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HUP0500042A2 - HMG fragmensek alkalmazása gyulladásgátló szerként - Google Patents

HMG fragmensek alkalmazása gyulladásgátló szerként

Info

Publication number
HUP0500042A2
HUP0500042A2 HU0500042A HUP0500042A HUP0500042A2 HU P0500042 A2 HUP0500042 A2 HU P0500042A2 HU 0500042 A HU0500042 A HU 0500042A HU P0500042 A HUP0500042 A HU P0500042A HU P0500042 A2 HUP0500042 A2 HU P0500042A2
Authority
HU
Hungary
Prior art keywords
hmg
box
polypeptide
subject
vertebrate
Prior art date
Application number
HU0500042A
Other languages
English (en)
Inventor
Kevin J. Tracey
Huan Yang
Howland Shaw Warren
Mitchell P. Fink
Original Assignee
North Shore-Long Island Jewish Research Institute
The General Hospital Corporation
University of Pittsburgh-of The Comonwealth System of Higher Education
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by North Shore-Long Island Jewish Research Institute, The General Hospital Corporation, University of Pittsburgh-of The Comonwealth System of Higher Education filed Critical North Shore-Long Island Jewish Research Institute
Publication of HUP0500042A2 publication Critical patent/HUP0500042A2/hu
Publication of HUP0500042A3 publication Critical patent/HUP0500042A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
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    • A61P25/04—Centrally acting analgesics, e.g. opioids
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    • A—HUMAN NECESSITIES
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/12—Antivirals
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    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
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    • A—HUMAN NECESSITIES
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    • A61P31/12—Antivirals
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Abstract

A találmány tárgya polipeptid, amely gerinces, nagy mozgékonyságúcsoporthoz tartozó fehérje A-box, azaz HMG A-box peptidet vagytermészetben nem előforduló HMG A-box peptidet, vagy biológiailagaktív fragmenseiket tartalmazza, amely képes gátolni aproinflammatorikus citokin felszabadulását a HMG fehérjével kezeltgerinces sejtből. A találmány tárgya továbbá polipeptid, amelygerinces HMG B-box peptidet, vagy természetben nem előforduló HMG B-box peptidet, vagy biológiailag elfogadható fragmenseiket tartalmazza,ahol a polipeptid képes előidézni a proinflammatorikus citokinfelszabadulását a gerinces sejtből. A találmány tárgya továbbá apolipeptideket kódoló vektor, illetve eljárás a gyulladássalkapcsolatos citokin-kaszkád aktiválódásával kapcsolatos betegségekkezelésére. Ó
HU0500042A 2001-05-15 2002-05-15 Use of hmg fragments as anti-inflammatory agents HUP0500042A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29103401P 2001-05-15 2001-05-15
PCT/US2002/015329 WO2002092004A2 (en) 2001-05-15 2002-05-15 Use of hmg fragment as anti-inflammatory agents

Publications (2)

Publication Number Publication Date
HUP0500042A2 true HUP0500042A2 (hu) 2005-03-29
HUP0500042A3 HUP0500042A3 (en) 2010-01-28

Family

ID=23118552

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0500042A HUP0500042A3 (en) 2001-05-15 2002-05-15 Use of hmg fragments as anti-inflammatory agents

Country Status (18)

Country Link
US (2) US20030060410A1 (hu)
EP (1) EP1392844A4 (hu)
JP (1) JP2005512507A (hu)
KR (1) KR20040018370A (hu)
CN (1) CN100447154C (hu)
AU (1) AU2002309829B2 (hu)
BR (1) BR0209689A (hu)
CA (1) CA2447576C (hu)
CZ (1) CZ20033402A3 (hu)
HU (1) HUP0500042A3 (hu)
IL (3) IL158643A0 (hu)
IS (1) IS7037A (hu)
MX (1) MXPA03010449A (hu)
NO (1) NO20035087L (hu)
NZ (1) NZ529423A (hu)
PL (1) PL367132A1 (hu)
SK (1) SK15422003A3 (hu)
WO (1) WO2002092004A2 (hu)

Families Citing this family (58)

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US7754217B2 (en) * 2001-03-16 2010-07-13 Bio3 Research Srl HMGB1 protein inhibitors and/or antagonists for the treatment of vascular diseases
US7304034B2 (en) 2001-05-15 2007-12-04 The Feinstein Institute For Medical Research Use of HMGB fragments as anti-inflammatory agents
US7220723B2 (en) 2001-05-15 2007-05-22 The Feinstein Institute For Medical Research Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents
CA2491321A1 (en) * 2002-07-03 2004-01-15 Fondazione Centro San Raffaele Del Monte Tabor Use of hmgb1 in the treatment of tissue damage and/or to promote tissue repair
EP1567544A4 (en) * 2002-11-20 2009-07-22 Long Island Jewish Res Inst USE OF HMGB POLYPEPTIDES TO INCREASE IMMUNE RESPONSES
US20040156851A1 (en) * 2002-11-20 2004-08-12 Critical Therapeutics, Inc. HMGB1 combination therapies
US20040141948A1 (en) * 2002-11-20 2004-07-22 Critical Therapeutics, Inc. Use of HMGB fragments as anti-inflammatory agents
US7273872B2 (en) * 2002-12-06 2007-09-25 The Feinstein Institute For Medical Research Inhibition of inflammation using α 7 receptor-binding cholinergic agonists
US20090069227A9 (en) * 2003-04-29 2009-03-12 Capogrossi Maurizio C Use of HMGB1 to promote stem cell migration and/or proliferation
US7696169B2 (en) * 2003-06-06 2010-04-13 The Feinstein Institute For Medical Research Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents
WO2005025604A2 (en) * 2003-09-10 2005-03-24 The General Hospital Corporation Use of hmgb and hmgb fragments to decrease specific immune response
CA2882022A1 (en) * 2003-09-11 2005-03-24 Walter Newman Monoclonal antibodies against hmgb1
WO2006083301A2 (en) 2004-06-17 2006-08-10 Medimmune, Inc. Immunogenic compositions comprising hmgb1 polypeptides
EP1814576A2 (en) * 2004-07-20 2007-08-08 Critical Therapeutics, Inc. Combination therapies of hmgb and complement inhibitors against inflammation
WO2006012415A2 (en) 2004-07-20 2006-02-02 Critical Therapeutics, Inc. Rage protein derivatives
JP5622351B2 (ja) * 2004-09-03 2014-11-12 クレアビリス・セラピューティクス・エスピーエー プロテアーゼ抵抗性ヒトおよび非ヒトＨＭＧＢ１Ｂｏｘ−Ａ変異体、ならびにそれらの治療／診断への使用
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DK2068935T3 (da) * 2006-09-15 2011-08-01 Creabilis Therapeutics S R L Polymerkonjugater af box-A af HMBG1 og boks-A-varianter af HMBG1
JP5225109B2 (ja) * 2007-02-15 2013-07-03 国立大学法人 熊本大学 ヒトｈｍｇｂ−１に特異的に結合する抗体を有効成分として含有する治療剤
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JP5285437B2 (ja) * 2007-02-15 2013-09-11 学校法人福岡大学 抗ｈｍｇｂ−１抗体を含む臓器移植拒絶抑制剤
BRPI0911439A2 (pt) 2008-04-30 2016-07-12 Genomix Co Ltd agentes e métodos para recrutamento de célula-tronco pluripotente derivada da medula óssea para a circulação periférica
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