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HUP0003121A2 - Eljárás perorálisan alkalmazható, szabályozott hatóanyag-leadású szilárd gyógyszerkészítmények előállítására - Google Patents

Eljárás perorálisan alkalmazható, szabályozott hatóanyag-leadású szilárd gyógyszerkészítmények előállítására

Info

Publication number
HUP0003121A2
HUP0003121A2 HU0003121A HUP0003121A HUP0003121A2 HU P0003121 A2 HUP0003121 A2 HU P0003121A2 HU 0003121 A HU0003121 A HU 0003121A HU P0003121 A HUP0003121 A HU P0003121A HU P0003121 A2 HUP0003121 A2 HU P0003121A2
Authority
HU
Hungary
Prior art keywords
solid pharmaceutical
active substance
controlled release
orally administered
pharmaceutical products
Prior art date
Application number
HU0003121A
Other languages
English (en)
Inventor
Michael Dittgen
Annette Eichardt
Sabine Fricke
Hagen Gerecke
Carsten Timpe
Original Assignee
Jenapharm Gmbh & Co. Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jenapharm Gmbh & Co. Kg filed Critical Jenapharm Gmbh & Co. Kg
Publication of HUP0003121A2 publication Critical patent/HUP0003121A2/hu
Publication of HUP0003121A3 publication Critical patent/HUP0003121A3/hu
Publication of HU226670B1 publication Critical patent/HU226670B1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A találmány tárgya eljárás perorálisan alkalmazható, szabályozotthatóanyag-leadású szilárd gyógyszerkészítmények előállítására. Az eljárásra jellemző, hogy négy sűrítmény közül legalább hármatkombinálnak. A négy sűrítmény hatóanyagot vagy hatóanyag-kombinációt,segéd- és/vagy hordozóanyagokat tartalmaz, és mindegyik mássebességgel adja le a hatóanyagot: az A-sűrítmény gyorsan, a B-sűrítmény késleltetve, a C-sűrítmény gyorsan, de csak a nyombélbe valóbeérkezése után (pH 6-7,5 mellett), és a D-sűrítmény késleltetve és 6-7,5 pH mellett. A négy sűrítmény kombinálásával, majd szilárdgyógyszerformává való feldolgozásával (például kapszulába töltésével)a hatóanyag felszabadulásának minden kívánt profilja állítható be. Ó
HU0003121A 1997-04-29 1998-04-07 Method for producing orally administered, solid pharmaceutical products with controlled release of the active substance HU226670B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19718012A DE19718012C1 (de) 1997-04-29 1997-04-29 Verfahren zur Herstellung peroral anwendbarer fester Arzneiformen mit gesteuerter Wirkstoffabgabe
PCT/DE1998/000979 WO1998048782A1 (de) 1997-04-29 1998-04-07 Verfahren zur herstellung peroral anwendbarer fester arzneiformen mit gesteuerter wirkstoffabgabe

Publications (3)

Publication Number Publication Date
HUP0003121A2 true HUP0003121A2 (hu) 2001-02-28
HUP0003121A3 HUP0003121A3 (en) 2001-03-28
HU226670B1 HU226670B1 (en) 2009-06-29

Family

ID=7828056

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0003121A HU226670B1 (en) 1997-04-29 1998-04-07 Method for producing orally administered, solid pharmaceutical products with controlled release of the active substance

Country Status (19)

