HUE050665T2 - Radiojelzett MGLUR2/3 PET ligandumok - Google Patents
Radiojelzett MGLUR2/3 PET ligandumokInfo
- Publication number
- HUE050665T2 HUE050665T2 HUE16812961A HUE16812961A HUE050665T2 HU E050665 T2 HUE050665 T2 HU E050665T2 HU E16812961 A HUE16812961 A HU E16812961A HU E16812961 A HUE16812961 A HU E16812961A HU E050665 T2 HUE050665 T2 HU E050665T2
- Authority
- HU
- Hungary
- Prior art keywords
- mglur2
- radiolabeled
- pet ligands
- ligands
- pet
- Prior art date
Links
- 101150016175 Grm2 gene Proteins 0.000 title 1
- 102100036837 Metabotropic glutamate receptor 2 Human genes 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15201240 | 2015-12-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
HUE050665T2 true HUE050665T2 (hu) | 2020-12-28 |
Family
ID=55023944
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HUE16812961A HUE050665T2 (hu) | 2015-12-18 | 2016-12-16 | Radiojelzett MGLUR2/3 PET ligandumok |
Country Status (17)
Country | Link |
---|---|
US (1) | US11033641B2 (hu) |
EP (1) | EP3389727B1 (hu) |
JP (1) | JP6927974B2 (hu) |
AU (1) | AU2016374571B2 (hu) |
CA (1) | CA3003998A1 (hu) |
CY (1) | CY1124935T1 (hu) |
DK (1) | DK3389727T3 (hu) |
ES (1) | ES2828976T3 (hu) |
HR (1) | HRP20201372T1 (hu) |
HU (1) | HUE050665T2 (hu) |
LT (1) | LT3389727T (hu) |
PL (1) | PL3389727T3 (hu) |
PT (1) | PT3389727T (hu) |
RS (1) | RS60981B1 (hu) |
SI (1) | SI3389727T1 (hu) |
SM (1) | SMT202000591T1 (hu) |
WO (1) | WO2017103182A1 (hu) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JOP20150177B1 (ar) | 2014-08-01 | 2021-08-17 | Janssen Pharmaceutica Nv | مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2 |
JOP20150179B1 (ar) | 2014-08-01 | 2021-08-17 | Janssen Pharmaceutica Nv | مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2 |
EP3226915B1 (en) | 2014-12-03 | 2019-02-20 | Janssen Pharmaceutica NV | Radiolabelled mglur2 pet ligands |
AU2015357167B2 (en) | 2014-12-03 | 2020-06-25 | Janssen Pharmaceutica Nv | 6,7-dihydropyrazolo(1,5-alpha)pyrazin-4(5H)-one compounds and their use as negative allosteric modulators of mGluR2 receptors |
HUE050665T2 (hu) | 2015-12-18 | 2020-12-28 | Janssen Pharmaceutica Nv | Radiojelzett MGLUR2/3 PET ligandumok |
ES2820823T3 (es) * | 2015-12-18 | 2021-04-22 | Janssen Pharmaceutica Nv | Ligandos PET mGluR2/3 radiomarcados |
JP7242548B2 (ja) | 2017-11-24 | 2023-03-20 | 住友ファーマ株式会社 | 6,7-ジヒドロピラゾロ[1,5-a]ピラジノン誘導体及びその医薬用途 |
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DE19653647A1 (de) | 1996-12-20 | 1998-06-25 | Hoechst Ag | Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung |
US6482821B2 (en) | 1996-12-20 | 2002-11-19 | Hoechst Aktiengellschaft | Vitronectin receptor antagonists, their preparation and their use |
US6831074B2 (en) | 2001-03-16 | 2004-12-14 | Pfizer Inc | Pharmaceutically active compounds |
US20030114448A1 (en) | 2001-05-31 | 2003-06-19 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
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US7329662B2 (en) | 2003-10-03 | 2008-02-12 | Hoffmann-La Roche Inc. | Pyrazolo-pyridine |
