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HUP0303350A2 - Szubsztituált imidazo[1,2-a]piridin-, imidazo[1,2-a]pirimidin- és imidazo[1,2-a] pirazin-3-il-amin származékok alkalmazása NOS-inhibitor gyógyszerkészítmények előállítására - Google Patents

Szubsztituált imidazo[1,2-a]piridin-, imidazo[1,2-a]pirimidin- és imidazo[1,2-a] pirazin-3-il-amin származékok alkalmazása NOS-inhibitor gyógyszerkészítmények előállítására

Info

Publication number
HUP0303350A2
HUP0303350A2 HU0303350A HUP0303350A HUP0303350A2 HU P0303350 A2 HUP0303350 A2 HU P0303350A2 HU 0303350 A HU0303350 A HU 0303350A HU P0303350 A HUP0303350 A HU P0303350A HU P0303350 A2 HUP0303350 A2 HU P0303350A2
Authority
HU
Hungary
Prior art keywords
imidazo
pyrazine
pyrimidine
pyridine
nos
Prior art date
Application number
HU0303350A
Other languages
English (en)
Inventor
Hagen-Heinrich Hennies
Corinna Maul
Johannes Schneider
Bernd Sundermann
Original Assignee
Grünenthal GmbH.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7659598&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0303350(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Grünenthal GmbH. filed Critical Grünenthal GmbH.
Publication of HUP0303350A2 publication Critical patent/HUP0303350A2/hu
Publication of HUP0303350A3 publication Critical patent/HUP0303350A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

A találmány tárgya az (I) általános képletű vegyületek vagygyógyszerészetileg alkalmazható sóinak alkalmazása NO-szintetázinhibitor hatású gyógyszerek közelebbről migrén, sklerosis multiplex,Parkinson-kór, Alzheimer-kór, Huntington-kór, cerebralis ischémia,diabétes, meningitis, arteriosklerosis kezelésére és/vagy sebgyógyuláselősegítésére használható gyógyszerek előállítására, ahol az (I)általános képletben X jelentése CR4 vagy N, Y jelentése CR5 vagy N, ésX és Y egyszerre nem lehet N, továbbá W jelentése NR8 vagy N. Ó
HU0303350A 2000-10-13 2001-10-10 Use of substituted imidazo[1,2-a]pyridine-, imidazo[1,2-a]pyrimidine and imidazo[1,2-a]pyrazine-3-yl-amine derivatives for producing nos-inhibiting pharmaceutical compositions HUP0303350A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10050663A DE10050663A1 (de) 2000-10-13 2000-10-13 Verwendung von substituierten Imidazo[1,2-a]pyridin-, -pyrimidin- und pyrazin-3-yl-amin-Derivaten zur Herstellung von Medikamenten zur NOS-Inhibierung
PCT/EP2001/011701 WO2002030428A1 (de) 2000-10-13 2001-10-10 Verwendung von substituierten imidazo[1,2-a]pyridin-, -pyrimidin- und -pyrazin-3-yl-amin-derivaten zur herstellung von medikamenten zur nos-inhibierung

Publications (2)

Publication Number Publication Date
HUP0303350A2 true HUP0303350A2 (hu) 2004-01-28
HUP0303350A3 HUP0303350A3 (en) 2006-02-28

Family

ID=7659598

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0303350A HUP0303350A3 (en) 2000-10-13 2001-10-10 Use of substituted imidazo[1,2-a]pyridine-, imidazo[1,2-a]pyrimidine and imidazo[1,2-a]pyrazine-3-yl-amine derivatives for producing nos-inhibiting pharmaceutical compositions

Country Status (17)

Country Link
US (1) US20040023972A1 (hu)
EP (1) EP1326613B2 (hu)
JP (1) JP2004510820A (hu)
AT (1) ATE268179T1 (hu)
AU (2) AU9189301A (hu)
CA (1) CA2425672A1 (hu)
DE (2) DE10050663A1 (hu)
DK (1) DK1326613T4 (hu)
ES (1) ES2220810T5 (hu)
HU (1) HUP0303350A3 (hu)
MX (1) MXPA03003200A (hu)
NZ (1) NZ525779A (hu)
PL (1) PL361807A1 (hu)
PT (1) PT1326613E (hu)
SI (1) SI1326613T2 (hu)
TR (1) TR200401545T4 (hu)
WO (1) WO2002030428A1 (hu)

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PT1326613E (pt) 2004-10-29
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ES2220810T3 (es) 2004-12-16
SI1326613T2 (sl) 2007-08-31
DK1326613T3 (da) 2004-10-11
AU2001291893B2 (en) 2006-05-18
CA2425672A1 (en) 2003-04-11
DE50102490D1 (de) 2004-07-08
AU9189301A (en) 2002-04-22
WO2002030428A1 (de) 2002-04-18
ATE268179T1 (de) 2004-06-15
EP1326613B1 (de) 2004-06-02
JP2004510820A (ja) 2004-04-08
EP1326613B2 (de) 2007-04-18
AU2001291893B8 (en) 2006-06-15
DE10050663A1 (de) 2002-04-18
NZ525779A (en) 2005-01-28
EP1326613A1 (de) 2003-07-16
HUP0303350A3 (en) 2006-02-28
ES2220810T5 (es) 2007-12-01
PL361807A1 (en) 2004-10-04
SI1326613T1 (en) 2004-10-31
AU2001291893B9 (en) 2006-11-09
DK1326613T4 (da) 2007-09-03
MXPA03003200A (es) 2003-07-14

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