HRP950096B1 - Process for making an epoxide - Google Patents

Process for making an epoxide

Info

Publication number: HRP950096B1
Authority: HR; Croatia
Prior art keywords: epoxide; making; renin; proteases; synthesizing
Prior art date: 1994-03-04

Application number

HR950096A

Other languages

English (en)

Inventor

David Askin

Kan K Eng

Peter E Maligres

Paul J Reider

Kai Rossen

Ralph P Volante

Veena Upadhyay

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-03-04

Filing date

1995-03-02

Publication date

2002-06-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22764868&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP950096(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1995-03-02 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1997-06-30 Publication of HRP950096A2 publication Critical patent/HRP950096A2/hr

2002-06-30 Publication of HRP950096B1 publication Critical patent/HRP950096B1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Virology (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
AIDS & HIV (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epoxy Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

HR950096A 1994-03-04 1995-03-02 Process for making an epoxide HRP950096B1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US20607494A	1994-03-04	1994-03-04

Publications (2)

Publication Number	Publication Date
HRP950096A2 HRP950096A2 (en)	1997-06-30
HRP950096B1 true HRP950096B1 (en)	2002-06-30

Family

ID=22764868

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR950096A HRP950096B1 (en)	1994-03-04	1995-03-02	Process for making an epoxide

Country Status (25)

Country	Link
EP (1)	EP0748319B1 (sv)
JP (1)	JP3871705B2 (sv)
KR (1)	KR100387741B1 (sv)
CN (1)	CN1066728C (sv)
AT (1)	ATE210662T1 (sv)
AU (1)	AU690231B2 (sv)
BR (1)	BR9506977A (sv)
CA (1)	CA2183976C (sv)
CZ (1)	CZ291816B6 (sv)
DE (1)	DE69524578T2 (sv)
DK (1)	DK0748319T3 (sv)
ES (1)	ES2167419T3 (sv)
FI (1)	FI120259B (sv)
HR (1)	HRP950096B1 (sv)
HU (1)	HU222750B1 (sv)
MX (1)	MX9603871A (sv)
NZ (1)	NZ281866A (sv)
PT (1)	PT748319E (sv)
RO (1)	RO117696B1 (sv)
RU (1)	RU2137769C1 (sv)
SK (1)	SK283067B6 (sv)
TW (1)	TW380137B (sv)
UA (1)	UA45968C2 (sv)
WO (1)	WO1995023797A1 (sv)
YU (1)	YU49010B (sv)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5728840A (en) *	1994-03-04	1998-03-17	Merck & Co., Inc.	Process for making an epoxide
TW415948B (en) *	1995-10-30	2000-12-21	Merck & Co Inc	Process for synthesizing epoxide and halohydrin
US5981759A (en) *	1997-06-20	1999-11-09	Merck & Co., Inc.	Process for indinavir intermediate
NZ568068A (en)	2005-11-09	2011-10-28	Proteolix Inc	Compounds for enzyme inhibition
SI2041158T1 (sl)	2006-06-19	2013-09-30	Onyx Therapeutics, Inc.	Peptidni epoksiketoni za inhibicijo proteasomov
AU2008307510A1 (en)	2007-10-04	2009-04-09	Onyx Therapeutics, Inc.	Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides
US20110236428A1 (en)	2008-10-21	2011-09-29	Onyx Therapeutics, Inc.	Combination therapy with peptide epoxyketones
TWI504598B (zh)	2009-03-20	2015-10-21	Onyx Therapeutics Inc	結晶性三肽環氧酮蛋白酶抑制劑
WO2011060179A1 (en)	2009-11-13	2011-05-19	Onyx Therapeutics, Inc	Use of peptide epoxyketones for metastasis suppression
US9359398B2 (en)	2010-03-01	2016-06-07	Onyx Therapeutics, Inc.	Compounds for immunoproteasome inhibition
SG185103A1 (en) *	2010-04-30	2012-12-28	Univ Indiana Res & Tech Corp	Processes for preparing linezolid
TW201414751A (zh)	2012-07-09	2014-04-16	歐尼克斯治療公司	肽環氧酮蛋白酶抑制劑之前驅藥物
CN104692987B (zh) *	2015-01-22	2017-05-17	北京大学	卤代醇及其衍生物的廉价高效合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2072237A1 (en) *	1991-07-02	1993-01-03	Merck & Co., Inc.	Stereoselective production of hydroxyamide compounds from chiral -amino epoxides
SG52731A1 (en) *	1991-11-08	1998-09-28	Merck & Co Inc	Hiv protease inhibitors useful for the treatment of aids

