IL102905A - Ophthalmic composition containing vitamin b-12 for neutralizing residual peroxide - Google Patents

Ophthalmic composition containing vitamin b-12 for neutralizing residual peroxide

Info

Publication number: IL102905A
Authority: IL; Israel
Prior art keywords: composition; solution; peroxide; component; vitamin
Prior art date: 1991-08-30

Application number

IL10290592A

Other languages

English (en)

Hebrew (he)

Other versions

IL102905A0 (en

Original Assignee

Allergan Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-08-30

Filing date

1992-08-21

Publication date

1996-11-14

1992-08-21 Application filed by Allergan Inc filed Critical Allergan Inc

1993-01-31 Publication of IL102905A0 publication Critical patent/IL102905A0/xx

1993-04-03 Priority to TW82102545A priority Critical patent/TW260615B/zh

1996-11-14 Publication of IL102905A publication Critical patent/IL102905A/en

Links

150000002978 peroxides Chemical class 0.000 title claims description 37
238000006386 neutralization reaction Methods 0.000 title description 4
239000011782 vitamin Substances 0.000 title description 3
235000013343 vitamin Nutrition 0.000 title description 3
229930003231 vitamin Natural products 0.000 title description 3
229940088594 vitamin Drugs 0.000 title description 3
150000003722 vitamin derivatives Chemical class 0.000 title description 3
MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims abstract description 139
239000000203 mixture Substances 0.000 claims abstract description 89
FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims abstract description 44
102000016938 Catalase Human genes 0.000 claims abstract description 33
108010053835 Catalase Proteins 0.000 claims abstract description 33
238000000034 method Methods 0.000 claims abstract description 18
241000220317 Rosa Species 0.000 claims abstract description 17
238000000576 coating method Methods 0.000 claims description 46
239000011248 coating agent Substances 0.000 claims description 42
230000003472 neutralizing effect Effects 0.000 claims description 29
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 22
150000001875 compounds Chemical class 0.000 claims description 16
230000003111 delayed effect Effects 0.000 claims description 11
239000000645 desinfectant Substances 0.000 claims description 11
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239000011780 sodium chloride Substances 0.000 claims description 7
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OSVXSBDYLRYLIG-UHFFFAOYSA-N dioxidochlorine(.) Chemical group O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 claims description 4
239000007787 solid Substances 0.000 claims description 3
239000004155 Chlorine dioxide Substances 0.000 claims description 2
235000019398 chlorine dioxide Nutrition 0.000 claims description 2
239000000843 powder Substances 0.000 claims description 2
150000003242 quaternary ammonium salts Chemical group 0.000 claims description 2
XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical group NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 claims 1
238000013329 compounding Methods 0.000 abstract description 3
239000000243 solution Substances 0.000 description 99
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RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 description 7
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
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UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 6
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WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 5
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150000001340 alkali metals Chemical class 0.000 description 5
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NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 4
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BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 4
239000000463 material Substances 0.000 description 4
KJFMBFZCATUALV-UHFFFAOYSA-N phenolphthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2C(=O)O1 KJFMBFZCATUALV-UHFFFAOYSA-N 0.000 description 4
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235000019422 polyvinyl alcohol Nutrition 0.000 description 4
238000004659 sterilization and disinfection Methods 0.000 description 4
239000003760 tallow Substances 0.000 description 4
ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 description 3
235000014469 Bacillus subtilis Nutrition 0.000 description 3
206010015946 Eye irritation Diseases 0.000 description 3
XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 3
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 3
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239000007983 Tris buffer Substances 0.000 description 3
LFVVNPBBFUSSHL-UHFFFAOYSA-N alexidine Chemical class CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC LFVVNPBBFUSSHL-UHFFFAOYSA-N 0.000 description 3
229950010221 alexidine Drugs 0.000 description 3
125000000217 alkyl group Chemical group 0.000 description 3
239000006172 buffering agent Substances 0.000 description 3
230000001627 detrimental effect Effects 0.000 description 3
231100000013 eye irritation Toxicity 0.000 description 3
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239000011734 sodium Substances 0.000 description 3
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BBMHARZCALWXSL-UHFFFAOYSA-M sodium dihydrogenphosphate monohydrate Chemical compound O.[Na+].OP(O)([O-])=O BBMHARZCALWXSL-UHFFFAOYSA-M 0.000 description 3
239000007909 solid dosage form Substances 0.000 description 3
LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 2
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CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Natural products OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
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GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical class C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 2
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150000004820 halides Chemical class 0.000 description 1
