IL124954A - Inhibitors of interleukin-1betaconverting enzyme and pharmaceutical compositions containing the same - Google Patents

Inhibitors of interleukin-1betaconverting enzyme and pharmaceutical compositions containing the same

Info

Publication number: IL124954A
Authority: IL; Israel
Prior art keywords: interleukin; pharmaceutical compositions; compounds; inhibitors; diseases
Prior art date: 1995-12-20

Application number

IL12495496A

Other languages

English (en)

Other versions

IL124954A0 (en

Original Assignee

Vertex Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-20

Filing date

1996-12-20

Publication date

2005-11-20

1996-12-20 Application filed by Vertex Pharma filed Critical Vertex Pharma

1999-01-26 Publication of IL124954A0 publication Critical patent/IL124954A0/xx

2005-11-20 Publication of IL124954A publication Critical patent/IL124954A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Physical Education & Sports Medicine (AREA)
Diabetes (AREA)
Neurology (AREA)
Molecular Biology (AREA)
Orthopedic Medicine & Surgery (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Rheumatology (AREA)
Biophysics (AREA)
Neurosurgery (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Endocrinology (AREA)
Oncology (AREA)
Hematology (AREA)
Crystallography & Structural Chemistry (AREA)
Urology & Nephrology (AREA)
Communicable Diseases (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Virology (AREA)
Psychiatry (AREA)

IL12495496A 1995-12-20 1996-12-20 Inhibitors of interleukin-1betaconverting enzyme and pharmaceutical compositions containing the same IL124954A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/575,648 US5843904A (en)	1995-12-20	1995-12-20	Inhibitors of interleukin-1βconverting enzyme
PCT/US1996/020370 WO1997022618A1 (en)	1995-12-20	1996-12-20	INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME

Publications (2)

Publication Number	Publication Date
IL124954A0 IL124954A0 (en)	1999-01-26
IL124954A true IL124954A (en)	2005-11-20

Family

ID=24301162

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12495496A IL124954A (en)	1995-12-20	1996-12-20	Inhibitors of interleukin-1betaconverting enzyme and pharmaceutical compositions containing the same

Country Status (21)

