IL126899A - Preparations for once-daily treatment of diseases mediated by cyclooxygenase-2 - Google Patents

Preparations for once-daily treatment of diseases mediated by cyclooxygenase-2

Info

Publication number: IL126899A
Authority: IL; Israel
Prior art keywords: treatment; phenyl; use according; furanone; once
Prior art date: 1996-05-17

Application number

IL12689997A

Other languages

English (en)

Hebrew (he)

Other versions

IL126899A0 (en

Original Assignee

Merck & Co Inc

Merck Frosst Canada Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-05-17

Filing date

1997-05-13

Publication date

2004-03-28

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26309472&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL126899(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1996-06-10 Priority claimed from GBGB9612063.9A external-priority patent/GB9612063D0/en

1997-05-13 Application filed by Merck & Co Inc, Merck Frosst Canada Inc filed Critical Merck & Co Inc

1999-09-22 Publication of IL126899A0 publication Critical patent/IL126899A0/xx

2004-03-28 Publication of IL126899A publication Critical patent/IL126899A/en

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

IL12689997A 1996-05-17 1997-05-13 Preparations for once-daily treatment of diseases mediated by cyclooxygenase-2 IL126899A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US1787896P	1996-05-17	1996-05-17
GBGB9612063.9A GB9612063D0 (en)	1996-06-10	1996-06-10	Compositions for a once a day treatment of cyclooxygenase-2 mediated diseases
PCT/US1997/008041 WO1997044028A1 (en)	1996-05-17	1997-05-13	Compositions for a once a day treatment of cyclooxygenase-2 mediated diseases

Publications (2)

Publication Number	Publication Date
IL126899A0 IL126899A0 (en)	1999-09-22
IL126899A true IL126899A (en)	2004-03-28

Family

ID=26309472

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12689997A IL126899A (en)	1996-05-17	1997-05-13	Preparations for once-daily treatment of diseases mediated by cyclooxygenase-2

Country Status (29)

