HUP9800882A2 - Enterális fluoxetin pelletek és eljárás előállításukra - Google Patents
Enterális fluoxetin pelletek és eljárás előállításukraInfo
- Publication number
- HUP9800882A2 HUP9800882A2 HU9800882A HUP9800882A HUP9800882A2 HU P9800882 A2 HUP9800882 A2 HU P9800882A2 HU 9800882 A HU9800882 A HU 9800882A HU P9800882 A HUP9800882 A HU P9800882A HU P9800882 A2 HUP9800882 A2 HU P9800882A2
- Authority
- HU
- Hungary
- Prior art keywords
- fluoxetine
- enteral
- subject
- preparation
- active ingredient
- Prior art date
Links
- RTHCYVBBDHJXIQ-MRXNPFEDSA-N (R)-fluoxetine Chemical compound O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-MRXNPFEDSA-N 0.000 title abstract 5
- 229960002464 fluoxetine Drugs 0.000 title abstract 5
- 239000008188 pellet Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 2
- 239000011230 binding agent Substances 0.000 abstract 2
- 229920000639 hydroxypropylmethylcellulose acetate succinate Polymers 0.000 abstract 2
- 239000010410 layer Substances 0.000 abstract 2
- ZUAAPNNKRHMPKG-UHFFFAOYSA-N acetic acid;butanedioic acid;methanol;propane-1,2-diol Chemical compound OC.CC(O)=O.CC(O)CO.OC(=O)CCC(O)=O ZUAAPNNKRHMPKG-UHFFFAOYSA-N 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 239000012055 enteric layer Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
A találmány a hatóanyagként az ismert antidepresszáns gyógyszerhatóanyagőt, a flűőxetint tartalmazó enterális készítményrevőnatkőzik. A jelen találmány tárgyát képező enterális flűőxetinpellet a) flűőxetinből és egy vagy több, gyógyszerészetilegelfőgadható kötőanyagból álló magőt; b) adőtt esetben elválasztóréteget; c) hidrőxiprőpil-metilcellűlóz-acetát-szűkcinátból (HPMCAS)és gyógyszerészetileg elfőgadható kötőanyagból álló enterális réteget;d) adőtt esetben végső főrmát adó réteget tartalmaz. A találmánytárgyát képezi tővábbá az enterális flűőxetin pellet előállításáraszőlgáló eljárás is. ŕ
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/867,196 US5910319A (en) | 1997-05-29 | 1997-05-29 | Fluoxetine enteric pellets and methods for their preparation and use |
Publications (3)
Publication Number | Publication Date |
---|---|
HU9800882D0 HU9800882D0 (en) | 1998-05-28 |
HUP9800882A2 true HUP9800882A2 (hu) | 2000-03-28 |
HUP9800882A3 HUP9800882A3 (en) | 2000-07-28 |
Family
ID=25349313
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9800882A HUP9800882A3 (en) | 1997-05-29 | 1998-04-15 | Fluoxetine enteric pellets and process for their preparation |
Country Status (45)
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2752732B1 (fr) * | 1996-08-28 | 1998-11-20 | Pf Medicament | Forme galenique a liberation prolongee de milnacipran |
CA2374039C (en) * | 1999-05-20 | 2011-01-11 | Elan Corporation Plc | Multiparticulate controlled release selective serotonin reuptake inhibitor formulations |
IE990406A1 (en) | 1999-05-20 | 2000-12-27 | Elan Corp Plc | Multiparticulate controlled release selective serotonin reuptake inhibitor formulations. |