Country	Link
US (2)	US5843904A (xx)
EP (1)	EP0876395B1 (xx)
JP (3)	JP4009320B2 (xx)
KR (1)	KR20000064454A (xx)
CN (2)	CN1127511C (xx)
AT (1)	ATE310011T1 (xx)
AU (1)	AU722936B2 (xx)
BR (1)	BR9612191A (xx)
CA (1)	CA2240489A1 (xx)
CZ (1)	CZ292633B6 (xx)
DE (1)	DE69635458T2 (xx)
HK (1)	HK1016611A1 (xx)
HU (1)	HUP9902254A3 (xx)
IL (1)	IL124954A (xx)
NO (1)	NO982774L (xx)
NZ (1)	NZ326555A (xx)
PL (1)	PL188813B1 (xx)
RU (1)	RU2213096C2 (xx)
TR (1)	TR199801168T2 (xx)
WO (1)	WO1997022618A1 (xx)
ZA (1)	ZA9610797B (xx)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5843904A (en) *	1995-12-20	1998-12-01	Vertex Pharmaceuticals, Inc.	Inhibitors of interleukin-1βconverting enzyme
CA2265928A1 (en) *	1996-09-12	1998-03-19	Idun Pharmaceuticals, Incorporated	C-terminal modified (n-substituted)-2-indolyl dipeptides as inhibitors of the ice/ced-3 family of cysteine proteases
US5869519A (en) *	1996-12-16	1999-02-09	Idun Pharmaceuticals, Inc.	C-terminal modified (n-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
US5877197A (en) *	1996-12-16	1999-03-02	Karanewsky; Donald S.	C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
US6184244B1 (en) *	1996-12-16	2001-02-06	Idun Pharmaceuticals, Inc.	C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
US6093742A (en) *	1997-06-27	2000-07-25	Vertex Pharmaceuticals, Inc.	Inhibitors of p38
US6184210B1 (en) *	1997-10-10	2001-02-06	Cytovia, Inc.	Dipeptide apoptosis inhibitors and the use thereof
US6054446A (en) *	1997-12-24	2000-04-25	Sri International	Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
ATE295177T1 (de) *	1998-03-16	2005-05-15	Cytovia Inc	Dipeptid kaspase inhibitoren und deren verwendung
US7157430B2 (en)	1998-10-22	2007-01-02	Idun Pharmaceuticals, Inc.	(Substituted)acyl dipeptidyl inhibitors of the ICE/CED-3 family of cysteine proteases
US6242422B1 (en) *	1998-10-22	2001-06-05	Idun Pharmacueticals, Inc.	(Substituted)Acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases
WO2000051998A1 (en)	1999-03-02	2000-09-08	Boehringer Ingelheim Pharmaceuticals, Inc.	Compounds useful as reversible inhibitors of cathepsin s
TW200404789A (en) *	1999-03-15	2004-04-01	Axys Pharm Inc	Novel compounds and compositions as protease inhibitors
AU3876600A (en)	1999-03-16	2000-10-04	Cytovia, Inc.	Substituted 2-aminobenzamide caspase inhibitors and the use thereof
AU4213500A (en)	1999-04-09	2000-11-14	Cytovia, Inc.	Caspase inhibitors and the use thereof
WO2001010457A2 (en) *	1999-08-09	2001-02-15	Tripep Ab	Pharmaceutical compositions containing tripeptides
EA200200301A1 (ru)	1999-08-27	2002-08-29	Сайтовиэ, Инк.	ЗАМЕЩЕННЫЕ α-ГИДРОКСИКИСЛОТЫ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СПОСОБ ИНГИБИРОВАНИЯ КЛЕТОЧНОЙ ГИБЕЛИ НА КЛЕТОЧНОМ ИЛИ ТКАНЕВОМ УРОВНЕ, СПОСОБ ЛЕЧЕНИЯ ИЛИ ОБЛЕГЧЕНИЯ СОСТОЯНИЯ ПРИ ГИБЕЛИ КЛЕТОК У ЖИВОТНОГО, СПОСОБ ЛЕЧЕНИЯ ИЛИ ПРОФИЛАКТИКИ РАЗЛИЧНЫХ БОЛЕЗНЕЙ
US6420364B1 (en)	1999-09-13	2002-07-16	Boehringer Ingelheim Pharmaceuticals, Inc.	Compound useful as reversible inhibitors of cysteine proteases
US6566338B1 (en)	1999-10-12	2003-05-20	Cytovia, Inc.	Caspase inhibitors for the treatment and prevention of chemotherapy and radiation therapy induced cell death
US6525024B1 (en)	2000-04-17	2003-02-25	Idun Pharmaceuticals, Inc.	Inhibitors of the ICE/ced-3 family of cysteine proteases
