[go: up one dir, main page]

IL116775A - Tricyclic azolobenzodiazepines and similar compounds their preparation and pharmaceutical compositions containing them - Google Patents

Tricyclic azolobenzodiazepines and similar compounds their preparation and pharmaceutical compositions containing them

Info

Publication number
IL116775A
IL116775A IL11677596A IL11677596A IL116775A IL 116775 A IL116775 A IL 116775A IL 11677596 A IL11677596 A IL 11677596A IL 11677596 A IL11677596 A IL 11677596A IL 116775 A IL116775 A IL 116775A
Authority
IL
Israel
Prior art keywords
azolobenzodiazepines
tricyclic
preparation
pharmaceutical compositions
compositions containing
Prior art date
Application number
IL11677596A
Other languages
English (en)
Other versions
IL116775A0 (en
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of IL116775A0 publication Critical patent/IL116775A0/xx
Publication of IL116775A publication Critical patent/IL116775A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
IL11677596A 1995-01-17 1996-01-16 Tricyclic azolobenzodiazepines and similar compounds their preparation and pharmaceutical compositions containing them IL116775A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/373,132 US5536718A (en) 1995-01-17 1995-01-17 Tricyclic benzazepine vasopressin antagonists

Publications (2)

Publication Number Publication Date
IL116775A0 IL116775A0 (en) 1996-05-14
IL116775A true IL116775A (en) 1999-08-17

Family

ID=23471110

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11677596A IL116775A (en) 1995-01-17 1996-01-16 Tricyclic azolobenzodiazepines and similar compounds their preparation and pharmaceutical compositions containing them

Country Status (24)

