IL141295A0 - Use of derivatives of aryl (or heteroaryl) azolycarbinols in the manufacture of a medicament for the treatment of disorders mediated by an excess of substance p - Google Patents

Use of derivatives of aryl (or heteroaryl) azolycarbinols in the manufacture of a medicament for the treatment of disorders mediated by an excess of substance p

Info

Publication number: IL141295A0
Authority: IL; Israel
Prior art keywords: azolycarbinols; heteroaryl; medicament; aryl; excess
Prior art date: 1998-08-07

Application number

IL14129501A

Other languages

English (en)

Original Assignee

Esteve Labor Dr

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-07

Filing date

2001-02-07

Publication date

2002-12-01

2001-02-07 Application filed by Esteve Labor Dr filed Critical Esteve Labor Dr

2002-12-01 Publication of IL141295A0 publication Critical patent/IL141295A0/xx

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Addiction (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)

IL14129501A 1998-08-07 2001-02-07 Use of derivatives of aryl (or heteroaryl) azolycarbinols in the manufacture of a medicament for the treatment of disorders mediated by an excess of substance p IL141295A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ES009801708A ES2150378B1 (es)	1998-08-07	1998-08-07	Empleo de derivados de aril(o heteroaril)azolilcarbinoles en la elaboracion de un medicamento para el tratamiento de los trastornos mediados por un exceso de substancia p.
PCT/ES1999/000255 WO2000007542A2 (es)	1998-08-07	1999-08-05	Empleo de derivados de aril(o heteroaril)azolilcarbinoles en la elaboracion de un medicamento para el tratamiento de los trastornos mediados por un exceso de substancia p

Publications (1)

Publication Number	Publication Date
IL141295A0 true IL141295A0 (en)	2002-12-01

Family

ID=8304839

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL14129501A IL141295A0 (en)	1998-08-07	2001-02-07	Use of derivatives of aryl (or heteroaryl) azolycarbinols in the manufacture of a medicament for the treatment of disorders mediated by an excess of substance p

Country Status (26)

