DK0748319T3 - Fremgangsmåde til fremstilling af et epoxid - Google Patents

Fremgangsmåde til fremstilling af et epoxid

Info

Publication number: DK0748319T3
Authority: DK; Denmark
Prior art keywords: epoxide; preparing; renin; proteases; synthesizing
Prior art date: 1994-03-04

Application number

DK95911105T

Other languages

Danish (da)

English (en)

Inventor

Ralph P Volante

Kai Rossen

David Askin

Kan K Eng

Peter E Maligres

Paul J Reider

Veena Upadhyay

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-03-04

Filing date

1995-02-27

Publication date

2002-03-18

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22764868&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0748319(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1995-02-27 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

2002-03-18 Application granted granted Critical

2002-03-18 Publication of DK0748319T3 publication Critical patent/DK0748319T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Virology (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
AIDS & HIV (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epoxy Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

DK95911105T 1994-03-04 1995-02-27 Fremgangsmåde til fremstilling af et epoxid DK0748319T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US20607494A	1994-03-04	1994-03-04
PCT/US1995/002347 WO1995023797A1 (en)	1994-03-04	1995-02-27	Process for making an epoxide

Publications (1)

Publication Number	Publication Date
DK0748319T3 true DK0748319T3 (da)	2002-03-18

Family

ID=22764868

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95911105T DK0748319T3 (da)	1994-03-04	1995-02-27	Fremgangsmåde til fremstilling af et epoxid

Country Status (25)

Country	Link
EP (1)	EP0748319B1 (sv)
JP (1)	JP3871705B2 (sv)
KR (1)	KR100387741B1 (sv)
CN (1)	CN1066728C (sv)
AT (1)	ATE210662T1 (sv)
AU (1)	AU690231B2 (sv)
BR (1)	BR9506977A (sv)
CA (1)	CA2183976C (sv)
CZ (1)	CZ291816B6 (sv)
DE (1)	DE69524578T2 (sv)
DK (1)	DK0748319T3 (sv)
ES (1)	ES2167419T3 (sv)
FI (1)	FI120259B (sv)
HR (1)	HRP950096B1 (sv)
HU (1)	HU222750B1 (sv)
MX (1)	MX9603871A (sv)
NZ (1)	NZ281866A (sv)
PT (1)	PT748319E (sv)
RO (1)	RO117696B1 (sv)
RU (1)	RU2137769C1 (sv)
SK (1)	SK283067B6 (sv)
TW (1)	TW380137B (sv)
UA (1)	UA45968C2 (sv)
WO (1)	WO1995023797A1 (sv)
YU (1)	YU49010B (sv)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5728840A (en) *	1994-03-04	1998-03-17	Merck & Co., Inc.	Process for making an epoxide
TW415948B (en) *	1995-10-30	2000-12-21	Merck & Co Inc	Process for synthesizing epoxide and halohydrin
US5981759A (en) *	1997-06-20	1999-11-09	Merck & Co., Inc.	Process for indinavir intermediate
NZ568068A (en)	2005-11-09	2011-10-28	Proteolix Inc	Compounds for enzyme inhibition
SI2041158T1 (sl)	2006-06-19	2013-09-30	Onyx Therapeutics, Inc.	Peptidni epoksiketoni za inhibicijo proteasomov
AU2008307510A1 (en)	2007-10-04	2009-04-09	Onyx Therapeutics, Inc.	Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides
US20110236428A1 (en)	2008-10-21	2011-09-29	Onyx Therapeutics, Inc.	Combination therapy with peptide epoxyketones
TWI504598B (zh)	2009-03-20	2015-10-21	Onyx Therapeutics Inc	結晶性三肽環氧酮蛋白酶抑制劑
WO2011060179A1 (en)	2009-11-13	2011-05-19	Onyx Therapeutics, Inc	Use of peptide epoxyketones for metastasis suppression
US9359398B2 (en)	2010-03-01	2016-06-07	Onyx Therapeutics, Inc.	Compounds for immunoproteasome inhibition
SG185103A1 (en) *	2010-04-30	2012-12-28	Univ Indiana Res & Tech Corp	Processes for preparing linezolid
TW201414751A (zh)	2012-07-09	2014-04-16	歐尼克斯治療公司	肽環氧酮蛋白酶抑制劑之前驅藥物
CN104692987B (zh) *	2015-01-22	2017-05-17	北京大学	卤代醇及其衍生物的廉价高效合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2072237A1 (en) *	1991-07-02	1993-01-03	Merck & Co., Inc.	Stereoselective production of hydroxyamide compounds from chiral -amino epoxides
SG52731A1 (en) *	1991-11-08	1998-09-28	Merck & Co Inc	Hiv protease inhibitors useful for the treatment of aids