WO2005061507A1 (en) | 2003-12-16 | 2005-07-07 | Pfizer Products Inc. | Bicyclic pyrazol-4-one cannabinoid receptor ligands and uses thereof |
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MX2007009106A (es) | 2005-02-11 | 2007-09-11 | Hoffmann La Roche | Derivados de pirazolo-pirimidina como antagonistas del receptor de glutamato metabotropico 2. |
AU2006226669B2 (en) | 2005-03-23 | 2011-12-08 | F. Hoffmann-La Roche Ag | Acetylenyl-pyrazolo-pvrimidine derivatives as mGluR2 antagonists |
US7998959B2 (en) | 2006-01-12 | 2011-08-16 | Incyte Corporation | Modulators of 11-β hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same |
US7553836B2 (en) | 2006-02-06 | 2009-06-30 | Bristol-Myers Squibb Company | Melanin concentrating hormone receptor-1 antagonists |
US8435970B2 (en) | 2006-06-29 | 2013-05-07 | Astex Therapeutics Limited | Pharmaceutical combinations of 1-cyclopropyl-3-[3-(5-morpholin-4-ylmethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-urea |
JP2010526836A (ja) | 2007-05-10 | 2010-08-05 | ジーイー・ヘルスケア・リミテッド | カンナビノイドCB2レセプターに対して活性を有するイミダゾール(1,2−a)ピリジン及び関連化合物 |
EP2085390A1 (en) | 2008-01-31 | 2009-08-05 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Labelled analogues of halobenzamides as multimodal radiopharmaceuticals and their precursors |
US9446995B2 (en) | 2012-05-21 | 2016-09-20 | Illinois Institute Of Technology | Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions |
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JPWO2010024258A1 (ja) | 2008-08-29 | 2012-01-26 | 塩野義製薬株式会社 | Pi3k阻害活性を有する縮環アゾール誘導体 |
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KR101753826B1 (ko) | 2009-05-12 | 2017-07-04 | 얀센 파마슈티칼즈, 인코포레이티드 | 1,2,4―트리아졸로[4,3―a]피리딘 유도체 및 신경정신 질환의 치료 또는 예방을 위한 이들의 용도 |
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JP2013189395A (ja) | 2012-03-14 | 2013-09-26 | Dainippon Sumitomo Pharma Co Ltd | ジヒドロピロロピラジノン誘導体 |
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BR112014031896A2 (pt) | 2012-06-20 | 2017-06-27 | Univ Vanderbilt | composto, composição farmacêutica, e, método para o tratamento de um distúrbio |
WO2013192347A1 (en) | 2012-06-20 | 2013-12-27 | Vanderbilt University | Substituted bicyclic cycloalkyl pyrazole lactam analogs as allosteric modulators of mglur5 receptors |
PL2870150T3 (pl) | 2012-07-03 | 2019-12-31 | 3-V Biosciences, Inc. | Heterocykliczne modulatory syntezy lipidów |
AR093077A1 (es) | 2012-10-23 | 2015-05-20 | Hoffmann La Roche | ANTAGONISTAS DE mGlu2/3 PARA EL TRATAMIENTO DE LOS TRASTORNOS AUTISTAS |
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HUE062265T2 (hu) | 2013-06-27 | 2023-10-28 | Pfizer | Heteroaromás vegyületek és azok alkalmazása dopamin D1 ligandumokként |
WO2014207082A1 (en) | 2013-06-27 | 2014-12-31 | Janssen R&D Ireland | Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases |
AU2015295301B2 (en) | 2014-08-01 | 2019-05-09 | Janssen Pharmaceutica Nv | 6,7-dihydropyrazolo[1,5-alpha]pyrazin-4(5H)-one compounds and their use as negative allosteric modulators of mGluR2 receptors |
