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IE39872B1 - 1 3-oxygenated 8a-oestratrienes - Google Patents

1 3-oxygenated 8a-oestratrienes

Info

Publication number
IE39872B1
IE39872B1 IE1461/74A IE146174A IE39872B1 IE 39872 B1 IE39872 B1 IE 39872B1 IE 1461/74 A IE1461/74 A IE 1461/74A IE 146174 A IE146174 A IE 146174A IE 39872 B1 IE39872 B1 IE 39872B1
Authority
IE
Ireland
Prior art keywords
compounds
oestratrienes
oxygenated
oestraoligoene
gb1479934a
Prior art date
Application number
IE1461/74A
Other versions
IE39872L (en
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2336431A external-priority patent/DE2336431C2/en
Priority claimed from DE19742426777 external-priority patent/DE2426777A1/en
Application filed by Schering Ag filed Critical Schering Ag
Publication of IE39872L publication Critical patent/IE39872L/en
Publication of IE39872B1 publication Critical patent/IE39872B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C07J1/0074—Esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J15/00—Stereochemically pure steroids containing carbon, hydrogen, halogen or oxygen having a partially or totally inverted skeleton, e.g. retrosteroids, L-isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)

Abstract

1,3-Dihydroxy-1,3,5(10)-8alpha-oestratrienes or their ethers or esters of the following formula <IMAGE> in which the substituents are defined in Claim 1 are prepared. The said compounds are obtained by hydrogenating the 8(9) and, if present, the 14(15) double bond in a corresponding oestraoligoene. It is possible in the resulting compounds to reduce a 17-ketone group, to eliminate ester and ether groups, to esterify or etherify free hydroxyl groups and, furthermore, react a 17-ketone compound with organometallic compounds to introduce a hydrocarbon radical. The said compounds display favourable oestrogenic dissociation and they can be used for the treatment of manifestations of oestrogen deficiency. [GB1479934A]
IE1461/74A 1973-07-13 1974-07-11 1 3-oxygenated 8a-oestratrienes IE39872B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2336431A DE2336431C2 (en) 1973-07-13 1973-07-13 1.3-oxygenated 8-alpha-estratrienes, processes for their production and pharmaceuticals containing them
DE19742426777 DE2426777A1 (en) 1974-05-31 1974-05-31 1,3-Oxygenated-8-alpha-oestratrienes for post-menopausal disorders - with vaginotropic, but low uterotrophic activity

Publications (2)

Publication Number Publication Date
IE39872L IE39872L (en) 1975-01-13
IE39872B1 true IE39872B1 (en) 1979-01-17

Family

ID=25765510

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1461/74A IE39872B1 (en) 1973-07-13 1974-07-11 1 3-oxygenated 8a-oestratrienes

Country Status (18)

Country Link
JP (1) JPS5821639B2 (en)
AT (1) ATA575574A (en)
AU (1) AU477010B2 (en)
CA (1) CA1030951A (en)
CH (2) CH614217A5 (en)
CS (2) CS182260B2 (en)
DD (1) DD114066A5 (en)
DK (1) DK133051C (en)
ES (1) ES428226A1 (en)
FI (1) FI54131C (en)
FR (1) FR2236505B1 (en)
GB (1) GB1479934A (en)
HU (1) HU169791B (en)
IE (1) IE39872B1 (en)
IL (1) IL45259A (en)
NO (1) NO742546L (en)
SE (1) SE7409151L (en)
SU (1) SU626705A3 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2551214C2 (en) * 1975-11-12 1984-07-12 Schering AG, 1000 Berlin und 4709 Bergkamen Process for the preparation of 1,3-oxygenated 8α-estatrienes
JPS5862734U (en) * 1981-10-22 1983-04-27 日工株式会社 formwork support sabot
JPS59146759A (en) * 1984-01-06 1984-08-22 株式会社日立製作所 Automatic screwing device
JPS60155376A (en) * 1984-01-24 1985-08-15 松下電器産業株式会社 Nut float detection apparatus
DE3710728A1 (en) * 1987-03-31 1988-10-13 Schering Ag METHOD FOR PRODUCING 17 (ALPHA) -ETHINYL-17SS-HYDROXY-18-METHYL-4.15-ESTRADIEN-3-ON AND THE NEW INTERMEDIATE PRODUCTS FOR THIS METHOD
US6011024A (en) 1991-08-28 2000-01-04 Imperial College Of Science Technology & Medicine Steroid sulphatase inhibitors
US6476011B1 (en) 1991-08-28 2002-11-05 Sterix Limited Methods for introducing an estrogenic compound
US6903084B2 (en) 1991-08-29 2005-06-07 Sterix Limited Steroid sulphatase inhibitors
US7335650B2 (en) 2000-01-14 2008-02-26 Sterix Limited Composition
GB0020498D0 (en) 2000-08-18 2000-10-11 Sterix Ltd Compound
RU2679625C1 (en) * 2018-11-08 2019-02-12 Ильясов Шамиль Сионович 3-o-sulfamoiloxy-6-oxa-7β-methyl-d-homo-8α-estra-1,3,5(10)-trien-17α-one application for the breast cancer treatment, including the triple negative form, and its production method

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3436411A (en) * 1967-12-28 1969-04-01 American Home Prod Process for cleaving an a-ring ether group in 13-alkylgona (and 8-isogona)-1,3,5(10)-trienes and delta-7-,delta-8(9)-,and delta-8(9),14(15)-dehydro derivatives thereof

Also Published As

Publication number Publication date
SU626705A3 (en) 1978-09-30
IL45259A (en) 1977-10-31
DK368074A (en) 1975-03-17
IL45259A0 (en) 1974-10-22
DK133051B (en) 1976-03-15
CS182260B2 (en) 1978-04-28
NO742546L (en) 1975-02-10
JPS5032160A (en) 1975-03-28
CH609064A5 (en) 1979-02-15
SE7409151L (en) 1975-01-14
FI54131C (en) 1978-10-10
FR2236505B1 (en) 1977-07-08
DD114066A5 (en) 1975-07-12
IE39872L (en) 1975-01-13
CA1030951A (en) 1978-05-09
GB1479934A (en) 1977-07-13
ES428226A1 (en) 1976-07-16
AU477010B2 (en) 1976-10-14
FR2236505A1 (en) 1975-02-07
FI213974A (en) 1975-01-14
DK133051C (en) 1976-08-16
CS182300B2 (en) 1978-04-28
ATA575574A (en) 1978-05-15
HU169791B (en) 1977-01-28
FI54131B (en) 1978-06-30
JPS5821639B2 (en) 1983-05-02
CH614217A5 (en) 1979-11-15
AU7112374A (en) 1976-01-15

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