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HUP0103517A2 - Javított eljárás tiazolidin-2,4-dion-származékok előállítására - Google Patents

Javított eljárás tiazolidin-2,4-dion-származékok előállítására

Info

Publication number
HUP0103517A2
HUP0103517A2 HU0103517A HUP0103517A HUP0103517A2 HU P0103517 A2 HUP0103517 A2 HU P0103517A2 HU 0103517 A HU0103517 A HU 0103517A HU P0103517 A HUP0103517 A HU P0103517A HU P0103517 A2 HUP0103517 A2 HU P0103517A2
Authority
HU
Hungary
Prior art keywords
formula
compound
thiazolidine
preparation
acid
Prior art date
Application number
HU0103517A
Other languages
English (en)
Inventor
Prabhakar Chebiyyam
Om Reddy Gaddam
Chinna Bakki Reddy Gade
Ramabhadra Sarma Mamillapalli
Rajender Kumar Potlapally
Balaram Mahanti Satish
Original Assignee
Dr. Reddy's Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr. Reddy's Research Foundation filed Critical Dr. Reddy's Research Foundation
Publication of HUP0103517A2 publication Critical patent/HUP0103517A2/hu
Publication of HUP0103517A3 publication Critical patent/HUP0103517A3/hu
Publication of HU229519B1 publication Critical patent/HU229519B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

A találmány tárgya eljárás az (1) képletű 5-[4-[(3-metil-4-oxo-3,4dihidrokinazolin-2-il)-metoxi]-benzil]-tiazolidin-2,4-dionelőállítására, ami abból áll, hogy (a) a (2') általános képletű - aholR jelentése 1-4 szénatomos alkilcsoport - vegyületet Raney-nikkel vagymagnézium/1-4 szénatomos alkohol keverék alkalmazásával redukálják, és- ha szükséges - 0-60 °C hőmérsékleten kénsavat használva ismétészterezik, a (3') általános képletű - ahol R jelentése azonos a fentimeghatározással - vegyületet nyerve; (b) a (3') általános képletűvegyületet hidrolizálják, a (4) képletű savhoz jutva; (c) a (4)képletű savat előaktiválás nélkül, közvetlenül kondenzálják a (7)képletű N-metil-antranilamiddal, az (1) képletű vegyülethez jutva; ésha szükséges, (d) az (1) képletű vegyületet gyógyászati szempontbólalkalmazható sójává alakítják. Ó
HU0103517A 1998-09-14 1999-09-10 Improved process for the preparation of thiazolidine-2,4-dione derivatives HU229519B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2060MA1998 IN187716B (hu) 1998-09-14 1998-09-14
PCT/IB1999/001530 WO2000015638A1 (en) 1998-09-14 1999-09-10 An improved process for the preparation of thiazolidine-2,4-dione derivatives

Publications (3)

Publication Number Publication Date
HUP0103517A2 true HUP0103517A2 (hu) 2002-05-29
HUP0103517A3 HUP0103517A3 (en) 2003-06-30
HU229519B1 HU229519B1 (en) 2014-01-28

Family

ID=11096874

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0103517A HU229519B1 (en) 1998-09-14 1999-09-10 Improved process for the preparation of thiazolidine-2,4-dione derivatives

Country Status (25)

