IL104941A - Indole derivatives and pharmaceutical compositions containing them - Google Patents

Indole derivatives and pharmaceutical compositions containing them

Info

Publication number: IL104941A
Authority: IL; Israel
Prior art keywords: compound; formula; ylmethyl; compounds; benzyl
Prior art date: 1992-03-05

Application number

IL104941A

Other languages

English (en)

Other versions

IL104941A0 (en

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-03-05

Filing date

1993-03-04

Publication date

1998-06-15

1993-03-04 Application filed by Pfizer filed Critical Pfizer

1993-03-04 Priority to IL11891093A priority Critical patent/IL118910A/en

1993-03-04 Priority to IL11891193A priority patent/IL118911A/xx

1993-07-08 Publication of IL104941A0 publication Critical patent/IL104941A0/xx

1998-06-15 Publication of IL104941A publication Critical patent/IL104941A/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Child & Adolescent Psychology (AREA)
Anesthesiology (AREA)
Diabetes (AREA)
Addiction (AREA)
Hematology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

IL104941A 1992-03-05 1993-03-04 Indole derivatives and pharmaceutical compositions containing them IL104941A (en)

Priority Applications (2)

Application Number	Priority Date	Filing Date	Title
IL11891093A IL118910A (en)	1992-03-05	1993-03-04	Intermediates for the synthesis of indole derivatives
IL11891193A IL118911A (en)	1992-03-05	1993-03-04	Intermediates for the synthesis of indole derivatives

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US84664092A	1992-03-05	1992-03-05

Publications (2)

Publication Number	Publication Date
IL104941A0 IL104941A0 (en)	1993-07-08
IL104941A true IL104941A (en)	1998-06-15

Family

ID=25298499

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL104941A IL104941A (en)	1992-03-05	1993-03-04	Indole derivatives and pharmaceutical compositions containing them

Country Status (30)

Country	Link
US (2)	US5594014A (xx)
EP (1)	EP0629199B1 (xx)
JP (1)	JPH07121943B2 (xx)
KR (1)	KR0179073B1 (xx)
CN (4)	CN1032309C (xx)
AT (1)	ATE218566T1 (xx)
AU (1)	AU666716B2 (xx)
BR (1)	BR9306012A (xx)
CA (1)	CA2117643C (xx)
CZ (1)	CZ282652B6 (xx)
DE (1)	DE69331988T2 (xx)
DK (1)	DK0629199T3 (xx)
EG (1)	EG20416A (xx)
ES (1)	ES2176199T3 (xx)
FI (1)	FI930968A (xx)
HU (1)	HU219489B (xx)
IL (1)	IL104941A (xx)
MX (1)	MX9301197A (xx)
MY (1)	MY109298A (xx)
NO (1)	NO302617B1 (xx)
NZ (1)	NZ249755A (xx)
PL (1)	PL172388B1 (xx)
PT (1)	PT629199E (xx)
RU (1)	RU2124012C1 (xx)
SK (1)	SK281938B6 (xx)
TW (1)	TW288010B (xx)
UA (1)	UA39866C2 (xx)
WO (1)	WO1993018032A1 (xx)
YU (1)	YU14893A (xx)
ZA (1)	ZA931539B (xx)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5559246A (en) *	1990-10-15	1996-09-24	Pfizer Inc.	Indole derivatives
US5545644A (en) *	1990-10-15	1996-08-13	Pfizer Inc.	Indole derivatives
US5559129A (en) *	1990-10-15	1996-09-24	Pfizer Inc	Indole derivatives
US5578612A (en) *	1990-10-15	1996-11-26	Pfizer Inc.	Indole derivatives
US5607951A (en) *	1990-10-15	1997-03-04	Pfizer Inc	Indole derivatives
CA2133413C (en)	1992-04-07	2001-04-10	John Eugene Macor	Indole derivatives as 5-ht1 antagonists
US6380233B1 (en)	1992-04-07	2002-04-30	Pfizer Inc	Indole derivatives as 5-HT1 agonists
CZ59996A3 (en) *	1993-08-31	1996-06-12	Pfizer	5-arylindole derivatives per se and for treating diseases, intermediates for their preparation and pharmaceutical compositions based thereon
GB9417310D0 (en)	1994-08-27	1994-10-19	Pfizer Ltd	Therapeutic agents
GB9420503D0 (en) *	1994-10-11	1994-11-23	Pfizer Ltd	Therapeutic agents
GB9420529D0 (en)	1994-10-12	1994-11-30	Pfizer Ltd	Indoles
US6288091B1 (en)	1995-12-29	2001-09-11	Boehringer Ingelheim Ltd.	Antiherpes virus compounds and methods for their preparation and use
IL124436A0 (en) *	1995-12-29	1998-12-06	Boehringer Ingelheim Phaarmace	Phenyl thiazole derivatives with anti herpes virus properties
US5994352A (en) *	1998-11-13	1999-11-30	Pfizer Inc.	5-arylindole derivatives
EE200300246A (et)	2000-11-27	2003-10-15	Pfizer Products Inc.	EP4 retseptori suhtes selektiivsed agonistid osteoporoosi raviks
JP2004526781A (ja) *	2001-04-20	2004-09-02	ワイス	５−ヒドロキシトリプトアミン−６リガンドとしてのヘテロシクリルアルコキシ−、−アルキルチオ−および−アルキルアミノベンザゾール誘導体
ITRM20020255A1 (it) *	2002-05-09	2003-11-10	Polifarma Spa	Tautomero enolico dell'acido 3-indolilpiruvico, suoi sali e usi terapeutici.
ES2199086B1 (es) *	2002-07-31	2005-06-01	Cepa Schwarz Pharma Sl	Nuevos derivados de cicloalcanodionas, procedimiento para su preparacion y sus aplicaciones farmacologicas.
WO2014078568A1 (en)	2012-11-14	2014-05-22	The Johns Hopkins University	Methods and compositions for treating schizophrenia
MX2022009528A (es) *	2020-02-04	2022-11-14	Mindset Pharma Inc	Derivados de 3-pirrolidina-indol como agentes psicodélicos serotoninérgicos para el tratamiento de trastornos del snc.
PL243119B1 (pl) *	2020-04-16	2023-06-26	Univ Jagiellonski	Rozpuszczalne w wodzie modyfikowane pochodne aminokwasowe nadające się do leczenia chorób o podłożu neurologicznym oraz zaburzeń psychiatrycznych