Country	Link
US (1)	US6063811A (et)
EP (1)	EP0910368A1 (et)
JP (1)	JPH11512754A (et)
KR (1)	KR100373622B1 (et)
CN (1)	CN1140267C (et)
AR (1)	AR012014A1 (et)
AU (1)	AU3004997A (et)
BG (1)	BG103000A (et)
BR (1)	BR9709097A (et)
CA (1)	CA2254061C (et)
CO (1)	CO5050370A1 (et)
CZ (1)	CZ291463B6 (et)
DZ (1)	DZ2200A1 (et)
EA (1)	EA001596B1 (et)
EE (1)	EE03746B1 (et)
HK (1)	HK1021623A1 (et)
HR (1)	HRP970262A2 (et)
HU (1)	HUP9902889A3 (et)
ID (1)	ID16921A (et)
IL (1)	IL126899A (et)
IS (1)	IS4891A (et)
MY (1)	MY116201A (et)
NO (1)	NO985342D0 (et)
NZ (1)	NZ332670A (et)
PE (1)	PE66998A1 (et)
PL (1)	PL188649B1 (et)
SK (1)	SK284330B6 (et)
TR (1)	TR199802345T2 (et)
WO (1)	WO1997044028A1 (et)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2322824A1 (en) *	1998-03-13	1999-09-16	Merck & Co., Inc.	Combination therapy and composition for acute coronary ischemic syndrome and related conditions
US6136804A (en) *	1998-03-13	2000-10-24	Merck & Co., Inc.	Combination therapy for treating, preventing, or reducing the risks associated with acute coronary ischemic syndrome and related conditions
SA99191255B1 (ar) *	1998-11-30	2006-11-25	جي دي سيرل اند كو	مركبات سيليكوكسيب celecoxib
CO5190664A1 (es)	1999-06-30	2002-08-29	Pfizer Prod Inc	Terapia de combinacion para el tratamiento de migrana administracion de un receptor 5ht, cafeina y un inhibidor de ciclooxigenasa-2
GB9920558D0 (en) *	1999-08-31	1999-11-03	Bradford Particle Design Ltd	Methods for particle formation and their products
PL355391A1 (en) *	1999-12-22	2004-04-19	Pharmacia Corporation	Sustained-release formulation of a cyclooxygenase-2 inhibitor
CA2411960C (en)	2000-06-13	2010-10-12	Wyeth	Analgesic and anti-inflammatory compositions containing cox-2 inhibitors
CN1638739A (zh) *	2000-08-18	2005-07-13	法玛西雅厄普约翰美国公司	治疗成瘾性障碍的化合物
NZ524124A (en) *	2000-08-18	2004-09-24	Pharmacia Corp	Rapidly disintegrating oral formulation of a cyclooxygenase-2 inhibitor
WO2002017896A2 (en) *	2000-08-29	2002-03-07	Peter Van Patten	Combination for the treatment of migraine comprising a cyclooxygenase-2 inhibitor and acetylsalicylic acid
PE20020351A1 (es) *	2000-09-11	2002-06-14	Novartis Ag	Composiciones farmaceuticas que comprenden acido 5-metil-2-(2'-cloro-6'-fluoroanilino)fenilacetico como inhibidor de la ciclooxigenasa-2
US7115565B2 (en) *	2001-01-18	2006-10-03	Pharmacia & Upjohn Company	Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
CA2445502A1 (en) *	2001-05-04	2002-11-14	Merck & Co., Inc.	Method and compositions for treating migraines
PE20030323A1 (es) *	2001-08-31	2003-05-12	Novartis Ag	Composicion farmaceutica
IL160855A0 (en) *	2001-09-26	2004-08-31	Pharmacia Corp	Intraorally disintegrating valdecoxib compositions
OA12666A (en) *	2001-10-10	2006-06-19	Pharmacia Corp Corporate Paten	Intraorally disintegrating valdecoxib compositionsprepared by spray drying process.
BR0308156A (pt) *	2002-03-07	2005-01-04	Novartis Ag	Composições farmacêuticas sólidas contendo lumiracoxib
ES2213485B1 (es)	2003-02-13	2005-12-16	Almirall Prodesfarma, S.A.	Derivados de la 2-fenilpiran-4-ona.
ES2214129B1 (es) *	2003-02-13	2005-12-01	Almirall Prodesfarma, S.A.	3-fenilfuran-2-onas.
EP1745791B1 (en)	2003-05-07	2013-06-26	Osteologix A/S	Treating cartilage/bone conditions with water-soluble strontium salts
TR200301552A1 (tr) *	2003-09-18	2005-10-21	Nobel İlaç Sanayi̇ Ve Ti̇caret A. Ş.	Rofekoksib' in yeni oral farmakolojik formülasyonları.
JP2010516679A (ja) *	2007-01-19	2010-05-20	マリンクロットインコーポレイテッド	診断用および治療用シクロオキシゲナーゼ−２結合リガンド
JP7291220B2 (ja)	2018-11-21	2023-06-14	トレモ― ファーマシューティカルズ，インコーポレーテッド	ロフェコキシブの精製形態、製造方法および使用
US20200323830A1 (en) *	2019-04-09	2020-10-15	Tremeau Pharmaceuticals, Inc.	Treatment of viral hemorrhagic fevers with etoricoxib
US10945992B1 (en)	2019-11-13	2021-03-16	Tremeau Pharmaceuticals, Inc.	Dosage forms of rofecoxib and related methods
US11161833B1 (en)	2021-04-09	2021-11-02	Tremeau Pharmaceuticals, Inc.	Deuterated etoricoxib, methods of manufacture, and use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5474995A (en) *	1993-06-24	1995-12-12	Merck Frosst Canada, Inc.	Phenyl heterocycles as cox-2 inhibitors
SG43841A1 (en) *	1994-01-10	1997-11-14	Merck Frosst Canada Inc	Phenyl heterocycles as cox-2 inhibitors

