IL103064A - דיאסטראומרים של 1- )איזופרופאוקסיקרבונילאוקסי(אתיל 3- צפאם-4-קרבוקסילאט ותהליכים להכנתם - Google Patents

דיאסטראומרים של 1- )איזופרופאוקסיקרבונילאוקסי(אתיל 3- צפאם-4-קרבוקסילאט ותהליכים להכנתם

Info

Publication number: IL103064A
Authority: IL; Israel
Prior art keywords: formula; acid; diastereomer; diastereomerically pure; solution
Prior art date: 1991-09-07

Application number

IL10306492A

Other languages

English (en)

Other versions

IL103064A0 (en

Inventor

Gerd Fischer

Elisabeth Defossa

Uwe Gerlach

Rolf Hoerlein

Norbert Krass

Rudolf Lattrell

Ulrich Stache

Theodor Wollmann

Dieter Isert

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-09-07

Filing date

1992-09-04

Publication date

1996-12-05

1992-09-04 Application filed by Hoechst Ag filed Critical Hoechst Ag

1993-02-21 Publication of IL103064A0 publication Critical patent/IL103064A0/xx

1996-12-05 Publication of IL103064A publication Critical patent/IL103064A/he

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
- C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)

IL10306492A 1991-09-07 1992-09-04 דיאסטראומרים של 1- )איזופרופאוקסיקרבונילאוקסי(אתיל 3- צפאם-4-קרבוקסילאט ותהליכים להכנתם IL103064A (he)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4129771		1991-09-07

Publications (2)

Publication Number	Publication Date
IL103064A0 IL103064A0 (en)	1993-02-21
IL103064A true IL103064A (he)	1996-12-05

Family

ID=6440090

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL10306492A IL103064A (he)	1991-09-07	1992-09-04	דיאסטראומרים של 1- )איזופרופאוקסיקרבונילאוקסי(אתיל 3- צפאם-4-קרבוקסילאט ותהליכים להכנתם

Country Status (30)

Country	Link
US (3)	US5461043A (he)
EP (1)	EP0531875B1 (he)
JP (1)	JP2667943B2 (he)
KR (1)	KR100239253B1 (he)
CN (1)	CN1040002C (he)
AT (1)	ATE262533T1 (he)
AU (1)	AU647307B2 (he)
BR (1)	BR9203464A (he)
CA (1)	CA2077562C (he)
CZ (1)	CZ282320B6 (he)
DE (1)	DE59209994D1 (he)
DK (1)	DK0531875T3 (he)
EG (1)	EG20237A (he)
ES (1)	ES2215161T3 (he)
FI (1)	FI108725B (he)
HR (1)	HRP920310A2 (he)
HU (1)	HU219588B (he)
IL (1)	IL103064A (he)
MA (1)	MA22646A1 (he)
MX (1)	MX9205081A (he)
NO (1)	NO302122B1 (he)
NZ (1)	NZ244224A (he)
PH (1)	PH30743A (he)
PL (1)	PL171644B1 (he)
PT (1)	PT531875E (he)
RS (1)	RS49877B (he)
RU (1)	RU2075480C1 (he)
SI (1)	SI9200204B (he)
SK (1)	SK276192A3 (he)
ZA (1)	ZA926710B (he)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL99898A (en) *	1990-11-09	1996-10-31	Eisai Co Ltd	7-Acyl-3-substituted carbamoyloxy cephem compounds their preparation and antibacterial compositions containing them
DE59209994D1 (de) *	1991-09-07	2004-04-29	Aventis Pharma Gmbh	Diastereomer des 3-Cephem-4-carbonsäure-1-(-isopropoxycarbonyloxy)ethylesters und Verfahren zu dessen Herstellung
TW212181B (he) *	1992-02-14	1993-09-01	Hoechst Ag
EP0570849B1 (de) *	1992-05-21	1998-03-25	Hoechst Aktiengesellschaft	Verfahren zur Spaltung von Cephalosporin Prodrugestern zu 7-Amino-3-methoxymethylceph-3-em-4-carbonsäure
US5817351A (en) *	1995-04-07	1998-10-06	Abbott Laboratories	Calcium fortified low pH beverage
US5928691A (en) *	1997-05-01	1999-07-27	Nestec S.A.	Calcium complex and a process of making a food fortified with calcium
US6024994A (en) *	1997-11-06	2000-02-15	Nestec S.A.	Calcium complexes for fortification of foods and process of making
AT413383B (de) *	1998-01-09	2006-02-15	Sandoz Ag	Verfahren zur isolierung eines diastereoisomerengemisches von cefpodoxim proxetil
US6036985A (en) *	1998-04-03	2000-03-14	Nestec S.A.	Calcium complex and food fortified therewith
US6039986A (en) *	1998-07-10	2000-03-21	Nestec S.A.	Fortification of foodstuff
AT408226B (de) *	1999-05-05	2001-09-25	Biochemie Gmbh	Kristalliner 7-(2-(2-formylaminothiazol-4-yl)-2
EP1178992A2 (en) *	1999-05-07	2002-02-13	Ranbaxy Laboratories, Limited	Process for the preparation of cefpodoxime acid
IN191496B (he) *	1999-07-30	2003-12-06	Ranbaxy Lab Ltd
US6740344B2 (en) *	2000-12-01	2004-05-25	General Mill, Inc.	Calcium fortified products and methods of preparation
US7045618B2 (en) *	2001-02-27	2006-05-16	Ranbaxy Laboratories Limited	Cefpodixime proxetil
AU2002368494A1 (en) *	2002-12-20	2004-07-14	Lupin Limited	A process for the preparation of cefpodoxime proxetil
EP2520578A1 (en)	2011-05-06	2012-11-07	Lupin Limited	Process for purification of cephalosporins