Country	Link
US (1)	US6518295B1 (cs)
EP (1)	EP1103243B1 (cs)
JP (1)	JP2002522359A (cs)
KR (1)	KR100558506B1 (cs)
CN (1)	CN1151789C (cs)
AR (1)	AR019999A1 (cs)
AT (1)	ATE257379T1 (cs)
AU (1)	AU754124B2 (cs)
BR (1)	BR9912807A (cs)
CA (1)	CA2339661C (cs)
CO (1)	CO5080747A1 (cs)
CZ (1)	CZ292065B6 (cs)
DE (1)	DE69914085T8 (cs)
DK (1)	DK1103243T3 (cs)
ES (2)	ES2150378B1 (cs)
HU (1)	HUP0105428A3 (cs)
IL (1)	IL141295A0 (cs)
NO (1)	NO20010634L (cs)
NZ (1)	NZ509645A (cs)
PL (1)	PL193802B1 (cs)
PT (1)	PT1103243E (cs)
RU (1)	RU2223116C2 (cs)
TR (1)	TR200100378T2 (cs)
TW (1)	TW445259B (cs)
WO (1)	WO2000007542A2 (cs)
ZA (1)	ZA200100867B (cs)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2174756B2 (es) *	2001-04-06	2003-11-16	Esteve Labor Dr	Derivados de aril (o heteroaril) azolilcarbinoles para el tratamiento de enfermedades respiratorias.
US20040142929A1 (en) *	2001-07-06	2004-07-22	Ramon Merce-Vidal	Derivatives of aryl (or heteroaryl) azolylcarbinoles for the treatment of urinary incontinence
ES2180449B1 (es) *	2001-07-06	2004-01-16	Esteve Labor Dr	Derivados de aril (o heteroaril) azolilcarbinoles para el tratamiento de la incontinencia urinaria.
DE10335566A1 (de) *	2003-07-31	2005-02-24	Grünenthal GmbH	Arzneimittel enthaltend Derivate von Aryl( oder Heteroaryl)azolylcarbinolen
ES2244326B1 (es) *	2004-04-05	2007-02-16	Laboratorios Del Dr. Esteve, S.A.	Combinacion de substancias activas.
EP1584335A3 (en) *	2004-04-05	2006-02-22	Laboratorios Del Dr. Esteve, S.A.	Active substance combination comprising a carbinol composition and an opioid
WO2006010627A1 (en) *	2004-07-30	2006-02-02	Laboratorios Del Dr. Esteve, S.A.	Aryl (or heteroaryl) azolylcarbinols
US20080045610A1 (en) *	2004-09-23	2008-02-21	Alexander Michalow	Methods for regulating neurotransmitter systems by inducing counteradaptations
JP2008514612A (ja) *	2004-09-23	2008-05-08	ミシャロウ、アレクサンダー	対抗適応を誘発することにより神経伝達物質系を調節する方法
WO2006087147A2 (en) *	2005-02-15	2006-08-24	Laboratorios Del Dr. Esteve, S.A.	Derivatives of aryl (or heteroaryl) azolylcarbinols for the treatment of fibromyalgia
EP1695704A1 (en) *	2005-02-28	2006-08-30	Laboratorios Del Dr. Esteve, S.A.	Derivatives of aryl (or heteroaryl) azolylcarbinols for the treatment of fibromyalgia
EP1690537A1 (en) *	2005-02-15	2006-08-16	Laboratorios Del Dr. Esteve, S.A.	Derivatives of aryl(or heteroaryl) azolycarbinols for the treatment of fibromyalgia
ES2286920B1 (es) *	2005-02-15	2008-08-16	Laboratorios Del Dr. Esteve, S.A.	Derivados de aril (o heteroaril)azolilcarbinoles para el tratamiento de la fibromialgia.
CN101374516A (zh) *	2006-01-27	2009-02-25	弗·哈夫曼-拉罗切有限公司	取代的咪唑啉的2-咪唑衍生物的用途
EP1820502A1 (en) *	2006-02-10	2007-08-22	Laboratorios Del Dr. Esteve, S.A.	Active substance combination comprising azolylcarbinol compounds
EP2076497B1 (en)	2006-10-19	2012-02-22	F. Hoffmann-La Roche AG	Aminomethyl-4-imidazoles
ES2375578T3 (es)	2006-11-02	2012-03-02	F. Hoffmann-La Roche Ag	2-imidazoles sustituidos como moduladores de receptores asociados a aminas trazas.
WO2008058867A2 (en)	2006-11-16	2008-05-22	F. Hoffmann-La Roche Ag	Substituted 4-imidazoles
CN101190330A (zh)	2006-11-30	2008-06-04	深圳市鼎兴生物医药技术开发有限公司	胆碱酯酶在拮抗速激肽药物中的应用
CA2672617A1 (en)	2006-12-13	2008-06-19	F. Hoffmann-La Roche Ag	Novel 2-imidazoles as ligands for trace amine associated receptors (taar)
WO2008092785A1 (en)	2007-02-02	2008-08-07	F. Hoffmann-La Roche Ag	Novel 2-aminooxazolines as taar1 ligands for cns disorders
RU2460725C2 (ru)	2007-02-15	2012-09-10	Ф. Хоффманн-Ля Рош Аг	Новые 2-аминооксазолины в качестве лигандов taar1
EP2173720A2 (en)	2007-07-02	2010-04-14	F. Hoffmann-Roche AG	2-imidazolines having a good affinity to the trace amine associated receptors (taars)
EP2173719A1 (en)	2007-07-03	2010-04-14	F. Hoffmann-Roche AG	4-imidazolines and their use as antidepressants
KR101133862B1 (ko)	2007-07-27	2012-04-06	에프. 호프만-라 로슈 아게	Ｔａａｒ 리간드로서의 2-아제티딘메테인아민 및 2-피롤리딘메테인아민
EP2185502A1 (en)	2007-08-03	2010-05-19	F. Hoffmann-Roche AG	Pyridinecarboxamide and benzamide derivatives as taar1 ligands
US8242153B2 (en)	2008-07-24	2012-08-14	Hoffmann-La Roche Inc.	4,5-dihydro-oxazol-2YL derivatives
US20100291151A1 (en) *	2009-04-21	2010-11-18	Auspex Pharmaceuticals, Inc.	1-methylpyrazole modulators of substance p, calcitonin gene-related peptide, adrenergic receptor, and/or 5-ht receptor
US8354441B2 (en)	2009-11-11	2013-01-15	Hoffmann-La Roche Inc.	Oxazoline derivatives
US9452980B2 (en)	2009-12-22	2016-09-27	Hoffmann-La Roche Inc.	Substituted benzamides
MX377836B (es)	2016-03-17	2025-03-11	F Hoffmann La Roche Ag	Derivado de 5-etil-4-metil-pirazol-3-carboxamida teniendo actividad como agonista de receptor asociado con aminas trazas (taar).