1995
- 1995-02-24 TW TW084101733A patent/TW380137B/zh not_active IP Right Cessation
- 1995-02-27 PT PT95911105T patent/PT748319E/pt unknown
- 1995-02-27 RO RO96-01750A patent/RO117696B1/ro unknown
- 1995-02-27 BR BR9506977A patent/BR9506977A/pt not_active IP Right Cessation
- 1995-02-27 CN CN95192714A patent/CN1066728C/zh not_active Expired - Lifetime
- 1995-02-27 EP EP95911105A patent/EP0748319B1/en not_active Expired - Lifetime
- 1995-02-27 MX MX9603871A patent/MX9603871A/es unknown
- 1995-02-27 AT AT95911105T patent/ATE210662T1/de active
- 1995-02-27 SK SK1122-96A patent/SK283067B6/sk not_active IP Right Cessation
- 1995-02-27 HU HU9602412A patent/HU222750B1/hu not_active IP Right Cessation
- 1995-02-27 NZ NZ281866A patent/NZ281866A/en not_active IP Right Cessation
- 1995-02-27 DK DK95911105T patent/DK0748319T3/da active
- 1995-02-27 WO PCT/US1995/002347 patent/WO1995023797A1/en active IP Right Grant
- 1995-02-27 DE DE69524578T patent/DE69524578T2/de not_active Expired - Lifetime
- 1995-02-27 ES ES95911105T patent/ES2167419T3/es not_active Expired - Lifetime
- 1995-02-27 CA CA002183976A patent/CA2183976C/en not_active Expired - Fee Related
- 1995-02-27 RU RU96120179A patent/RU2137769C1/ru not_active IP Right Cessation
- 1995-02-27 KR KR1019960704836A patent/KR100387741B1/ko not_active Expired - Fee Related
- 1995-02-27 UA UA96103798A patent/UA45968C2/uk unknown
- 1995-02-27 AU AU18828/95A patent/AU690231B2/en not_active Ceased
- 1995-02-27 CZ CZ19962543A patent/CZ291816B6/cs not_active IP Right Cessation
- 1995-02-27 JP JP52294995A patent/JP3871705B2/ja not_active Expired - Fee Related
- 1995-03-02 HR HR950096A patent/HRP950096B1/xx not_active IP Right Cessation
- 1995-03-03 YU YU14595A patent/YU49010B/sh unknown
1996
- 1996-09-03 FI FI963452A patent/FI120259B/sv not_active IP Right Cessation