Country Link
US (1) US6117450A (hu)
EP (1) EP0979069B1 (hu)
JP (1) JP2002511849A (hu)
AR (1) AR010414A1 (hu)
AT (1) ATE286723T1 (hu)
AU (1) AU8009998A (hu)
BR (1) BR9809328A (hu)
CA (1) CA2290017C (hu)
CO (1) CO5070636A1 (hu)
CZ (1) CZ300174B6 (hu)
DE (2) DE19718012C1 (hu)
ES (1) ES2236908T3 (hu)
HU (1) HU226670B1 (hu)
PL (1) PL191692B1 (hu)
PT (1) PT979069E (hu)
RU (1) RU2193396C2 (hu)
SK (1) SK147999A3 (hu)
UA (1) UA49952C2 (hu)
WO (1) WO1998048782A1 (hu)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2775599B1 (fr) * 1998-03-09 2001-08-17 Besins Iscovesco Lab Composition pharmaceutique a base de progesterone naturelle de synthese et d'oestradiol et son procede de preparation
US6419960B1 (en) 1998-12-17 2002-07-16 Euro-Celtique S.A. Controlled release formulations having rapid onset and rapid decline of effective plasma drug concentrations
US6544553B1 (en) 1999-12-28 2003-04-08 Watson Pharmaceuticals, Inc. Dosage forms and methods for oral delivery of progesterone
US6991807B2 (en) * 2000-02-24 2006-01-31 Advancis Pharmaceutical, Corp. Antibiotic composition
WO2001062231A1 (en) * 2000-02-24 2001-08-30 Advancis Pharmaceutical Corporation Antibiotic composition with inhibitor
WO2001062229A1 (en) * 2000-02-24 2001-08-30 Advanced Pharma, Inc. Therapeutic product, use and formulation thereof
US7025989B2 (en) * 2000-02-24 2006-04-11 Advancis Pharmaceutical Corp. Multiple-delayed released antibiotic product, use and formulation thereof
EP1267765A4 (en) * 2000-02-24 2008-12-24 Middlebrook Pharmaceuticals In ANTIBIOTIC AND MUSHROOM AGENTS
GB0007419D0 (en) † 2000-03-27 2000-05-17 Smithkline Beecham Gmbh Composition
EP1349531A1 (en) * 2001-01-12 2003-10-08 Sun Pharmaceuticals Industries Ltd. Spaced drug delivery system
RU2351317C2 (ru) * 2001-01-12 2009-04-10 Сан Фармасьютикал Индастриз Лимитед Система раздельной доставки лекарственных средств
US20040156900A1 (en) * 2001-04-10 2004-08-12 Shanghvi Dilip Shantilal Time pulsed release composition
GB0119848D0 (en) * 2001-08-15 2001-10-10 Univ Sheffield Delayed and sustained drug release
AU2007202779B2 (en) * 2001-08-15 2008-08-07 University Of Sheffield Delayed and sustained drug release
US20030083286A1 (en) * 2001-08-22 2003-05-01 Ching-Leou Teng Bioadhesive compositions and methods for enhanced intestinal drug absorption
US20030124196A1 (en) * 2001-08-22 2003-07-03 Susan Weinbach Pulsatile release compositions and methods for enhanced intestinal drug absorption
WO2003075852A2 (en) * 2002-03-07 2003-09-18 Advancis Pharmaceuticals Corporation Antibiotic composition
WO2004108067A2 (en) * 2003-04-03 2004-12-16 Sun Pharmaceutical Industries Limited Programmed drug delivery system
AU2004258944B2 (en) * 2003-07-21 2011-02-10 Shionogi, Inc. Antibiotic product, use and formulation thereof
EP1648415A4 (en) * 2003-07-21 2011-11-16 Middlebrook Pharmaceuticals Inc ANTIBIOTIC PRODUCT, ITS USE AND FORMULATION
EP1648407A4 (en) * 2003-07-21 2011-08-31 Middlebrook Pharmaceuticals Inc ANTIBIOTIC PRODUCT, CORRESPONDING USE AND FORMULATION
CA2535398C (en) * 2003-08-12 2013-11-12 Advancis Pharmaceuticals Corporation Antibiotic product, use and formulation thereof
CA2535780A1 (en) * 2003-08-29 2005-03-17 Advancis Pharmaceuticals Corporation Antibiotic product, use and formulation thereof
EP1663169A4 (en) * 2003-09-15 2010-11-24 Middlebrook Pharmaceuticals In ANTIBIOTICS, ITS USE AND FORMULATION
SE0401031D0 (sv) 2004-04-22 2004-04-22 Duocort Ab A new glucocorticoid replacement therapy
CA2563609C (en) 2004-04-22 2012-11-06 Duocort Ab Pharmaceutical compositions for acute glucocorticoid therapy
US20080014257A1 (en) * 2006-07-14 2008-01-17 Par Pharmaceutical, Inc. Oral dosage forms
GB0817120D0 (en) * 2008-09-19 2008-10-29 Diurnal Ltd Treatment of adrenal insufficiency
WO2010115615A1 (en) * 2009-04-07 2010-10-14 Duocort Pharma Ab Improved glucocorticoid therapy
US20110312927A1 (en) * 2010-06-18 2011-12-22 Satish Kumar Nachaegari Progesterone Containing Oral Dosage Forms and Related Methods
US20110312928A1 (en) * 2010-06-18 2011-12-22 Lipocine Inc. Progesterone Containing Oral Dosage Forms and Related Methods
US9375437B2 (en) 2010-06-18 2016-06-28 Lipocine Inc. Progesterone containing oral dosage forms and kits
CN105412016B (zh) * 2010-10-27 2019-01-22 上海宣泰医药科技有限公司 一种含番茄红素、白藜芦醇或褪黑素的肠溶固体制剂及其制备方法
US8951996B2 (en) 2011-07-28 2015-02-10 Lipocine Inc. 17-hydroxyprogesterone ester-containing oral compositions and related methods
EP3936133A1 (en) 2011-11-23 2022-01-12 TherapeuticsMD, Inc. Natural combination hormone replacement formulations and therapies
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
GB201202433D0 (en) 2012-02-13 2012-03-28 Diurnal Ltd Controlled drug release
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
WO2015179693A1 (en) 2014-05-22 2015-11-26 Isis Pharmaceuticals, Inc. Conjugated antisense compounds and their use
AR100562A1 (es) 2014-05-22 2016-10-12 Therapeuticsmd Inc Composición farmacéutica de estradiol y progesterona para terapia de reemplazo hormonal
CA2936740C (en) 2014-10-31 2017-10-10 Purdue Pharma Methods and compositions particularly for treatment of attention deficit disorder
US20170035781A1 (en) 2015-06-22 2017-02-09 Lipocine Inc. 17-hydroxyprogesterone ester-containing oral compositions and related methods
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
AU2017239645A1 (en) 2016-04-01 2018-10-18 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
WO2017173044A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd Inc. Steroid hormone compositions in medium chain oils
US10722473B2 (en) 2018-11-19 2020-07-28 Purdue Pharma L.P. Methods and compositions particularly for treatment of attention deficit disorder
US11633405B2 (en) 2020-02-07 2023-04-25 Therapeuticsmd, Inc. Steroid hormone pharmaceutical formulations

