NO302617B1 - Indol-derivater som 5-HT1 agonister - Google Patents

Indol-derivater som 5-HT1 agonister

Info

Publication number: NO302617B1
Authority: NO; Norway
Prior art keywords: pct; compounds; agonists; sec; nitrogen
Prior art date: 1992-03-05

Application number

NO943261A

Other languages

English (en)

Other versions

NO943261L (no

NO943261D0 (no

Inventor

John E Macor

Jolanta T Nowakowski

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-03-05

Filing date

1994-09-02

Publication date

1998-03-30

1994-09-02 Application filed by Pfizer filed Critical Pfizer

1994-09-02 Publication of NO943261L publication Critical patent/NO943261L/no

1994-09-02 Publication of NO943261D0 publication Critical patent/NO943261D0/no

1998-03-30 Publication of NO302617B1 publication Critical patent/NO302617B1/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Child & Adolescent Psychology (AREA)
Anesthesiology (AREA)
Obesity (AREA)
Addiction (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO943261A 1992-03-05 1994-09-02 Indol-derivater som 5-HT1 agonister NO302617B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US84664092A	1992-03-05	1992-03-05
PCT/US1993/001667 WO1993018032A1 (en)	1992-03-05	1993-03-03	Indole derivatives as 5-ht1 agonists

Publications (3)

Publication Number	Publication Date
NO943261L NO943261L (no)	1994-09-02
NO943261D0 NO943261D0 (no)	1994-09-02
NO302617B1 true NO302617B1 (no)	1998-03-30

Family

ID=25298499

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO943261A NO302617B1 (no)	1992-03-05	1994-09-02	Indol-derivater som 5-HT1 agonister

Country Status (30)

Country	Link
US (2)	US5594014A (no)
EP (1)	EP0629199B1 (no)
JP (1)	JPH07121943B2 (no)
KR (1)	KR0179073B1 (no)
CN (4)	CN1032309C (no)
AT (1)	ATE218566T1 (no)
AU (1)	AU666716B2 (no)
BR (1)	BR9306012A (no)
CA (1)	CA2117643C (no)
CZ (1)	CZ282652B6 (no)
DE (1)	DE69331988T2 (no)
DK (1)	DK0629199T3 (no)
EG (1)	EG20416A (no)
ES (1)	ES2176199T3 (no)
FI (1)	FI930968A7 (no)
HU (1)	HU219489B (no)
IL (1)	IL104941A (no)
MX (1)	MX9301197A (no)
MY (1)	MY109298A (no)
NO (1)	NO302617B1 (no)
NZ (1)	NZ249755A (no)
PL (1)	PL172388B1 (no)
PT (1)	PT629199E (no)
RU (1)	RU2124012C1 (no)
SK (1)	SK281938B6 (no)
TW (1)	TW288010B (no)
UA (1)	UA39866C2 (no)
WO (1)	WO1993018032A1 (no)
YU (1)	YU14893A (no)
ZA (1)	ZA931539B (no)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5559246A (en) *	1990-10-15	1996-09-24	Pfizer Inc.	Indole derivatives
US5607951A (en) *	1990-10-15	1997-03-04	Pfizer Inc	Indole derivatives
US5545644A (en) *	1990-10-15	1996-08-13	Pfizer Inc.	Indole derivatives
US5559129A (en) *	1990-10-15	1996-09-24	Pfizer Inc	Indole derivatives
US5578612A (en) *	1990-10-15	1996-11-26	Pfizer Inc.	Indole derivatives
US6380233B1 (en)	1992-04-07	2002-04-30	Pfizer Inc	Indole derivatives as 5-HT1 agonists
KR0179072B1 (ko)	1992-04-07	1999-03-20	알렌 제이. 스피겔	5-ht1 작동약으로서의 인돌 유도체
EP0716649B1 (en) *	1993-08-31	1998-09-09	Pfizer Inc.	5-arylindole derivatives
GB9417310D0 (en)	1994-08-27	1994-10-19	Pfizer Ltd	Therapeutic agents
GB9420503D0 (en) *	1994-10-11	1994-11-23	Pfizer Ltd	Therapeutic agents
GB9420529D0 (en)	1994-10-12	1994-11-30	Pfizer Ltd	Indoles
US6288091B1 (en)	1995-12-29	2001-09-11	Boehringer Ingelheim Ltd.	Antiherpes virus compounds and methods for their preparation and use
EE9800154A (et) *	1995-12-29	1998-12-15	Boehringer Ingelheim Pharmaceuticals, Inc.	Herpesviirusevastaste omadustega fenüültiasoolderivaadid
US5994352A (en) *	1998-11-13	1999-11-30	Pfizer Inc.	5-arylindole derivatives
MXPA03004623A (es)	2000-11-27	2003-09-05	Pfizer Prod Inc	Agonistas selectivos del receptor ep4 en el tratamiento de la osteoporosis.
KR20030088507A (ko) *	2001-04-20	2003-11-19	와이어쓰	5-하이드록시트립타민-6 리간드로서의헤테로사이클릴알콕시-, -알킬티오- 및-알킬아미노벤즈아졸 유도체
ITRM20020255A1 (it) *	2002-05-09	2003-11-10	Polifarma Spa	Tautomero enolico dell'acido 3-indolilpiruvico, suoi sali e usi terapeutici.
ES2199086B1 (es) *	2002-07-31	2005-06-01	Cepa Schwarz Pharma Sl	Nuevos derivados de cicloalcanodionas, procedimiento para su preparacion y sus aplicaciones farmacologicas.
GB0317229D0 (en) *	2003-07-23	2003-08-27	Pfizer Ltd	Improved process
EP3610890A1 (en)	2012-11-14	2020-02-19	The Johns Hopkins University	Methods and compositions for treating schizophrenia
BR112022015379A2 (pt) *	2020-02-04	2022-09-27	Mindset Pharma Inc	Derivados de 3-pirrolidino-indol como agentes psicodélicos serotonérgicos para o tratamento de distúrbios do snc
PL243119B1 (pl) *	2020-04-16	2023-06-26	Univ Jagiellonski	Rozpuszczalne w wodzie modyfikowane pochodne aminokwasowe nadające się do leczenia chorób o podłożu neurologicznym oraz zaburzeń psychiatrycznych

