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HUP0203649A2 - Az 1-deoxi-D-xilulóz bioszintézis-útvonal génjei - Google Patents

Az 1-deoxi-D-xilulóz bioszintézis-útvonal génjei

Info

Publication number
HUP0203649A2
HUP0203649A2 HU0203649A HUP0203649A HUP0203649A2 HU P0203649 A2 HUP0203649 A2 HU P0203649A2 HU 0203649 A HU0203649 A HU 0203649A HU P0203649 A HUP0203649 A HU P0203649A HU P0203649 A2 HUP0203649 A2 HU P0203649A2
Authority
HU
Hungary
Prior art keywords
xylulose
deoxy
desoxy
genes
biosynthetic pathway
Prior art date
Application number
HU0203649A
Other languages
English (en)
Inventor
Hassan Jomaa
Original Assignee
Jomaa Pharmaka Gmbh.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19923567A external-priority patent/DE19923567A1/de
Application filed by Jomaa Pharmaka Gmbh. filed Critical Jomaa Pharmaka Gmbh.
Publication of HUP0203649A2 publication Critical patent/HUP0203649A2/hu

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0093—Oxidoreductases (1.) acting on CH or CH2 groups (1.17)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1022—Transferases (2.) transferring aldehyde or ketonic groups (2.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01267—1-Deoxy-D-xylulose-5-phosphate reductoisomerase (1.1.1.267)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y117/00—Oxidoreductases acting on CH or CH2 groups (1.17)
    • C12Y117/07—Oxidoreductases acting on CH or CH2 groups (1.17) with an iron-sulfur protein as acceptor (1.17.7)
    • C12Y117/07001—(E)-4-Hydroxy-3-methylbut-2-enyl-diphosphate synthase (1.17.7.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y202/00—Transferases transferring aldehyde or ketonic groups (2.2)
    • C12Y202/01—Transketolases and transaldolases (2.2.1)
    • C12Y202/01007—1-Deoxy-D-xylulose-5-phosphate synthase (2.2.1.7)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

%-1> A találmány tárgya a 1-dezoxi-D-xilulóz-5-foszfátreduktoizo-meráz, valamint -szintáz génje és az 1-dezoxi-Dxylulóz-5-foszfátmetabolitikus útvonal gcpE-génje, alkalmazásuk vektorok,gazdaszervezetek és növények transzformálására, a bioszintetikusreakcióutat gátló anyagok és az eljárás a DOXP-szintetáz és a DOXP-reduktoizomeráz aktivitásának kombinált meghatározására, továbbá agének által kódolt, a 1-deoxi-D-xylulóz-5-foszfát metabolitikusútvonalban résztvevő fehérjék. A találmány szerinti megoldás azizoprenoid-bioszintézis befolyásolása területén alkalmazható. Ó
HU0203649A 1998-09-22 1999-09-22 Az 1-deoxi-D-xilulóz bioszintézis-útvonal génjei HUP0203649A2 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19843279 1998-09-22
DE19923567A DE19923567A1 (de) 1998-09-22 1999-05-21 Gene des 1-Desoxy-D-xylulose-Biosynthesewegs
PCT/EP1999/007055 WO2000017233A2 (de) 1998-09-22 1999-09-22 Gene des 1-desoxy-d-xylulose-biosynthesewegs

Publications (1)

Publication Number Publication Date
HUP0203649A2 true HUP0203649A2 (hu) 2003-02-28

Family

ID=26048996

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0203649A HUP0203649A2 (hu) 1998-09-22 1999-09-22 Az 1-deoxi-D-xilulóz bioszintézis-útvonal génjei

Country Status (23)

