BR9506977A - Processo para sintetizar um epóxido e composto - Google Patents

Processo para sintetizar um epóxido e composto

Info

Publication number: BR9506977A
Authority: BR; Brazil
Prior art keywords: epoxide; synthesizing; compound; renin; proteases
Prior art date: 1994-03-04

Application number

BR9506977A

Other languages

English (en)

Inventor

David Askin

Kan K Eng

Peter E Maligres

Paul J Reider

Kai Rossen

Ralph P Volante

Veena Upadhyay

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-03-04

Filing date

1995-02-27

Publication date

1997-09-02

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22764868&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9506977(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1995-02-27 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1997-09-02 Publication of BR9506977A publication Critical patent/BR9506977A/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Veterinary Medicine (AREA)
Virology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
AIDS & HIV (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epoxy Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyridine Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

BR9506977A 1994-03-04 1995-02-27 Processo para sintetizar um epóxido e composto BR9506977A (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US20607494A	1994-03-04	1994-03-04
PCT/US1995/002347 WO1995023797A1 (en)	1994-03-04	1995-02-27	Process for making an epoxide

Publications (1)

Publication Number	Publication Date
BR9506977A true BR9506977A (pt)	1997-09-02

Family

ID=22764868

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR9506977A BR9506977A (pt)	1994-03-04	1995-02-27	Processo para sintetizar um epóxido e composto

Country Status (25)

Country	Link
EP (1)	EP0748319B1 (pt)
JP (1)	JP3871705B2 (pt)
KR (1)	KR100387741B1 (pt)
CN (1)	CN1066728C (pt)
AT (1)	ATE210662T1 (pt)
AU (1)	AU690231B2 (pt)
BR (1)	BR9506977A (pt)
CA (1)	CA2183976C (pt)
CZ (1)	CZ291816B6 (pt)
DE (1)	DE69524578T2 (pt)
DK (1)	DK0748319T3 (pt)
ES (1)	ES2167419T3 (pt)
FI (1)	FI120259B (pt)
HR (1)	HRP950096B1 (pt)
HU (1)	HU222750B1 (pt)
MX (1)	MX9603871A (pt)
NZ (1)	NZ281866A (pt)
PT (1)	PT748319E (pt)
RO (1)	RO117696B1 (pt)
RU (1)	RU2137769C1 (pt)
SK (1)	SK283067B6 (pt)
TW (1)	TW380137B (pt)
UA (1)	UA45968C2 (pt)
WO (1)	WO1995023797A1 (pt)
YU (1)	YU49010B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5728840A (en) *	1994-03-04	1998-03-17	Merck & Co., Inc.	Process for making an epoxide
TW415948B (en) *	1995-10-30	2000-12-21	Merck & Co Inc	Process for synthesizing epoxide and halohydrin
US5981759A (en) *	1997-06-20	1999-11-09	Merck & Co., Inc.	Process for indinavir intermediate
SI2623113T1 (sl)	2005-11-09	2017-08-31	Onyx Therapeutics, Inc.	Spojina za inhibicijo encimov
NZ597545A (en)	2006-06-19	2013-07-26	Proteolix Inc	Peptide epoxyketones for proteasome inhibition
PL2207791T5 (pl)	2007-10-04	2020-07-27	Onyx Therapeutics, Inc.	Krystaliczne peptydo- epoksy ketonowe inhibitory proteazy i synteza keto-epoksydów Aminokwasowych
KR20110073584A (ko)	2008-10-21	2011-06-29	오닉스 세라퓨틱스, 인크.	펩티드 에폭시케톤과의 병용 요법
TWI504598B (zh)	2009-03-20	2015-10-21	Onyx Therapeutics Inc	結晶性三肽環氧酮蛋白酶抑制劑
EP2498793B1 (en)	2009-11-13	2019-07-10	Onyx Therapeutics, Inc.	Oprozomib for use in metastasis suppression
EP2542238B1 (en)	2010-03-01	2015-08-12	Onyx Therapeutics, Inc.	Compounds for immunoproteasome inhibition
BR112012027901A2 (pt) *	2010-04-30	2015-09-08	Univ Indiana Res & Tech Corp	processos para preparar linezolida
US9309283B2 (en)	2012-07-09	2016-04-12	Onyx Therapeutics, Inc.	Prodrugs of peptide epoxy ketone protease inhibitors
CN104692987B (zh) *	2015-01-22	2017-05-17	北京大学	卤代醇及其衍生物的廉价高效合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2072237A1 (en) *	1991-07-02	1993-01-03	Merck & Co., Inc.	Stereoselective production of hydroxyamide compounds from chiral -amino epoxides
CA2081970C (en) *	1991-11-08	1997-07-08	Joseph P. Vacca	Hiv protease inhibitors useful for the treatment of aids

1995
- 1995-02-24 TW TW084101733A patent/TW380137B/zh not_active IP Right Cessation
- 1995-02-27 MX MX9603871A patent/MX9603871A/es unknown
- 1995-02-27 BR BR9506977A patent/BR9506977A/pt not_active IP Right Cessation
- 1995-02-27 KR KR1019960704836A patent/KR100387741B1/ko not_active Expired - Fee Related
- 1995-02-27 RO RO96-01750A patent/RO117696B1/ro unknown
- 1995-02-27 JP JP52294995A patent/JP3871705B2/ja not_active Expired - Fee Related
- 1995-02-27 CN CN95192714A patent/CN1066728C/zh not_active Expired - Lifetime
- 1995-02-27 NZ NZ281866A patent/NZ281866A/en not_active IP Right Cessation
- 1995-02-27 HU HU9602412A patent/HU222750B1/hu not_active IP Right Cessation
- 1995-02-27 AU AU18828/95A patent/AU690231B2/en not_active Ceased
- 1995-02-27 DK DK95911105T patent/DK0748319T3/da active
- 1995-02-27 UA UA96103798A patent/UA45968C2/uk unknown
- 1995-02-27 RU RU96120179A patent/RU2137769C1/ru not_active IP Right Cessation
- 1995-02-27 DE DE69524578T patent/DE69524578T2/de not_active Expired - Lifetime
- 1995-02-27 AT AT95911105T patent/ATE210662T1/de active
- 1995-02-27 CZ CZ19962543A patent/CZ291816B6/cs not_active IP Right Cessation
- 1995-02-27 WO PCT/US1995/002347 patent/WO1995023797A1/en active IP Right Grant
- 1995-02-27 ES ES95911105T patent/ES2167419T3/es not_active Expired - Lifetime
- 1995-02-27 SK SK1122-96A patent/SK283067B6/sk not_active IP Right Cessation
- 1995-02-27 CA CA002183976A patent/CA2183976C/en not_active Expired - Fee Related
- 1995-02-27 PT PT95911105T patent/PT748319E/pt unknown
- 1995-02-27 EP EP95911105A patent/EP0748319B1/en not_active Expired - Lifetime
- 1995-03-02 HR HR950096A patent/HRP950096B1/xx not_active IP Right Cessation
- 1995-03-03 YU YU14595A patent/YU49010B/sh unknown
1996
- 1996-09-03 FI FI963452A patent/FI120259B/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69524578D1 (de)	2002-01-24
CA2183976A1 (en)	1995-09-08
PT748319E (pt)	2002-05-31
KR970701714A (ko)	1997-04-12
RU2137769C1 (ru)	1999-09-20
AU690231B2 (en)	1998-04-23
HRP950096A2 (en)	1997-06-30
FI120259B (fi)	2009-08-31
CZ291816B6 (cs)	2003-06-18
DE69524578T2 (de)	2002-07-18
KR100387741B1 (ko)	2003-10-04
SK112296A3 (en)	1997-02-05
NZ281866A (en)	1998-05-27
CN1146768A (zh)	1997-04-02
CA2183976C (en)	2005-02-01
HRP950096B1 (en)	2002-06-30
TW380137B (en)	2000-01-21
EP0748319B1 (en)	2001-12-12
YU14595A (sh)	1997-12-05
JPH09509929A (ja)	1997-10-07
YU49010B (sh)	2003-04-30
MX9603871A (es)	1997-07-31
CN1066728C (zh)	2001-06-06
ATE210662T1 (de)	2001-12-15
JP3871705B2 (ja)	2007-01-24
HUT75611A (en)	1997-05-28
SK283067B6 (sk)	2003-02-04
CZ254396A3 (en)	1997-01-15
ES2167419T3 (es)	2002-05-16
EP0748319A1 (en)	1996-12-18
FI963452A0 (fi)	1996-09-03
UA45968C2 (uk)	2002-05-15
HU222750B1 (hu)	2003-09-29
RO117696B1 (ro)	2002-06-28
FI963452L (fi)	1996-09-03
AU1882895A (en)	1995-09-18
DK0748319T3 (da)	2002-03-18
HU9602412D0 (en)	1996-11-28
WO1995023797A1 (en)	1995-09-08

Publication	Publication Date	Title
DK0443449T3 (da)	1997-11-24	Fremgangsmåde til fremstilling af oxetanoner
BR9506977A (pt)	1997-09-02	Processo para sintetizar um epóxido e composto
NO983099D0 (no)	1998-07-03	Nye retrovirale proteasehemmere
IL160440A (en)	2009-09-01	Dihydropteridinones, method for producing the same and the use thereof as medicaments
TR200001199T2 (tr)	2000-08-21	Oksazolidinonların üretimi için işlem
DK0641333T3 (da)	1996-09-02	Fremgangsmåde til fremstilling af mellemprodukter, som er anvendelige ved syntese af retrovirus- protease-inhibitorer
WO2001057014A3 (en)	2002-04-18	Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one
EA200300804A1 (ru)	2003-12-25	Усовершенствованный способ получения карбапенема
ATE239716T1 (de)	2003-05-15	Synthese von 3,6-dialkyl-5,6-dihydro-4-hydroxy-2h-pyran-2-on
BR9606981A (pt)	1997-11-04	Processo para preparação de intermediários inibidores de protease retroviral
NO975679L (no)	1998-02-02	Fremgangsmåte for fremstilling av N-monosubstituerte og N,N'-disubstituerte, usymmetriske, cykliske ureaer
EA200100040A1 (ru)	2001-06-25	Химический синтез морфолиновых производных
ATE233249T1 (de)	2003-03-15	Verfahren zur herstellung von hiv protease inhibitoren
YU55900A (sh)	2003-02-28	Postupak za sintezu inhibitora hiv proteaze
YU45896A (sh)	1999-06-15	Postupak za dobijanje epoksida
LV12825B (lv)	2002-09-20	Hiv proteāzes inhibitora iegūšana
HUP9903318A2 (hu)	2000-06-28	Intermedierek taxol előállítására
EA199700235A1 (ru)	1998-04-30	Способ получения ингибитора протеазы вич из (2-s)-4-пиколил-2-пиперазин-трет-бутилкарбоксамида
ATE336493T1 (de)	2006-09-15	Tricyclische epoxide
DE69816095D1 (de)	2003-08-07	Herstellung von beta-mehtylcarbapenem-zwischenprodukten

Legal Events

Date	Code	Title	Description
2004-08-03	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
2004-12-07	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
2005-04-19	B07B	Technical examination (opinion): publication cancelled [chapter 7.2 patent gazette]
2005-05-03	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
2006-03-21	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2006-05-23	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 23/05/2006, OBSERVADAS AS CONDICOES LEGAIS.
2011-04-05	B25D	Requested change of name of applicant approved	Owner name: MERCK SHARP AND DOHME CORP. (US) Free format text: NOME ALTERADO DE: MERCK AND CO., INC.
2013-10-08	B22O	Other matters related to patents and certificates of addition of invention: legal action concerning patent	Free format text: INPI-52400.061577/2013 ORIGEM: JUIZO DA 013A VARA FEDERAL DO RIO DE JANEIRO PROCESSO NO 0132353-78.2013.4.02.5101 ACAO DE NULIDADE DAS PATENTES SUBMETIDAS AO MAILBOX (ART. 229, PARAGRAFO UNICO DA LPI); ALTERNATIVAMENTE, A DECRETACAO DA NULIDADE PARCIAL PARA CORRECAO DO PRAZO DE VIGENCIA; SUBSIDIARIAMENTE, CASO SE ENTENDA NAO SER O CASO DE NULIDADE, A CORRECAO DO ATO ADMINISTRATIVO PARA ADEQUACAO DA VIGENCIA DAS PATENTES. AUTOR: INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL - INPI REU: KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO, LONDON BIOTECHNOLOGY LIMITED, MERCK SHARP AND DOHME, N.V. ORGANON, NICOX S.A.
2013-12-17	B21F	Lapse acc. art. 78, item iv - on non-payment of the annual fees in time	Free format text: REFERENTE A 19A ANUIDADE.
2017-05-30	B24J	Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)
2019-10-22	B19A	Notification of judicial decision: notification of judicial decision	Free format text: INPI-52400.061577/2013-10 SECAO JUDICIARIA DO RIO DE JANEIRO 9A VARA FEDERAL DO RIO DE JANEIRO PROCESSO: NO0132353-78.2013.4.02.5101APELANTE: MERCK SHARP AND DOHME CORP E OUTROS APELADO: INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL ? INPI DECISAO: A CONTROVERSIA SOBRE O PRAZO DE VIGENCIA DAS PATENTES MAILBOX FOI DEVIDAMENTE APRECIADA POR ESTE TRIBUNAL NO AMBITO DAS TURMAS ESPECIALIZADAS, ASSIM COMO TAMBEM NO DA SECAO, ALEM DO E. STJ, TENDO SIDO CONSOLIDADO O ENTENDIMENTO NO SENTIDO DE QUE O PARAGRAFO UNICO DO ARTIGO 40 DA LEI NO9.279/96 NAO SE APLICA AS PATENTES ?MAILBOX?, DIANTE DA LIMITACAO ESTABELECIDA PELO ARTIGO 229, PARAGRAFO UNICO, DA MESMA LEI DEVENDO SER APLICADO O PRAZO DE VIGE