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HUP0101898A2 - Meiózist szabályozó szteroid-származékok és ezek felhasználása gyógyszerkészítmények előállítására - Google Patents

Meiózist szabályozó szteroid-származékok és ezek felhasználása gyógyszerkészítmények előállítására

Info

Publication number
HUP0101898A2
HUP0101898A2 HU0101898A HUP0101898A HUP0101898A2 HU P0101898 A2 HUP0101898 A2 HU P0101898A2 HU 0101898 A HU0101898 A HU 0101898A HU P0101898 A HUP0101898 A HU P0101898A HU P0101898 A2 HUP0101898 A2 HU P0101898A2
Authority
HU
Hungary
Prior art keywords
compounds
meiosis
pharmaceutical compositions
steroid derivatives
producing pharmaceutical
Prior art date
Application number
HU0101898A
Other languages
English (en)
Inventor
Thorsten Blume
Jens Breinholt
Peter Faarup
Frederik Christian Gronvald
Anthony Murray
Original Assignee
Novo Nordisk A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27220846&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0101898(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from EP98250166A external-priority patent/EP0957108A1/en
Application filed by Novo Nordisk A/S filed Critical Novo Nordisk A/S
Publication of HUP0101898A2 publication Critical patent/HUP0101898A2/hu
Publication of HUP0101898A3 publication Critical patent/HUP0101898A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Reproductive Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pregnancy & Childbirth (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • General Induction Heating (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Farming Of Fish And Shellfish (AREA)
  • Prostheses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

A jelen tal lm ny t rgy t farmakológiailag hat sos (I) ltal nosképletű vegyületek - amely képletben a szubsztituensek kül"nb"zőatomokat vagy csoportokat jelenthetnek - és e vegyületekgyógyszerkészítmények elő llít s ra való alkalmaz sa képezi. A fentivegyületek felhaszn lhatók a meiózis befoly sol s ra. K"zelebbről, atal lm ny az oocit k és a hímivarú csírasejtek meiózis nak befoly sols ra haszn lható új szteroidsz rmazékokkal foglalkozik. A tal lm ny trgy t képezik tov bb hím- és nőivarú - elsősorban - emlős"k, főkéntemberek meddőségének gyógyít s ra szolg ló vegyületek, valamint hím-és nőivarú - elsősorban - emlős"k, főként emberek fogamz sg tlójakénthaszn lt vegyületek. Ó
HU0101898A 1998-05-13 1999-05-11 Meiosis regulating steroid derivatives and use thereof for producing pharmaceutical compositions HUP0101898A3 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DK65798 1998-05-13
EP98250166A EP0957108A1 (en) 1998-05-14 1998-05-14 Unsaturated cholestane derivatives, pharmaceutical compositions comprising them and use of these derivatives for the preparation of meiosis regulating medicaments
US8630698P 1998-05-21 1998-05-21
DK81198 1998-06-19
US9298398P 1998-07-16 1998-07-16
PCT/DK1999/000263 WO1999058549A1 (en) 1998-05-13 1999-05-11 Meiosis regulating compounds

Publications (2)

Publication Number Publication Date
HUP0101898A2 true HUP0101898A2 (hu) 2002-04-29
HUP0101898A3 HUP0101898A3 (en) 2002-06-28

Family

ID=27220846

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0101898A HUP0101898A3 (en) 1998-05-13 1999-05-11 Meiosis regulating steroid derivatives and use thereof for producing pharmaceutical compositions

Country Status (12)