230000036541 health Effects 0.000 description 1
DQOCFCZRZOAIBN-WZHZPDAFSA-L hydroxycobalamin Chemical compound O.[Co+2].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O DQOCFCZRZOAIBN-WZHZPDAFSA-L 0.000 description 1
235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
239000001863 hydroxypropyl cellulose Substances 0.000 description 1
235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 1
229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 description 1
230000000415 inactivating effect Effects 0.000 description 1
230000001939 inductive effect Effects 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
208000014674 injury Diseases 0.000 description 1
230000003993 interaction Effects 0.000 description 1
230000007794 irritation Effects 0.000 description 1
229940026239 isoascorbic acid Drugs 0.000 description 1
108010059345 keratinase Proteins 0.000 description 1
TYQCGQRIZGCHNB-JLAZNSOCSA-N l-ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(O)=C(O)C1=O TYQCGQRIZGCHNB-JLAZNSOCSA-N 0.000 description 1
239000007942 layered tablet Substances 0.000 description 1
235000019421 lipase Nutrition 0.000 description 1
150000002632 lipids Chemical class 0.000 description 1
239000012705 liquid precursor Substances 0.000 description 1
239000006193 liquid solution Substances 0.000 description 1
FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
239000011159 matrix material Substances 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
125000005397 methacrylic acid ester group Chemical group 0.000 description 1
XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 description 1
JEWJRMKHSMTXPP-BYFNXCQMSA-M methylcobalamin Chemical compound C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O JEWJRMKHSMTXPP-BYFNXCQMSA-M 0.000 description 1
235000007672 methylcobalamin Nutrition 0.000 description 1
239000011585 methylcobalamin Substances 0.000 description 1
239000004531 microgranule Substances 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
229940045641 monobasic sodium phosphate Drugs 0.000 description 1
PJUIMOJAAPLTRJ-UHFFFAOYSA-N monothioglycerol Chemical compound OCC(O)CS PJUIMOJAAPLTRJ-UHFFFAOYSA-N 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
150000002823 nitrates Chemical class 0.000 description 1
239000002736 nonionic surfactant Substances 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
108090000021 oryzin Proteins 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
229940055695 pancreatin Drugs 0.000 description 1
239000002245 particle Substances 0.000 description 1
108040007629 peroxidase activity proteins Proteins 0.000 description 1
JRKICGRDRMAZLK-UHFFFAOYSA-L persulfate group Chemical group S(=O)(=O)([O-])OOS(=O)(=O)[O-] JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 description 1
235000021317 phosphate Nutrition 0.000 description 1
125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
239000002504 physiological saline solution Substances 0.000 description 1
239000006187 pill Substances 0.000 description 1
229920001515 polyalkylene glycol Polymers 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920002338 polyhydroxyethylmethacrylate Polymers 0.000 description 1
229920000056 polyoxyethylene ether Polymers 0.000 description 1
229920001282 polysaccharide Polymers 0.000 description 1
239000005017 polysaccharide Substances 0.000 description 1
150000004804 polysaccharides Chemical class 0.000 description 1
229920000136 polysorbate Polymers 0.000 description 1
229950008882 polysorbate Drugs 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
239000001103 potassium chloride Substances 0.000 description 1
235000011164 potassium chloride Nutrition 0.000 description 1
230000002265 prevention Effects 0.000 description 1
HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
229940107700 pyruvic acid Drugs 0.000 description 1
230000000630 rising effect Effects 0.000 description 1
238000002791 soaking Methods 0.000 description 1
235000015424 sodium Nutrition 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical class [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 1
235000010265 sodium sulphite Nutrition 0.000 description 1
241000894007 species Species 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
238000003860 storage Methods 0.000 description 1
150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
229940033663 thimerosal Drugs 0.000 description 1
229940035024 thioglycerol Drugs 0.000 description 1
150000004764 thiosulfuric acid derivatives Chemical class 0.000 description 1
239000012929 tonicity agent Substances 0.000 description 1
239000003440 toxic substance Substances 0.000 description 1
230000008733 trauma Effects 0.000 description 1
239000012588 trypsin Substances 0.000 description 1
229960001322 trypsin Drugs 0.000 description 1
239000012224 working solution Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/30—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving catalase
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A61L12/10—Halogens or compounds thereof
- A61L12/102—Chlorine dioxide (ClO2)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A61L12/12—Non-macromolecular oxygen-containing compounds, e.g. hydrogen peroxide or ozone
- A61L12/124—Hydrogen peroxide; Peroxy compounds
- A61L12/126—Hydrogen peroxide; Peroxy compounds neutralised with catalase or peroxidase
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Public Health (AREA)
Molecular Biology (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Urology & Nephrology (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
Physics & Mathematics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
Zoology (AREA)
Hematology (AREA)
Microbiology (AREA)
Food Science & Technology (AREA)
Biophysics (AREA)
Pathology (AREA)
General Physics & Mathematics (AREA)
Medicinal Chemistry (AREA)
Cell Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Eyeglasses (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Apparatus For Disinfection Or Sterilisation (AREA)
Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Investigating Or Analysing Biological Materials (AREA)