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2613720B1 (fr) *	1987-04-10	1990-01-19	Esteve Labor Dr	Derives d'aryl-heteroaryl carbinols avec activite analgesique
FR2681322B1 (fr) *	1991-09-12	1993-12-17	Laboratorios Dr Esteve Sa	Derives d'aryl-heteroaryl-{n-[2-(3,4-dimethoxyphenyl)-ethyl]-n-methyl-3-aminopropoxy}-methane leur preparation et leur application en tant que medicaments .
CA2154116A1 (en) *	1994-07-22	1996-01-23	Philip Arthur Hipskind	1-aryl-2-acetamidopentanone derivatives for use as tachykinin receptor antagonists
AU732633B2 (en) *	1996-12-02	2001-04-26	Merck Sharp & Dohme Limited	Use of NK-1 receptor antagonists for treating schizophrenic disorders
JP2001504848A (ja) *	1996-12-02	2001-04-10	メルクシヤープエンドドームリミテツド	重症不安障害の治療のためのｎｋ−１受容体拮抗薬の使用
JP2001504847A (ja) *	1996-12-02	2001-04-10	メルクシヤープエンドドームリミテツド	重抑鬱障害の治療のためのｎｋ−１受容体拮抗薬の使用
ATE293975T1 (de) *	1996-12-02	2005-05-15	Merck Sharp & Dohme	Die verwendung von nk-1 rezeptor antagonisten für die behandlung von kognitiven störungen
ES2150353B1 (es) *	1998-04-15	2001-07-01	Esteve Labor Dr	Tienilazolilalcoxietanaminas, su preparacion y su aplicacion como medicamentos.

1998
- 1998-08-07 ES ES009801708A patent/ES2150378B1/es not_active Expired - Fee Related
1999
- 1999-08-04 CO CO99049291A patent/CO5080747A1/es unknown
- 1999-08-04 AR ARP990103870A patent/AR019999A1/es unknown
- 1999-08-05 EP EP99940199A patent/EP1103243B1/en not_active Expired - Lifetime
- 1999-08-05 DE DE69914085T patent/DE69914085T8/de not_active Expired - Fee Related
- 1999-08-05 PT PT99940199T patent/PT1103243E/pt unknown
- 1999-08-05 KR KR1020017001560A patent/KR100558506B1/ko not_active IP Right Cessation
- 1999-08-05 JP JP2000563228A patent/JP2002522359A/ja active Pending
- 1999-08-05 NZ NZ509645A patent/NZ509645A/xx unknown
- 1999-08-05 DK DK99940199T patent/DK1103243T3/da active
- 1999-08-05 CZ CZ2001412A patent/CZ292065B6/cs not_active IP Right Cessation
- 1999-08-05 TW TW088113353A patent/TW445259B/zh not_active IP Right Cessation
- 1999-08-05 RU RU2001106644/15A patent/RU2223116C2/ru not_active IP Right Cessation
- 1999-08-05 TR TR2001/00378T patent/TR200100378T2/xx unknown
- 1999-08-05 CA CA002339661A patent/CA2339661C/en not_active Expired - Fee Related
- 1999-08-05 HU HU0105428A patent/HUP0105428A3/hu unknown
- 1999-08-05 AU AU54229/99A patent/AU754124B2/en not_active Ceased
- 1999-08-05 BR BR9912807-1A patent/BR9912807A/pt not_active Application Discontinuation
- 1999-08-05 CN CNB998109150A patent/CN1151789C/zh not_active Expired - Fee Related
- 1999-08-05 US US09/762,079 patent/US6518295B1/en not_active Expired - Fee Related
- 1999-08-05 WO PCT/ES1999/000255 patent/WO2000007542A2/es active IP Right Grant
- 1999-08-05 AT AT99940199T patent/ATE257379T1/de not_active IP Right Cessation
- 1999-08-05 PL PL99346221A patent/PL193802B1/pl not_active IP Right Cessation
- 1999-08-05 ES ES99940199T patent/ES2213380T3/es not_active Expired - Lifetime
2001
- 2001-01-31 ZA ZA200100867A patent/ZA200100867B/en unknown
- 2001-02-06 NO NO20010634A patent/NO20010634L/no not_active Application Discontinuation
- 2001-02-07 IL IL14129501A patent/IL141295A0/xx unknown