ES2162560B1 (es) * | 1999-06-25 | 2002-07-16 | Rodriguez Concepcion Pena | Uso de fluoxetina, paroxetina y otros isrs para la fabricacion de medicamentos con el fin de aumentar la capacidad de abstenerse de substancias o actividades que crean dependencia. |
UA75580C2 (uk) | 1999-09-03 | 2006-05-15 | Апбі Холдінгс, Ллк | Застосування дапоксетину або його фармацевтично прийнятної солі в лікарському засобі для лікування розладу статевої функції та промисловий виріб для його застосування |
CN1094347C (zh) * | 1999-11-15 | 2002-11-20 | 广东药学院药物研究所 | 一种治疗前列腺良性增生症的控释微丸及其制备方法 |
US6273260B1 (en) | 2000-03-08 | 2001-08-14 | Eli Lilly And Company | Pharmaceutical packaging system |
ES2185452B2 (es) * | 2000-08-01 | 2004-03-16 | Cinfa S A Lab | Composicion farmaceutica de fluoxetina en comprimido dispersable recubierto y su proceso de fabricacion. |
JP4181738B2 (ja) * | 2000-08-25 | 2008-11-19 | 信越化学工業株式会社 | 腸溶性コーティング製剤の製造方法 |
US6482440B2 (en) * | 2000-09-21 | 2002-11-19 | Phase 2 Discovery, Inc. | Long acting antidepressant microparticles |
WO2002038126A2 (en) * | 2000-11-08 | 2002-05-16 | Aeromatic-Fielder Ag | A process for production of particles for pharmaceutical compositions having increased bioavailability |
US20040170688A1 (en) * | 2001-08-06 | 2004-09-02 | Deshmukh Abhijit Mukund | Enteric formulation of fluoxetin |
CA2457385A1 (en) | 2001-08-06 | 2003-02-20 | Dr. Reddy's Laboratories Ltd. | Improved enteric formulation of fluoxetin |
US20040220153A1 (en) * | 2002-09-24 | 2004-11-04 | Jost-Price Edward Roydon | Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines |
AU2002361495A1 (en) * | 2002-12-24 | 2004-07-22 | Lupin Limited | Enteric coated fluoxetine composition |
US8614247B2 (en) * | 2003-04-10 | 2013-12-24 | Institut National De La Sante Et De La Recherche Medicale | Methods for preventing, attenuating or treating pulmonary hypertension using a serotonin transporter inhibitor, and pharmaceutical compositions for the treatment thereof |
MXPA05012900A (es) | 2003-05-30 | 2006-02-22 | Ranbaxy Lab Ltd | Derivados de pirrol sustituidos. |
US20050176693A1 (en) * | 2003-08-12 | 2005-08-11 | Boissonneault Roger M. | Method of intermittent administration of a pharmaceutical for the treatment of conditions associated with a female's menstrual cycle |
EP1699458A4 (en) * | 2003-12-30 | 2012-04-25 | Reddys Lab Ltd Dr | PHARMACEUTICAL COMPOSITION |
JP4277904B2 (ja) * | 2004-04-30 | 2009-06-10 | アステラス製薬株式会社 | 経口投与用時限放出型粒子状医薬組成物及び該組成物を含有する口腔内速崩壊錠 |
KR100920856B1 (ko) * | 2004-11-30 | 2009-10-09 | (주)아모레퍼시픽 | 선택적 세로토닌 재흡수 억제제의 연장방출 제제 및 그제조방법 |
TWI306858B (en) * | 2004-12-23 | 2009-03-01 | Teva Pharma | Process for preparing pharmaceutically acceptable salts of duloxetine and intermediates thereof |
JP5153629B2 (ja) * | 2005-08-02 | 2013-02-27 | ルピン・リミテッド | 選択的セロトニン再取り込み阻害剤の新規の制御放出組成物 |
CA2627599A1 (en) | 2005-11-08 | 2007-05-18 | Ranbaxy Laboratories Limited | Process for (3r,5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-[(4-hydroxy methyl phenyl amino)carbonyl]-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid hemi calcium salt |