IL10290592A 1991-08-30 1992-08-21 Ophthalmic composition containing vitamin b-12 for neutralizing residual peroxide IL102905A (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
TW82102545A TW260615B (es)	1992-08-21	1993-04-03

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US75232091A	1991-08-30	1991-08-30

Publications (2)

Publication Number	Publication Date
IL102905A0 IL102905A0 (en)	1993-01-31
IL102905A true IL102905A (en)	1996-11-14

Family

ID=25025800

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL10290592A IL102905A (en)	1991-08-30	1992-08-21	Ophthalmic composition containing vitamin b-12 for neutralizing residual peroxide

Country Status (23)

Country	Link
US (2)	US5578240A (es)
EP (1)	EP0555464B1 (es)
JP (2)	JP3234600B2 (es)
KR (1)	KR100256116B1 (es)
AT (1)	ATE156367T1 (es)
AU (1)	AU653432B2 (es)
BR (1)	BR9205382A (es)
CA (1)	CA2095022C (es)
DE (2)	DE555464T1 (es)
DK (1)	DK0555464T3 (es)
ES (1)	ES2106882T3 (es)
FI (1)	FI931940A0 (es)
GR (1)	GR3024488T3 (es)
HU (1)	HU219128B (es)
IL (1)	IL102905A (es)
MX (1)	MX9204912A (es)
NO (1)	NO305538B1 (es)
NZ (1)	NZ243749A (es)
PL (2)	PL172353B1 (es)
PT (1)	PT100825B (es)
RU (1)	RU2114638C1 (es)
WO (1)	WO1993004706A1 (es)
ZA (1)	ZA926522B (es)