EP1712239A3 (en) *	2000-05-12	2007-08-22	Immunex Corporation	Interleukin-1 inhibitors in the treatment of diseases
PE20011350A1 (es)	2000-05-19	2002-01-15	Vertex Pharma	PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
US6613801B2 (en) *	2000-05-30	2003-09-02	Transtech Pharma, Inc.	Method for the synthesis of compounds of formula I and their uses thereof
CA2421172A1 (en)	2000-09-08	2002-03-14	Merck Frosst Canada & Co.	Gamma-ketoacid dipeptides as inhibitors of caspase-3
US6800619B2 (en) *	2000-09-13	2004-10-05	Vertex Pharmaceuticals Incorporated	Caspase inhibitors and uses thereof
AR035720A1 (es) *	2000-12-20	2004-07-07	Bristol Myers Squibb Pharma Co	Derivados de amida ,composicion farmaceutica que lo comprende y su uso en la fabricacion de medicamentos para modular la actividad de quimioquinas
AR035773A1 (es)	2000-12-20	2004-07-14	Bristol Myers Squibb Pharma Co	Compuestos diamino ciclico, composicion farmaceutica y su uso en la fabricacion de un medicamento util para modular la actividad de una quimioquina
US20050074434A1 (en) *	2001-02-23	2005-04-07	Tomoaki Hoshino	Remedies for metabolic bone diseases
CN1235583C (zh)	2001-03-05	2006-01-11	特兰斯泰克制药公司	用作治疗剂的苯并咪唑衍生物
CA2440042C (en)	2001-03-05	2011-09-27	Transtech Pharma, Inc.	Carboxamide derivatives as therapeutic agents
MXPA04001187A (es) *	2001-08-07	2004-07-08	Immunex Corp	Receptores de interleucina-1 en el tratamiento de enfermedades.
US6593455B2 (en) *	2001-08-24	2003-07-15	Tripep Ab	Tripeptide amides that block viral infectivity and methods of use thereof
WO2003024995A1 (en) *	2001-09-19	2003-03-27	Tripep Ab	Molecules that block viral infectivity and methods of use thereof
AU2002357137A1 (en) *	2001-12-10	2003-06-23	Bristol-Myers Squibb Company	(1-phenyl-2-heteroaryl)ethyl-guanidine compounds as inhibitors of mitochondrial f1f0 atp hydrolase
EP2324830A1 (en)	2002-03-05	2011-05-25	TransTech Pharma Inc.	Process for the preparation of a monocyclic azole derivative that inhibits the interaction of ligands with rage
EP1483241A4 (en)	2002-03-08	2006-12-13	Bristol Myers Squibb Co	CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
CN1656237A (zh) *	2002-04-22	2005-08-17	马里兰大学,巴尔的摩县	衣壳蛋白的抗病毒抑制
US20040180893A1 (en) *	2003-02-21	2004-09-16	Balzarini Jan Maria Rene	Identification of compounds that inhibit replication of human immunodeficiency virus
US20050096319A1 (en) *	2003-02-21	2005-05-05	Balzarini Jan M.R.	Identification of compounds that inhibit replication of human immunodeficiency virus
GB0329572D0 (en) *	2003-12-20	2004-01-28	Astrazeneca Ab	Amide derivatives
PT2399915E (pt)	2004-03-12	2015-03-30	Vertex Pharma	Processo e intermediários para a preparação de inibidores de caspase de acetal de ácido aspártico
CN1980648A (zh) *	2004-05-15	2007-06-13	沃泰克斯药物股份有限公司	使用ice抑制剂治疗癫痫发作
GB0411056D0 (en)	2004-05-18	2004-06-23	Novartis Ag	Organic compounds
ATE529430T1 (de)	2005-07-28	2011-11-15	Vertex Pharma	Caspase-hemmer-propharmaka
TWI517850B (zh)	2009-09-30	2016-01-21	Ｖｔｖ治療有限責任公司	經取代之咪唑衍生物及其使用方法
US9956260B1 (en)	2011-07-22	2018-05-01	The J. David Gladstone Institutes	Treatment of HIV-1 infection and AIDS
CN104650016A (zh) *	2015-01-29	2015-05-27	武汉大学	拟三肽类化合物及其制备方法
CN112979636A (zh) *	2021-02-06	2021-06-18	绍兴文理学院	一种含苯硫醚结构的噻唑类化合物及其制备方法和应用
WO2022238507A1 (en) *	2021-05-11	2022-11-17	Awakn Ls Europe Holdings Limited	Therapeutic aminoindane compounds and compositions