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA795239B (en) *	1978-10-12	1980-11-26	Glaxo Group Ltd	Heterocyclic compounds
BE889931A (fr) *	1980-08-12	1982-02-11	Glaxo Group Ltd	Derives indoliques, leur preparation et leurs applications en tant que medicaments
GB8600397D0 (en) *	1986-01-08	1986-02-12	Glaxo Group Ltd	Chemical compounds
GB8719167D0 (en) *	1987-08-13	1987-09-23	Glaxo Group Ltd	Chemical compounds
GB8724912D0 (en) *	1987-10-23	1987-11-25	Wellcome Found	Indole derivatives
GB8819024D0 (en) *	1988-08-10	1988-09-14	Glaxo Group Ltd	Chemical compounds
IL96891A0 (en) *	1990-01-17	1992-03-29	Merck Sharp & Dohme	Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them
CA2042295A1 (fr) *	1990-05-15	1991-11-16	Jacques Chauveau	Derives de mediateurs endogenes, leurs sels, procede de preparation, applications, et compositions les renfermant
IL114690A (en) *	1990-06-07	1997-02-18	Wellcome Found	Antimigraine oxazolidinone substituted indole derivatives
JP2575272B2 (ja) *	1990-10-15	1997-01-22	フアイザー・インコーポレイテツド	インドール誘導体
US5208248A (en) *	1991-01-11	1993-05-04	Merck Sharpe & Dohme, Ltd.	Indazole-substituted five-membered heteroaromatic compounds
CZ283018B6 (cs) *	1991-02-01	1997-12-17	Merck Sharp And Dohme Limited	Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi
TW263508B (xx) *	1991-02-12	1995-11-21	Pfizer