WO2007062119A1 (en) * | 2005-11-23 | 2007-05-31 | Auspex Pharmaceuticals, Inc. | Substituted aryloxypropylamines with serotoninergic and/or norepinephrinergic activity |
US7759500B2 (en) * | 2005-12-05 | 2010-07-20 | Teva Pharmaceutical Industries Ltd. | 2-(N-methyl-propanamine)-3-(2-naphthol)thiophene, an impurity of duloxetine hydrochloride |
BRPI0708191A2 (pt) * | 2006-02-24 | 2012-05-29 | Teva Pharma | " composições farmacêuticas de fluvastatina sódica " |
CN101057837B (zh) * | 2006-04-20 | 2010-12-22 | 湖南九典制药有限公司 | 一种右旋酮洛芬肠溶微丸及制备方法 |
EP2016066A4 (en) * | 2006-05-10 | 2010-11-24 | Reddys Lab Ltd Dr | PROCESS FOR PREPARING DULOXETINE |
RU2008148547A (ru) * | 2006-05-22 | 2010-06-27 | Тева Фармасьютикл Индастриес Лтд. (Il) | Фармацевтические композиции, включающие дулоксетина гидрохлорид с замедленным высвобождением |
WO2007138606A2 (en) * | 2006-06-01 | 2007-12-06 | Dexcel Pharma Technologies Ltd. | Multiple unit pharmaceutical formulation |
JP5052051B2 (ja) * | 2006-06-16 | 2012-10-17 | トーアエイヨー株式会社 | 腸溶性顆粒剤及びその製造方法 |
BRPI0714915A2 (pt) * | 2006-07-28 | 2013-05-28 | Reddys Lab Ltd Dr | composiÇço farmacÊuticas; formas de dosagem farmacÊutica; e processo para o preparo de uma composiÇço farmacÊutica |
US20080033050A1 (en) | 2006-08-04 | 2008-02-07 | Richards Patricia Allison Tewe | Method of treating thermoregulatory disfunction with paroxetine |
WO2008020286A2 (en) * | 2006-08-14 | 2008-02-21 | Torrent Pharmaceuticals Limited | Pharmaceutical compositions of duloxetine |
US20080103105A1 (en) * | 2006-09-22 | 2008-05-01 | Braincells, Inc. | HMG CoA REDUCTASE MEDIATED MODULATION OF NEUROGENESIS |
US20080226711A1 (en) * | 2007-03-12 | 2008-09-18 | Torrent Pharmaceuticals Ltd. | Pharmaceutical compositions of duloxetine |
US20090226517A1 (en) * | 2008-02-06 | 2009-09-10 | Vinita Umashankar Vyas | Pharmaceutical formulations comprising duloxetine |
NZ590852A (en) | 2008-07-16 | 2013-03-28 | Richter Gedeon Nyrt | Pharmaceutical formulations containing dopamine receptor ligands trans-1{ 4-[2-[4-(2,3-dichlorophenyl)-piperizin-1-yl]-ethyl]-cyclohexyl} -3,3-dimethyl-urea also known as cariprazine |
US20110172249A1 (en) * | 2008-09-03 | 2011-07-14 | Takeda Pharmaceutical Company Limted | Method for improving absorbability of preparation, and preparation having improved absorbability |
CN101804145B (zh) * | 2009-02-12 | 2012-11-14 | 杭州赛利药物研究所有限公司 | 一种大蒜油肠溶微丸胶囊及其制备方法 |
EP2477614A2 (en) * | 2009-09-17 | 2012-07-25 | Cadila Healthcare Limited | Pharmaceutical compositions for reducing alcohol-induced dose dumping |
EP2540318B1 (en) * | 2010-02-22 | 2018-10-24 | Daiichi Sankyo Company, Limited | Sustained-release solid preparation for oral use |
RU2442572C1 (ru) * | 2010-12-23 | 2012-02-20 | Ольга Львовна Титова | Энтеросолюбильная оболочка и композиция для ее получения |
EP2844297B1 (en) | 2012-05-02 | 2018-08-15 | Capsugel Belgium NV | Aqueous dispersions of controlled release polymers and shells and capsules thereof |
CN102716084B (zh) * | 2012-06-29 | 2013-09-25 | 海南美大制药有限公司 | 盐酸氟西汀脂质体固体制剂 |