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4276298A (en) *	1978-03-24	1981-06-30	Merck & Co., Inc.	2-Aryl-1,2-benzisothiazolinone-1,1-dioxides and their use as selective protease inhibitors
US4369183A (en) *	1979-09-06	1983-01-18	Merck & Co., Inc.	2-Pyridyl-1,2-benzisothiazolinone-1,1-dioxides and their use as selective protease inhibitors
US4584397A (en) *	1983-05-09	1986-04-22	G. D. Searle & Co.	Protease inhibitors
US4499295A (en) *	1983-05-09	1985-02-12	G. D. Searle & Co.	Protease inhibitors
US4551279A (en) *	1984-01-09	1985-11-05	G. D. Searle & Co.	Protease inhibitors
US5055451A (en) *	1986-12-22	1991-10-08	Syntex Inc.	Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors
US5158936A (en) *	1986-12-22	1992-10-27	Syntex (U.S.A.) Inc.	Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors
NZ223148A (en) *	1987-01-16	1989-10-27	Merrell Dow Pharma	Peptide derivatives having peptidase inhibition activity
US5081228A (en) *	1988-02-25	1992-01-14	Immunex Corporation	Interleukin-1 receptors
WO1989004838A1 (en) *	1987-11-25	1989-06-01	Immunex Corporation	Interleukin-1 receptors
US4968607A (en) *	1987-11-25	1990-11-06	Immunex Corporation	Interleukin-1 receptors
US5008245A (en) *	1988-10-27	1991-04-16	University Of Kentucky Research Foundation	Novel peptidyl carbamate inhibitors of the enzyme elastase
NZ233521A (en) *	1989-05-04	1992-05-26	Sterling Drug Inc	2-substituted saccharin derivatives, preparation and pharmaceutical compositions thereof
US5527882A (en) *	1989-07-07	1996-06-18	The Regents Of The University Of California	Polypeptide having an amino acid replaced with N-benzylglycine
ZA905737B (en) *	1989-07-26	1991-05-29	Merrell Dow Pharma	Novel peptidase inhibitors
NZ235155A (en) *	1989-09-11	1993-04-28	Merrell Dow Pharma	Peptidase substrates in which the carboxy terminal group has been replaced by a tricarbonyl radical
US5416013A (en) *	1990-04-04	1995-05-16	Sterling Winthrop Inc.	Interleukin 1β protease and interleukin 1β protease inhibitors
AU7775991A (en) *	1990-04-04	1991-10-30	Immunex Corporation	Interleukin 1beta protease
IL99527A (en) *	1990-09-28	1997-08-14	Lilly Co Eli	Tripeptide antithrombotic agents
EP0504938A3 (en) *	1991-03-22	1993-04-14	Suntory Limited	Prophylactic and therapeutic agent for bone diseases comprising di- or tripeptide derivative as active ingredient
CA2071674C (en) *	1991-06-21	2003-08-19	Kevin T. Chapman	Peptidyl derivatives as inhibitors of interleukin-1.beta. converting enzyme
JP3190431B2 (ja) *	1991-07-01	2001-07-23	三菱化学株式会社	ケトン誘導体
EP0533226A3 (en) *	1991-08-16	1993-08-18	Merck & Co. Inc.	Novel chromophore containing compounds
US5278061A (en) *	1991-08-16	1994-01-11	Merck & Co., Inc.	Affinity chromatography matrix useful in purifying interleukin-1β converting enzyme
DE69229252T2 (de) *	1991-08-16	1999-12-16	Merck & Co., Inc.	DNS, welche das Interleukin-1B-Vorläufer-Converting-Enzym kodiert
US6348570B1 (en) *	1991-08-16	2002-02-19	Merck & Co., Inc.	Chromophore containing compounds and their use in determining interleukin-1β convertase activity
DK0600880T3 (da) *	1991-08-30	2004-04-13	Vertex Pharma	Interleukin 1-beta-protease og interleukin 1-beta-proteasehæmmere
GB9123326D0 (en) *	1991-11-04	1991-12-18	Sandoz Ltd	Improvements in or relating to organic compounds
WO1993014777A1 (en) *	1992-01-31	1993-08-05	Merck & Co., Inc.	PEPTIDYL DERIVATIVES AS INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME
JP3386125B2 (ja) *	1992-02-21	2003-03-17	メルクエンドカンパニーインコーポレーテッド	インターロイキン−１β変換酵素阻害剤としてのペプチジル誘導体
WO1993025685A1 (en) *	1992-06-12	1993-12-23	Massachusetts Institute Of Technology	Cloning and characterization of the cell death genes ced-3 and ced-4
WO1993025683A1 (en) *	1992-06-12	1993-12-23	Massachusetts Institute Of Technology	A gene which prevents programmed cell death
JPH08500482A (ja) *	1992-06-12	1996-01-23	マサチューセッツインスティテュートオブテクノロジー	Ｃｅｄ−３及び関連蛋白質のインヒビター
CA2136981A1 (en) *	1992-06-24	1994-01-06	Andrew D. Howard	Dna encoding precursor interleukin 1.beta. converting enzyme
DE69319432T2 (de) *	1992-07-31	1998-10-29	Pfizer	Peptide aus Derivaten der 4-Amino-2.2.-Difluoro-3-Oxo-1.6-Hexandisäure als Wirkstoffe gegen Entzündungen
US5374623A (en) *	1992-08-20	1994-12-20	Prototek, Inc.	Cysteine protease inhibitors effective for in vivo use
CA2109646C (en) *	1992-11-24	2000-03-07	Gaston O. Daumy	Para-nitroanilide peptides
EP0618223A3 (en) *	1993-03-08	1996-06-12	Sandoz Ltd	Peptides, the release of Interleukin 1-Bêta, useful as anti-inflammatory agents.
US5462939A (en) *	1993-05-07	1995-10-31	Sterling Winthrop Inc.	Peptidic ketones as interleukin-1β-converting enzyme inhibitors
US5411985A (en) *	1993-05-17	1995-05-02	Merck & Co., Inc.	Gamma-pyrone-3-acetic acid as an inhibitor or interleukin-1 β inventory enzyme
JPH0789951A (ja) *	1993-06-03	1995-04-04	Sterling Winthrop Inc	インターロイキン−１β転換酵素阻害剤
EP0644197B1 (en) *	1993-06-04	1998-09-09	Vertex Pharmaceuticals Incorporated	Peptidic phosphinyloxymethyl ketones as interleukin-1beta-converting enzyme inhibitors
DK0628550T3 (da) *	1993-06-08	1998-09-28	Vertex Pharma	Pyridazin som interleukin-1 beta-omdannede enzyminhibitorer
JPH08511690A (ja) *	1993-06-24	1996-12-10	ザ・ジェネラル・ホスピタル・コーポレーション	プログラムされた細胞死遺伝子及びタンパク質
US5866545A (en) *	1993-08-13	1999-02-02	Merck & Co., Inc.	Substituted ketone derivatives as inhibitors of interleukin-1β converting enzyme
US5486623A (en) *	1993-12-08	1996-01-23	Prototek, Inc.	Cysteine protease inhibitors containing heterocyclic leaving groups
US5508262A (en) *	1993-12-15	1996-04-16	University Of South Florida	Interleukin-1 receptor antagonist decreases severity of acute pancreatitis
CA2186511C (en) *	1994-03-31	2009-02-10	Roland E. Dolle	Pyrimidinyl derivatives as interleukin inhibitors
EP0758891A4 (en) *	1994-04-29	1997-12-03	Sanofi Winthrop Inc	HALOMETHYLAMIDES AS IL-1 BETA PROTEASE INHIBITORS
US5552400A (en) *	1994-06-08	1996-09-03	Sterling Winthrop Inc.	Fused-bicyclic lactams as interleukin-1β converting enzyme inhibitors
US5716929A (en) *	1994-06-17	1998-02-10	Vertex Pharmaceuticals, Inc.	Inhibitors of interleukin-1β converting enzyme
US5565430A (en) *	1994-08-02	1996-10-15	Sterling Winthrop Inc.	Azaaspartic acid analogs as interleukin-1β converting enzyme inhibitors
US5498616A (en) *	1994-11-04	1996-03-12	Cephalon, Inc.	Cysteine protease and serine protease inhibitors
US5843904A (en) *	1995-12-20	1998-12-01	Vertex Pharmaceuticals, Inc.	Inhibitors of interleukin-1βconverting enzyme