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4668783A (en) *	1974-12-19	1987-05-26	Takeda Chemical Industries, Ltd.	Thiazolylacetamido cephalosporin compounds
JPS5760345B2 (he) *	1974-12-19	1982-12-18	Takeda Chemical Industries Ltd
DK154939C (da) *	1974-12-19	1989-06-12	Takeda Chemical Industries Ltd	Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
US4203899A (en) *	1974-12-19	1980-05-20	Takeda Chemical Industries, Ltd.	Thiazolylacetamido compounds
US4298606A (en) *	1974-12-19	1981-11-03	Takeda Chemical Industries, Ltd.	Thiazolylacetamido compounds
DE2760123C2 (de) *	1976-01-23	1986-04-30	Roussel-Uclaf, Paris	7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
JPS6011713B2 (ja) *	1976-09-08	1985-03-27	武田薬品工業株式会社	セフアロスポリン誘導体およびその製造法
DE2714880A1 (de) *	1977-04-02	1978-10-26	Hoechst Ag	Cephemderivate und verfahren zu ihrer herstellung
US4409215A (en) *	1979-11-19	1983-10-11	Fujisawa Pharmaceutical Co., Ltd.	7-Acylamino-3-substituted cephalosporanic acid derivatives and processes for the preparation thereof
FR2476087A1 (fr) *	1980-02-18	1981-08-21	Roussel Uclaf	Nouvelles oximes derivees de l'acide 3-alkyloxy ou 3-alkyl-thiomethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
JPS5759894A (en) *	1980-09-30	1982-04-10	Sankyo Co Ltd	Cephalosporin for oral administration
US4486425A (en) *	1980-09-30	1984-12-04	Sankyo Company Limited	7-[2-(2-Aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]-3-methoxymethyl-3-cephem-4-carboxylates
JPS5896091A (ja) *	1981-12-01	1983-06-07	Sankyo Co Ltd	３−アルコキシメチルセフアロスポリン類の製造法
US4688783A (en) *	1983-04-20	1987-08-25	Dubois R Clark	Bottom feed sheet feeding apparatus
JPS604189A (ja) *	1983-06-20	1985-01-10	Sankyo Co Ltd	β−ラクタム系化合物の製造法
JPS604190A (ja) *	1983-06-21	1985-01-10	Sankyo Co Ltd	セフアロスポリン誘導体の製法
JPS60260584A (ja) *	1985-05-14	1985-12-23	Sankyo Co Ltd	セフアロスポリン誘導体
DE3804841A1 (de) *	1988-02-17	1989-08-31	Hoechst Ag	Cephalosporinderivate und verfahren zu ihrer herstellung
DE3901405A1 (de) *	1989-01-19	1990-07-26	Hoechst Ag	Cephalosporinderivate und verfahren zu ihrer herstellung
DE3910093A1 (de) *	1989-03-29	1990-10-04	Hoechst Ag	Cephalosporinderivate und verfahren zu ihrer herstellung
US5063224A (en) *	1990-07-09	1991-11-05	Eli Lilly And Company	R-cefuroxime axetil
DE59209994D1 (de) *	1991-09-07	2004-04-29	Aventis Pharma Gmbh	Diastereomer des 3-Cephem-4-carbonsäure-1-(-isopropoxycarbonyloxy)ethylesters und Verfahren zu dessen Herstellung