CA2883077C (en) | 2012-09-03 | 2017-03-07 | Daiichi Sankyo Company, Limited | Hydromorphone hydrochloride-containing oral sustained-release pharmaceutical composition |
JP6440625B2 (ja) | 2012-11-14 | 2018-12-19 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 精神分裂病を処置するための方法および組成物 |
CN106456555B (zh) * | 2014-05-20 | 2019-05-07 | 陶氏环球技术有限责任公司 | 包含酯化纤维素醚的胶囊壳 |
US10179110B2 (en) | 2014-05-20 | 2019-01-15 | Dow Global Technologies Llc | Dispersion comprising a partially neutralized esterified cellulose ether |
WO2015187874A1 (en) * | 2014-06-07 | 2015-12-10 | Structure-Ase, Inc. | A method for the detection and/or diagnosis of eating disorders and malnutrition using x-ray diffraction |
US10471152B2 (en) | 2014-08-29 | 2019-11-12 | Capsugel Belgium Nv | Colloidal dispersion comprising HPMCAS |
US20170042806A1 (en) | 2015-04-29 | 2017-02-16 | Dexcel Pharma Technologies Ltd. | Orally disintegrating compositions |
US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
US11274087B2 (en) | 2016-07-08 | 2022-03-15 | Richter Gedeon Nyrt. | Industrial process for the preparation of cariprazine |
AU2018250628A1 (en) * | 2017-04-13 | 2019-12-05 | Chase Therapeutics Corporation | Pharmaceutical combination and its use for treating synucleinopathies |
HUP1700253A1 (hu) | 2017-06-13 | 2019-01-28 | Richter Gedeon Nyrt | Szilárd orális gyógyszerkészítmények |
CN107898942B (zh) * | 2017-11-24 | 2021-01-26 | 一力制药(罗定)有限公司 | 一种感冒清热胶囊及其制备方法 |
US11547707B2 (en) | 2019-04-10 | 2023-01-10 | Richter Gedeon Nyrt. | Carbamoyl cyclohexane derivatives for treating autism spectrum disorder |
WO2022115054A1 (en) * | 2020-11-27 | 2022-06-02 | Santa Farma Ilac Sanayii A.S. | Enteric coated duloxetine compositions |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4194009A (en) | 1974-01-10 | 1980-03-18 | Eli Lilly And Company | Aryloxyphenylpropylamines for obtaining a psychotropic effect |
US4314081A (en) * | 1974-01-10 | 1982-02-02 | Eli Lilly And Company | Arloxyphenylpropylamines |
US4626549A (en) * | 1974-01-10 | 1986-12-02 | Eli Lilly And Company | Treatment of obesity with aryloxyphenylpropylamines |
US4018895A (en) | 1974-01-10 | 1977-04-19 | Eli Lilly And Company | Aryloxyphenylpropylamines in treating depression |
JPS517116A (en) | 1974-06-11 | 1976-01-21 | Shinetsu Chemical Co | Choyoseihifukuyakuzaino seizohoho |
CH649216A5 (de) | 1979-08-16 | 1985-05-15 | Sandoz Ag | Verfahren zur auftragung eines magensaftresistenten filmes auf einen heilmittelkern und feste einheitsdosierungsform mit magensaftresistentem film. |
JPS5855125B2 (ja) * | 1980-03-10 | 1983-12-08 | 信越化学工業株式会社 | 固形薬剤用腸溶性コ−テイング剤組成物 |
US4444778A (en) * | 1981-08-27 | 1984-04-24 | Coughlin Shaun R | Method and composition for treating atherosclerosis |
US4797286A (en) | 1985-11-12 | 1989-01-10 | Eli Lilly And Company | Orally administerable sustained release pharmaceutical formulations |
US4847092A (en) * | 1985-11-12 | 1989-07-11 | Eli Lilly And Company | Orally administerable sustained release pharmaceutical formulations |
GB2189699A (en) | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated acid-labile medicaments |
