PT689436E - Taxanos que nao possuem um grupo oxo em c-9 e composicoes farmaceuticas que os contem - Google Patents

Taxanos que nao possuem um grupo oxo em c-9 e composicoes farmaceuticas que os contem

Info

Publication number: PT689436E
Authority: PT; Portugal
Prior art keywords: contain; pharmaceutical compositions; taxans; oxo group; furyl
Prior art date: 1993-03-22

Application number

PT94910982T

Other languages

English (en)

Inventor

Yukio Suzuki

Ki-Byung Chai

Hossain Nadizadeh

Hamid Idmoumaz

Robert A Holton

Kasthuri Rengan

Chunlin Tao

Original Assignee

Univ Florida State

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-03-22

Filing date

1994-03-21

Publication date

2004-04-30

1994-03-21 Application filed by Univ Florida State filed Critical Univ Florida State

2004-04-30 Publication of PT689436E publication Critical patent/PT689436E/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/60—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members
- C07C2603/62—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members containing three- or four-membered rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Hematology (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pyrrole Compounds (AREA)
Orthopedics, Nursing, And Contraception (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

PT94910982T 1993-03-22 1994-03-21 Taxanos que nao possuem um grupo oxo em c-9 e composicoes farmaceuticas que os contem PT689436E (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US3485293A	1993-03-22	1993-03-22
US9471793A	1993-07-20	1993-07-20

Publications (1)

Publication Number	Publication Date
PT689436E true PT689436E (pt)	2004-04-30

Family

ID=26711460

Family Applications (5)

Application Number	Title	Priority Date	Filing Date
PT02009840T PT1227093E (pt)	1993-03-22	1994-03-21	Beta-cactamas uteis para a preparacao de taxanos possuindo cadeia lateral substituida com furilo ou tienilo
PT94911675T PT690867E (pt)	1993-03-22	1994-03-21	Taxanos possuindo uma cadeia lateral substituida com furilo ou tienilo
PT02019282T PT1260223E (pt)	1993-03-22	1994-03-21	Taxanos possuindo uma cadeia lateral substituida com furilo ou tienilo
PT02009839T PT1228759E (pt)	1993-03-22	1994-03-21	Composicoes farmaceuticas contendo um taxano possuindo uma cadeia lateral substituida com furilo ou tienilo
PT94910982T PT689436E (pt)	1993-03-22	1994-03-21	Taxanos que nao possuem um grupo oxo em c-9 e composicoes farmaceuticas que os contem

Family Applications Before (4)

Application Number	Title	Priority Date	Filing Date
PT02009840T PT1227093E (pt)	1993-03-22	1994-03-21	Beta-cactamas uteis para a preparacao de taxanos possuindo cadeia lateral substituida com furilo ou tienilo
PT94911675T PT690867E (pt)	1993-03-22	1994-03-21	Taxanos possuindo uma cadeia lateral substituida com furilo ou tienilo
PT02019282T PT1260223E (pt)	1993-03-22	1994-03-21	Taxanos possuindo uma cadeia lateral substituida com furilo ou tienilo
PT02009839T PT1228759E (pt)	1993-03-22	1994-03-21	Composicoes farmaceuticas contendo um taxano possuindo uma cadeia lateral substituida com furilo ou tienilo

Country Status (12)