Also Published As

Publication number	Publication date
DE69914085T2 (de)	2004-11-25
JP2002522359A (ja)	2002-07-23
ES2150378B1 (es)	2001-07-01
CA2339661A1 (en)	2000-02-17
CZ292065B6 (cs)	2003-07-16
KR100558506B1 (ko)	2006-03-07
AU754124B2 (en)	2002-11-07
CZ2001412A3 (cs)	2001-08-15
CA2339661C (en)	2006-10-17
CO5080747A1 (es)	2001-09-25
DK1103243T3 (da)	2004-05-03
AR019999A1 (es)	2002-03-27
KR20010079616A (ko)	2001-08-22
DE69914085D1 (de)	2004-02-12
PL193802B1 (pl)	2007-03-30
WO2000007542A2 (es)	2000-02-17
NO20010634D0 (no)	2001-02-06
TR200100378T2 (tr)	2001-06-21
ATE257379T1 (de)	2004-01-15
EP1103243A2 (en)	2001-05-30
AU5422999A (en)	2000-02-28
PL346221A1 (en)	2002-01-28
US6518295B1 (en)	2003-02-11
ZA200100867B (en)	2001-08-16
WO2000007542A3 (es)	2000-05-11
RU2223116C2 (ru)	2004-02-10
DE69914085T8 (de)	2005-04-21
CN1317966A (zh)	2001-10-17
HUP0105428A3 (en)	2003-01-28
ES2150378A1 (es)	2000-11-16
BR9912807A (pt)	2001-10-16
ES2213380T3 (es)	2004-08-16
HUP0105428A2 (hu)	2002-05-29
PT1103243E (pt)	2004-05-31
NZ509645A (en)	2003-01-31
EP1103243B1 (en)	2004-01-07
CN1151789C (zh)	2004-06-02
TW445259B (en)	2001-07-11
NO20010634L (no)	2001-04-06

Publication	Publication Date	Title
IL141295A0 (en)	2002-12-01	Use of derivatives of aryl (or heteroaryl) azolycarbinols in the manufacture of a medicament for the treatment of disorders mediated by an excess of substance p
AUPP609198A0 (en)	1998-10-15	Use of non-peptidyl compounds for the treatment of insulin related ailments
IL196301A0 (en)	2009-09-22	Medicament for the treatment of hapatitis c
HUP0200644A3 (en)	2004-07-28	1,4-benzothiazepine-1,1-dioxide derivatives substituted by sugar radicals, methods for the production thereof, medicaments containing these compounds and the use thereof
NO20006630D0 (no)	2000-12-22	Farmasöytisk sammensetning for behandlingen av diabetes
AU1050401A (en)	2001-05-08	Device for cardiac therapy
AU6777300A (en)	2001-03-13	Treatment apparatus for wounds
AU3673499A (en)	1999-11-23	Hydrogel for the therapeutic treatment of aneurysms
NO20013369D0 (no)	2001-07-06	Arylpiperazinyl-cykloheksyl-indol-derivater for behandling av depresjon
NO20022087L (no)	2002-06-24	Fremgangsmåte for behandling av diabetes
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AU6910600A (en)	2001-03-19	Methods for the treatment of mental disorders
ZA983602B (en)	1998-11-02	Use of tetrahydropyridine derivatives for the preparation of drugs for the treatment of diseases which cause demyelination
FI20020072A (fi)	2002-03-13	Applikaattori kõytettõvõksi refleksoterapiassa
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AU2508597A (en)	1997-10-29	Drug for the treatment of tumours
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AUPQ232599A0 (en)	1999-09-09	Drug for treating fractures
ZA97872B (en)	1997-08-04	Use of pyrolidine derivatives for the manufacture of medicaments.
AU6076000A (en)	2001-02-19	Cyclic amine derivatives for the treatment of neurological diseases
AU2566201A (en)	2001-07-09	Compounds and methods for the treatment of pain
AU5847299A (en)	2001-04-10	Medical device for treating narrow nostrils
GB0212790D0 (en)	2002-07-10	Medicament for the treatment of diabetes