1992
- 1992-09-02 DE DE59209994T patent/DE59209994D1/de not_active Expired - Lifetime
- 1992-09-02 ES ES92114982T patent/ES2215161T3/es not_active Expired - Lifetime
- 1992-09-02 AT AT92114982T patent/ATE262533T1/de active
- 1992-09-02 PT PT92114982T patent/PT531875E/pt unknown
- 1992-09-02 EP EP92114982A patent/EP0531875B1/de not_active Expired - Lifetime
- 1992-09-02 DK DK92114982T patent/DK0531875T3/da active
- 1992-09-03 US US07/940,367 patent/US5461043A/en not_active Expired - Lifetime
- 1992-09-04 BR BR929203464A patent/BR9203464A/pt not_active Application Discontinuation
- 1992-09-04 HR HR920310A patent/HRP920310A2/hr not_active IP Right Cessation
- 1992-09-04 RU SU925052750A patent/RU2075480C1/ru active
- 1992-09-04 PH PH44890A patent/PH30743A/en unknown
- 1992-09-04 IL IL10306492A patent/IL103064A/he not_active IP Right Cessation
- 1992-09-04 RS YUP-813/92A patent/RS49877B/sr unknown
- 1992-09-04 SK SK2761-92A patent/SK276192A3/sk not_active IP Right Cessation
- 1992-09-04 MX MX9205081A patent/MX9205081A/es unknown
- 1992-09-04 NZ NZ244224A patent/NZ244224A/en not_active IP Right Cessation
- 1992-09-04 NO NO923452A patent/NO302122B1/no not_active IP Right Cessation
- 1992-09-04 FI FI923966A patent/FI108725B/fi not_active IP Right Cessation
- 1992-09-04 PL PL92295834A patent/PL171644B1/pl unknown
- 1992-09-04 CA CA002077562A patent/CA2077562C/en not_active Expired - Lifetime
- 1992-09-04 CZ CS922761A patent/CZ282320B6/cs not_active IP Right Cessation
- 1992-09-04 ZA ZA926710A patent/ZA926710B/xx unknown
- 1992-09-05 KR KR1019920016174A patent/KR100239253B1/ko not_active IP Right Cessation
- 1992-09-05 EG EG52192A patent/EG20237A/xx active
- 1992-09-05 CN CN92110493A patent/CN1040002C/zh not_active Expired - Lifetime
- 1992-09-07 MA MA22936A patent/MA22646A1/fr unknown
- 1992-09-07 SI SI9200204A patent/SI9200204B/sl unknown
- 1992-09-07 HU HU9202861A patent/HU219588B/hu unknown
- 1992-09-07 JP JP4280421A patent/JP2667943B2/ja not_active Expired - Lifetime
- 1992-09-08 AU AU22183/92A patent/AU647307B2/en not_active Expired
1995
- 1995-05-22 US US08/447,229 patent/US5550232A/en not_active Expired - Lifetime
- 1995-05-22 US US08/447,249 patent/US5614623A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA2077562C (en)	2003-07-15
AU647307B2 (en)	1994-03-17
JP2667943B2 (ja)	1997-10-27
NZ244224A (en)	1995-04-27
EP0531875A2 (de)	1993-03-17
DE59209994D1 (de)	2004-04-29
CN1040002C (zh)	1998-09-30
US5614623A (en)	1997-03-25
RS49877B (sr)	2008-08-07
ZA926710B (en)	1993-04-28
CA2077562A1 (en)	1993-03-08
NO302122B1 (no)	1998-01-26
SK279013B6 (sk)	1998-05-06
HRP920310B1 (he)	2004-12-31
HU219588B (hu)	2001-05-28
HRP920310A2 (en)	1994-08-31
FI923966A (fi)	1993-03-08
BR9203464A (pt)	1993-04-13
PH30743A (en)	1997-10-17
KR100239253B1 (ko)	2000-03-02
MX9205081A (es)	1993-03-01
FI108725B (fi)	2002-03-15
CZ282320B6 (cs)	1997-06-11
IL103064A0 (en)	1993-02-21
EP0531875A3 (en)	1993-03-24
DK0531875T3 (da)	2004-06-21
SK276192A3 (en)	1998-05-06
NO923452L (no)	1993-03-08
HUT64544A (en)	1994-01-28
AU2218392A (en)	1993-03-11
EP0531875B1 (de)	2004-03-24
CZ276192A3 (en)	1993-08-11
HU9202861D0 (en)	1992-11-30
PL295834A1 (en)	1993-03-22
MA22646A1 (fr)	1993-04-01
RU2075480C1 (ru)	1997-03-20
ATE262533T1 (de)	2004-04-15
PT531875E (pt)	2004-08-31
ES2215161T3 (es)	2004-10-01
PL171644B1 (en)	1997-05-30
US5461043A (en)	1995-10-24
CN1070405A (zh)	1993-03-31
US5550232A (en)	1996-08-27
FI923966A0 (fi)	1992-09-04
SI9200204A (en)	1993-03-31
EG20237A (en)	1998-05-31
SI9200204B (en)	2001-12-31
JPH05213969A (ja)	1993-08-24
KR930006031A (ko)	1993-04-20
YU81392A (sr)	1996-01-09
NO923452D0 (no)	1992-09-04