1997
- 1997-05-13 US US09/180,647 patent/US6063811A/en not_active Expired - Lifetime
- 1997-05-13 HU HU9902889A patent/HUP9902889A3/hu unknown
- 1997-05-13 EA EA199801017A patent/EA001596B1/ru not_active IP Right Cessation
- 1997-05-13 JP JP9542486A patent/JPH11512754A/ja active Pending
- 1997-05-13 SK SK1567-98A patent/SK284330B6/sk unknown
- 1997-05-13 BR BR9709097A patent/BR9709097A/pt not_active IP Right Cessation
- 1997-05-13 CA CA002254061A patent/CA2254061C/en not_active Expired - Fee Related
- 1997-05-13 TR TR1998/02345T patent/TR199802345T2/xx unknown
- 1997-05-13 EE EE9800393A patent/EE03746B1/et not_active IP Right Cessation
- 1997-05-13 WO PCT/US1997/008041 patent/WO1997044028A1/en not_active Application Discontinuation
- 1997-05-13 KR KR10-1998-0709239A patent/KR100373622B1/ko not_active IP Right Cessation
- 1997-05-13 CN CNB971963150A patent/CN1140267C/zh not_active Expired - Fee Related
- 1997-05-13 IL IL12689997A patent/IL126899A/en not_active IP Right Cessation
- 1997-05-13 CZ CZ19983738A patent/CZ291463B6/cs not_active IP Right Cessation
- 1997-05-13 EP EP97924688A patent/EP0910368A1/en not_active Withdrawn
- 1997-05-13 AU AU30049/97A patent/AU3004997A/en not_active Abandoned
- 1997-05-13 NZ NZ332670A patent/NZ332670A/xx unknown
- 1997-05-14 AR ARP970102021A patent/AR012014A1/es unknown
- 1997-05-14 DZ DZ970087A patent/DZ2200A1/fr active
- 1997-05-15 PE PE1997000379A patent/PE66998A1/es not_active Application Discontinuation
- 1997-05-16 MY MYPI97002138A patent/MY116201A/en unknown
- 1997-05-16 CO CO97026568A patent/CO5050370A1/es unknown
- 1997-05-16 ID IDP971640A patent/ID16921A/id unknown
- 1997-05-16 HR HR9612063.9A patent/HRP970262A2/xx not_active Application Discontinuation
1998
- 1998-11-10 IS IS4891A patent/IS4891A/is unknown
- 1998-11-16 NO NO985342A patent/NO985342D0/no not_active Application Discontinuation
- 1998-12-08 BG BG103000A patent/BG103000A/xx unknown
1999
- 1999-01-11 PL PL97329940A patent/PL188649B1/pl not_active IP Right Cessation
2000
- 2000-02-02 HK HK00100645A patent/HK1021623A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
CZ373898A3 (cs)	1999-06-16
EE03746B1 (et)	2002-06-17
SK284330B6 (sk)	2005-01-03
HRP970262A2 (en)	1998-06-30
NO985342L (no)	1998-11-16
EP0910368A1 (en)	1999-04-28
IS4891A (is)	1998-11-10
US6063811A (en)	2000-05-16
MY116201A (en)	2003-11-28
TR199802345T2 (xx)	1999-03-22
IL126899A0 (en)	1999-09-22
EA199801017A1 (ru)	1999-04-29
SK156798A3 (en)	2000-01-18
CN1140267C (zh)	2004-03-03
BR9709097A (pt)	1999-08-03
CN1225010A (zh)	1999-08-04
CZ291463B6 (cs)	2003-03-12
PE66998A1 (es)	1998-10-24
CO5050370A1 (es)	2001-06-27
DZ2200A1 (fr)	2004-06-20
AU3004997A (en)	1997-12-09
PL188649B1 (pl)	2005-03-31
HK1021623A1 (en)	2000-06-23
PL329940A1 (en)	1999-04-26
KR100373622B1 (ko)	2003-07-12
NZ332670A (en)	2000-07-28
JPH11512754A (ja)	1999-11-02
KR20000011082A (ko)	2000-02-25
HUP9902889A2 (hu)	2002-01-28
HUP9902889A3 (en)	2002-04-29
WO1997044028A1 (en)	1997-11-27
ID16921A (id)	1997-11-20
AR012014A1 (es)	2000-09-27
BG103000A (en)	1999-09-30
NO985342D0 (no)	1998-11-16
CA2254061C (en)	2003-12-02
EE9800393A (et)	1999-06-15
CA2254061A1 (en)	1997-11-27
EA001596B1 (ru)	2001-06-25