US4918242A (en) | 1988-03-30 | 1990-04-17 | Aldrich Chemical Company, Inc. | Novel optically 1,3-phenoxypropylhalides |
CA1337955C (en) * | 1988-09-26 | 1996-01-23 | Thomas A. Almquist | Recoating of stereolithographic layers |
US4999382A (en) * | 1988-10-26 | 1991-03-12 | Massachusetts Institute Of Technology | Compositions for treating tobacco withdrawal symptoms and methods for their use |
US5356934A (en) * | 1990-03-29 | 1994-10-18 | Eli Lilly And Company | Selected serotonin subtype receptor agonist to treat sleep apnea |
US5589511A (en) * | 1990-08-13 | 1996-12-31 | Sepracor Inc. | Method for treating migraine headaches using optically pure S(+) fluoxetine |
US5104899A (en) * | 1990-08-13 | 1992-04-14 | Sepracor, Inc. | Methods and compositions for treating depression using optically pure fluoxetine |
JPH04202124A (ja) * | 1990-11-29 | 1992-07-22 | Fuji Kagaku Kogyo Kk | 噴霧乾燥造粒法による薬物放出の制御された製剤の製造法 |
AU1429092A (en) * | 1991-02-04 | 1992-09-07 | Timothy J Barberich | Methods of use and compositions of r(-) fluoxetine |
WO1992019241A1 (en) * | 1991-05-07 | 1992-11-12 | Dynagen, Inc. | A controlled, sustained release delivery system for smoking cessation |
AU668386B2 (en) * | 1992-03-25 | 1996-05-02 | Depomed Systems, Incorporated | Alkyl-substituted cellulose-based sustained-release oral drug dosage forms |
US5518730A (en) * | 1992-06-03 | 1996-05-21 | Fuisz Technologies Ltd. | Biodegradable controlled release flash flow melt-spun delivery system |
JPH06293633A (ja) * | 1993-04-05 | 1994-10-21 | Shin Etsu Chem Co Ltd | 水性腸溶性エマルジョンの製造方法 |
US5362886A (en) | 1993-10-12 | 1994-11-08 | Eli Lilly And Company | Asymmetric synthesis |
ATE198547T1 (de) * | 1993-11-03 | 2001-01-15 | Isomed Inc | Mizelleförmige feinteilige pharmazeutische zusammensetzungen |
CA2134038C (en) * | 1994-06-16 | 1997-06-03 | David Taiwai Wong | Potentiation of drug response |
US5508276A (en) * | 1994-07-18 | 1996-04-16 | Eli Lilly And Company | Duloxetine enteric pellets |
ES2082723B1 (es) * | 1994-07-20 | 1996-10-01 | Lilly Sa | Formulacion farmaceutica de fluoxetina en forma dispersable. |
JPH08109126A (ja) * | 1994-10-07 | 1996-04-30 | Amano Pharmaceut Co Ltd | 耐衝撃性腸溶性顆粒剤およびこれを含有する錠剤 |
JPH08245423A (ja) * | 1995-03-06 | 1996-09-24 | Shionogi & Co Ltd | 水系腸溶性コーティング液 |
GB9514842D0 (en) * | 1995-07-20 | 1995-09-20 | Smithkline Beecham Plc | Novel formulation |
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1997
- 1997-05-29 US US08/867,196 patent/US5910319A/en not_active Ceased
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1998
- 1998-04-13 IL IL12407398A patent/IL124073A/en not_active IP Right Cessation
- 1998-04-14 RO RO98-00869A patent/RO120043B1/ro unknown
- 1998-04-14 CA CA002234826A patent/CA2234826C/en not_active Expired - Lifetime
- 1998-04-14 RU RU98106998/14A patent/RU2164405C2/ru active
- 1998-04-15 RS YUP-165/98A patent/RS49827B/sr unknown
- 1998-04-15 UA UA98041929A patent/UA48193C2/uk unknown
- 1998-04-15 CZ CZ19981143A patent/CZ290582B6/cs not_active IP Right Cessation
