HRP20211575T1 - Fuzijski proteini za liječenje metaboličkih poremećaja - Google Patents
Fuzijski proteini za liječenje metaboličkih poremećaja Download PDFInfo
- Publication number
- HRP20211575T1 HRP20211575T1 HRP20211575TT HRP20211575T HRP20211575T1 HR P20211575 T1 HRP20211575 T1 HR P20211575T1 HR P20211575T T HRP20211575T T HR P20211575TT HR P20211575 T HRP20211575 T HR P20211575T HR P20211575 T1 HRP20211575 T1 HR P20211575T1
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- Prior art keywords
- fusion protein
- disease
- amino acid
- seq
- fgf21
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Claims (7)
1. Fuzijski protein, naznačen time, da obuhvaća divlji tip proteina FGF21 i Fc područje, pri čemu je Fc područje fuzionirano na N-terminalni kraj od proteina FGF21 preko aminokiselinskog veznika s aminokiselinskim slijedom odabranim od GS i GGGGSGGGGSGGGGS (SEQ ID NO: 6), i pritom fuzijski protein posjeduje amkinokiselinski slijed SEQ ID NO: 7 ili SEQ ID NO: 8.
2. Fuzijski protein prema patentnom zahtjevu 1, naznačen time, da se upotrebljava u liječenju poremećaja koji su povezani s FGF21, a biraju se iz skupine koju čine pretilost, dijabetes mellitus tipa 1 i tipa 2, pankreatitis, dislipidemija, nealkoholna bolest masne jetre (NAFLD), nealkoholni steatohepatitis (NASH), otpornost na inzulin, hiperinzulinemija, netolerancija na glukozu, hiperglikemija, metabolički sindrom, akutni infarkt miokarda, hipertenzija, kardiovaskularna bolest, ateroskleroza, bolest perifernih arterija, moždani udar, zatajenje srca, koronarna srčana bolest, bubrežno oboljenje, dijabetičke komplikacije, neuropatija, gastropareza i poremećaji koji su povezani s teškim neaktivirajućim mutacijama u receptoru inzulina.
3. Farmaceutski pripravak, naznačen time, da obuhvaća fuzijski protein u skladu s patentnim zahtjevom 1, i farmaceutski prihvatljivo formulacijsko sredstvo.
4. Farmaceutski pripravak prema patentnom zahtjevu 3, naznačen time, da se upotrebljava u liječenju metaboličkog poremećaja.
5. Polinukleotid, naznačen time, da on kodira fuzijski protein u skladu s patentnim zahtjevom 1.
6. Vektor, naznačen time, da sadrži polinukleotid prema patentnom zahtjevu 5.
7. Stanica domaćina, naznačena time, da ona prenosi vektor prema patentnom zahtjevu 6 ili polinukleotid prema patentnom zahtjevu 5.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161539280P | 2011-09-26 | 2011-09-26 | |
| EP17201957.2A EP3321276B1 (en) | 2011-09-26 | 2012-09-26 | Fusion proteins for treating metabolic disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20211575T1 true HRP20211575T1 (hr) | 2022-02-04 |
Family
ID=46970456
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20211575TT HRP20211575T1 (hr) | 2011-09-26 | 2012-09-26 | Fuzijski proteini za liječenje metaboličkih poremećaja |
| HRP20181558TT HRP20181558T1 (hr) | 2011-09-26 | 2012-09-26 | Fuzijski proteini za liječenje metaboličkih poremećaja |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20181558TT HRP20181558T1 (hr) | 2011-09-26 | 2012-09-26 | Fuzijski proteini za liječenje metaboličkih poremećaja |
Country Status (42)
Families Citing this family (67)
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