Country Link
US (3) US5536718A (zh)
EP (1) EP0804438B1 (zh)
JP (2) JP4163252B2 (zh)
KR (1) KR100443438B1 (zh)
CN (1) CN1065244C (zh)
AR (1) AR002022A1 (zh)
AT (1) ATE320429T1 (zh)
AU (1) AU707982B2 (zh)
BR (1) BR9607182A (zh)
CZ (1) CZ297797B6 (zh)
DE (1) DE69635922T2 (zh)
DK (1) DK0804438T3 (zh)
EA (1) EA001143B1 (zh)
ES (1) ES2258267T3 (zh)
HK (1) HK1004132A1 (zh)
HU (1) HUP9800646A3 (zh)
IL (1) IL116775A (zh)
MX (1) MX9705313A (zh)
NZ (1) NZ302111A (zh)
PT (1) PT804438E (zh)
TW (1) TW403752B (zh)
UA (1) UA54383C2 (zh)
WO (1) WO1996022293A1 (zh)
ZA (1) ZA96297B (zh)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5736540A (en) * 1993-07-29 1998-04-07 American Cyanamid Company Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
US7071133B2 (en) * 1993-11-16 2006-07-04 Ppg Industries Ohio, Inc. Colored glass compositions and-automotive vision panels with-reduced transmitted-color shift
SG67930A1 (en) * 1994-06-10 1999-10-19 Smithkline Beecham Plc Benzopyrans and their use as therapeutic agents
EP0783506A1 (de) * 1994-09-30 1997-07-16 Basf Aktiengesellschaft Neue heterocyclische substituierte imidazolo-chinoxalinone, ihre herstellung und verwendung
US5700796A (en) * 1995-01-17 1997-12-23 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5753648A (en) * 1995-01-17 1998-05-19 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5880122A (en) * 1996-11-01 1999-03-09 American Home Products Corporation 3-Carboxamide derivatives of 5H-pyrrolo 2,1-c! 1,4!-benzodiazepines
US20030039843A1 (en) * 1997-03-14 2003-02-27 Christopher Johnson Photoactive coating, coated article, and method of making same
US7096692B2 (en) * 1997-03-14 2006-08-29 Ppg Industries Ohio, Inc. Visible-light-responsive photoactive coating, coated article, and method of making same
US20020155299A1 (en) 1997-03-14 2002-10-24 Harris Caroline S. Photo-induced hydrophilic article and method of making same
AU732214C (en) * 1997-03-31 2001-10-25 Wakamoto Pharmaceutical Co., Ltd. Biphenyl derivatives and drug composition
WO1998046596A1 (en) * 1997-04-15 1998-10-22 Eli Lilly And Company Method for providing neuro-protective effects
US20030022889A1 (en) * 1997-04-15 2003-01-30 Bymaster Franklin P. Method for providing neuro-protective effects
US6511974B1 (en) 1997-07-30 2003-01-28 Wyeth Tricyclic vasopressin agonists
US6194407B1 (en) 1997-07-30 2001-02-27 American Home Products Corporation Tricyclic pyrido vasopressin agonists
US6090803A (en) * 1998-07-24 2000-07-18 American Home Products Corporation Tricyclic vasopressin agonists
US7138393B2 (en) * 1998-07-24 2006-11-21 Wyeth Biologically active vasopressin agonist metabolites
US6297234B1 (en) 1999-02-04 2001-10-02 American Home Products Corporation Arylthiophene vasopressin agonists
US6235900B1 (en) 1999-02-04 2001-05-22 American Home Products Corporation Tricyclic pyridine N-oxides vasopressin agonists
AU7615200A (en) * 1999-09-27 2001-04-30 American Cyanamid Company Vasopressin agonist formulation and process
US20050203092A1 (en) * 2000-08-08 2005-09-15 Benjamin Elfrida R. 4-Pyrimidinamine derivatives, pharmaceutical compositions and related methods
IL154267A0 (en) * 2000-08-08 2003-09-17 Ortho Mcneil Pharm Inc Neuroprotective 2-pyridinamine compositions and related methods
US6677063B2 (en) 2000-08-31 2004-01-13 Ppg Industries Ohio, Inc. Methods of obtaining photoactive coatings and/or anatase crystalline phase of titanium oxides and articles made thereby
US7323249B2 (en) * 2000-08-31 2008-01-29 Ppg Industries Ohio, Inc. Methods of obtaining photoactive coatings and/or anatase crystalline phase of titanium oxides and articles made thereby
US7326700B2 (en) * 2001-04-12 2008-02-05 Wyeth Cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
CA2443870A1 (en) * 2001-04-12 2002-10-24 Wyeth Cyclohexylphenyl vasopressin agonists
US6900200B2 (en) 2001-04-12 2005-05-31 Wyeth Tricyclic hydroxy carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
US7109193B2 (en) 2001-04-12 2006-09-19 Wyeth Tricyclic diazepines tocolytic oxytocin receptor antagonists
DE60218646T2 (de) 2001-04-12 2007-11-22 Wyeth N-biphenylcarbonyl- und n-phenylpyridylcarbonyl substituierte bi- und tricyclische azepine und diazepine als vasopressin-agonisten
US7202239B2 (en) * 2001-04-12 2007-04-10 Wyeth Cyclohexylphenyl carboxamides tocolytic oxytocin receptor antagonists
US7022699B2 (en) 2001-04-12 2006-04-04 Wyeth Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators
US7064120B2 (en) * 2001-04-12 2006-06-20 Wyeth Tricyclic pyridyl carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
US6977254B2 (en) * 2001-04-12 2005-12-20 Wyeth Hydroxy cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
SE0102299D0 (sv) 2001-06-26 2001-06-26 Astrazeneca Ab Compounds
SE0102764D0 (sv) 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
US7232615B2 (en) * 2001-10-22 2007-06-19 Ppg Industries Ohio, Inc. Coating stack comprising a layer of barrier coating
US20040010010A1 (en) * 2002-04-30 2004-01-15 Ebetino Frank Hallock Melanocortin receptor ligands
WO2004080377A2 (en) * 2003-03-11 2004-09-23 Neurosearch A/S Kcnq channel modulating compounds and their pharmaceutical use
US20060029754A1 (en) * 2004-08-05 2006-02-09 Medwick Paul A Coated substrate with improved solar control properties
EP1632494A1 (en) * 2004-08-24 2006-03-08 Ferring B.V. Vasopressin v1a antagonists
US20060046089A1 (en) * 2004-09-01 2006-03-02 O'shaughnessy Dennis J Metal based coating composition and related coated substrates
US7947373B2 (en) * 2004-10-14 2011-05-24 Pittsburgh Glass Works, Llc High luminance coated glass
WO2006068928A1 (en) * 2004-12-20 2006-06-29 Wyeth Pyrrolo[1,2-a]quinoxalin-5-(4h)-yl)sulfonyls and carbonyls and their use as estrogenic agents
US7473471B2 (en) * 2005-03-21 2009-01-06 Ppg Industries Ohio, Inc. Coating composition with solar properties
UY30117A1 (es) * 2006-01-31 2007-06-29 Tanabe Seiyaku Co Compuesto amina trisustituido
US20100124642A1 (en) * 2008-11-19 2010-05-20 Ppg Industries Ohio, Inc. Undercoating layers providing improved conductive topcoat functionality
US8133599B2 (en) * 2008-11-19 2012-03-13 Ppg Industries Ohio, Inc Undercoating layers providing improved photoactive topcoat functionality
US7998586B2 (en) 2008-11-19 2011-08-16 Ppg Industries Ohio, Inc. Undercoating layers providing improved topcoat functionality
JP5343133B2 (ja) 2008-11-19 2013-11-13 ピーピージー・インダストリーズ・オハイオ・インコーポレイテッド トップコートの機能を向上させるアンダーコーティング層
WO2010116176A1 (en) 2009-04-09 2010-10-14 Astrazeneca Ab Pyrazolo [4, 5-e] pyrimidine derivative and its use to treat diabetes and obesity
US9224892B2 (en) 2009-12-21 2015-12-29 Ppg Industries Ohio, Inc. Silicon thin film solar cell having improved haze and methods of making the same
US20110146768A1 (en) 2009-12-21 2011-06-23 Ppg Industries Ohio, Inc. Silicon thin film solar cell having improved underlayer coating
RU2518102C1 (ru) * 2012-11-01 2014-06-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кубанский государственный технологический университет" (ФГБОУ ВПО "КубГТУ") Способ получения производных 2-диалкиламинопирроло[1,2-альфа][1,4]бензодиазепина
JP7089649B2 (ja) * 2016-12-12 2022-06-23 キノシス・セラピューティクス・ピーティーワイ・リミテッド 非ペプチドオキシトシン受容体アゴニスト
KR101798840B1 (ko) * 2017-05-17 2017-11-17 주식회사 레고켐 바이오사이언스 신규 오토탁신 저해 화합물 및 이를 함유하는 약제학적 조성물
US10961242B2 (en) 2017-05-17 2021-03-30 Legochem Biosciences, Inc. Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same
EP3651752B1 (en) 2017-07-11 2024-11-20 Vertex Pharmaceuticals Incorporated Carboxamides as modulators of sodium channels

