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HUE027165T2 - Emberi antitestek, amelyek kötnek CXCR4-et, és felhasználásaik - Google Patents

Emberi antitestek, amelyek kötnek CXCR4-et, és felhasználásaik Download PDF

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Publication number
HUE027165T2
HUE027165T2 HUE07867192A HUE07867192A HUE027165T2 HU E027165 T2 HUE027165 T2 HU E027165T2 HU E07867192 A HUE07867192 A HU E07867192A HU E07867192 A HUE07867192 A HU E07867192A HU E027165 T2 HUE027165 T2 HU E027165T2
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antibody
cxcr4
antibodies
human
seq
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HUE07867192A
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Michelle Kuhne
Peter Brams
Dawn M Tanamachi
Alan Korman
Josephine M Cardarelli
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Squibb & Sons Llc
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Application filed by Squibb & Sons Llc filed Critical Squibb & Sons Llc
Publication of HUE027165T2 publication Critical patent/HUE027165T2/hu

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • C07K—PEPTIDES
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    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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Claims (8)

  1. Szabstdalmi igénypontok t Emberi monotdfet atîtitest, vagy axmak aráigéxtkótó x&m·.. amely ^eciSfcusan k,öt natív .Emberi CXi3K.41tez, amely sebmlnietert van eapresszalva es tartalmaz: xtehez láncé variábilis régiót CDiéi, amely tartalmaz atnmosavakat, amelyeknek vas SEQ ID NO: i-bea felsorolt 8zeSrv«cíája; aeMat Dacé variábilis régiót CDR2, amely tarcafmaz ammosavakat, amelyeknek van SEQ ID NO: 5-ixm felsorolt szelevc&csp; mkéz láncé variábilis régtől €DR3, amely tartalmas aminosavakat, antslyekxtek yars SEQ ID NO; 9~»en Mwdh szefeveacïàja; kiknyli láncé variábilis régiós CDRL amely tartalmas axnmnsavakst amelyeknek van SEQ 1D NO: B-b&n felsorolt: szekvenciái»; kfesnyii láncé variábilis régiós CDR?. amely tartalmas axeltmsavakat, amelyeknek. %m SEQ 10 NO: 17-hen felsorolt: szekvenmaife és kénnyé láncé variábilis régiós CD1R3, amely tartalmas amlsmsavakat, amelyeknek: van SEQ ID NO: 21 -bee felsorolt: szekvenciája.
  2. 2, As I,, igénypottc szerimi mérnökiért amtiert, vagy stmak »ntlgénkótó része, amely tartalmaz; neben láncé variábilis régiót, amely tartalmaz amtsosavakal:, amelyeknek. van SEQ ID NO: 25-bsxi felsorolt .szekvenciája és könnyé láncé variábilis régiós, amely tartalmaz amrnosavskat, amelyeknek vas SEQ 10 NO: 29-ben felsorolt szekvenciáta,
  3. 3, Az k vagy 2. igénygom: szérián mono klón antitest ahol a mostoklön antitest teljes hosszúságú artsätest. 4, A .3, igénypont szerinti mérnökiért antitest, ahol a mossoklőn antitest IgO I - vagy Íg04 jgotípus.
    3, Az I, vagy 2. igOryportt szerinti monokliért antitest enttgéakdté rész, ahol az anitgétlköiö rész Fan iapneai, F(ah!}:·. fisgmerst Eab‘ Iragnsoxtt, fá fisgörent Fv Iragment, vagy scEv,
  4. 6, Az 3.. Igénypont.szerinti monokli® antitest ardigétfebtó fesz, ahol az afeigénkötó fesz i (sb');· fesgtmmt. X lémmnkmijegák amely tartalmazza az 1-6.· igétryoottfek bámtelylke szerinti monokli® smtitesfet, vagy annak atfegértkeíó részét, amely terápiás szerhez van kötve; opcionálisán. áttol a tetép sás szer citotoxfe vagy radioaktív izoiipus, $, Blspeeifikus molekula, amely tartalmaz» az 1-6.. ig&typom szerinti mtmbfcl&n antitestek vagy annak attágéakőSS feszég amely egy második Innkefenális résszel van összekötve, amelynek küiötsbözo kötési specific kása vnn, mbit; a mpsmklon afeliestifek vagy mmak arttigéPkóló feszénck:
  5. 9. Nompozidó, amely tartalmaz gyögysserészehfeg dvbgndható hordozóanyagot és vágy (a) az 1-6, igênypmwk bármelyike szerinti meamkiön antitestet vagy amtak antigénkötö részét; •bt » 7. igénysmnt szerinti imtmmlosmugatot; vagy (o) a i>> igénypont szerinti bispeciritoas molekulát 1Ó. Izolált rsokieihsav,: amely kódolta az 1-6. igénypontok bármelyike szerinti monokiótt antitestei:, ·; .-.gy tarnak aotigénkótó részét.
    1. Express®© vektor. amely tartalmazza a Kl. igénypontszerinti naMeinsavat
  6. 12. Host sett, anxtly ga*Mattz$s a 11, igénypíxnt szemá expresszié vektort.
  7. 13. Eljárás atm-CX€.R4 astfeest, vagy annak anbgénköto része előállítására, amely tamtesaszsa· a* antitest vagy annak arálgéakötő tészimk ekpresszálását a 12.. igénypont -szeri«« host sejifcea és az antitest vagy annak anilgexskolö része izolálását a kost sebből, 14. ín-vlim eljárás E5ÍC14 aktivitás mobtxiálására sejtlres, amely tarlaimszza a sejt koatakiálásáí az 1-6, igénypoxtíok bárasdyíke szerinti Mörioktéa· aiőarsite!, vagy annak sníígéxiköíö részévek úgy hogy a CXCK4 aktivitás·.« sejtben mcsdulálva veit; opcionálisan ahol: (a) a sejt tantor sejt, amely expresszáí CXCM-et és az eljárás a lantot' sejt növekedésének, gátlását vagy a üaoor sejt meiasztézisának gátlását eredményezi; (l>) a sejt T sejt, amely eypresszál €X€R4n: és az eljárás HÍV bslépéséxmk gátlásár a sejtbe emthnényszi;: (n) a sejt egy limfedta gyulladásos rendellenességben és az eljárás gyulladás gátlását eredményezi; vagy (à)· a sejt be van vonva a vasenlsrizáeiobíí és-angiogeneeb modulációját eredeményezk
  8. 15. Az Hé, igérrypontek bármelyike szerinti taosoklón axttltesu vagy annak anbgéxtkötő része, ieihaszaáiásra CXC1Í4 aktivitás nmdaiálásra alany sejtjében, ahol: ja) a sejt tumor sejt, amely s&ptm®M €X€R4-et és az eljárás a .tumor sejt riovekedósémm. gátlását vagy a mmrn sejt matasztáztsánsk gátlását eredményezi alanyban; (bt a sejt T sejt, amely ezpusszái €X€R.4-i és az eljárás HÍV belépésének gátlását a sejtbe eredményez!; alanyban jé) a sejt egy lirnibcita gyulladásos remiellenességben és az éijásás a gyulladás gátlását eredtnényezi alanyban; vagy (à): a sejt be van vonva a vaseularizáeiőba és axtglogenezis módújáé lóját eredeményezi alanyban, ib. A 15. igextypont szerinti monoklik aníhesi vagy annak anhgénkőső része, felhasználásra, .ahol a tumor sejt ki van választva mellrák, petefészek rák, prosztata rák, nsrn kissejtes fűdé rák, hasnyálmirigy rák, pajzsmirigy rák, naaopbarpgealis karelnosna, mdenoma, vese sejt kmcinoxoa. lynxphoma,: nemoblasztoma, gkoidasztprea, rhabdontyoszarkéma, ooloreksábs rák, vese rák, osteoszaíkóma, akut lymphoblast leukémia, akut myeloid leukémia, kissejtes tudó kareinorna, és meiastattkos lödé rák sejtjéből; {7, Az 1 -6. igénypontok bármelyike szerintt namokhm antitest, vagy annak axtfígénkóie része feihaszsxálásra transzplanfáeios eljárásban, amely tartalmazza CD34" őssejtek möbillzátásáoák siisnulálását csontvelőből perifériás: védte; opcionálisan ahol az eljárás továbbá tartalmazza a €104"' őssejtek gynjtesét a periled ás vérből.
HUE07867192A 2006-10-02 2007-10-01 Emberi antitestek, amelyek kötnek CXCR4-et, és felhasználásaik HUE027165T2 (hu)

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SG178712A1 (en) * 2006-10-02 2012-03-29 Medarex Inc Human antibodies that bind cxcr4 and uses thereof
FR2915102B1 (fr) * 2007-04-23 2014-05-16 Pf Medicament Utilisation d'un anticorps anti-cxcr4 pour le traitement du cancer
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