Country	Link
EP (6)	EP0690867B1 (pt)
JP (2)	JPH08508255A (pt)
AT (5)	ATE295363T1 (pt)
AU (3)	AU6367994A (pt)
CA (2)	CA2158862C (pt)
DE (5)	DE69434373T2 (pt)
DK (5)	DK0690867T3 (pt)
ES (5)	ES2241923T3 (pt)
IL (4)	IL180090A0 (pt)
PT (5)	PT1227093E (pt)
SG (3)	SG73401A1 (pt)
WO (2)	WO1994021651A1 (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2712289B1 (fr) *	1993-11-08	1996-01-05	Rhone Poulenc Rorer Sa	Nouveaux dérivés de taxicine, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5677470A (en) *	1994-06-28	1997-10-14	Tanabe Seiyaku Co., Ltd.	Baccatin derivatives and processes for preparing the same
US6500858B2 (en)	1994-10-28	2002-12-31	The Research Foundation Of The State University Of New York	Taxoid anti-tumor agents and pharmaceutical compositions thereof
WO1996013495A1 (en) *	1994-10-28	1996-05-09	The Research Foundation Of State University Of New York	Taxoid derivatives, their preparation and their use as antitumor agents
US6458976B1 (en)	1994-10-28	2002-10-01	The Research Foundation Of State University Of New York	Taxoid anti-tumor agents, pharmaceutical compositions, and treatment methods
CA2162759A1 (en) *	1994-11-17	1996-05-18	Kenji Tsujihara	Baccatin derivatives and processes for preparing the same
TW480262B (en)	1995-04-28	2002-03-21	Daiichi Seiyaku Co	A taxol derivative having an antitumor activity and a pharmaceutical composition comprising the same
JP2001524067A (ja) *	1995-09-13	2001-11-27	フロリダ・ステイト・ユニバーシティ	放射線感作性タキサン類およびその医薬製剤
FR2745814B1 (fr) *	1996-03-06	1998-04-03	Rhone Poulenc Rorer Sa	Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2746797B1 (fr) *	1996-03-27	1998-06-19	Centre Nat Rech Scient	Nouveaux derives du 10-acetyldocetaxel et leur procede de preparation
JP2000510470A (ja) *	1996-05-06	2000-08-15	フロリダ・ステイト・ユニバーシティ	１―デオキシバッカチンｉｉｉ、１―デオキシタキソールおよび１―デオキシタキソール類似体、ならびにこれらの製造方法
US6410756B1 (en)	1996-10-24	2002-06-25	Institut National De La Recherche Scientifique	Family of Canadensol taxanes, the semi-synthetic preparation and therapeutic use thereof
PL202957B1 (pl) *	2000-02-02	2009-08-31	Univ Florida State Res Found	Podstawione grupą estrową C10 taksany, kompozycja farmaceutyczna zawierająca te związki i zastosowanie tych związków do wytwarzania leku
HUP0200651A3 (en) *	2000-02-02	2002-10-28	Univ Florida State Res Found	C7 heterosubstituted acetate taxanes as antitumor agents and pharmaceutical compositions containing them
AR030188A1 (es) *	2000-02-02	2003-08-13	Univ Florida State Res Found	Compuestos de taxano sustituidos con esteres en el c7; composiciones farmaceuticas que los contienen y proceso para tratar un sujeto mamifero que sufre de una condicion que responde a los taxanos
EP1785416A3 (en)	2003-09-25	2007-05-30	Tapestry Pharmaceuticals, Inc.	9, 10-alpha, alpha-OH-Taxane Analogs and methods for production thereof
SI1664033T1 (sl) *	2003-09-25	2008-04-30	Tapestry Pharmaceuticals Inc	Analogi 9,10-alfa,alfa-oh-taksana in postopki za proizvodnjo le-teh
AR048078A1 (es) *	2004-03-05	2006-03-29	Univ Florida State Res Found	Taxanos con sustituyente lactiloxilo en el c7
US20060281918A1 (en) *	2005-06-10	2006-12-14	Florida State University Research Foundation, Inc.	Resolution of enantiomeric mixtures of beta-lactams
US11786504B2 (en)	2006-09-28	2023-10-17	Tapestry Pharmaceuticals, Inc.	Taxane analogs for the treatment of brain cancer
US11873308B2 (en)	2006-11-06	2024-01-16	Tapestry Pharmaceuticals, Inc.	Biologically active taxane analogs and methods of treatment by oral administration
WO2008121476A1 (en)	2007-03-28	2008-10-09	Tapestry Pharmaceuticals, Inc.	Biologically active taxane analogs and methods of treatment by oral administration
WO2008109360A1 (en)	2007-02-28	2008-09-12	Tapestry Pharmaceuticals, Inc	Taxane analogs for the treatment of brain cancer