1995
- 1995-02-24 TW TW084101733A patent/TW380137B/zh not_active IP Right Cessation
- 1995-02-27 PT PT95911105T patent/PT748319E/pt unknown
- 1995-02-27 RO RO96-01750A patent/RO117696B1/ro unknown
- 1995-02-27 BR BR9506977A patent/BR9506977A/pt not_active IP Right Cessation
- 1995-02-27 CN CN95192714A patent/CN1066728C/zh not_active Expired - Lifetime
- 1995-02-27 EP EP95911105A patent/EP0748319B1/en not_active Expired - Lifetime
- 1995-02-27 MX MX9603871A patent/MX9603871A/es unknown
- 1995-02-27 AT AT95911105T patent/ATE210662T1/de active
- 1995-02-27 SK SK1122-96A patent/SK283067B6/sk not_active IP Right Cessation
- 1995-02-27 HU HU9602412A patent/HU222750B1/hu not_active IP Right Cessation
- 1995-02-27 NZ NZ281866A patent/NZ281866A/en not_active IP Right Cessation
- 1995-02-27 DK DK95911105T patent/DK0748319T3/da active
- 1995-02-27 WO PCT/US1995/002347 patent/WO1995023797A1/en active IP Right Grant
- 1995-02-27 DE DE69524578T patent/DE69524578T2/de not_active Expired - Lifetime
- 1995-02-27 ES ES95911105T patent/ES2167419T3/es not_active Expired - Lifetime
- 1995-02-27 CA CA002183976A patent/CA2183976C/en not_active Expired - Fee Related
- 1995-02-27 RU RU96120179A patent/RU2137769C1/ru not_active IP Right Cessation
- 1995-02-27 KR KR1019960704836A patent/KR100387741B1/ko not_active Expired - Fee Related
- 1995-02-27 UA UA96103798A patent/UA45968C2/uk unknown
- 1995-02-27 AU AU18828/95A patent/AU690231B2/en not_active Ceased
- 1995-02-27 CZ CZ19962543A patent/CZ291816B6/cs not_active IP Right Cessation
- 1995-02-27 JP JP52294995A patent/JP3871705B2/ja not_active Expired - Fee Related
- 1995-03-02 HR HR950096A patent/HRP950096B1/xx not_active IP Right Cessation
- 1995-03-03 YU YU14595A patent/YU49010B/sh unknown
1996
- 1996-09-03 FI FI963452A patent/FI120259B/sv not_active IP Right Cessation

Also Published As

Publication number	Publication date
MX9603871A (es)	1997-07-31
HUT75611A (en)	1997-05-28
HU222750B1 (hu)	2003-09-29
RU2137769C1 (ru)	1999-09-20
YU14595A (sh)	1997-12-05
JPH09509929A (ja)	1997-10-07
BR9506977A (pt)	1997-09-02
KR970701714A (ko)	1997-04-12
FI963452A0 (sv)	1996-09-03
HU9602412D0 (en)	1996-11-28
TW380137B (en)	2000-01-21
CZ291816B6 (cs)	2003-06-18
KR100387741B1 (ko)	2003-10-04
CA2183976A1 (en)	1995-09-08
CN1146768A (zh)	1997-04-02
CZ254396A3 (en)	1997-01-15
NZ281866A (en)	1998-05-27
DE69524578D1 (de)	2002-01-24
FI120259B (sv)	2009-08-31
UA45968C2 (uk)	2002-05-15
YU49010B (sh)	2003-04-30
AU1882895A (en)	1995-09-18
PT748319E (pt)	2002-05-31
DK0748319T3 (da)	2002-03-18
SK112296A3 (en)	1997-02-05
HRP950096A2 (en)	1997-06-30
ES2167419T3 (es)	2002-05-16
FI963452L (sv)	1996-09-03
CA2183976C (en)	2005-02-01
ATE210662T1 (de)	2001-12-15
SK283067B6 (sk)	2003-02-04
CN1066728C (zh)	2001-06-06
WO1995023797A1 (en)	1995-09-08
RO117696B1 (ro)	2002-06-28
AU690231B2 (en)	1998-04-23
DE69524578T2 (de)	2002-07-18
JP3871705B2 (ja)	2007-01-24
EP0748319A1 (en)	1996-12-18
EP0748319B1 (en)	2001-12-12

Publication	Publication Date	Title
BRPI0013885B8 (pt)	2021-05-25	comprimidos aperfeiçoados
HUT75611A (en)	1997-05-28	Process for making an epoxide
NZ237132A (en)	1993-04-28	Preparation of substituted oxetanones from beta-hydroxy-omega-lactones; various beta-hydroxy and beta-keto-omega-lactones
IL160440A (en)	2009-09-01	Dihydropteridinones, method for producing the same and the use thereof as medicaments
HU9601857D0 (en)	1996-08-28	New benzyl-piperidine- or -tetrahydro-pyridine derivatives and processes for producing them
HU9302331D0 (en)	1993-10-28	New method for producing 7-(substituted)-9-\|(substituted glycyl)-amido¨-6-desmethyl-6-desoxy-tetracyclines
WO2002055383A3 (en)	2002-10-03	Monolithic part and process for making the same
WO2001057014A3 (en)	2002-04-18	Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one
CA2333192A1 (en)	2001-08-04	Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-2h-pyran-2-one
YU55900A (sh)	2003-02-28	Postupak za sintezu inhibitora hiv proteaze
YU45896A (sh)	1999-06-15	Postupak za dobijanje epoksida
LV12825B (lv)	2002-09-20	Hiv proteāzes inhibitora iegūšana
HUP9903318A2 (hu)	2000-06-28	Intermedierek taxol előállítására
IL151168A0 (en)	2003-04-10	Process for producing a pentacyclic compound as an intermediate for the production of ecteinascidin and phthalascidin compounds
IT1309601B1 (it)	2002-01-24	Processo per la preparazione di 1,4,7,10 tetraazaciclododecano.
GB2369356B (en)	2004-02-04	Process
YU37902A (sh)	2005-07-19	Supstituisani 1,2,3,4,5,6-heksahidro-2,6-metano-3- benzazocini i njihova primena kao lekova
TW200420553A (en)	2004-10-16	Process for the synthesis of 3, 3a, 6, 6a-tetrahydro-2H-cyclopentan[b]furan-2-one
MY115259A (en)	2003-04-30	Process for the preparation of nmda antagonists
MXPA04004537A (es)	2004-08-11	Derivados de gabusectina, metodo para produccion de los mismos y uso de los mismos.
TW200611691A (en)	2006-04-16	Retroviral protease inhibiting compounds
IL152387A0 (en)	2003-05-29	Production of 2-ethyl-3-methyl-1,4-diazine
MX9708347A (es)	1998-05-31	Polieter polialcoholes iniciados por amina y un procedimiento para su preparacion.

Legal Events

Date	Code	Title	Description
1997-06-30	A1OB	Publication of a patent application
1997-12-23	AIPI	Request for the grant of a patent on the basis of a substantive examination of a patent application
2002-06-30	B1PR	Patent granted
2010-04-08	PNAN	Change of the applicant name, address/residence	Owner name: MERCK SHARP & DOHME CORP., US
2012-02-29	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20120229 Year of fee payment: 18
2013-09-05	PBON	Lapse due to non-payment of renewal fee	Effective date: 20130303