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HRP20160692T1 - Postupak za proizvodnju intermedijera estetrola - Google Patents

Postupak za proizvodnju intermedijera estetrola

Info

Publication number
HRP20160692T1
HRP20160692T1 HRP20160692TT HRP20160692T HRP20160692T1 HR P20160692 T1 HRP20160692 T1 HR P20160692T1 HR P20160692T T HRP20160692T T HR P20160692TT HR P20160692 T HRP20160692 T HR P20160692T HR P20160692 T1 HRP20160692 T1 HR P20160692T1
Authority
HR
Croatia
Prior art keywords
production
estetrol
intermediates
estetrol intermediates
Prior art date
Application number
HRP20160692TT
Other languages
English (en)
Inventor
Jean-Claude Pascal
Original Assignee
Estetra S.P.R.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Estetra S.P.R.L. filed Critical Estetra S.P.R.L.
Publication of HRP20160692T1 publication Critical patent/HRP20160692T1/hr
Publication of HRP20160692T2 publication Critical patent/HRP20160692T2/hr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HRP20160692TT 2011-06-01 2012-06-01 Postupak za proizvodnju intermedijera estetrola HRP20160692T2 (hr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161492300P 2011-06-01 2011-06-01
EP11168561 2011-06-01
EP12729054.2A EP2714710B1 (en) 2011-06-01 2012-06-01 Process for the production of estetrol intermediates
PCT/EP2012/060447 WO2012164096A1 (en) 2011-06-01 2012-06-01 Process for the production of estetrol intermediates

Publications (2)

Publication Number Publication Date
HRP20160692T1 true HRP20160692T1 (hr) 2016-08-12
HRP20160692T2 HRP20160692T2 (hr) 2016-09-23

Family

ID=45003353

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20160692TT HRP20160692T2 (hr) 2011-06-01 2012-06-01 Postupak za proizvodnju intermedijera estetrola

Country Status (24)

Country Link
US (1) US11053274B2 (hr)
EP (1) EP2714710B1 (hr)
JP (2) JP6425540B2 (hr)
KR (1) KR101994805B1 (hr)
CN (2) CN103703014A (hr)
AU (1) AU2012264602B2 (hr)
BR (1) BR112013030830B1 (hr)
CA (1) CA2835981C (hr)
CY (1) CY1118150T1 (hr)
DK (1) DK2714710T3 (hr)
EA (1) EA023991B1 (hr)
ES (1) ES2579175T3 (hr)
HR (1) HRP20160692T2 (hr)
HU (1) HUE029252T2 (hr)
ME (1) ME02454B (hr)
MX (1) MX341561B (hr)
PL (1) PL2714710T3 (hr)
PT (1) PT2714710T (hr)
RS (1) RS54880B1 (hr)
SG (1) SG195118A1 (hr)
SI (1) SI2714710T1 (hr)
SM (1) SMT201600206B (hr)
WO (1) WO2012164096A1 (hr)
ZA (1) ZA201308446B (hr)

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BR112013030833B1 (pt) 2011-06-01 2019-09-03 Estetra S A processo para a preparação de um composto de fórmula (i) e processo para a preparação de estetrol
DK2714710T3 (en) 2011-06-01 2016-06-27 Estetra Sprl A process for the preparation of intermediates estetrol
EP2383279A1 (en) 2011-07-19 2011-11-02 Pantarhei Bioscience B.V. Process for the preparation of estetrol
US8987484B2 (en) 2011-10-07 2015-03-24 Estetra S.P.R.L. Process for the production of estetrol
PT3701944T (pt) 2015-06-18 2022-01-11 Estetra Srl Dose unitária orodispersível contendo um composto de estetrol
GEP20217308B (en) 2015-06-18 2021-10-25 Estetra Sprl Orodispersible dosage unit containing an estetrol component
CA2988485A1 (en) 2015-06-18 2016-12-22 Mithra Pharmaceuticals S.A. Orodispersible tablet containing estetrol
MA44206B1 (fr) 2015-06-18 2021-04-30 Estetra Sprl Comprimé orodispersible comprenant estetrol
CN105837424A (zh) * 2016-03-31 2016-08-10 常州大学 一种1-氯-3-甲基-3-丁烯-2-酮的合成方法
CA3178291A1 (en) 2016-08-05 2018-04-12 Estetra Srl Method for the management of dysmenorrhea and menstrual pain
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JOP20200260A1 (ar) 2018-04-19 2019-10-19 Estetra Sprl مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث
TWI801561B (zh) 2018-04-19 2023-05-11 比利時商依思特拉私人有限責任公司 化合物及其用於緩解絕經相關症狀的用途
IT201900017414A1 (it) 2019-09-27 2021-03-27 Ind Chimica Srl Processo per la preparazione di (15α,16α,17β)-estra-1,3,5(10)-triene-3,15,16,17-tetrolo (Estetrolo) ed intermedi di detto processo
MX2022003688A (es) 2019-09-27 2022-04-26 Ind Chimica Srl Proceso para preparar (15alfa,16alfa,17beta)-estra-1,3,5(10)-trien o-3,15,16,17-tetrol (estetrol) e intermedios de dicho proceso.
IT201900021879A1 (it) 2019-11-22 2021-05-22 Ind Chimica Srl PROCESSO PER LA PREPARAZIONE DI (15α,16α,17β)-ESTRA-1,3,5(10)-TRIENE-3,15,16,17-TETROLO (ESTETROLO) ED INTERMEDI DI DETTO PROCESSO
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HU231651B1 (hu) 2021-10-01 2025-05-28 Industriale Chimica S.R.L. Eljárás (15alfa,16alfa,17béta)-ösztra-1,3,5(10)-trién-3,15,16,17-tetrol (esztetrol) és esztetrol-monohidrát előállítására
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Also Published As

Publication number Publication date
PT2714710T (pt) 2016-07-12
SG195118A1 (en) 2013-12-30
EP2714710A1 (en) 2014-04-09
ME02454B (me) 2016-09-20
CN107266514A (zh) 2017-10-20
JP6425540B2 (ja) 2018-11-21
DK2714710T3 (en) 2016-06-27
ZA201308446B (en) 2016-08-31
US20140107358A1 (en) 2014-04-17
EA201301316A1 (ru) 2014-04-30
HRP20160692T2 (hr) 2016-09-23
WO2012164096A1 (en) 2012-12-06
MX2013014045A (es) 2014-08-22
JP6479912B2 (ja) 2019-03-06
HUE029252T2 (en) 2017-02-28
CA2835981C (en) 2018-07-24
KR20140036205A (ko) 2014-03-25
BR112013030830B1 (pt) 2019-12-03
NZ617613A (en) 2015-12-24
RS54880B1 (sr) 2016-10-31
AU2012264602B2 (en) 2017-03-09
EA023991B1 (ru) 2016-08-31
CY1118150T1 (el) 2017-06-28
SI2714710T1 (sl) 2016-08-31
CA2835981A1 (en) 2012-12-06
PL2714710T3 (pl) 2017-03-31
JP2018024673A (ja) 2018-02-15
KR101994805B1 (ko) 2019-07-01
BR112013030830A2 (pt) 2016-08-30
MX341561B (es) 2016-08-25
ES2579175T3 (es) 2016-08-05
SMT201600206B (it) 2016-08-31
JP2014518199A (ja) 2014-07-28
US11053274B2 (en) 2021-07-06
EP2714710B1 (en) 2016-04-06
CN103703014A (zh) 2014-04-02

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