Publication	Publication Date	Title
IL126899A (en)	2004-03-28	Preparations for once-daily treatment of diseases mediated by cyclooxygenase-2
FI112222B (fi)	2003-11-14	Menetelmä uusien, terapeuttisesti käyttökelpoisten furanonijohdannaisten valmistamiseksi
US5521213A (en)	1996-05-28	Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2
JP2788677B2 (ja)	1998-08-20	Ｃｏｘ−２阻害剤としてのフェニル複素環
US6020343A (en)	2000-02-01	(Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors
KR100382619B1 (ko)	2003-05-09	2,3-디아릴-피라졸로[1,5-ｂ]피리다진 유도체, 그의 제조방법 및 시클로옥시게나제 2(ｃｏｘ-2) 억제제로서의 용도
EP0828724B1 (en)	2001-12-05	Diaryl-5-oxygenated-2-(5h)-furanones as cox-2 inhibitors
JPH11501049A (ja)	1999-01-26	イミダゾ〔１，２−ａ〕ピリジン誘導体
RO118585B1 (ro)	2003-07-30	Procedeu pentru prepararea unor derivati de furanona folositi ca inhibitori de ciclooxigenaza - 2
JP2001199954A (ja)	2001-07-24	Ｃｏｘ−２インヒビターとしての（メチルスルホニル）フェニル−２−（５ｈ）−フラノン類
WO1996037468A1 (en)	1996-11-28	N-benzyl-3-indoleacetic acids as cyclooxygenase-2-inhibitors and antiinflammatory drugs
EP0808305A1 (en)	1997-11-26	3,4-diaryl substituted pyridines for the treatment of inflammation
JPH11500748A (ja)	1999-01-19	Ｃｏｘ−２阻害剤のプロドラッグとしての３，４−ジアリール−２−ヒドロキシ−２，５−ジヒドロフラン
KR20010079602A (ko)	2001-08-22	선택적인 ｃｏｘ-2 저해제인 치환된 이미다조[1,2ａ]아진
NO311761B1 (no)	2002-01-21	2-(3H)-Oksazolonderivater og deres anvendelse
CN101910144A (zh)	2010-12-08	对羟基苯丙烯酸衍生物及其应用
CA2301590C (en)	2007-05-01	2-aminopyridines as inhibitors of cyclooxygenase-2
AU6818298A (en)	1998-10-22	Alpha-methylene gamma lactones as selective cyclooxygenase-2 inhibitors
WO1997044027A1 (en)	1997-11-27	Compositions for a once a day treatment of cyclooxygenase-2 mediated diseases
AU4622101A (en)	2001-07-26	Compositions for a once a day treatment of cyclooxygenase-2 mediated diseases
EP1090915B1 (en)	2009-05-27	Polymorphic B form of 3-(cyclopropylmethoxy)-4-¬-4-(methylsulfonyl)phenyl - 5,5-dimethyl-5H-furan-2-one
US5939417A (en)	1999-08-17	1,3,6-trihydro-6-aza-3-oxapentalen-2-one derivatives for the treatment of neoplasia
US6455703B2 (en)	2002-09-24	1,3,6,-Trihydro-6-aza-3-oxapentalen-2-one derivatives for the treatment of neoplasia

Legal Events

Date	Code	Title
2005-09-25	FF	Patent granted
2005-09-25	KB	Patent renewed
2007-07-06	KB	Patent renewed
2015-12-31	MM9K	Patent not in force due to non-payment of renewal fees