[go: up one dir, main page]

HUP0100616A2 - Eljárás izopropil-metil-[2-(3-propoxi-fenoxi)-etil]-amin előállítására - Google Patents

Eljárás izopropil-metil-[2-(3-propoxi-fenoxi)-etil]-amin előállítására

Info

Publication number
HUP0100616A2
HUP0100616A2 HU0100616A HUP0100616A HUP0100616A2 HU P0100616 A2 HUP0100616 A2 HU P0100616A2 HU 0100616 A HU0100616 A HU 0100616A HU P0100616 A HUP0100616 A HU P0100616A HU P0100616 A2 HUP0100616 A2 HU P0100616A2
Authority
HU
Hungary
Prior art keywords
ethyl
amine
reacted
propoxyphenoxy
isopropyl
Prior art date
Application number
HU0100616A
Other languages
English (en)
Inventor
Ulf Larsson
Original Assignee
Astrazeneca Ab,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab, filed Critical Astrazeneca Ab,
Publication of HUP0100616A2 publication Critical patent/HUP0100616A2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/20—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Anesthesiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

A találmány tárgyát izopropil-metil-[2-(3-propoxi-fenoxi)-etil]-aminelőállítására szolgáló új eljárás, az eljárás egy új közbenső terméke,az eljárásban adott esetben alkalmazható tisztítási lépés képezi. Azeljárás szerint 1) 3-propoxi-fenolt szilárd-folyadék fázistranszferkatalízis körülményei között etilén-karbonáttal reagáltatnak, 2) akapott 2-(3-propoxi-fenoxi)-etanolból alkalmas reagenssel halogenidetvagy szulfonát-észtert készítenek, 3) ezt a vegyületet egy szervesoldószerben, víz jelenlétében izopropil-aminnal reagáltatják, 4) akapott vizes oldatot palládiumos szén jelenlétében formaldehiddelreagáltatják, és 5) az így kapott izopropil-metil-[2-(3-propoxi-fenoxi)-etil]-amint adott esetben monofoszfát sóvá alakítvakristályosítással tisztítják, majd lúggal ismét felszabadítják. Ó
HU0100616A 1997-12-22 1998-12-15 Eljárás izopropil-metil-[2-(3-propoxi-fenoxi)-etil]-amin előállítására HUP0100616A2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9704834A SE9704834D0 (sv) 1997-12-22 1997-12-22 New process

Publications (1)

Publication Number Publication Date
HUP0100616A2 true HUP0100616A2 (hu) 2002-05-29

Family

ID=20409537

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0100616A HUP0100616A2 (hu) 1997-12-22 1998-12-15 Eljárás izopropil-metil-[2-(3-propoxi-fenoxi)-etil]-amin előállítására

Country Status (21)

Country Link
EP (1) EP1045826A1 (hu)
JP (1) JP2001526253A (hu)
KR (1) KR20010024790A (hu)
CN (1) CN1283177A (hu)
AR (1) AR017198A1 (hu)
AU (1) AU1989199A (hu)
BR (1) BR9814377A (hu)
CA (1) CA2314988A1 (hu)
EE (1) EE200000369A (hu)
HU (1) HUP0100616A2 (hu)
ID (1) ID27591A (hu)
IL (1) IL136825A0 (hu)
IS (1) IS5523A (hu)
NO (1) NO20002944D0 (hu)
PL (1) PL341438A1 (hu)
SE (1) SE9704834D0 (hu)
SK (1) SK8052000A3 (hu)
TR (1) TR200001976T2 (hu)
TW (1) TW436474B (hu)
WO (1) WO1999032430A1 (hu)
ZA (1) ZA9811238B (hu)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140350181A1 (en) * 2011-05-26 2014-11-27 Solvay Specialty Polymers Italy S.P.A. Hydro-fluorocompounds
JP6247992B2 (ja) * 2014-04-17 2017-12-13 株式会社ダイセル ハロゲン化合物の製造方法
JP6635999B2 (ja) * 2017-10-13 2020-01-29 株式会社ダイセル カリウム塩の製造方法、及びカリウム塩