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NZ243749A (en) *	1991-08-30	1994-11-25	Allergan Inc	Composition for neutralising and indicating the absence of peroxide comprising a neutralising compound and vitamin b-12
US6024954A (en) *	1994-12-12	2000-02-15	Allergan	Compositions and methods for disinfecting contact lenses and preserving contact lens care products
EP0734732A1 (en) *	1995-03-31	1996-10-02	A.C. Obbens Beheer B.V.	A composition for cleaning contact lenses and a method for cleaning contact lenses
US5882687A (en) *	1997-01-10	1999-03-16	Allergan	Compositions and methods for storing contact lenses
US20030129083A1 (en) *	1997-11-26	2003-07-10	Advanced Medical Optics, Inc.	Multi purpose contact lens care compositions including propylene glycol or glycerin
US6099800A (en) *	1998-08-14	2000-08-08	Sinphar Pharmaceutical Co., Ltd.	Process for cleaning and disinfecting contact lens and hydrogen peroxide destroying composition having a delayed release function for use therein
WO2000056139A2 (en) *	1999-03-25	2000-09-28	Cargill, Incorporated	Method and composition for the prevention of struvite in fish
TW476651B (en) *	2000-04-20	2002-02-21	Novartis Ag	Coloured ophthalmic product
DE10046995B4 (de) *	2000-09-22	2006-01-05	Henkel Kgaa	Reinigungsmittel
US20070104744A1 (en) *	2000-11-08	2007-05-10	Fxs Ventures, Llc	Ophthalmic and contact lens solutions containing forms of vitamin b
US9308264B2 (en)	2000-11-08	2016-04-12	Fxs Ventures, Llc	Ophthalmic contact lens solutions containing forms of vitamin B
EP1992340B1 (en) *	2000-11-08	2016-05-11	FXS Ventures, LLC	Improved ophthalmic and contact lens solution
US7923469B2 (en) *	2001-04-30	2011-04-12	Allergen, Inc.	Compositions including vitamin-based surfactants and methods for using same
US7105350B2 (en)	2002-08-30	2006-09-12	Tropicana Products, Inc.	Closure integrity test method for hot-fill bottling operation
US6737645B2 (en)	2002-08-30	2004-05-18	Tropicana Products, Inc.	Method for qualifying bottle rinser
GB0417332D0 (en) *	2004-08-04	2004-09-08	Reckitt Benckiser Nv	Improvements in aqueous compositions
JP5069293B2 (ja) *	2006-07-13	2012-11-07	ノバルティスアーゲー	レンズケア方法及びキット
ATE526043T1 (de)	2006-08-16	2011-10-15	Novartis Ag	Enzymatischer abbau von farbstoffen in linsenpflegelösungen
CA2660100C (en) *	2006-08-16	2014-10-21	Novartis Ag	Temporal photo-bleaching of colored lens care solutions and use thereof
JP5947723B2 (ja) *	2009-11-17	2016-07-06	ノバルティスアーゲー	コンタクトレンズの消毒のための過酸化水素溶液及びキット
US9254400B2 (en)	2010-03-02	2016-02-09	Ecolab Usa Inc.	Method for processing peroxygen solutions
MY164100A (en)	2011-12-31	2017-11-30	Novartis Ag	Method of making contact lenses with identifying mark
KR20180064399A (ko)	2015-09-03	2018-06-14	더 어드미니스트레이터 오브 더 튜레인 에듀케이셔널 펀드	다목적 소독 및 멸균 용액을 위한 조성물 및 방법