1995
- 1995-12-20 US US08/575,648 patent/US5843904A/en not_active Expired - Lifetime
1996
- 1996-12-20 KR KR1019980704611A patent/KR20000064454A/ko not_active Application Discontinuation
- 1996-12-20 WO PCT/US1996/020370 patent/WO1997022618A1/en active IP Right Grant
- 1996-12-20 AU AU14658/97A patent/AU722936B2/en not_active Ceased
- 1996-12-20 ZA ZA9610797A patent/ZA9610797B/xx unknown
- 1996-12-20 CZ CZ19981905A patent/CZ292633B6/cs not_active IP Right Cessation
- 1996-12-20 CN CN96199733A patent/CN1127511C/zh not_active Expired - Fee Related
- 1996-12-20 CA CA002240489A patent/CA2240489A1/en not_active Abandoned
- 1996-12-20 JP JP52300897A patent/JP4009320B2/ja not_active Expired - Fee Related
- 1996-12-20 RU RU98113932/04K patent/RU2213096C2/ru not_active IP Right Cessation
- 1996-12-20 DE DE69635458T patent/DE69635458T2/de not_active Expired - Lifetime
- 1996-12-20 BR BR9612191A patent/BR9612191A/pt not_active Application Discontinuation
- 1996-12-20 NZ NZ326555A patent/NZ326555A/xx unknown
- 1996-12-20 HU HU9902254A patent/HUP9902254A3/hu unknown
- 1996-12-20 AT AT96945237T patent/ATE310011T1/de not_active IP Right Cessation
- 1996-12-20 CN CNA031589928A patent/CN1500781A/zh active Pending
- 1996-12-20 IL IL12495496A patent/IL124954A/xx not_active IP Right Cessation
- 1996-12-20 EP EP96945237A patent/EP0876395B1/en not_active Expired - Lifetime
- 1996-12-20 PL PL96327333A patent/PL188813B1/pl not_active IP Right Cessation
- 1996-12-20 TR TR1998/01168T patent/TR199801168T2/xx unknown
1998
- 1998-02-17 US US09/024,537 patent/US6162790A/en not_active Expired - Lifetime
- 1998-06-16 NO NO982774A patent/NO982774L/no not_active Application Discontinuation
1999
- 1999-04-09 HK HK99101441A patent/HK1016611A1/xx not_active IP Right Cessation
2003
- 2003-12-05 JP JP2003408331A patent/JP2004143182A/ja not_active Withdrawn
2007
- 2007-11-09 JP JP2007292640A patent/JP2008101008A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
AU722936C (en)	1997-07-14
CN1127511C (zh)	2003-11-12
BR9612191A (pt)	1999-07-13
NZ326555A (en)	2000-03-27
CZ292633B6 (cs)	2003-11-12
NO982774D0 (no)	1998-06-16
US6162790A (en)	2000-12-19
US5843904A (en)	1998-12-01
AU1465897A (en)	1997-07-14
KR20000064454A (ko)	2000-11-06
NO982774L (no)	1998-08-19
JP2008101008A (ja)	2008-05-01
CZ190598A3 (cs)	1998-11-11
ATE310011T1 (de)	2005-12-15
CN1207743A (zh)	1999-02-10
DE69635458T2 (de)	2006-06-14
ZA9610797B (en)	1997-06-26
AU722936B2 (en)	2000-08-17
CN1500781A (zh)	2004-06-02
CA2240489A1 (en)	1997-06-26
HK1016611A1 (en)	1999-11-05
HUP9902254A2 (hu)	1999-09-28
JP2004143182A (ja)	2004-05-20
EP0876395B1 (en)	2005-11-16
RU2213096C2 (ru)	2003-09-27
MX9805015A (es)	1998-09-30
WO1997022618A1 (en)	1997-06-26
HUP9902254A3 (en)	2001-04-28
DE69635458D1 (de)	2005-12-22
IL124954A0 (en)	1999-01-26
TR199801168T2 (xx)	1998-09-21
PL188813B1 (pl)	2005-04-29
EP0876395A1 (en)	1998-11-11
PL327333A1 (en)	1998-12-07
JP4009320B2 (ja)	2007-11-14

