HUP9900401A2 - Allergiás megbetegedések kezelésére alkalmas, helyettesített N-metil-N-(4-(4-(1H-benzimidazol-2-il)[1,4]diazepan-1-il)-2-(aril)-butil)-benzamidok, ezeket tartalmazó gyógyászati készítmények és alkalmazásuk - Google Patents
Allergiás megbetegedések kezelésére alkalmas, helyettesített N-metil-N-(4-(4-(1H-benzimidazol-2-il)[1,4]diazepan-1-il)-2-(aril)-butil)-benzamidok, ezeket tartalmazó gyógyászati készítmények és alkalmazásukInfo
- Publication number
- HUP9900401A2 HUP9900401A2 HU9900401A HUP9900401A HUP9900401A2 HU P9900401 A2 HUP9900401 A2 HU P9900401A2 HU 9900401 A HU9900401 A HU 9900401A HU P9900401 A HUP9900401 A HU P9900401A HU P9900401 A2 HUP9900401 A2 HU P9900401A2
- Authority
- HU
- Hungary
- Prior art keywords
- powder
- pipe
- ch2ch
- carbon
- hydrogen atom
- Prior art date
Links
- 208000026935 allergic disease Diseases 0.000 title 1
- 229940054066 benzamide antipsychotics Drugs 0.000 title 1
- 150000003936 benzamides Chemical class 0.000 title 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000000843 powder Substances 0.000 abstract 22
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 229910052799 carbon Inorganic materials 0.000 abstract 4
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 102000000543 Histamine Receptors Human genes 0.000 abstract 1
- 108010002059 Histamine Receptors Proteins 0.000 abstract 1
- 101100406879 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) par-2 gene Proteins 0.000 abstract 1
- -1 carbon atom aldehyde Chemical class 0.000 abstract 1
- 125000000219 ethylidene group Chemical group [H]C(=[*])C([H])([H])[H] 0.000 abstract 1
- 229960001340 histamine Drugs 0.000 abstract 1
- 239000003453 histamine agonist Substances 0.000 abstract 1
- 125000000654 isopropylidene group Chemical group C(C)(C)=* 0.000 abstract 1
- OSFBJERFMQCEQY-UHFFFAOYSA-N propylidene Chemical compound [CH]CC OSFBJERFMQCEQY-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 239000002466 tachykinin receptor agonist Substances 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
A találmány tárgya az új, (I) általánős képletű vegyületek, ahől aképletben R' jelentése egymástól függetlenül 1-3 szűbsztitűens a hidrőgénatőm,halőgénatőm, -OCF3 csőpőrt, 1-6 szénatőmős alkilcsőpőrt és 1-6szénatőmős alkőxicsőpőrt; R'' jelentése hidrőgénatőm vagy valamely (a) és (b) képletű csőpőrt,ahől R20 jelentése hidrőgénatőm, 1-4 szénatőmős alkilcsőpőrt és -CF3csőpőrt; R3 jelentése egymástól függetlenül 1-3 szűbsztitűens a hidrőgénatőm,halőgénatőm, 1-6 szénatőmős alkilcsőpőrt és 1-6 szénatőmősalkőxicsőpőrt; Ar1 jelentése valamely (c), (d), (e) vagy (f) képletű csőpőrt R4 jelentése hidrőgénatőm, 1-6 szénatőmős alkilcsőpőrt, -(CH2)w-O-(CH2)tCO2R8 csőpőrt, -(CH2)jCN csőpőrt, -(CH2)űCO2R6 csőpőrt, -(CH2)űC(O)NR16R17 csőpőrt, -(CH2)pAr2 csőpőrt, -(CH2)w-O-R7 csőpőrt, -CH2CF3 csőpőrt, -CH2CH2CH2CF3 csőpőrt, -(CH2)2CH=CH2 csőpőrt, -CH2CH=CH2 csőpőrt, -CH2CH=CHCH3 csőpőrt, -CH2CH=CHCH2CH3 csőpőrt, -CH2CH=C(CH3)2 csőpőrt és -(CH2)gS(O)kR19 csőpőrt, ahől W jelentése 2-5; t jelentése 1-3; j jelentése 1-5; ű jelentése 1-5; p jelentése 1 vagy 2; g jelentése 2 vagy 3; k jelentése 0, 1 vagy 2;és annak sztereőizőmerjei és gyógyászatilag elfőgadható sói. Atalálmány szerinti vegyületek hisztamin és tachykinin receptőrantagőnisták. ŕ
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60459096A | 1996-02-21 | 1996-02-21 | |
| US78199797A | 1997-01-06 | 1997-01-06 | |
| PCT/US1997/001601 WO1997030991A1 (en) | 1996-02-21 | 1997-01-29 | Novel substituted n-methyl-n-(4-(4-(1h-benzimidazol-2-yl)[1,4]diazepan-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9900401A2 true HUP9900401A2 (hu) | 2000-03-28 |
| HUP9900401A3 HUP9900401A3 (en) | 2002-10-28 |
Family
ID=27084698
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9900401A HUP9900401A3 (en) | 1996-02-21 | 1997-01-29 | Novel substituted n-methyl-n-(4-(4-(1h-benzimidazol-2-yl)[1,4]diazepan-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases, pharmaceutical compositions containing them and their use |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0888338B1 (hu) |
