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HUE034598T2 - Vegyület rák kezelésére - Google Patents

Vegyület rák kezelésére Download PDF

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Publication number
HUE034598T2
HUE034598T2 HUE15168526A HUE15168526A HUE034598T2 HU E034598 T2 HUE034598 T2 HU E034598T2 HU E15168526 A HUE15168526 A HU E15168526A HU E15168526 A HUE15168526 A HU E15168526A HU E034598 T2 HUE034598 T2 HU E034598T2
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HU
Hungary
Prior art keywords
compound
cancer
administered
use according
compounds
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HUE15168526A
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English (en)
Inventor
Duane D Miller
Li Wei
Zhao Wang
Yan Lu
Jianjun Chen
James T Dalton
Chien Ming Li
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Univ Tennessee Res Found
Univ Ohio State Res Found
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Application filed by Univ Tennessee Res Found, Univ Ohio State Res Found filed Critical Univ Tennessee Res Found
Publication of HUE034598T2 publication Critical patent/HUE034598T2/hu

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    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A61K31/4164—1,3-Diazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A—HUMAN NECESSITIES
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07—ORGANIC CHEMISTRY
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    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
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    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms
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    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Claims (17)

Vegyidet rák kezelésére Szabadalmi igénypontok
1. Vegyidet, ahol a vegyüleí (2n lHnndol-3di)irrndazol~4dí}(3í4,54rimeíoxitentl )metaíiotn
2. Gyógyászati készítmény, mely egy í. Igénypont szerinti vegyüieteí és egy gyógyászatílag elfogadható hordozót tartalmaz.
3. Kgy I. igénypont szerinti vegyüleí gyógyszerként történő alkalmazásra.
4. Egy I, igénypont szerinti vegyüleí alkalmazása prosztatarák, tüdőrák, végbéírák, leukémia, veserák vagy központi idegrendszeri rák, vagy ezek kombinációi kezelésére szolgáló gyógyszer előállítására.
5. A 4. igénypont szerinti alkalmazás, ahol a gyógyszert sysiemásan adagoljuk.
6. A <4, igénypont szerinti alkalmazás, ahol a gyógyszert orálisan, transzdermálisan, parenterálisan, szubkután, intravénásán, intramuszkuiárisan, intraperitoneáüsan, orrba csepegtetve, íntracavitárisan vagy intravesikálisan csepegtetve, intraokuiárisan, iniraaríeriálisan, intraíezkmálisan vagy a nyálkahártyára történő felvitellel adagoljuk.
7. A 4. igénypont szerinti alkalmazás, ahol a gyógyszert közvetlenül a rákos sejtek jelenlétének helyére adagoljuk.
8. A 4. igénypont szerinti alkalmazás, ahol a gyógyszert körülbelül 0.01 és körülbelül 100 mg vegyüiet/testsúly kg közötti dózisban adagoljuk,
9. A 4. igénypont szerinti alkalmazás, ahol a gyógyszert periodikusan adagoljuk,
10. A 4. igénypont szerinti alkalmazás, ahol a gyógyszert egy másik rákterápiával kombinálva adagoljuk.
11. Az 1. igénypont szerinti vegyidet prosztatarák, tüdőrák, végbéirák, leukémia, veserák vagy központi idegrendszeri rák, vagy ezek kombinációi kezdésében történő alkalmazásra.
12. A vegyület a 11. igénypont szerinti alkalmazásra, ahol. a vegyületei systemásan adagoljuk,
13. A vegyület all. igénypont szerinti alkalmazásra, ahol a vegyületet orálisan, transzdermáiisan, parenteráiisan, szubkután, intravénásán, intramuszkulárisan, Intraperitoneálisaii:, orrba csepegtetve, íntracavítarisan vagy intravesíkáliaan csepegtetve, intraokuíárisan, intraarleriálisan, intralezionálisan vagy a nyálkahártyára történő felvitellel adagoljuk,
14. A vegyidet all. igénypont szerinti alkalmazásra, ahol a vegyületei közvetlenül a rákos sejtek jelenlétének helyére adagoljuk.....
15. A vegyület all. igénypont szerinti alkalmazásra, ahol a vegyületet körülbelüli Ö.Oi és körülbelül 100 mg vegyüíet/testsűly kg közötti dózisban adagoljuk.
16. A vegyület a Π. igénypont szerinti alkalmazásra, ahol a vegyületet periodikusan, adagoljuk.
17. A vegyület all. igénypont szerinti alkalmazásra, ahol a vegyületet egy másik rákterápiával kombinálva adagoljuk.
HUE15168526A 2008-06-16 2009-06-16 Vegyület rák kezelésére HUE034598T2 (hu)

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HUE15168526A HUE034598T2 (hu) 2008-06-16 2009-06-16 Vegyület rák kezelésére
HUE17196904A HUE060249T2 (hu) 2008-06-16 2009-06-16 Vegyületek rák kezelésére

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US (2) US8592465B2 (hu)
EP (3) EP3289876B1 (hu)
JP (2) JP5507552B2 (hu)
KR (4) KR20110022672A (hu)
CN (2) CN104610230A (hu)
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