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CY1124935T1 - Ραδιοσημασμενα mglur2/3 προσδεματα για pet - Google Patents

Ραδιοσημασμενα mglur2/3 προσδεματα για pet

Info

Publication number
CY1124935T1
CY1124935T1 CY20201101051T CY201101051T CY1124935T1 CY 1124935 T1 CY1124935 T1 CY 1124935T1 CY 20201101051 T CY20201101051 T CY 20201101051T CY 201101051 T CY201101051 T CY 201101051T CY 1124935 T1 CY1124935 T1 CY 1124935T1
Authority
CY
Cyprus
Prior art keywords
compounds
mglur2
radiolabeled
pet
compositions
Prior art date
Application number
CY20201101051T
Other languages
English (en)
Inventor
José Ignacio Andrés-Gil
Michiel Luc Maria Van Gool
Guy Maurits R. Bormans
Joost Verbeek
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of CY1124935T1 publication Critical patent/CY1124935T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Η παρούσα εφεύρεση σχετίζεται με καινοτόμα, ραδιοσημασμένα mGluR2/3 προσδέματα, επιλεκτικά 5 έναντι άλλων mGlu υποδοχέων, που είναι χρήσιμα για την απεικόνιση και ποσοτικοποίηση των μεταβοτροπικών υποδοχέων γλουταμινικού οξέος mGlu2 και 3 σε ιστούς, με χρήση τομογραφίας εκπομπής ποζιτρονίων (PET). Η εφεύρεση κατευθύνεται επίσης προς συνθέσεις οι οποίες συνίστανται στις εν λόγω ενώσεις, προς διεργασίες για την παρασκευή των εν λόγω ενώσεων και συνθέσεων, προς τη χρήση των εν λόγω ενώσεων και συνθέσεων για την απεικόνιση ενός ιστού, κυττάρων ή θηλαστικού in vitro ή 10 in vivo και προς τους προδρόμους αυτών των ενώσεων.
CY20201101051T 2015-12-18 2020-11-09 Ραδιοσημασμενα mglur2/3 προσδεματα για pet CY1124935T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15201240 2015-12-18
PCT/EP2016/081542 WO2017103182A1 (en) 2015-12-18 2016-12-16 Radiolabelled mglur2/3 pet ligands

Publications (1)

Publication Number Publication Date
CY1124935T1 true CY1124935T1 (el) 2022-07-22

Family

ID=55023944

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20201101051T CY1124935T1 (el) 2015-12-18 2020-11-09 Ραδιοσημασμενα mglur2/3 προσδεματα για pet

Country Status (17)

Country Link
US (1) US11033641B2 (el)
EP (1) EP3389727B1 (el)
JP (1) JP6927974B2 (el)
AU (1) AU2016374571B2 (el)
CA (1) CA3003998A1 (el)
CY (1) CY1124935T1 (el)
DK (1) DK3389727T3 (el)
ES (1) ES2828976T3 (el)
HR (1) HRP20201372T1 (el)
HU (1) HUE050665T2 (el)
LT (1) LT3389727T (el)
PL (1) PL3389727T3 (el)
PT (1) PT3389727T (el)
RS (1) RS60981B1 (el)
SI (1) SI3389727T1 (el)
SM (1) SMT202000591T1 (el)
WO (1) WO2017103182A1 (el)

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JOP20150177B1 (ar) 2014-08-01 2021-08-17 Janssen Pharmaceutica Nv مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2
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Also Published As

Publication number Publication date
DK3389727T3 (da) 2020-11-02
US20200306389A1 (en) 2020-10-01
HRP20201372T1 (hr) 2020-11-27
ES2828976T3 (es) 2021-05-28
SMT202000591T1 (it) 2020-11-10
CA3003998A1 (en) 2017-06-22
WO2017103182A1 (en) 2017-06-22
HUE050665T2 (hu) 2020-12-28
PL3389727T3 (pl) 2021-02-08
AU2016374571B2 (en) 2021-05-06
SI3389727T1 (sl) 2020-10-30
AU2016374571A1 (en) 2018-05-17
EP3389727A1 (en) 2018-10-24
US11033641B2 (en) 2021-06-15
JP2019502700A (ja) 2019-01-31
EP3389727B1 (en) 2020-08-12
RS60981B1 (sr) 2020-11-30
JP6927974B2 (ja) 2021-09-01
PT3389727T (pt) 2020-10-30
LT3389727T (lt) 2020-10-12

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