5280224A1 (es) | 2003-05-30 |
Family
ID=22658029
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO01007075A CO5280224A1 (es) | 2000-02-02 | 2001-01-31 | Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen |
Country Status (35)
| Country | Link |
|---|---|
| US (3) | US6610860B2 (es) |
| EP (1) | EP1183253B8 (es) |
| JP (1) | JP2003522167A (es) |
| KR (1) | KR100784161B1 (es) |
| CN (1) | CN1362955A (es) |
| AR (1) | AR030188A1 (es) |
| AT (1) | ATE396188T1 (es) |
| AU (1) | AU776051B2 (es) |
| BG (1) | BG65279B1 (es) |
| BR (1) | BR0104749A (es) |
| CA (1) | CA2368993C (es) |
| CO (1) | CO5280224A1 (es) |
| CZ (1) | CZ298484B6 (es) |
| DE (1) | DE60134094D1 (es) |
| DK (1) | DK1183253T3 (es) |
| ES (1) | ES2307588T3 (es) |
| GE (1) | GEP20043322B (es) |
| HK (1) | HK1047938A1 (es) |
| HU (1) | HUP0200917A3 (es) |
| IL (1) | IL145641A0 (es) |
| MX (1) | MXPA01009901A (es) |
| MY (1) | MY137637A (es) |
| NO (1) | NO327982B1 (es) |
| NZ (1) | NZ514409A (es) |
| PL (1) | PL202668B1 (es) |
| PT (1) | PT1183253E (es) |
| RO (1) | RO121777B1 (es) |
| RU (1) | RU2265017C2 (es) |
| SA (1) | SA01220045B1 (es) |
| SK (1) | SK13712001A3 (es) |
| TR (1) | TR200102856T1 (es) |
| TW (1) | TWI291873B (es) |
| UA (1) | UA75573C2 (es) |
| WO (1) | WO2001057027A1 (es) |
| ZA (1) | ZA200108060B (es) |
Families Citing this family (40)
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|---|---|---|---|---|
| CO5280224A1 (es) * | 2000-02-02 | 2003-05-30 | Univ Florida State Res Found | Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen |
| JP2003521545A (ja) * | 2000-02-02 | 2003-07-15 | フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド | 改良された溶解性を有するタキサン製剤 |
| CA2354486A1 (en) * | 2001-07-31 | 2003-01-31 | Florida State University Research Foundation, Inc. | C7 ester substituted taxanes |
| KR100819578B1 (ko) * | 2001-08-01 | 2008-04-04 | 플로리다 스테이트 유니버시티 리서치 파운데이션, 인크 | Ｃ７ 에스테르 치환된 탁산 |
| SG125889A1 (en) * | 2001-08-01 | 2006-10-30 | Univ Florida State Res Found | C7 ester subsituted taxanes |
| US20030082229A1 (en) * | 2001-11-01 | 2003-05-01 | Board Of Regents, The University Of Texas Systems | Parenteral chlorambucil for treatment of malignant and autoimmune disease and methods of use |
| US8012950B2 (en) * | 2003-08-29 | 2011-09-06 | Wisconsin Alumni Research Foundation | Method to diagnose and treat degenerative joint disease |
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| WO2008098138A1 (en) | 2007-02-07 | 2008-08-14 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Synthetic macrocyclic compounds for treating cancer |
| WO2008109360A1 (en) | 2007-02-28 | 2008-09-12 | Tapestry Pharmaceuticals, Inc | Taxane analogs for the treatment of brain cancer |
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| KR20110038696A (ko) | 2008-07-31 | 2011-04-14 | 지오팜 온콜로지 인코포레이티드 | 이소포스포르아미드 머스타드의 염 및 이의 유사체의 합성 및 제형 |
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| JP6130495B2 (ja) | 2012-05-25 | 2017-05-17 | アメリカ合衆国 | カンナビノイド受容体活性関連障害及び疾患を調節する方法 |
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| CA3096305A1 (en) | 2018-04-10 | 2019-10-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Combination of near infrared photoimmunotherapy targeting cancer cells and host-immune activation |