Country Link
US (1) US6469167B1 (hu)
EP (1) EP1114047B1 (hu)
JP (2) JP2002524563A (hu)
KR (1) KR100448179B1 (hu)
CN (2) CN1231481C (hu)
AT (1) ATE234834T1 (hu)
AU (1) AU762353B2 (hu)
BR (1) BR9914493A (hu)
CA (1) CA2343883C (hu)
CZ (1) CZ300933B6 (hu)
DE (1) DE69906100T2 (hu)
DK (1) DK1114047T3 (hu)
ES (1) ES2195600T3 (hu)
HK (1) HK1077814A1 (hu)
HU (1) HU229519B1 (hu)
IL (1) IL141737A0 (hu)
IN (2) IN187716B (hu)
NO (1) NO317383B1 (hu)
NZ (1) NZ510316A (hu)
PL (1) PL195617B1 (hu)
PT (1) PT1114047E (hu)
RU (1) RU2223961C2 (hu)
UA (1) UA70962C2 (hu)
WO (1) WO2000015638A1 (hu)
ZA (1) ZA200101699B (hu)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1623984B1 (en) * 2002-03-15 2011-11-02 Dr. Reddy's Laboratories Limited Polymorphic form I of 5-[4-[[3-methyl-4-oxo-3,4-dihydroquinazolin-2yl]methoxy]benzyl] thiazolidine-2,4-dione potassium salt
CN103288757B (zh) * 2013-05-16 2015-07-01 苏州明锐医药科技有限公司 6-氨基-7-羟基-3,4-二氢喹唑啉-4-酮的制备方法
KR101677340B1 (ko) 2014-11-28 2016-11-29 이청주 광고용 열기구
KR20160134615A (ko) 2016-11-11 2016-11-23 이청주 광고용 열기구
CN109867765A (zh) * 2019-02-28 2019-06-11 中山大学惠州研究院 一种长效缓释可降解防污聚氨酯及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB306228A (en) * 1927-12-15 1929-02-21 Bohn Aluminium & Brass Corp Improvements in pistons
EP0306228B1 (en) * 1987-09-04 1999-11-17 Beecham Group Plc Substituted thiazolidinedione derivatives
ATE205206T1 (de) * 1990-04-27 2001-09-15 Sankyo Co Benzylidenthiazolidinderivate, ihre herstellung und ihre anwendung als lipidperoxid-inhibitoren
FR2696743B1 (fr) * 1992-10-12 1994-12-23 Adir Nouveaux composés de thiazolidine dione, leur procédé de préparation et les compositions pharmaceutiques les contenant.
TW399051B (en) * 1996-01-31 2000-07-21 Ssp Co Ltd A novel benzoazine thiazolidinedione derivative and pharmaceutical composition for reducing blood glucose
CZ298812B6 (cs) * 1996-07-01 2008-02-13 Dr. Reddy's Laboratories Limited Azolidindionové deriváty, způsob jejich přípravy, farmaceutické kompozice s jejich obsahem a jejich použití v léčbě diabetu a příbuzných nemocí
US5885997A (en) * 1996-07-01 1999-03-23 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
IL127296A (en) * 1996-12-31 2003-01-12 Reddy Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
BR9914493A (pt) 2001-06-26
DE69906100T2 (de) 2003-12-11
HK1077814A1 (en) 2006-02-24
JP2011144179A (ja) 2011-07-28
CA2343883A1 (en) 2000-03-23
EP1114047A1 (en) 2001-07-11
NO20011265L (no) 2001-05-14
AU5439999A (en) 2000-04-03
HU229519B1 (en) 2014-01-28
NO20011265D0 (no) 2001-03-13
EP1114047B1 (en) 2003-03-19
CN1323305A (zh) 2001-11-21
DK1114047T3 (da) 2003-06-23
ZA200101699B (en) 2002-05-28
NO317383B1 (no) 2004-10-18
PL346532A1 (en) 2002-02-11
IL141737A0 (en) 2002-03-10
KR100448179B1 (ko) 2004-09-10
CN1616439A (zh) 2005-05-18
ES2195600T3 (es) 2003-12-01
NZ510316A (en) 2002-11-26
IN187716B (hu) 2002-06-15
UA70962C2 (uk) 2004-11-15
RU2223961C2 (ru) 2004-02-20
AU762353B2 (en) 2003-06-26
CZ300933B6 (cs) 2009-09-16
WO2000015638A1 (en) 2000-03-23
CZ2001825A3 (cs) 2001-08-15
US6469167B1 (en) 2002-10-22
KR20010075088A (ko) 2001-08-09
PT1114047E (pt) 2003-07-31
HUP0103517A3 (en) 2003-06-30
IN189187B (hu) 2003-01-04
JP2002524563A (ja) 2002-08-06
ATE234834T1 (de) 2003-04-15
CA2343883C (en) 2010-02-16
CN1295222C (zh) 2007-01-17
DE69906100D1 (de) 2003-04-24
CN1231481C (zh) 2005-12-14
PL195617B1 (pl) 2007-10-31

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Legal Events

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MM4A Lapse of definitive patent protection due to non-payment of fees