Country Link
EP (1) EP1115849B1 (hu)
JP (1) JP2002526061A (hu)
CN (1) CN1319134A (hu)
AP (1) AP2001002104A0 (hu)
AT (1) ATE317007T1 (hu)
AU (1) AU767213B2 (hu)
BG (1) BG105361A (hu)
BR (1) BR9914028A (hu)
CA (1) CA2343919A1 (hu)
CZ (1) CZ2001990A3 (hu)
DE (1) DE59913101D1 (hu)
EE (1) EE200100174A (hu)
HR (1) HRP20010215A2 (hu)
HU (1) HUP0203649A2 (hu)
ID (1) ID29772A (hu)
IL (1) IL141888A0 (hu)
IS (1) IS5872A (hu)
NO (1) NO20011459L (hu)
OA (1) OA11656A (hu)
PL (1) PL348428A1 (hu)
SK (1) SK3922001A3 (hu)
TR (1) TR200100836T2 (hu)
WO (1) WO2000017233A2 (hu)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100724004B1 (ko) 1998-04-14 2007-06-04 교와 학꼬 고교 가부시키가이샤 항균 또는 제초 활성을 갖는 물질의 탐색 방법
ATE316578T1 (de) 1999-04-15 2006-02-15 Calgene Llc Nukleinsäuresequenzen für proteine, die an der tocopherolbiosynthese beteiligt sind
DE19918949A1 (de) * 1999-04-27 2000-11-23 Basf Ag Überexpression einer DNA-Sequenz codierend für eine 1-Desoxy-D-Xylulose-5-Phosphat Reduktoisomerase in Pflanzen
BR0011289A (pt) * 1999-05-21 2002-02-26 Jomaa Pharmaka Gmbh Uso de genes das vias biossintéticas do desoxi-d-xilulose fosfato para a alteração da concentração de isoprenóide
AU6280300A (en) 1999-08-04 2001-03-05 Adelbert Bacher Isoprenoid biosynthesis
US6872815B1 (en) 2000-10-14 2005-03-29 Calgene Llc Nucleic acid sequences to proteins involved in tocopherol synthesis
DE10021688A1 (de) * 2000-05-05 2001-11-15 Hassan Jomaa Gene des 1-Desoxy-D-xylulose-Biosynthesewegs
DE10027821A1 (de) * 2000-06-05 2001-12-06 Adelbert Bacher Der Mevalonat-unabhängige Isoprenoidbiosyntheseweg
AU9052201A (en) * 2000-08-07 2002-02-18 Monsanto Technology Llc Methyl-d-erythritol phosphate pathway genes
DE10201458A1 (de) 2001-04-11 2002-10-17 Adelbert Bacher Intermediate und Enzyme des Mevalonat-unabhängigen Isoprenoidbiosyntheseweg
JP2004533244A (ja) 2001-05-09 2004-11-04 モンサント テクノロジー リミテッド ライアビリティー カンパニー ＴｙｒＡ遺伝子及びその使用法
US7161061B2 (en) 2001-05-09 2007-01-09 Monsanto Technology Llc Metabolite transporters
PT1408984E (pt) * 2001-07-20 2008-12-26 Bioagency Ag Compostos organofosforosos para activar células t gama/delta
AU2002329759A1 (en) 2001-08-17 2003-03-03 Monsanto Technology Llc Methyltransferase genes and uses thereof
AR036962A1 (es) 2001-10-25 2004-10-13 Monsanto Technology Llc Metiltransferasas aromaticas y usos de las mismas
BRPI0308740B1 (pt) 2002-03-19 2018-11-21 Monsanto Technology Llc molécula de ácido nucléico codificando uma homogentisato prenil transferase (“hpt”) e método de produzir planta tendo semente com nível de tocoferol aumentado
WO2004013312A2 (en) 2002-08-05 2004-02-12 Monsanto Technology, Llc Tocopherol biosynthesis related genes and uses thereof
CN106978425B (zh) * 2017-02-17 2019-10-18 华中农业大学 东方巴贝斯虫1-脱氧-d-木酮糖-5-磷酸还原异构酶基因及其编码的蛋白
CA3084263A1 (en) 2017-12-07 2019-06-13 Zymergen Inc. Engineered biosynthetic pathways for production of (6e)-8-hydroxygeraniol by fermentation
JP2021506316A (ja) 2017-12-21 2021-02-22 ザイマージェン インコーポレイテッド ネペタラクトールオキシドレダクターゼ、ネペタラクトールシンターゼ、及びネペタラクトンを産生する能力がある微生物
CN109342634A (zh) * 2018-12-07 2019-02-15 西北大学 一种柱前衍生-hplc测定dxs酶催化活性的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19752700A1 (de) * 1997-11-28 1999-06-02 Hoechst Schering Agrevo Gmbh 1-Desoxy-D-xylulose-5-phosphat Synthase, Verfahren zur Identifizierung von Effektoren der 1-Desoxy-D-xylulose-5-phosphat Synthase und Effektoren der 1-Desoxy-D-xylulose-5-phosphat Synthase
SK15232000A3 (sk) * 1998-04-14 2001-05-10 Hassan Jomaa Spôsob identifikácie chemických účinných látok a prostriedkov inhibície biosyntetickej cesty 1-deoxy-d-xylulóza-5-fosfátu

Also Published As

Publication number Publication date
WO2000017233A2 (de) 2000-03-30
AP2001002104A0 (en) 2001-03-31
DE59913101D1 (de) 2006-04-13
JP2002526061A (ja) 2002-08-20
NO20011459D0 (no) 2001-03-22
NO20011459L (no) 2001-05-22
EE200100174A (et) 2002-08-15
BG105361A (en) 2001-10-31
CN1319134A (zh) 2001-10-24
EP1115849B1 (de) 2006-02-01
AU6194799A (en) 2000-04-10
EP1115849A2 (de) 2001-07-18
TR200100836T2 (tr) 2001-10-22
IS5872A (is) 2001-02-28
ID29772A (id) 2001-10-11
PL348428A1 (en) 2002-05-20
BR9914028A (pt) 2001-07-03
ATE317007T1 (de) 2006-02-15
WO2000017233A3 (de) 2000-05-25
CA2343919A1 (en) 2000-03-30
OA11656A (en) 2004-12-08
SK3922001A3 (en) 2001-09-11
AU767213B2 (en) 2003-11-06
HRP20010215A2 (en) 2002-06-30
IL141888A0 (en) 2002-03-10
CZ2001990A3 (cs) 2002-01-16

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