Also Published As

Publication number	Publication date
MX9603871A (es)	1997-07-31
HUT75611A (en)	1997-05-28
HU222750B1 (hu)	2003-09-29
RU2137769C1 (ru)	1999-09-20
YU14595A (sh)	1997-12-05
JPH09509929A (ja)	1997-10-07
HRP950096B1 (en)	2002-06-30
BR9506977A (pt)	1997-09-02
KR970701714A (ko)	1997-04-12
FI963452A0 (sv)	1996-09-03
HU9602412D0 (en)	1996-11-28
TW380137B (en)	2000-01-21
CZ291816B6 (cs)	2003-06-18
KR100387741B1 (ko)	2003-10-04
CA2183976A1 (en)	1995-09-08
CN1146768A (zh)	1997-04-02
CZ254396A3 (en)	1997-01-15
NZ281866A (en)	1998-05-27
DE69524578D1 (de)	2002-01-24
FI120259B (sv)	2009-08-31
UA45968C2 (uk)	2002-05-15
YU49010B (sh)	2003-04-30
AU1882895A (en)	1995-09-18
PT748319E (pt)	2002-05-31
SK112296A3 (en)	1997-02-05
HRP950096A2 (en)	1997-06-30
ES2167419T3 (es)	2002-05-16
FI963452L (sv)	1996-09-03
CA2183976C (en)	2005-02-01
ATE210662T1 (de)	2001-12-15
SK283067B6 (sk)	2003-02-04
CN1066728C (zh)	2001-06-06
WO1995023797A1 (en)	1995-09-08
RO117696B1 (ro)	2002-06-28
AU690231B2 (en)	1998-04-23
DE69524578T2 (de)	2002-07-18
JP3871705B2 (ja)	2007-01-24
EP0748319A1 (en)	1996-12-18
EP0748319B1 (en)	2001-12-12

Publication	Publication Date	Title
DK0748319T3 (da)	2002-03-18	Fremgangsmåde til fremstilling af et epoxid
NO910712D0 (no)	1991-02-22	Fremgangsmaate ved fremstilling av oksetanoner.
YU27304A (sh)	2006-08-17	Novi dihidropteridinoni, postupak za njihovo dobijanje i njihova primena kao lekova
PT931083E (pt)	2003-07-31	Processo para a producao de compostos de ecteinascidina
LU91339I2 (fr)	2007-07-23	Darunavir ou un sel, ester ou promédicament pharmaceutiquement acceptable de celui-ci (prezista)
UA50730C2 (uk)	2002-11-15	Спосіб одержання 1-(тіометил)циклопропаноцтової кислоти та проміжних сполук для її одержання
WO2001057014A3 (en)	2002-04-18	Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one
EA199800792A1 (ru)	1999-02-25	Способы получения промежуточных соединений для пестицидов
ATE239716T1 (de)	2003-05-15	Synthese von 3,6-dialkyl-5,6-dihydro-4-hydroxy-2h-pyran-2-on
YU45896A (sh)	1999-06-15	Postupak za dobijanje epoksida
LV12825B (lv)	2002-09-20	Hiv proteāzes inhibitora iegūšana
MX9300361A (es)	1994-06-30	Derivado de 4-aril-3-heteroarilureidoquinolina como agentes antihipercolesterolemicos y antiateroscleroticos.
YU55900A (sh)	2003-02-28	Postupak za sintezu inhibitora hiv proteaze
HUP9903318A2 (hu)	2000-06-28	Intermedierek taxol előállítására
DK1105392T3 (da)	2002-12-30	Fremgangsmåde til fremstilling af mellemprodukter for imidazodiazepin
GB2369356B (en)	2004-02-04	Process
IT1309601B1 (it)	2002-01-24	Processo per la preparazione di 1,4,7,10 tetraazaciclododecano.
ATE336493T1 (de)	2006-09-15	Tricyclische epoxide
DK1331218T3 (da)	2007-04-10	Fremgangsmåde til fremstilling af beskyttet 3-amino-1,2-dihydroxypropanacetal og derivater deraf
TW200611691A (en)	2006-04-16	Retroviral protease inhibiting compounds
ATE188470T1 (de)	2000-01-15	Chinolondisulfide als zwischenverbindungen
ATE247646T1 (de)	2003-09-15	Herstellung von 2-ethyl-3-methyl-1,4-diazin
DK1268441T3 (da)	2007-09-03	Mellemprodukt og fremgangsmåde til dets syntese