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL90704A (en) * 1989-06-21 1994-10-07 Makhteshim Chem Works Ltd Method for the preparation of N-N-) 2,4,6-trichlorophenoxy (environmentally reliable ethylene)
AR004691A1 (es) * 1995-10-27 1999-03-10 Astrazeneca Ab Nuevos derivados de [3-alcoxi-fenoxi-)-etil]-dialquilamina, una composicion farmaceutica que los comprende, su uso como anestesicos locales y unprocedimiento para su preparacion

Also Published As

Publication number Publication date
SE9704834D0 (sv) 1997-12-22
ID27591A (id) 2001-04-12
IL136825A0 (en) 2001-06-14
AR017198A1 (es) 2001-08-22
CA2314988A1 (en) 1999-07-01
JP2001526253A (ja) 2001-12-18
CN1283177A (zh) 2001-02-07
SK8052000A3 (en) 2001-02-12
NO20002944L (no) 2000-06-08
ZA9811238B (en) 1999-06-22
EP1045826A1 (en) 2000-10-25
AU1989199A (en) 1999-07-12
KR20010024790A (ko) 2001-03-26
NO20002944D0 (no) 2000-06-08
PL341438A1 (en) 2001-04-09
TW436474B (en) 2001-05-28
WO1999032430A1 (en) 1999-07-01
EE200000369A (et) 2001-12-17
IS5523A (is) 2000-06-07
BR9814377A (pt) 2000-10-10
TR200001976T2 (tr) 2000-11-21

Similar Documents

Publication Publication Date Title
FI78457B (fi) Foerfarande foer framstaellning av propargylammoniumklorider.
US4297282A (en) Resolution of mercaptopropionic acids
US4319040A (en) Process for the production of optically active threo-3-(3,4-dihydroxyphenyl)serine
JPH06234715A (ja) アラニルグルタミンの製造法
HUP0100616A2 (hu) Eljárás izopropil-metil-[2-(3-propoxi-fenoxi)-etil]-amin előállítására
EE200200460A (et) Meetod tuntud tetrasooli derivaadi sünteesiks
AU2002220596A1 (en) Synthesis of r(+)alpha-lipoic acid
HU229188B1 (hu) Új eljárás N-[(S)-1-karboxibutil]-(S)-alanin-észterek elõállítására, és a perindopril szintézisnél történõ alkalmazása
EP1063232B1 (en) Process for producing erythro-3-amino-2-hydroxybutyric acid derivatives
ATE373667T1 (de) Verfahren zur herstellung von ceftiofur
CN108409589A (zh) 一种带手性的β-氨基酸酯的制备方法
US4767880A (en) Process for racemizing optically active alpha-phenoxypropionic acid and derivatives thereof
HU213315B (en) Process for producing arylacetic acids and their alkali metal salts
HU181708B (en) Process for producing treo-bracket-p-nitrophenyl-bracket closed-serin and hydrochloric acid additional salt
US6346649B1 (en) Process for the recovery and recycle of D-tartaric acid
US4411836A (en) Racemization of an α-methyl-β-acylthiopropionic acid
US4611088A (en) Process for preparing D-α-(6-methoxy-2-naphtyl) propionic acid
JP3888402B2 (ja) 光学活性Ｎ−カルボベンゾキシ−ｔｅｒｔ−ロイシンの製造法
CA2575912C (en) Process for the preparation of optically pure indoline-2-carboxylic acid
JP3303050B2 (ja) アゾニアアダマンタン化合物およびこのものからのアザアダマンタン化合物の製造方法並びに該アゾニアアダマンタン化合物の製造方法
CA3108358C (en) Preparation method for (1r,3s)-3-amino-1-cyclopentanol and salts thereof
JP2840560B2 (ja) 塩化プロパルギルアンモニウム誘導体の製造方法
KR100302833B1 (ko) 엘-페닐알라닌 메틸 에스테르의 제조방법
KR100325682B1 (ko) 2',3'-디디하이드로-2',3'-디데옥시시티딘 유도체의 제조방법
US6281379B1 (en) Process for producing norstatin derivatives