1993
- 1993-02-09 TW TW082100871A patent/TW288010B/zh active
- 1993-03-03 MX MX9301197A patent/MX9301197A/es unknown
- 1993-03-03 KR KR1019940703076A patent/KR0179073B1/ko not_active IP Right Cessation
- 1993-03-03 ES ES93906214T patent/ES2176199T3/es not_active Expired - Lifetime
- 1993-03-03 US US08/284,662 patent/US5594014A/en not_active Expired - Fee Related
- 1993-03-03 EG EG12893A patent/EG20416A/xx active
- 1993-03-03 EP EP93906214A patent/EP0629199B1/en not_active Expired - Lifetime
- 1993-03-03 PL PL93305051A patent/PL172388B1/pl not_active IP Right Cessation
- 1993-03-03 AU AU37330/93A patent/AU666716B2/en not_active Ceased
- 1993-03-03 UA UA94095775A patent/UA39866C2/uk unknown
- 1993-03-03 SK SK1052-94A patent/SK281938B6/sk unknown
- 1993-03-03 JP JP5515745A patent/JPH07121943B2/ja not_active Expired - Fee Related
- 1993-03-03 DE DE69331988T patent/DE69331988T2/de not_active Expired - Fee Related
- 1993-03-03 CZ CZ942125A patent/CZ282652B6/cs not_active IP Right Cessation
- 1993-03-03 DK DK93906214T patent/DK0629199T3/da active
- 1993-03-03 PT PT93906214T patent/PT629199E/pt unknown
- 1993-03-03 CA CA002117643A patent/CA2117643C/en not_active Expired - Fee Related
- 1993-03-03 AT AT93906214T patent/ATE218566T1/de not_active IP Right Cessation
- 1993-03-03 WO PCT/US1993/001667 patent/WO1993018032A1/en active IP Right Grant
- 1993-03-03 BR BR9306012A patent/BR9306012A/pt not_active Application Discontinuation
- 1993-03-03 RU RU94040914/04A patent/RU2124012C1/ru not_active IP Right Cessation
- 1993-03-04 ZA ZA931539A patent/ZA931539B/xx unknown
- 1993-03-04 HU HU9300593A patent/HU219489B/hu not_active IP Right Cessation
- 1993-03-04 IL IL104941A patent/IL104941A/en not_active IP Right Cessation
- 1993-03-04 FI FI930968A patent/FI930968A/fi not_active Application Discontinuation
- 1993-03-04 YU YU14893A patent/YU14893A/sh unknown
- 1993-03-04 CN CN93104036A patent/CN1032309C/zh not_active Expired - Fee Related
- 1993-03-04 MY MYPI93000388A patent/MY109298A/en unknown
- 1993-05-03 NZ NZ249755A patent/NZ249755A/en unknown
1994
- 1994-09-02 NO NO943261A patent/NO302617B1/no not_active IP Right Cessation
1995
- 1995-11-17 CN CN95118795A patent/CN1044909C/zh not_active Expired - Fee Related
- 1995-11-17 CN CN95118796A patent/CN1044910C/zh not_active Expired - Fee Related
- 1995-11-17 CN CN95118794A patent/CN1082815C/zh not_active Expired - Fee Related
1996
- 1996-12-31 US US08/777,835 patent/US5717102A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69331988D1 (de)	2002-07-11
NO943261D0 (no)	1994-09-02
ATE218566T1 (de)	2002-06-15
CN1032309C (zh)	1996-07-17
CN1136566A (zh)	1996-11-27
CN1082044A (zh)	1994-02-16
ES2176199T3 (es)	2002-12-01
HU9300593D0 (en)	1993-05-28
HUT64061A (en)	1993-11-29
PT629199E (pt)	2002-09-30
TW288010B (xx)	1996-10-11
AU666716B2 (en)	1996-02-22
CN1136432A (zh)	1996-11-27
SK105294A3 (en)	1995-05-10
IL104941A0 (en)	1993-07-08
UA39866C2 (uk)	2001-07-16
PL172388B1 (pl)	1997-09-30
CZ282652B6 (cs)	1997-08-13
RU94040914A (ru)	1996-08-10
FI930968A0 (fi)	1993-03-04
YU14893A (sh)	1996-05-20
SK281938B6 (sk)	2001-09-11
FI930968A (fi)	1993-09-06
AU3733093A (en)	1993-10-05
US5594014A (en)	1997-01-14
CN1044910C (zh)	1999-09-01
ZA931539B (en)	1994-09-05
BR9306012A (pt)	1997-11-18
NO943261L (no)	1994-09-02
NZ249755A (en)	1996-08-27
CA2117643A1 (en)	1993-09-16
EP0629199B1 (en)	2002-06-05
CN1082815C (zh)	2002-04-17
JPH07500353A (ja)	1995-01-12
MX9301197A (es)	1993-09-01
KR950700291A (ko)	1995-01-16
CA2117643C (en)	2000-03-14
NO302617B1 (no)	1998-03-30
EP0629199A1 (en)	1994-12-21
WO1993018032A1 (en)	1993-09-16
CN1044909C (zh)	1999-09-01
CZ212594A3 (en)	1995-06-14
DK0629199T3 (da)	2002-07-15
US5717102A (en)	1998-02-10
DE69331988T2 (de)	2002-09-19
RU2124012C1 (ru)	1998-12-27
MY109298A (en)	1996-12-31
JPH07121943B2 (ja)	1995-12-25
KR0179073B1 (ko)	1999-03-20
HU219489B (hu)	2001-04-28
CN1136565A (zh)	1996-11-27
EG20416A (en)	1999-02-28

Publication	Publication Date	Title
US6387937B1 (en)	2002-05-14	Indole derivatives
CA2117643C (en)	2000-03-14	Indole derivatives
US20080090797A1 (en)	2008-04-17	{Beta}-Lactamyl vasopression V1a antagonists and methods of use
EP0635015B1 (en)	1997-01-29	Acylaminoindole derivatives as 5-ht1 agonists
NZ267487A (en)	1997-09-22	5-arylindole derivatives and pharmaceutical compositions thereof
AP632A (en)	1998-03-30	Therapeutic heterocyclic compounds.
IL118910A (en)	1999-01-26	Intermediates for the synthesis of indole derivatives
US6380233B1 (en)	2002-04-30	Indole derivatives as 5-HT1 agonists
IL121326A (en)	2002-09-12	N-substituted pyrolidin-2-yl methyl indole derivatives

Legal Events

Date	Code	Title
1998-11-26	FF	Patent granted
1999-04-11	KB	Patent renewed
1999-09-22	KB	Patent renewed
2003-05-29	KB	Patent renewed
2007-12-03	MM9K	Patent not in force due to non-payment of renewal fees