- 1998-04-15 HU HU9800882A patent/HUP9800882A3/hu not_active Application Discontinuation
- 1998-04-15 ZA ZA9803173A patent/ZA983173B/xx unknown
- 1998-04-15 NZ NZ330192A patent/NZ330192A/xx not_active IP Right Cessation
- 1998-04-15 GB GB9807939A patent/GB2325623B/en not_active Expired - Lifetime
- 1998-04-16 MY MYPI98001702A patent/MY118139A/en unknown
- 1998-04-16 FI FI980846A patent/FI119971B/fi active IP Right Grant
- 1998-04-17 SE SE9801336A patent/SE522914C2/sv not_active IP Right Cessation
- 1998-04-17 SG SG1998000871A patent/SG72805A1/en unknown
- 1998-04-20 KR KR1019980014014A patent/KR100549473B1/ko not_active Expired - Lifetime
- 1998-04-22 LT LT98-058A patent/LT4477B/lt not_active IP Right Cessation
- 1998-04-24 CN CNB981087787A patent/CN1161109C/zh not_active Expired - Lifetime
- 1998-04-24 JP JP15350198A patent/JP3210288B2/ja not_active Expired - Lifetime
- 1998-04-28 SV SV1998000052A patent/SV1998000052A/es unknown
- 1998-04-28 IT IT98MI000908A patent/ITMI980908A1/it unknown
- 1998-04-28 ES ES009800899A patent/ES2161574B1/es not_active Expired - Fee Related
- 1998-04-29 SI SI9800128A patent/SI9800128B/sl unknown
- 1998-05-01 PL PL326134A patent/PL192293B1/pl unknown
- 1998-05-07 AR ARP980102130A patent/AR011728A1/es not_active Application Discontinuation
- 1998-05-08 PT PT102152A patent/PT102152B/pt active IP Right Grant
- 1998-05-11 TW TW087107241A patent/TWI239838B/zh not_active IP Right Cessation
- 1998-05-12 CO CO98026349A patent/CO4940407A1/es unknown
- 1998-05-13 FR FR9806040A patent/FR2763846B1/fr not_active Expired - Lifetime
- 1998-05-14 NO NO19982197A patent/NO317743B1/no not_active IP Right Cessation
- 1998-05-19 BR BR9801989-9A patent/BR9801989A/pt not_active Application Discontinuation
- 1998-05-20 LU LU90245A patent/LU90245B1/fr active
- 1998-05-20 BE BE9800383A patent/BE1011925A3/fr not_active IP Right Cessation
- 1998-05-25 LV LVP-98-121A patent/LV12176B/xx unknown
- 1998-05-26 NL NL1009259A patent/NL1009259C2/nl not_active IP Right Cessation
- 1998-05-26 CH CH01157/98A patent/CH693018A5/de not_active IP Right Cessation
- 1998-05-27 TR TR1998/00937A patent/TR199800937A3/tr unknown
- 1998-05-28 GR GR980100188A patent/GR980100188A/el unknown
- 1998-05-28 DK DK199800728A patent/DK176776B1/da not_active IP Right Cessation
- 1998-05-28 PE PE1998000430A patent/PE75399A1/es not_active Application Discontinuation
- 1998-05-28 DE DE19823940A patent/DE19823940B4/de not_active Expired - Lifetime
- 1998-05-28 ID IDP980791A patent/ID20343A/id unknown
- 1998-05-28 AU AU69048/98A patent/AU726690B2/en not_active Expired
- 1998-05-29 AT AT0093198A patent/AT408068B/de not_active IP Right Cessation
-
1999
- 1999-03-10 US US09/265,610 patent/US5985322A/en not_active Expired - Lifetime
-
2000
- 2000-07-25 CN CNB001222090A patent/CN1212834C/zh not_active Expired - Lifetime
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2002
- 2002-01-28 US US10/058,891 patent/USRE39030E1/en not_active Expired - Lifetime
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