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA795239B (en) *	1978-10-12	1980-11-26	Glaxo Group Ltd	Heterocyclic compounds
BE889931A (fr) *	1980-08-12	1982-02-11	Glaxo Group Ltd	Derives indoliques, leur preparation et leurs applications en tant que medicaments
GB8600397D0 (en) *	1986-01-08	1986-02-12	Glaxo Group Ltd	Chemical compounds
GB8719167D0 (en) *	1987-08-13	1987-09-23	Glaxo Group Ltd	Chemical compounds
GB8724912D0 (en) *	1987-10-23	1987-11-25	Wellcome Found	Indole derivatives
GB8819024D0 (en) *	1988-08-10	1988-09-14	Glaxo Group Ltd	Chemical compounds
IL96891A0 (en) *	1990-01-17	1992-03-29	Merck Sharp & Dohme	Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them
CA2042295A1 (fr) *	1990-05-15	1991-11-16	Jacques Chauveau	Derives de mediateurs endogenes, leurs sels, procede de preparation, applications, et compositions les renfermant
US5399574A (en) *	1990-06-07	1995-03-21	Burroughs Wellcome Co.	Indolyl tetrahydropyridines for treating migraine
RO111767B1 (ro) *	1990-10-15	1997-01-30	Pfizer	Derivati de indol, procedee si intermediari pentru prepararea acestora, compozitii farmaceutice si metoda pentru tratarea unor afectiuni
US5208248A (en) *	1991-01-11	1993-05-04	Merck Sharpe & Dohme, Ltd.	Indazole-substituted five-membered heteroaromatic compounds
SK278998B6 (sk) *	1991-02-01	1998-05-06	Merck Sharp & Dohme Limited	Deriváty imidazolu, triazolu a tetrazolu, spôsob i
TW263508B (no) *	1991-02-12	1995-11-21	Pfizer