EP3174882B1 (en) | 2014-08-01 | 2018-11-07 | Janssen Pharmaceutica NV | 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5h)-one compounds and their use as negative allosteric modulators of mglu2 receptors |
JOP20150177B1 (ar) | 2014-08-01 | 2021-08-17 | Janssen Pharmaceutica Nv | مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2 |
JO3601B1 (ar) | 2014-08-01 | 2020-07-05 | Janssen Pharmaceutica Nv | مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2 |
JOP20150179B1 (ar) | 2014-08-01 | 2021-08-17 | Janssen Pharmaceutica Nv | مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2 |
EP3226915B1 (en) | 2014-12-03 | 2019-02-20 | Janssen Pharmaceutica NV | Radiolabelled mglur2 pet ligands |
AU2015357167B2 (en) | 2014-12-03 | 2020-06-25 | Janssen Pharmaceutica Nv | 6,7-dihydropyrazolo(1,5-alpha)pyrazin-4(5H)-one compounds and their use as negative allosteric modulators of mGluR2 receptors |
JP2016124810A (ja) | 2014-12-26 | 2016-07-11 | 大日本住友製薬株式会社 | 新規縮合ピラゾール誘導体およびその医薬用途 |
ES2820823T3 (es) * | 2015-12-18 | 2021-04-22 | Janssen Pharmaceutica Nv | Ligandos PET mGluR2/3 radiomarcados |
HUE050665T2 (hu) | 2015-12-18 | 2020-12-28 | Janssen Pharmaceutica Nv | Radiojelzett MGLUR2/3 PET ligandumok |
-
2016
- 2016-12-16 HU HUE16812961A patent/HUE050665T2/hu unknown
- 2016-12-16 LT LTEP16812961.7T patent/LT3389727T/lt unknown
- 2016-12-16 RS RS20201288A patent/RS60981B1/sr unknown
- 2016-12-16 PT PT168129617T patent/PT3389727T/pt unknown
- 2016-12-16 DK DK16812961.7T patent/DK3389727T3/da active
- 2016-12-16 CA CA3003998A patent/CA3003998A1/en active Pending
- 2016-12-16 SM SM20200591T patent/SMT202000591T1/it unknown
- 2016-12-16 EP EP16812961.7A patent/EP3389727B1/en active Active
- 2016-12-16 US US16/061,437 patent/US11033641B2/en active Active
- 2016-12-16 JP JP2018531628A patent/JP6927974B2/ja active Active
- 2016-12-16 SI SI201630916T patent/SI3389727T1/sl unknown
- 2016-12-16 ES ES16812961T patent/ES2828976T3/es active Active
- 2016-12-16 WO PCT/EP2016/081542 patent/WO2017103182A1/en active Application Filing
- 2016-12-16 AU AU2016374571A patent/AU2016374571B2/en not_active Ceased
- 2016-12-16 PL PL16812961T patent/PL3389727T3/pl unknown
-
2020
- 2020-08-28 HR HRP20201372TT patent/HRP20201372T1/hr unknown
- 2020-11-09 CY CY20201101051T patent/CY1124935T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP3389727A1 (en) | 2018-10-24 |
AU2016374571A1 (en) | 2018-05-17 |
US11033641B2 (en) | 2021-06-15 |
ES2828976T3 (es) | 2021-05-28 |
SMT202000591T1 (it) | 2020-11-10 |
PL3389727T3 (pl) | 2021-02-08 |
WO2017103182A1 (en) | 2017-06-22 |
PT3389727T (pt) | 2020-10-30 |
JP6927974B2 (ja) | 2021-09-01 |
US20200306389A1 (en) | 2020-10-01 |
LT3389727T (lt) | 2020-10-12 |
CA3003998A1 (en) | 2017-06-22 |
DK3389727T3 (da) | 2020-11-02 |
CY1124935T1 (el) | 2022-07-22 |
SI3389727T1 (sl) | 2020-10-30 |
AU2016374571B2 (en) | 2021-05-06 |
HRP20201372T1 (hr) | 2020-11-27 |
EP3389727B1 (en) | 2020-08-12 |
JP2019502700A (ja) | 2019-01-31 |
RS60981B1 (sr) | 2020-11-30 |
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