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2403080A1 (fr) * 1977-09-15 1979-04-13 Heyden Chem Fab Preparation de nitrofurantoine a effet retard pour administration orale et son procede de fabrication
DE2749749A1 (de) * 1977-11-07 1979-05-10 Sumitomo Chemical Co Verfahren zur herstellung von 5-carboxy-2-acetylthiophen
DE2836355A1 (de) * 1978-08-19 1980-02-28 Boehringer Sohn Ingelheim Neue mexiletin-retardform
IT1101649B (it) * 1978-12-15 1985-10-07 Lehner Ag Composizione farmaceutica ad azione prolungata contenente acidi biliari
US4728512A (en) * 1985-05-06 1988-03-01 American Home Products Corporation Formulations providing three distinct releases
US5229131A (en) * 1990-02-05 1993-07-20 University Of Michigan Pulsatile drug delivery system
IT1243341B (it) * 1990-07-13 1994-06-10 Farcon Ag Composizione farmaceutica per uso orale a rilascio modificato di antiinfiammatori non steroidei
ZA919510B (en) * 1990-12-05 1992-10-28 Smithkline Beecham Corp Pharmaceutical compositions
IT1252198B (it) * 1991-12-12 1995-06-05 Bayer Italia Spa Sistema farmaceutico per la somministrazione a rilascio controllato dididropiridine terapeuticamente attive e metodo di preparazione
DE4443175A1 (de) * 1994-12-05 1996-06-13 Jenapharm Gmbh Neue pulsatile Arzneiform
EP0722732A1 (en) * 1995-01-24 1996-07-24 Mitsui Toatsu Chemicals, Inc. Long-acting drug formulation containing pyrimidinedione derivatives
DE19651551C2 (de) * 1996-12-11 2000-02-03 Klinge Co Chem Pharm Fab Opioidantagonisthaltige galenische Formulierung
JP2001507359A (ja) * 1997-01-03 2001-06-05 エラン コーポレーション ピーエルシー 徐放性シサプリドミニ錠剤製剤

Also Published As

Publication number Publication date
PL336572A1 (en) 2000-07-03
WO1998048782A1 (de) 1998-11-05
BR9809328A (pt) 2000-07-04
ATE286723T1 (de) 2005-01-15
EP0979069B1 (de) 2005-01-12
CA2290017C (en) 2004-06-29
CZ380499A3 (cs) 2000-04-12
AR010414A1 (es) 2000-06-07
PL191692B1 (pl) 2006-06-30
CZ300174B6 (cs) 2009-03-04
UA49952C2 (uk) 2002-10-15
CO5070636A1 (es) 2001-08-28
US6117450A (en) 2000-09-12
PT979069E (pt) 2005-05-31
DE19718012C1 (de) 1998-10-08
ES2236908T3 (es) 2005-07-16
RU2193396C2 (ru) 2002-11-27
HU226670B1 (en) 2009-06-29
HUP0003121A3 (en) 2001-03-28
SK147999A3 (en) 2000-07-11
EP0979069A1 (de) 2000-02-16
CA2290017A1 (en) 1998-11-05
DE59812485D1 (de) 2005-02-17
JP2002511849A (ja) 2002-04-16
AU8009998A (en) 1998-11-24

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Legal Events

Date Code Title Description
GB9A Succession in title

Owner name: JENAPHARM GMBH & CO. KG, DE

Free format text: FORMER OWNER(S): JENAPHARM GMBH & CO. KG, DE; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT, DE; SCHERING AKTIENGESELLSCHAFT, DE

HC9A Change of name, address

Owner name: JENAPHARM GMBH & CO. KG, DE

Free format text: FORMER OWNER(S): JENAPHARM GMBH & CO. KG, DE; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT, DE; SCHERING AKTIENGESELLSCHAFT, DE

MM4A Lapse of definitive patent protection due to non-payment of fees