Publication	Publication Date	Title
IL124954A (en)	2005-11-20	Inhibitors of interleukin-1betaconverting enzyme and pharmaceutical compositions containing the same
MX9606546A (es)	1997-03-29	Compuestos inhibidores de la enzima conversiva de interleukina-1 beta.
MX9805016A (es)	1998-09-30	INHIBIDORES DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1 beta.
UA66745C2 (en)	2004-06-15	INTERLEUKIN-1b-CONVERTING ENZYME INHIBITORS, PHARMACEUTICAL COMPOSITION AND A METHOD FOR TREATMENT OF DISEASES
AU7624798A (en)	1998-06-29	Inhibitors of interleukin-1 beta converting enzyme
UA96113C2 (xx)	2011-10-10	Інгібітори каспаз$ингибиторы каспаз
PT966465E (pt)	2003-11-28	Inibidores do enzima imfdh
AP1498A (en)	2005-11-21	Inhibitors of impdh enzyme.
MY141384A (en)	2010-04-30	Prevention of loss and restoration of bone mass by certain prostaglandin agonists
BG104780A (en)	2001-10-31	Inhibitors of phospholipase enzymes
AU5896098A (en)	1998-06-29	Inhibitors of interleukin-1beta converting enzyme
AU2901899A (en)	1999-09-27	1,2-diazepane derivatives as interleukin-1beta converting enzyme inhibitors
DE69836678D1 (de)	2007-02-01	Chinolin- und chinazolinderivate als antagonisten des corticotropin freisetzenden faktors (crf)
MXPA01003501A (es)	2004-04-05	Metodo para moderar el estres o tension de las plantas.
MXPA03007413A (es)	2003-11-18	Composicion y metodo para tratar enfermedades inflamatorias.

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