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6075458A (ja) *	1983-06-17	1985-04-27	Osaka Soda Co Ltd	３，４−ジフエニル−１−（４−置換）アリ−ルメチルアゼチジン−２−オンの製法
US4751299A (en) *	1983-11-18	1988-06-14	Takeda Chemical Industries, Ltd.	Optically active β-lactams and method of their production
JPS61243079A (ja) *	1985-04-01	1986-10-29	Mect Corp	１−（アルコキシカルボニルアルキル）−４−（２−フリル）−３−置換−２−アゼチジノン及びその製造方法
FR2601675B1 (fr) *	1986-07-17	1988-09-23	Rhone Poulenc Sante	Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US5006650A (en) *	1987-02-11	1991-04-09	The Upjohn Company	Novel N-1 substituted beta-lactams as antibiotics
US4942184A (en) *	1988-03-07	1990-07-17	The United States Of America As Represented By The Department Of Health And Human Services	Water soluble, antineoplastic derivatives of taxol
US5175315A (en) *	1989-05-31	1992-12-29	Florida State University	Method for preparation of taxol using β-lactam
AU637109B2 (en) *	1989-06-22	1993-05-20	Rijksuniversiteit Utrecht	Improved synthesis of beta-lactams using a metal compound
US5136060A (en) *	1989-11-14	1992-08-04	Florida State University	Method for preparation of taxol using an oxazinone
US5229526A (en) *	1991-09-23	1993-07-20	Florida State University	Metal alkoxides
US5283253A (en) *	1991-09-23	1994-02-01	Florida State University	Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
JP3304088B2 (ja) *	1991-09-23	2002-07-22	フロリダ・ステイト・ユニバーシティ	１０−デスアセトキシタキソール誘導体
US5284864A (en) *	1991-09-23	1994-02-08	Florida State University	Butenyl substituted taxanes and pharmaceutical compositions containing them
EP1193252B1 (en) *	1991-09-23	2006-12-27	Florida State University	Beta-Lactams useful for preparation of substituted isoserine esters using metal alkoxides
US5243045A (en) *	1991-09-23	1993-09-07	Florida State University	Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5227400A (en) *	1991-09-23	1993-07-13	Florida State University	Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US5250683A (en) *	1991-09-23	1993-10-05	Florida State University	Certain substituted taxanes and pharmaceutical compositions containing them
FR2688518B1 (fr) *	1992-03-13	1994-05-06	Rhone Poulenc Rorer Sa	Procede de preparation de derives du taxane.
CA2130578A1 (en) *	1992-04-17	1993-10-28	Geewananda P. Gunawardana	Taxol derivatives
FR2696460B1 (fr) *	1992-10-05	1994-11-25	Rhone Poulenc Rorer Sa	Procédé de préparation de dérivés du taxane.

1994
- 1994-03-21 CA CA002158862A patent/CA2158862C/en not_active Expired - Fee Related
- 1994-03-21 ES ES02009840T patent/ES2241923T3/es not_active Expired - Lifetime
- 1994-03-21 SG SG1996006328A patent/SG73401A1/en unknown
- 1994-03-21 DK DK94911675T patent/DK0690867T3/da active
- 1994-03-21 DE DE69434373T patent/DE69434373T2/de not_active Expired - Fee Related
- 1994-03-21 DK DK02019282T patent/DK1260223T3/da active
- 1994-03-21 AT AT02009840T patent/ATE295363T1/de not_active IP Right Cessation
- 1994-03-21 PT PT02009840T patent/PT1227093E/pt unknown
- 1994-03-21 PT PT94911675T patent/PT690867E/pt unknown
- 1994-03-21 ES ES02009839T patent/ES2232694T3/es not_active Expired - Lifetime
- 1994-03-21 DE DE69432141T patent/DE69432141T2/de not_active Expired - Fee Related
- 1994-03-21 DK DK02009840T patent/DK1227093T3/da active
- 1994-03-21 AT AT02009839T patent/ATE284689T1/de not_active IP Right Cessation
- 1994-03-21 SG SG9801036A patent/SG68049A1/en unknown
- 1994-03-21 IL IL180090A patent/IL180090A0/en unknown
- 1994-03-21 IL IL10905094A patent/IL109050A0/xx unknown
- 1994-03-21 PT PT02019282T patent/PT1260223E/pt unknown
- 1994-03-21 AT AT94911675T patent/ATE232871T1/de not_active IP Right Cessation
- 1994-03-21 IL IL109052A patent/IL109052A/en not_active IP Right Cessation
- 1994-03-21 ES ES94911675T patent/ES2193155T3/es not_active Expired - Lifetime
- 1994-03-21 WO PCT/US1994/003097 patent/WO1994021651A1/en active IP Right Grant
- 1994-03-21 DE DE69433355T patent/DE69433355T2/de not_active Expired - Fee Related
- 1994-03-21 CA CA002158454A patent/CA2158454C/en not_active Expired - Fee Related
- 1994-03-21 PT PT02009839T patent/PT1228759E/pt unknown
- 1994-03-21 PT PT94910982T patent/PT689436E/pt unknown
- 1994-03-21 DE DE69434190T patent/DE69434190T2/de not_active Expired - Fee Related
- 1994-03-21 DK DK02009839T patent/DK1228759T3/da active
- 1994-03-21 WO PCT/US1994/003053 patent/WO1994021250A1/en active IP Right Grant
- 1994-03-21 JP JP6521330A patent/JPH08508255A/ja active Pending
- 1994-03-21 SG SG9904638A patent/SG89298A1/en unknown
- 1994-03-21 AU AU63679/94A patent/AU6367994A/en not_active Abandoned
- 1994-03-21 ES ES94910982T patent/ES2211879T3/es not_active Expired - Lifetime
- 1994-03-21 AT AT02019282T patent/ATE295164T1/de not_active IP Right Cessation
- 1994-03-21 DE DE69434374T patent/DE69434374T2/de not_active Expired - Fee Related
- 1994-03-21 JP JP6521307A patent/JPH08508469A/ja active Pending
- 1994-03-21 EP EP94911675A patent/EP0690867B1/en not_active Expired - Lifetime
- 1994-03-21 AU AU64138/94A patent/AU691804B2/en not_active Ceased
- 1994-03-21 EP EP03027078A patent/EP1398028A3/en not_active Withdrawn
- 1994-03-21 AT AT94910982T patent/ATE254914T1/de not_active IP Right Cessation
- 1994-03-21 ES ES02019282T patent/ES2242807T3/es not_active Expired - Lifetime
- 1994-03-21 DK DK94910982T patent/DK0689436T3/da active
- 1994-03-21 EP EP02009839A patent/EP1228759B1/en not_active Expired - Lifetime
- 1994-03-21 EP EP02019282A patent/EP1260223B1/en not_active Expired - Lifetime
- 1994-03-21 EP EP94910982A patent/EP0689436B1/en not_active Expired - Lifetime
- 1994-03-21 EP EP02009840A patent/EP1227093B1/en not_active Expired - Lifetime
1998
- 1998-08-03 AU AU78636/98A patent/AU714180B2/en not_active Ceased
2008
- 2008-04-17 IL IL190945A patent/IL190945A0/en unknown