Publication	Publication Date	Title
US5461043A (en)	1995-10-24	Diastereomers of 1-(isopropoxycarbonyloxy)ethyl 3-cephem-4-carboxylate
US7405294B2 (en)	2008-07-29	Intermediate cefdinir salts
US7045618B2 (en)	2006-05-16	Cefpodixime proxetil
AU613164B2 (en)	1991-07-25	Cephalosporin derivatives and processes for their preparation
JPH05178861A (ja)	1993-07-20	ジアステレオマー的に純粋な１−（２，２−ジメチルプロピオニルオキシ）−エチル３−セフェム−４−カルボキシレートの結晶性の酸付加塩
EP0949262B1 (en)	2001-08-22	Cephem compounds
EP0321562B1 (en)	1993-11-24	Crystalline cephalosporin compounds, process for their preparation, and intermediates for their preparation
JP2898054B2 (ja)	1999-05-31	セファロスポリン誘導体およびその製法
US20030162763A1 (en)	2003-08-28	Novel cephalosporin compounds and process for preparing the same
LT3870B (en)	1996-04-25	Diastereomers of 3-cefem-4-carboxylic acid 1-(isopropoxy-carbonyloxy)ethyl ester, process for preparingthereof, antibacteric preparations based on same and process for preparation thereof
JPH08504808A (ja)	1996-05-28	抗菌活性を有するセフェム化合物
JPS638956B2 (he)	1988-02-25

Legal Events

Date	Code	Title
1997-06-10	FF	Patent granted
1998-02-08	KB	Patent renewed
1999-01-26	KB	Patent renewed
2002-11-10	KB	Patent renewed
2006-12-07	KB	Patent renewed
2010-11-30	KB	Patent renewed
2013-04-30	EXP	Patent expired