| EA202290208A1 (ru) | 2019-07-02 | 2022-03-25 | Дзе Юнайтед Стейтс Оф Эмерика, Эз Репрезентед Бай Дзе Секретэри, Дипартмент Оф Хелт Энд Хьюман Сервисиз | МОНОКЛОНАЛЬНЫЕ АНТИТЕЛА, КОТОРЫЕ СВЯЗЫВАЮТ EGFRvIII, И ИХ ПРИМЕНЕНИЕ |
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| KR20240004764A (ko) | 2021-04-30 | 2024-01-11 | 칼리버 임뮤노쎄라퓨틱스, 인크. | 변형된 mhc 발현을 위한 종양용해성 바이러스 |
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| JP2003521545A (ja) * | 2000-02-02 | 2003-07-15 | フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド | 改良された溶解性を有するタキサン製剤 |
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-
2001
- 2001-01-31 CO CO01007075A patent/CO5280224A1/es not_active Application Discontinuation
- 2001-01-31 AR ARP010100463A patent/AR030188A1/es not_active Application Discontinuation
- 2001-02-02 EP EP01905349A patent/EP1183253B8/en not_active Expired - Lifetime
- 2001-02-02 JP JP2001557859A patent/JP2003522167A/ja active Pending
- 2001-02-02 BR BR0104749-3A patent/BR0104749A/pt not_active IP Right Cessation
- 2001-02-02 RO ROA200101085A patent/RO121777B1/ro unknown
- 2001-02-02 WO PCT/US2001/003385 patent/WO2001057027A1/en active IP Right Grant
- 2001-02-02 MY MYPI20010481A patent/MY137637A/en unknown
- 2001-02-02 CN CN01800306A patent/CN1362955A/zh active Pending
- 2001-02-02 ES ES01905349T patent/ES2307588T3/es not_active Expired - Lifetime
- 2001-02-02 DK DK01905349T patent/DK1183253T3/da active
- 2001-02-02 TR TR2001/02856T patent/TR200102856T1/xx unknown
- 2001-02-02 NZ NZ514409A patent/NZ514409A/xx unknown
- 2001-02-02 GE GE4514A patent/GEP20043322B/en unknown
- 2001-02-02 IL IL14564101A patent/IL145641A0/xx unknown
- 2001-02-02 CA CA002368993A patent/CA2368993C/en not_active Expired - Fee Related
- 2001-02-02 CZ CZ20013503A patent/CZ298484B6/cs not_active IP Right Cessation
- 2001-02-02 RU RU2001129507/04A patent/RU2265017C2/ru not_active IP Right Cessation
- 2001-02-02 HK HK03100173.6A patent/HK1047938A1/zh unknown
- 2001-02-02 US US09/775,851 patent/US6610860B2/en not_active Expired - Fee Related
- 2001-02-02 KR KR1020017012600A patent/KR100784161B1/ko not_active Expired - Fee Related
- 2001-02-02 PL PL350026A patent/PL202668B1/pl not_active IP Right Cessation
- 2001-02-02 AU AU33239/01A patent/AU776051B2/en not_active Ceased
- 2001-02-02 SK SK1371-2001A patent/SK13712001A3/sk unknown
- 2001-02-02 MX MXPA01009901A patent/MXPA01009901A/es active IP Right Grant
- 2001-02-02 HU HU0200917A patent/HUP0200917A3/hu unknown
- 2001-02-02 DE DE60134094T patent/DE60134094D1/de not_active Expired - Fee Related
- 2001-02-02 UA UA2001106734A patent/UA75573C2/uk unknown
- 2001-02-02 PT PT01905349T patent/PT1183253E/pt unknown
- 2001-02-02 AT AT01905349T patent/ATE396188T1/de not_active IP Right Cessation
- 2001-03-06 TW TW090102237A patent/TWI291873B/zh active
- 2001-04-11 SA SA1220045A patent/SA01220045B1/ar unknown
- 2001-10-01 ZA ZA200108060A patent/ZA200108060B/en unknown
- 2001-10-01 BG BG105967A patent/BG65279B1/bg unknown
- 2001-10-01 NO NO20014759A patent/NO327982B1/no not_active IP Right Cessation
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2003
- 2003-06-25 US US10/606,027 patent/US7186849B2/en not_active Expired - Fee Related
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2007
- 2007-01-09 US US11/621,321 patent/US20070249708A1/en not_active Abandoned
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