Also Published As

Publication number	Publication date
ATE295363T1 (de)	2005-05-15
EP1227093A2 (en)	2002-07-31
IL109050A0 (en)	1994-06-24
ATE254914T1 (de)	2003-12-15
ES2241923T3 (es)	2005-11-01
CA2158454A1 (en)	1994-09-29
DK1227093T3 (da)	2005-08-29
DE69433355D1 (de)	2004-01-08
AU6367994A (en)	1994-10-11
PT1227093E (pt)	2005-09-30
EP1260223A1 (en)	2002-11-27
DE69434374T2 (de)	2005-11-24
ES2211879T3 (es)	2004-07-16
AU7863698A (en)	1998-10-01
EP1398028A2 (en)	2004-03-17
CA2158862A1 (en)	1994-09-29
DE69434373D1 (de)	2005-06-16
EP0690867A4 (en)	1996-03-20
EP1398028A3 (en)	2004-03-24
CA2158454C (en)	2006-05-23
EP0689436B1 (en)	2003-11-26
EP0690867B1 (en)	2003-02-19
JPH08508255A (ja)	1996-09-03
DK0690867T3 (da)	2003-06-10
AU691804B2 (en)	1998-05-28
DE69434190D1 (de)	2005-01-20
DE69434374D1 (de)	2005-06-16
IL109052A0 (en)	1994-06-24
DE69434373T2 (de)	2006-03-09
SG89298A1 (en)	2002-06-18
EP0689436A4 (pt)	1996-02-07
EP1228759A3 (en)	2002-09-25
PT1260223E (pt)	2005-09-30
PT1228759E (pt)	2005-04-29
WO1994021651A1 (en)	1994-09-29
IL190945A0 (en)	2009-02-11
DE69433355T2 (de)	2004-05-27
DE69432141T2 (de)	2003-07-31
DE69432141D1 (de)	2003-03-27
JPH08508469A (ja)	1996-09-10
DE69434190T2 (de)	2005-05-25
EP1227093B1 (en)	2005-05-11
AU714180B2 (en)	1999-12-23
AU6413894A (en)	1994-10-11
CA2158862C (en)	2006-10-10
ATE232871T1 (de)	2003-03-15
IL109052A (en)	2009-07-20
EP1260223B1 (en)	2005-05-11
SG68049A1 (en)	2001-08-21
EP1228759A2 (en)	2002-08-07
EP1227093A3 (en)	2002-08-07
EP0690867A1 (en)	1996-01-10
DK0689436T3 (da)	2004-03-29
EP1228759B1 (en)	2004-12-15
DK1260223T3 (da)	2005-09-05
IL180090A0 (en)	2007-05-15
ES2193155T3 (es)	2003-11-01
ES2242807T3 (es)	2005-11-16
EP0689436A1 (en)	1996-01-03
ES2232694T3 (es)	2005-06-01
WO1994021250A1 (en)	1994-09-29
SG73401A1 (en)	2000-06-20
PT690867E (pt)	2003-06-30
DK1228759T3 (da)	2005-04-18
ATE284689T1 (de)	2005-01-15
ATE295164T1 (de)	2005-05-15

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