Country Link
EP (1) EP1077992B1 (hu)
JP (1) JP2003522728A (hu)
CN (1) CN1326461A (hu)
AT (1) ATE256144T1 (hu)
AU (1) AU3701199A (hu)
BR (1) BR9910415A (hu)
CA (1) CA2331962A1 (hu)
DE (1) DE69913513T2 (hu)
HU (1) HUP0101898A3 (hu)
NO (1) NO20005667L (hu)
PL (1) PL344155A1 (hu)
WO (1) WO1999058549A1 (hu)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EE200100592A (et) * 1999-05-10 2003-02-17 Schering Aktiengesellschaft 14ß-H-steroolid, neid sisaldavad farmatseutilisedkompositsioonid ja nende derivaatide kasutamine meioosi reguleerivate ravimite valmistamiseks
EP1245572A1 (en) * 2001-03-26 2002-10-02 Schering Aktiengesellschaft Aminosterol compounds, their use in the preparation of meiosis-regulating medicaments and method for their preparation
CN1620499A (zh) * 2001-12-21 2005-05-25 哥本哈根大学医院 哺乳动物的配子募集和发育能力－通过抑制固醇从头生物合成和/或促进固醇外流
US8399441B2 (en) 2004-10-25 2013-03-19 Virginia Commonwealth University Nuclear sulfated oxysterol, potent regulator of lipid homeostasis, for therapy of hypercholesterolemia, hypertriglycerides, fatty liver diseases, and atherosclerosis
WO2006047022A1 (en) 2004-10-25 2006-05-04 Virginia Commonwealth University Nuclear sulfated oxysterol, potent regulator of cholesterol homeostasis, for therapy of hypercholesterolemia, hyperlipidemia, and atherosclerosis
US9034859B2 (en) 2011-04-06 2015-05-19 Virginia Commonwealth University Sulfated oxysterol and oxysterol sulfation by hydroxysterol sulfotransferase promote lipid homeostasis and liver proliferation
IL280068B1 (en) 2013-03-13 2025-02-01 Sage Therapeutics Inc Neuroactivity is modulated at position 24 by hydroxy and alkyl/alkenyl/alkynyl 3beta–hydroxy–cholane and 3beta–hydroxy–chol–5–ene derivatives
HUE057649T2 (hu) 2013-12-24 2022-05-28 Us Gov Veterans Affairs Oxigenált koleszterinszulfátok (OCS) alkalmazása az akut májelégtelenség kezelésére
US9637514B1 (en) 2015-10-26 2017-05-02 MAX BioPharma, Inc. Oxysterols and hedgehog signaling
HUE059768T2 (hu) 2016-08-02 2022-12-28 Univ Virginia Commonwealth 5-kolesztén-3,25-diol, 3-szulfátot (25HC3S) vagy annak gyógyszerészetileg elfogadható sóját és legalább egy ciklikus oligoszacharidot tartalmazó készítmények
CN112521438B (zh) * 2020-12-08 2021-11-23 苏利制药科技江阴有限公司 一种β-谷甾醇的合成工艺

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994018225A1 (en) * 1993-02-11 1994-08-18 The Du Pont Merck Pharmaceutical Company 15-oxasterols as hypocholesterolemics
US5716777A (en) * 1994-06-23 1998-02-10 Novo Nordisk A/S Regulation of meiosis using sterols
ATE238339T1 (de) * 1996-12-20 2003-05-15 Novo Nordisk As Verbindungen zur regulierung der meiose
AU726016B2 (en) * 1997-05-16 2000-10-26 Akzo Nobel N.V. 20-aralkyl-5alpha-pregnane derivatives
PL337188A1 (en) * 1997-06-04 2000-08-14 Akzo Nobel Nv Derivatives of 17beta - allyloxy (thio) alkyl - androstane for modulation of meiosis

Also Published As

Publication number Publication date
EP1077992A1 (en) 2001-02-28
AU3701199A (en) 1999-11-29
HUP0101898A3 (en) 2002-06-28
WO1999058549A1 (en) 1999-11-18
CN1326461A (zh) 2001-12-12
CA2331962A1 (en) 1999-11-18
PL344155A1 (en) 2001-10-08
DE69913513T2 (de) 2004-09-30
BR9910415A (pt) 2001-01-09
ATE256144T1 (de) 2003-12-15
NO20005667D0 (no) 2000-11-10
NO20005667L (no) 2001-01-12
DE69913513D1 (de) 2004-01-22
EP1077992B1 (en) 2003-12-10
JP2003522728A (ja) 2003-07-29

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