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4766108A (en) * 1986-12-04 1988-08-23 Smith Kline Beckman Corporation Tyr-Arg-vasopressin antagonists
US5055448A (en) * 1987-06-25 1991-10-08 Medical College Of Ohio Linear derivatives of arginine vasopressin antagonists
ES2056259T3 (es) * 1989-02-10 1994-10-01 Otsuka Pharma Co Ltd Derivados de carboestirilo.
DE122009000062I2 (de) * 1989-10-20 2011-01-13 Otsuka Pharma Co Ltd Benzoheterozyklische verbindungen
US5258510A (en) * 1989-10-20 1993-11-02 Otsuka Pharma Co Ltd Benzoheterocyclic compounds
US5070187A (en) * 1989-11-03 1991-12-03 Trustees Of Boston University Pharmacologically effective antagonists of arginine-vasopressin
TW199153B (zh) * 1990-08-07 1993-02-01 Dtsuka Seiyaku Kk
JPH04163252A (ja) * 1990-10-25 1992-06-08 Teijin Ltd エアーバッグ
TW198715B (zh) * 1991-04-19 1993-01-21 Dtsuka Seiyaku Kk
JP3147902B2 (ja) * 1991-06-14 2001-03-19 ファルマシア・アンド・アップジョン・カンパニー イミダゾ〔１，５−ａ〕キノキサリン
EP0533240A3 (en) * 1991-09-16 1993-09-29 Merck & Co. Inc. Substituted amine derivatives of piperazinylcamphorsulfonyl oxytocin antagonists
US5204349A (en) * 1991-09-16 1993-04-20 Merck & Co., Inc. Amide-substituted derivatives of spiroindanylcamphorsulfonyl oxytocin antagonists
EP0533242A3 (en) * 1991-09-16 1993-09-15 Merck & Co. Inc. Substituted derivatives of piperazinylcamphorsulfonyl oxytocin antagonists
EP0533243B1 (en) * 1991-09-16 1997-12-17 Merck & Co. Inc. Hydantoin and succinimide-substituted spiroindanylcamphorsulfonyl derivatives
AU657431B2 (en) * 1992-08-20 1995-03-09 Otsuka Pharmaceutical Co., Ltd. Benzoheterocyclic compounds as oxytocin and vasopressin antagonists
AU5533894A (en) * 1992-11-25 1994-06-22 Yamanouchi Pharmaceutical Co., Ltd. Benzanilide derivative
WO1994014796A1 (en) * 1992-12-21 1994-07-07 Yamanouchi Pharmaceutical Co., Ltd. Novel n-(pyridylcarbonyl)benzazepine derivative and intermediate therefor
AU6219994A (en) * 1993-03-11 1994-09-26 Yamanouchi Pharmaceutical Co., Ltd. Compound with vasopressin antagonism
GB9307527D0 (en) * 1993-04-13 1993-06-02 Fujisawa Pharmaceutical Co New venzamide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
US5516774A (en) * 1993-07-29 1996-05-14 American Cyanamid Company Tricyclic diazepine vasopressin antagonists and oxytocin antagonists