| JP (1) | JP2000505083A (hu) |
| KR (1) | KR19990087130A (hu) |
| CN (1) | CN1143856C (hu) |
| AR (1) | AR005897A1 (hu) |
| AT (1) | ATE282609T1 (hu) |
| AU (1) | AU708738B2 (hu) |
| BR (1) | BR9710712A (hu) |
| CA (1) | CA2246994C (hu) |
| DE (1) | DE69731620D1 (hu) |
| HU (1) | HUP9900401A3 (hu) |
| IL (1) | IL125605A0 (hu) |
| NO (1) | NO983829L (hu) |
| NZ (1) | NZ330909A (hu) |
| TW (1) | TW440565B (hu) |
| WO (1) | WO1997030991A1 (hu) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6194406B1 (en) | 1995-12-20 | 2001-02-27 | Aventis Pharmaceuticals Inc. | Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease |
| US6423704B2 (en) | 1995-12-20 | 2002-07-23 | Aventis Pharmaceuticals Inc. | Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases |
| US7030150B2 (en) * | 2001-05-11 | 2006-04-18 | Trimeris, Inc. | Benzimidazole compounds and antiviral uses thereof |
| US8093268B2 (en) | 2007-01-24 | 2012-01-10 | Glaxo Group Limited | Pharmaceutical compositions comprising 2-methoxy-5-(5-trifluoromethyl-tetrazol-1-yl-benzyl)-(2S-phenylpiperidin-3S-yl-) |
| CN112778279B (zh) * | 2021-01-25 | 2021-09-28 | 苏州正永生物医药有限公司 | 一种依美斯汀化合物的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5879983A (ja) * | 1981-11-06 | 1983-05-13 | Kanebo Ltd | 新規なベンズイミダゾ−ル誘導体、その製造法およびその医薬組成物 |
| IL99320A (en) * | 1990-09-05 | 1995-07-31 | Sanofi Sa | Arylalkylamines, their preparation and pharmaceutical preparations containing them |
| GB9310713D0 (en) * | 1993-05-24 | 1993-07-07 | Zeneca Ltd | Aryl substituted heterocycles |
| ATE177095T1 (de) * | 1994-08-25 | 1999-03-15 | Merrell Pharma Inc | Substituierte piperidine für die behandlung von allergischen krankheiten |
| US5607936A (en) * | 1994-09-30 | 1997-03-04 | Merck & Co., Inc. | Substituted aryl piperazines as neurokinin antagonists |
-
1997
- 1997-01-29 IL IL12560597A patent/IL125605A0/xx unknown
- 1997-01-29 CN CNB971923833A patent/CN1143856C/zh not_active Expired - Fee Related
- 1997-01-29 HU HU9900401A patent/HUP9900401A3/hu unknown
- 1997-01-29 EP EP97905700A patent/EP0888338B1/en not_active Expired - Lifetime
- 1997-01-29 NZ NZ330909A patent/NZ330909A/en unknown
- 1997-01-29 JP JP9530170A patent/JP2000505083A/ja not_active Abandoned
- 1997-01-29 WO PCT/US1997/001601 patent/WO1997030991A1/en active IP Right Grant
- 1997-01-29 AT AT97905700T patent/ATE282609T1/de not_active IP Right Cessation
- 1997-01-29 KR KR1019980706521A patent/KR19990087130A/ko not_active Application Discontinuation
- 1997-01-29 AU AU22531/97A patent/AU708738B2/en not_active Ceased
- 1997-01-29 BR BR9710712A patent/BR9710712A/pt not_active IP Right Cessation
- 1997-01-29 DE DE69731620T patent/DE69731620D1/de not_active Expired - Lifetime
- 1997-01-29 CA CA002246994A patent/CA2246994C/en not_active Expired - Fee Related
- 1997-02-18 TW TW086101884A patent/TW440565B/zh not_active IP Right Cessation
- 1997-02-19 AR ARP970100646A patent/AR005897A1/es not_active Application Discontinuation
-
1998
- 1998-08-20 NO NO983829A patent/NO983829L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2253197A (en) | 1997-09-10 |
| NO983829L (no) | 1998-10-20 |
| CA2246994A1 (en) | 1997-08-28 |
| ATE282609T1 (de) | 2004-12-15 |
| CN1211248A (zh) | 1999-03-17 |
| DE69731620D1 (de) | 2004-12-23 |
| CA2246994C (en) | 2002-04-30 |
| EP0888338B1 (en) | 2004-11-17 |
| JP2000505083A (ja) | 2000-04-25 |
| KR19990087130A (ko) | 1999-12-15 |
| TW440565B (en) | 2001-06-16 |
| WO1997030991A1 (en) | 1997-08-28 |
| EP0888338A1 (en) | 1999-01-07 |
| HUP9900401A3 (en) | 2002-10-28 |
| NO983829D0 (no) | 1998-08-20 |
| BR9710712A (pt) | 1999-08-17 |
| IL125605A0 (en) | 1999-03-12 |
| NZ330909A (en) | 2001-04-27 |
| AR005897A1 (es) | 1999-07-21 |
| AU708738B2 (en) | 1999-08-12 |
| CN1143856C (zh) | 2004-03-31 |
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