1993
- 1993-02-09 TW TW082100871A patent/TW288010B/zh active
- 1993-03-03 DE DE69331988T patent/DE69331988T2/de not_active Expired - Fee Related
- 1993-03-03 AU AU37330/93A patent/AU666716B2/en not_active Ceased
- 1993-03-03 ES ES93906214T patent/ES2176199T3/es not_active Expired - Lifetime
- 1993-03-03 PT PT93906214T patent/PT629199E/pt unknown
- 1993-03-03 UA UA94095775A patent/UA39866C2/uk unknown
- 1993-03-03 KR KR1019940703076A patent/KR0179073B1/ko not_active Expired - Fee Related
- 1993-03-03 JP JP5515745A patent/JPH07121943B2/ja not_active Expired - Fee Related
- 1993-03-03 EP EP93906214A patent/EP0629199B1/en not_active Expired - Lifetime
- 1993-03-03 AT AT93906214T patent/ATE218566T1/de not_active IP Right Cessation
- 1993-03-03 US US08/284,662 patent/US5594014A/en not_active Expired - Fee Related
- 1993-03-03 CA CA002117643A patent/CA2117643C/en not_active Expired - Fee Related
- 1993-03-03 DK DK93906214T patent/DK0629199T3/da active
- 1993-03-03 BR BR9306012A patent/BR9306012A/pt not_active Application Discontinuation
- 1993-03-03 EG EG12893A patent/EG20416A/xx active
- 1993-03-03 PL PL93305051A patent/PL172388B1/pl not_active IP Right Cessation
- 1993-03-03 SK SK1052-94A patent/SK281938B6/sk unknown
- 1993-03-03 WO PCT/US1993/001667 patent/WO1993018032A1/en active IP Right Grant
- 1993-03-03 RU RU94040914/04A patent/RU2124012C1/ru not_active IP Right Cessation
- 1993-03-03 CZ CZ942125A patent/CZ282652B6/cs not_active IP Right Cessation
- 1993-03-03 MX MX9301197A patent/MX9301197A/es unknown
- 1993-03-04 MY MYPI93000388A patent/MY109298A/en unknown
- 1993-03-04 HU HU9300593A patent/HU219489B/hu not_active IP Right Cessation
- 1993-03-04 FI FI930968A patent/FI930968A7/fi not_active Application Discontinuation
- 1993-03-04 IL IL104941A patent/IL104941A/en not_active IP Right Cessation
- 1993-03-04 ZA ZA931539A patent/ZA931539B/xx unknown
- 1993-03-04 CN CN93104036A patent/CN1032309C/zh not_active Expired - Fee Related
- 1993-03-04 YU YU14893A patent/YU14893A/sh unknown
- 1993-05-03 NZ NZ249755A patent/NZ249755A/en unknown
1994
- 1994-09-02 NO NO943261A patent/NO302617B1/no not_active IP Right Cessation
1995
- 1995-11-17 CN CN95118796A patent/CN1044910C/zh not_active Expired - Fee Related
- 1995-11-17 CN CN95118794A patent/CN1082815C/zh not_active Expired - Fee Related
- 1995-11-17 CN CN95118795A patent/CN1044909C/zh not_active Expired - Fee Related
1996
- 1996-12-31 US US08/777,835 patent/US5717102A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DK0629199T3 (da)	2002-07-15
TW288010B (no)	1996-10-11
YU14893A (sh)	1996-05-20
SK105294A3 (en)	1995-05-10
CN1044910C (zh)	1999-09-01
CZ212594A3 (en)	1995-06-14
RU94040914A (ru)	1996-08-10
SK281938B6 (sk)	2001-09-11
IL104941A (en)	1998-06-15
MX9301197A (es)	1993-09-01
KR950700291A (ko)	1995-01-16
CA2117643A1 (en)	1993-09-16
US5594014A (en)	1997-01-14
ATE218566T1 (de)	2002-06-15
UA39866C2 (uk)	2001-07-16
CN1082044A (zh)	1994-02-16
DE69331988D1 (de)	2002-07-11
US5717102A (en)	1998-02-10
CN1032309C (zh)	1996-07-17
CN1136566A (zh)	1996-11-27
HU9300593D0 (en)	1993-05-28
NZ249755A (en)	1996-08-27
NO943261L (no)	1994-09-02
ES2176199T3 (es)	2002-12-01
DE69331988T2 (de)	2002-09-19
CZ282652B6 (cs)	1997-08-13
JPH07121943B2 (ja)	1995-12-25
JPH07500353A (ja)	1995-01-12
EG20416A (en)	1999-02-28
IL104941A0 (en)	1993-07-08
NO943261D0 (no)	1994-09-02
KR0179073B1 (ko)	1999-03-20
BR9306012A (pt)	1997-11-18
PT629199E (pt)	2002-09-30
RU2124012C1 (ru)	1998-12-27
AU666716B2 (en)	1996-02-22
HU219489B (hu)	2001-04-28
CN1136432A (zh)	1996-11-27
PL172388B1 (pl)	1997-09-30
CA2117643C (en)	2000-03-14
ZA931539B (en)	1994-09-05
EP0629199B1 (en)	2002-06-05
CN1082815C (zh)	2002-04-17
EP0629199A1 (en)	1994-12-21
HUT64061A (en)	1993-11-29
FI930968A0 (fi)	1993-03-04
WO1993018032A1 (en)	1993-09-16
MY109298A (en)	1996-12-31
FI930968A7 (fi)	1993-09-06
AU3733093A (en)	1993-10-05
CN1044909C (zh)	1999-09-01
CN1136565A (zh)	1996-11-27

Publication	Publication Date	Title
NO302617B1 (no)	1998-03-30	Indol-derivater som 5-HT1 agonister
EG21209A (en)	2001-01-31	Indole derivatives
CA2194984A1 (en)	1996-02-08	4-indole derivatives as serotonin agonists and antagonists
EP0354777A3 (en)	1991-04-10	3-(4-piperidine)-5-(2-sulfonylaminoethyl) indole derivatives
RU94045902A (ru)	1996-08-27	Производные ациламиноиндола в качестве 5-hti агонистов, фармацевтическая композиция и способ лечения
DE69528288D1 (de)	2002-10-24	Indolderivate zur behandlung von migräne
CA2350089A1 (en)	1996-12-07	Indole derivatives

Legal Events

Date	Code	Title	Description
2004-12-27	MM1K	Lapsed by not paying the annual fees