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US326A (en) *		1837-07-31		Mode of constrtjctiire paddle-wheels fob
US32672A (en) *		1861-07-02		Manjsr
EP0082798B2 (de) *	1981-12-21	1991-11-27	Ciba-Geigy Ag	Verfahren zur Desinfektion und Reinigung von Kontaktlinsen
US4568517A (en) *	1983-08-25	1986-02-04	Barnes-Hind, Inc.	Disinfection of contact lenses
GB8507678D0 (en) *	1985-03-25	1985-05-01	Univ Bath	Cleaning/disinfection of contact lenses
GB8515079D0 (en) *	1985-06-14	1985-07-17	Kellway Pharma	Contact lens cleaning & disinfection
EP0209071B2 (de) *	1985-07-10	1998-07-15	Novartis AG	Kontaktlinsenpflegesatz
USRE32672E (en) *	1985-09-09	1988-05-24	Allergan, Inc.	Method for simultaneously cleaning and disinfecting contact lenses using a mixture of peroxide and proteolytic enzyme
DE3622391A1 (de) *	1986-07-03	1988-01-14	Henkel Kgaa	Verfahren und vorrichtung zur kontaktlinsenpflege
US5055287A (en) *	1986-12-29	1991-10-08	Kessler Jack H	Methods to control color during disinfecting peroxidase reactions
DE3701129A1 (de) *	1987-01-16	1988-07-28	Henkel Kgaa	Verfahren zur herstellung von desinfizierend wirkenden kontaktlinsen-reinigungsmitteltabletten
AU636908B2 (en) *	1989-08-01	1993-05-13	Schering Corporation	Contact lens disinfecting system
CA2026714A1 (en) *	1989-11-03	1991-05-04	Peter Gyulai	Hydrogen peroxide destroying compositions and methods of using same
WO1991012825A1 (en) *	1990-02-27	1991-09-05	Allergan, Inc.	Hydrogen peroxide destroying compositions and methods of making and using same
ZA913506B (en) *	1990-05-22	1992-02-26	Alcon Lab Inc	Double redox system for disinfecting contact lenses
US5395621A (en) *	1990-09-25	1995-03-07	Allergan, Inc.	Apparatus and method for disinfecting a contact lens and detecting the presence of an oxidative disinfectant
WO1992004921A1 (en) *	1990-09-25	1992-04-02	Allergan, Inc.	Apparatus and method for disinfecting a contact lens and detecting the presence of an oxidative disinfectant
NZ243749A (en) *	1991-08-30	1994-11-25	Allergan Inc	Composition for neutralising and indicating the absence of peroxide comprising a neutralising compound and vitamin b-12
US5382599A (en) *	1993-10-13	1995-01-17	Allergan, Inc.	Method of inhibiting protozoan growth in eye care products using a polyvalent cation chelating agent