Also Published As

Publication number Publication date
DK0804438T3 (da) 2006-06-12
HK1004132A1 (en) 1998-11-20
EA001143B1 (ru) 2000-10-30
JP2008101012A (ja) 2008-05-01
CN1065244C (zh) 2001-05-02
BR9607182A (pt) 1997-11-11
WO1996022293A1 (en) 1996-07-25
IL116775A0 (en) 1996-05-14
ZA96297B (en) 1997-07-15
AR002022A1 (es) 1998-01-07
DE69635922D1 (de) 2006-05-11
KR100443438B1 (ko) 2004-10-14
AU4769896A (en) 1996-08-07
HUP9800646A2 (hu) 1998-08-28
JPH11500106A (ja) 1999-01-06
CN1198746A (zh) 1998-11-11
AU707982B2 (en) 1999-07-22
US5536718A (en) 1996-07-16
MX9705313A (es) 1998-07-31
EP0804438A1 (en) 1997-11-05
EP0804438B1 (en) 2006-03-15
US5612334A (en) 1997-03-18
DE69635922T2 (de) 2006-08-17
ATE320429T1 (de) 2006-04-15
EA199700117A1 (ru) 1997-12-30
NZ302111A (en) 1999-04-29
TW403752B (en) 2000-09-01
US5610156A (en) 1997-03-11
CZ297797B6 (cs) 2007-04-04
PT804438E (pt) 2006-07-31
JP4163252B2 (ja) 2008-10-08
HUP9800646A3 (en) 1998-12-28
UA54383C2 (uk) 2003-03-17
ES2258267T3 (es) 2006-08-16
CZ224997A3 (en) 1997-12-17

Similar Documents

Publication Publication Date Title
IL116775A (en) Tricyclic azolobenzodiazepines and similar compounds their preparation and pharmaceutical compositions containing them
IL116774A0 (en) Tricyclic benzazepine compounds their preparation and pharmaceutical compositions containing them
IL122618A0 (en) Substituted imidazolylacetonitrile compounds their preparation and pharmaceutical compositions containing them
IL117860A0 (en) Substituted 1-phenyl-3-pyrazolecarboxamides their preparation and pharmaceutical compositions containing them
AU7289596A (en) Tricyclic fused compounds and pharmaceutical compositions containing them
IL121236A0 (en) Cycloalkano-pyridines their preparation and pharmaceutical compositions containing them
ZA962399B (en) Taxoids their preparation and pharmaceutical compositions containing them
IL122293A0 (en) Substituted 4-phenylaminothiazoles their preparation and pharmaceutical compositions containing them
IL116957A0 (en) Substituted heterocyclic compounds their preparation and pharmaceutical compositions containing them
IL112248A0 (en) Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
ZA9610737B (en) Taxoids their preparation and pharmaceutical compositions containing them
IL116773A (en) Tricyclic benzazepine compounds their preparation and pharmaceutical compositions containing them
IL119559A0 (en) Purin -6- one derivatives their preparation and pharmaceutical compositions containing them
IL122717A0 (en) Compounds and pharmaceutical compositions containing them
IL125710A0 (en) Arylglycinamide derivatives their preparation and pharmaceutical compositions containing them
IL115905A0 (en) Sordarin derivatives their preparation and pharmaceutical compositions containing them
IL117554A0 (en) Imidazoquinazolines their preparation and pharmaceutical compositions containing them
IL118410A0 (en) Substituted camptothecin derivatives their preparation and pharmaceutical compositions containing them
IL100061A0 (en) Tricyclic compounds,their preparation and pharmaceutical compositions containing them
IL117815A0 (en) Ascomycins their preparation and pharmaceutical compositions containing them
IL117878A (en) Taxoids their preparation and pharmaceutical compositions containing them
IL108073A0 (en) Substituted 6-azaandrostenones their preparation and pharmaceutical compositions containing them
IL117817A0 (en) N-subsituted azaheterocyclic compounds their preparation and pharmaceutical compositions containing them
ZA962633B (en) Taxoids their preparation and pharmaceutical compositions containing them
IL118672A (en) Benzisothiazolyl-substituted aminomethylchromans their preparation and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees