DK0748319T3 - Fremgangsmåde til fremstilling af et epoxid - Google Patents

Fremgangsmåde til fremstilling af et epoxid

Info

Publication number: DK0748319T3
Authority: DK; Denmark
Prior art keywords: epoxide; preparing; renin; proteases; synthesizing
Prior art date: 1994-03-04

Application number

DK95911105T

Other languages

Danish (da)

English (en)

Inventor

Ralph P Volante

Kai Rossen

David Askin

Kan K Eng

Peter E Maligres

Paul J Reider

Veena Upadhyay

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-03-04

Filing date

1995-02-27

Publication date

2002-03-18

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22764868&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0748319(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1995-02-27 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

2002-03-18 Application granted granted Critical

2002-03-18 Publication of DK0748319T3 publication Critical patent/DK0748319T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Virology (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Epoxy Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyridine Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

DK95911105T 1994-03-04 1995-02-27 Fremgangsmåde til fremstilling af et epoxid DK0748319T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US20607494A	1994-03-04	1994-03-04
PCT/US1995/002347 WO1995023797A1 (en)	1994-03-04	1995-02-27	Process for making an epoxide

Publications (1)

Publication Number	Publication Date
DK0748319T3 true DK0748319T3 (da)	2002-03-18

Family

ID=22764868

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95911105T DK0748319T3 (da)	1994-03-04	1995-02-27	Fremgangsmåde til fremstilling af et epoxid

Country Status (25)

Country	Link
EP (1)	EP0748319B1 (pt)
JP (1)	JP3871705B2 (pt)
KR (1)	KR100387741B1 (pt)
CN (1)	CN1066728C (pt)
AT (1)	ATE210662T1 (pt)
AU (1)	AU690231B2 (pt)
BR (1)	BR9506977A (pt)
CA (1)	CA2183976C (pt)
CZ (1)	CZ291816B6 (pt)
DE (1)	DE69524578T2 (pt)
DK (1)	DK0748319T3 (pt)
ES (1)	ES2167419T3 (pt)
FI (1)	FI120259B (pt)
HR (1)	HRP950096B1 (pt)
HU (1)	HU222750B1 (pt)
MX (1)	MX9603871A (pt)
NZ (1)	NZ281866A (pt)
PT (1)	PT748319E (pt)
RO (1)	RO117696B1 (pt)
RU (1)	RU2137769C1 (pt)
SK (1)	SK283067B6 (pt)
TW (1)	TW380137B (pt)
UA (1)	UA45968C2 (pt)
WO (1)	WO1995023797A1 (pt)
YU (1)	YU49010B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5728840A (en) *	1994-03-04	1998-03-17	Merck & Co., Inc.	Process for making an epoxide
TW415948B (en) *	1995-10-30	2000-12-21	Merck & Co Inc	Process for synthesizing epoxide and halohydrin
US5981759A (en) *	1997-06-20	1999-11-09	Merck & Co., Inc.	Process for indinavir intermediate
ES2415756T3 (es)	2005-11-09	2013-07-26	Onyx Therapeutics, Inc.	Compuestos para la inhibición de enzimas
WO2007149512A2 (en)	2006-06-19	2007-12-27	Proteolix, Inc.	Peptide epoxyketones for pr0teas0me inhibition
NZ598436A (en)	2007-10-04	2014-03-28	Onyx Therapeutics Inc	Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides
KR20110073584A (ko)	2008-10-21	2011-06-29	오닉스 세라퓨틱스, 인크.	펩티드 에폭시케톤과의 병용 요법
TWI504598B (zh)	2009-03-20	2015-10-21	Onyx Therapeutics Inc	結晶性三肽環氧酮蛋白酶抑制劑
JP5919196B2 (ja)	2009-11-13	2016-05-18	オニキスセラピューティクス，インク．ＯｎｙｘＴｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ．	転移抑制のためのペプチドエポキシケトンの使用
CA2791651C (en)	2010-03-01	2019-08-20	Onyx Therapeutics, Inc.	Compounds for immunoproteasome inhibition
AU2011245302A1 (en)	2010-04-30	2012-11-22	Indiana University Research And Technology Corporation	Processes for preparing linezolid
US9309283B2 (en)	2012-07-09	2016-04-12	Onyx Therapeutics, Inc.	Prodrugs of peptide epoxy ketone protease inhibitors
CN104692987B (zh) *	2015-01-22	2017-05-17	北京大学	卤代醇及其衍生物的廉价高效合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2072237A1 (en) *	1991-07-02	1993-01-03	Merck & Co., Inc.	Stereoselective production of hydroxyamide compounds from chiral -amino epoxides
SG52731A1 (en) *	1991-11-08	1998-09-28	Merck & Co Inc	Hiv protease inhibitors useful for the treatment of aids

1995
- 1995-02-24 TW TW084101733A patent/TW380137B/zh not_active IP Right Cessation
- 1995-02-27 JP JP52294995A patent/JP3871705B2/ja not_active Expired - Fee Related
- 1995-02-27 SK SK1122-96A patent/SK283067B6/sk not_active IP Right Cessation
- 1995-02-27 KR KR1019960704836A patent/KR100387741B1/ko not_active Expired - Fee Related
- 1995-02-27 AU AU18828/95A patent/AU690231B2/en not_active Ceased
- 1995-02-27 HU HU9602412A patent/HU222750B1/hu not_active IP Right Cessation
- 1995-02-27 CA CA002183976A patent/CA2183976C/en not_active Expired - Fee Related
- 1995-02-27 BR BR9506977A patent/BR9506977A/pt not_active IP Right Cessation
- 1995-02-27 EP EP95911105A patent/EP0748319B1/en not_active Expired - Lifetime
- 1995-02-27 AT AT95911105T patent/ATE210662T1/de active
- 1995-02-27 UA UA96103798A patent/UA45968C2/uk unknown
- 1995-02-27 NZ NZ281866A patent/NZ281866A/en not_active IP Right Cessation
- 1995-02-27 DE DE69524578T patent/DE69524578T2/de not_active Expired - Lifetime
- 1995-02-27 CN CN95192714A patent/CN1066728C/zh not_active Expired - Lifetime
- 1995-02-27 WO PCT/US1995/002347 patent/WO1995023797A1/en active IP Right Grant
- 1995-02-27 RU RU96120179A patent/RU2137769C1/ru not_active IP Right Cessation
- 1995-02-27 RO RO96-01750A patent/RO117696B1/ro unknown
- 1995-02-27 ES ES95911105T patent/ES2167419T3/es not_active Expired - Lifetime
- 1995-02-27 CZ CZ19962543A patent/CZ291816B6/cs not_active IP Right Cessation
- 1995-02-27 DK DK95911105T patent/DK0748319T3/da active
- 1995-02-27 MX MX9603871A patent/MX9603871A/es unknown
- 1995-02-27 PT PT95911105T patent/PT748319E/pt unknown
- 1995-03-02 HR HR950096A patent/HRP950096B1/xx not_active IP Right Cessation
- 1995-03-03 YU YU14595A patent/YU49010B/sh unknown
1996
- 1996-09-03 FI FI963452A patent/FI120259B/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2183976C (en)	2005-02-01
FI963452L (fi)	1996-09-03
JP3871705B2 (ja)	2007-01-24
CN1066728C (zh)	2001-06-06
AU690231B2 (en)	1998-04-23
CN1146768A (zh)	1997-04-02
SK112296A3 (en)	1997-02-05
RO117696B1 (ro)	2002-06-28
HUT75611A (en)	1997-05-28
HU9602412D0 (en)	1996-11-28
HU222750B1 (hu)	2003-09-29
WO1995023797A1 (en)	1995-09-08
RU2137769C1 (ru)	1999-09-20
JPH09509929A (ja)	1997-10-07
KR100387741B1 (ko)	2003-10-04
SK283067B6 (sk)	2003-02-04
PT748319E (pt)	2002-05-31
HRP950096B1 (en)	2002-06-30
EP0748319B1 (en)	2001-12-12
KR970701714A (ko)	1997-04-12
DE69524578T2 (de)	2002-07-18
ATE210662T1 (de)	2001-12-15
YU14595A (sh)	1997-12-05
CZ291816B6 (cs)	2003-06-18
NZ281866A (en)	1998-05-27
TW380137B (en)	2000-01-21
MX9603871A (es)	1997-07-31
ES2167419T3 (es)	2002-05-16
FI963452A0 (fi)	1996-09-03
AU1882895A (en)	1995-09-18
CA2183976A1 (en)	1995-09-08
UA45968C2 (uk)	2002-05-15
HRP950096A2 (en)	1997-06-30
DE69524578D1 (de)	2002-01-24
CZ254396A3 (en)	1997-01-15
BR9506977A (pt)	1997-09-02
FI120259B (fi)	2009-08-31
EP0748319A1 (en)	1996-12-18
YU49010B (sh)	2003-04-30

Publication	Publication Date	Title
DK0443449T3 (da)	1997-11-24	Fremgangsmåde til fremstilling af oxetanoner
DK0748319T3 (da)	2002-03-18	Fremgangsmåde til fremstilling af et epoxid
MXPA04002067A (es)	2004-06-07	Nuevas dihidropteridinonas, procedimientos para su preparacion y su uso como medicamento.
DK0641333T3 (da)	1996-09-02	Fremgangsmåde til fremstilling af mellemprodukter, som er anvendelige ved syntese af retrovirus- protease-inhibitorer
PT931083E (pt)	2003-07-31	Processo para a producao de compostos de ecteinascidina
DK0547910T3 (da)	1997-03-24	Fremgangsmåde til fremstilling af 2-chlor-2-deoxyadenosin
WO2001057014A3 (en)	2002-04-18	Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one
MXPA02012471A (es)	2003-06-06	Procedimiento de fabricacion del oxirano que comprende la separacion del oxirano del medio de reaccion.
YU45896A (sh)	1999-06-15	Postupak za dobijanje epoksida
EA200100040A1 (ru)	2001-06-25	Химический синтез морфолиновых производных
LV12825B (lv)	2002-09-20	Hiv proteāzes inhibitora iegūšana
YU55900A (sh)	2003-02-28	Postupak za sintezu inhibitora hiv proteaze
DE69432176D1 (de)	2003-04-03	Verfahren zur herstellung von hiv protease inhibitoren
EA199900772A1 (ru)	2000-04-24	Способ селективного эпоксидирования для получения лекарственных соединений
HUP9903318A2 (hu)	2000-06-28	Intermedierek taxol előállítására
DK1105392T3 (da)	2002-12-30	Fremgangsmåde til fremstilling af mellemprodukter for imidazodiazepin
GB2369356B (en)	2004-02-04	Process
ATE253553T1 (de)	2003-11-15	Verfahren zur herstellung von 2- alkylthiobenzonitril-derivaten
DK1331218T3 (da)	2007-04-10	Fremgangsmåde til fremstilling af beskyttet 3-amino-1,2-dihydroxypropanacetal og derivater deraf
TW200611691A (en)	2006-04-16	Retroviral protease inhibiting compounds