1992
- 1992-07-28 NZ NZ243749A patent/NZ243749A/en unknown
- 1992-08-21 IL IL10290592A patent/IL102905A/en not_active IP Right Cessation
- 1992-08-25 AT AT92919302T patent/ATE156367T1/de active
- 1992-08-25 DK DK92919302.7T patent/DK0555464T3/da active
- 1992-08-25 JP JP50526193A patent/JP3234600B2/ja not_active Expired - Lifetime
- 1992-08-25 EP EP92919302A patent/EP0555464B1/en not_active Expired - Lifetime
- 1992-08-25 DE DE0555464T patent/DE555464T1/de active Pending
- 1992-08-25 BR BR9205382A patent/BR9205382A/pt not_active IP Right Cessation
- 1992-08-25 AU AU25573/92A patent/AU653432B2/en not_active Expired
- 1992-08-25 RU RU93033091A patent/RU2114638C1/ru not_active IP Right Cessation
- 1992-08-25 CA CA002095022A patent/CA2095022C/en not_active Expired - Lifetime
- 1992-08-25 DE DE69221463T patent/DE69221463T2/de not_active Expired - Lifetime
- 1992-08-25 PL PL92315281A patent/PL172353B1/pl not_active IP Right Cessation
- 1992-08-25 WO PCT/US1992/007195 patent/WO1993004706A1/en active IP Right Grant
- 1992-08-25 PL PL92299186A patent/PL171875B1/pl not_active IP Right Cessation
- 1992-08-25 HU HU9301239A patent/HU219128B/hu unknown
- 1992-08-25 ES ES92919302T patent/ES2106882T3/es not_active Expired - Lifetime
- 1992-08-25 KR KR1019930701320A patent/KR100256116B1/ko not_active Expired - Fee Related
- 1992-08-26 MX MX9204912A patent/MX9204912A/es unknown
- 1992-08-28 PT PT100825A patent/PT100825B/pt not_active IP Right Cessation
- 1992-08-28 ZA ZA926522A patent/ZA926522B/xx unknown
1993
- 1993-04-29 NO NO931571A patent/NO305538B1/no unknown
- 1993-04-29 FI FI931940A patent/FI931940A0/fi not_active Application Discontinuation
1994
- 1994-04-14 US US08/227,707 patent/US5578240A/en not_active Expired - Lifetime
1996
- 1996-10-30 US US08/741,081 patent/US5989847A/en not_active Expired - Lifetime
1997
- 1997-08-21 GR GR970402127T patent/GR3024488T3/el unknown
2001
- 2001-06-20 JP JP2001186442A patent/JP3904851B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
RU2114638C1 (ru)	1998-07-10
DE69221463T2 (de)	1998-03-05
NZ243749A (en)	1994-11-25
PL172353B1 (pl)	1997-09-30
DE69221463D1 (de)	1997-09-11
US5578240A (en)	1996-11-26
FI931940L (fi)	1993-04-29
EP0555464B1 (en)	1997-08-06
DK0555464T3 (da)	1998-02-09
JP2002082055A (ja)	2002-03-22
DE555464T1 (de)	1996-02-15
JP3234600B2 (ja)	2001-12-04
IL102905A0 (en)	1993-01-31
PT100825B (pt)	1999-07-30
PT100825A (pt)	1994-02-28
NO305538B1 (no)	1999-06-21
ZA926522B (en)	1993-04-28
EP0555464A1 (en)	1993-08-18
AU653432B2 (en)	1994-09-29
JP3904851B2 (ja)	2007-04-11
KR100256116B1 (ko)	2000-06-01
HUT64240A (en)	1993-12-28
MX9204912A (es)	1993-02-01
CA2095022A1 (en)	1993-03-01
JPH06501643A (ja)	1994-02-24
GR3024488T3 (en)	1997-11-28
PL171875B1 (pl)	1997-06-30
CA2095022C (en)	2001-01-30
FI931940A0 (fi)	1993-04-29
HU219128B (hu)	2001-02-28
HU9301239D0 (en)	1993-08-30
PL299186A1 (en)	1993-12-27
US5989847A (en)	1999-11-23
NO931571D0 (no)	1993-04-29
NO931571L (no)	1993-04-29
ATE156367T1 (de)	1997-08-15
AU2557392A (en)	1993-04-05
WO1993004706A1 (en)	1993-03-18
ES2106882T3 (es)	1997-11-16
BR9205382A (pt)	1994-03-08

Publication	Publication Date	Title
CA2095022C (en)	2001-01-30	Compositions and methods for identifying a solution
AU653769B2 (en)	1994-10-13	Hydrogen peroxide destroying compositions and methods of making and using same
US5521091A (en)	1996-05-28	Compositions and method for destroying hydrogen peroxide on contact lens
AU724073B2 (en)	2000-09-14	Hydrogen peroxide destroying compositions and methods of using same
US5746972A (en)	1998-05-05	Compositions and methods for disinfecting and cleaning contact lenses
CA2154179C (en)	2003-05-27	Compositions and methods to disinfect contact lenses
WO1995027515A1 (en)	1995-10-19	Phospholipid preservation of hydrogen peroxide-containing compositions

Legal Events

Date	Code	Title
1997-04-15	FF	Patent granted
1999-06-20	NE	Application for restoration - patent lapsed through non-payment of renewal fees (section 60, patents law, 5727-1967)
1999-08-17	RH	Patent void
2002-11-10	HP	Change in proprietorship
2002-11-10	KB	Patent renewed
2006-10-30	KB	Patent renewed
2010-11-30	KB	Patent renewed
2013-04-30	EXP	Patent expired