HRP20140627T1 - Kristalna monotosilatna sol od 2-metil-2-[4-(3-metil-2-okso-8-kinolin-3-il-2,3-dihidro-imidazo[4,5-c]kinolin-1-il)-fenil]-propionitrila - Google Patents
Kristalna monotosilatna sol od 2-metil-2-[4-(3-metil-2-okso-8-kinolin-3-il-2,3-dihidro-imidazo[4,5-c]kinolin-1-il)-fenil]-propionitrila Download PDFInfo
- Publication number
- HRP20140627T1 HRP20140627T1 HRP20140627TT HRP20140627T HRP20140627T1 HR P20140627 T1 HRP20140627 T1 HR P20140627T1 HR P20140627T T HRP20140627T T HR P20140627TT HR P20140627 T HRP20140627 T HR P20140627T HR P20140627 T1 HRP20140627 T1 HR P20140627T1
- Authority
- HR
- Croatia
- Prior art keywords
- cancer
- quinolin
- methyl
- crystalline form
- crystalline
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
- C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Claims (5)
1. Monotosilatna sol od spoja formule I
[image]
u kristalnom obliku A, naznačena time, da je taj oblik A određen preko difrakcijskih vršnih vrijednosti s kutevima difrakcije 2teta od 5,4°, 5,7° i 17,2° +/- 0,3, prema mjerenju uz pomoć radijacijskog izvora Cu-K-alfa.
2. Kristalni oblik prema zahtjevu 1, naznačen time, da je određen preko difrakcijskih vršnih vrijednosti s kutevima difrakcije 2teta od 5,4°, 5,7°, 16,4°, 17,2°, 18,3°, 19,0°, 22,0°, 23,1°, 23,4°, 27,5° +/- 0,3.
3. Farmaceutski sastav, naznačen time, da obuhvaća kristalni oblik prema zahtjevu 1 ili 2, te po potrebi barem jedan farmaceutski prikladan nosač.
4. Farmaceutski sastav prema zahtjevu 3, naznačen time, da obuhvaća od1% do20% djelotvorne tvari ili djelotvornih tvari.
5. Kristalni oblik prema zahtjevu 1 ili 2, naznačen time, da se upotrebljava za liječenje proliferativne bolesti odabrane između sljedećih: benigni ili maligni tumor, karcinom mozga, bubrega, jetre, nadbubrežne žlijezde, mjehura, dojke, želuca, gastrički tumori, karcinom jajnika, debelog crijeva, zadnjeg crijeva, prostate, gušterače, pluća, vagine ili tiroidne žlijezde, sarkom, glioblastomi, višestruki mijelom ili gastrointestinalni rak, posebno karcinom debelog crijeva ili kolorektalni adenom ili tumor vrata i glave, epidermalna hiperproliferacija, psorijaza, hiperplazija prostate, neoplazija, neoplazija epitelijalnih karakteristika, limfomi, karcinom maternice, leukemija, Cowdenov sindrom, Lhermitte-Dudos-bolest i sindrom Bannayan-Zonana.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86648306P | 2006-11-20 | 2006-11-20 | |
| PCT/US2007/084893 WO2008064093A2 (en) | 2006-11-20 | 2007-11-16 | Salts and crystal forms of 2-methyl-2-[4-(3-methyl-2-oxo-8-quinolin-3-yl-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl)-phenyl]-propionitrile |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20140627T1 true HRP20140627T1 (hr) | 2014-09-26 |
Family
ID=39345299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20140627TT HRP20140627T1 (hr) | 2006-11-20 | 2007-11-16 | Kristalna monotosilatna sol od 2-metil-2-[4-(3-metil-2-okso-8-kinolin-3-il-2,3-dihidro-imidazo[4,5-c]kinolin-1-il)-fenil]-propionitrila |
Country Status (35)
| Country | Link |
|---|---|
| US (2) | US8436177B2 (hr) |
| EP (2) | EP2094700B1 (hr) |
| JP (2) | JP5562033B2 (hr) |
| KR (3) | KR20140091718A (hr) |
| CN (5) | CN106045993A (hr) |
| AR (1) | AR064256A1 (hr) |
| AU (1) | AU2007323820B2 (hr) |
| BR (1) | BRPI0719112A2 (hr) |
| CA (1) | CA2669199C (hr) |
| CL (1) | CL2007003316A1 (hr) |
| CO (1) | CO6382134A2 (hr) |
| CR (1) | CR10757A (hr) |
| DO (1) | DOP2009000116A (hr) |
| EA (1) | EA015677B1 (hr) |
| EC (1) | ECSP099340A (hr) |
| GE (1) | GEP20125436B (hr) |
| GT (1) | GT200900133A (hr) |
| HR (1) | HRP20140627T1 (hr) |
| IL (2) | IL198467A (hr) |
| JO (1) | JO2903B1 (hr) |
| MA (1) | MA30967B1 (hr) |
| MX (1) | MX2009005360A (hr) |
| MY (1) | MY150216A (hr) |
| NI (1) | NI200900091A (hr) |
| NO (1) | NO20092227L (hr) |
| NZ (1) | NZ576357A (hr) |
| PE (2) | PE20120083A1 (hr) |
| PH (1) | PH12013502100A1 (hr) |
| RS (1) | RS53335B (hr) |
| SM (1) | SMP200900041B (hr) |
| TN (1) | TN2009000191A1 (hr) |
| TW (2) | TWI417292B (hr) |
| UA (1) | UA98473C2 (hr) |
| UY (1) | UY30728A1 (hr) |
| WO (1) | WO2008064093A2 (hr) |
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| BRPI0906474A2 (pt) | 2008-01-04 | 2015-07-14 | Intellikine Inc | Certas entidades químicas, composições e métodos |
| US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
| EP2276488A1 (en) * | 2008-03-26 | 2011-01-26 | Novartis AG | 5imidazoquinolines and pyrimidine derivatives as potent modulators of vegf-driven angiogenic processes |
| WO2010036380A1 (en) | 2008-09-26 | 2010-04-01 | Intellikine, Inc. | Heterocyclic kinase inhibitors |
| WO2010129816A2 (en) | 2009-05-07 | 2010-11-11 | Intellikine, Inc. | Heterocyclic compounds and uses thereof |
| PE20120224A1 (es) | 2009-06-04 | 2012-04-04 | Novartis Ag | Derivados de 1h-imidazo-[4,5-c]-quinolinona |
| SG183155A1 (en) | 2010-02-03 | 2012-09-27 | Signal Pharm Llc | Identification of lkb1 mutation as a predictive biomarker for sensitivity to tor kinase inhibitors |
| JP5951600B2 (ja) | 2010-05-21 | 2016-07-13 | インフィニティー ファーマシューティカルズ， インコーポレイテッド | キナーゼ調節のための、化合物、組成物および方法 |
| DE102010035744A1 (de) * | 2010-08-28 | 2012-03-01 | Merck Patent Gmbh | Imidazolonylchinoline |
| AU2011326427B2 (en) | 2010-11-10 | 2016-01-07 | Infinity Pharmaceuticals Inc. | Heterocyclic compounds and uses thereof |
| CN103648499B (zh) * | 2011-01-10 | 2017-02-15 | 无限药品股份有限公司 | 用于制备异喹啉酮的方法及异喹啉酮的固体形式 |
| US8969363B2 (en) | 2011-07-19 | 2015-03-03 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| WO2013012918A1 (en) | 2011-07-19 | 2013-01-24 | Infinity Pharmaceuticals Inc. | Heterocyclic compounds and uses thereof |
| TW201311663A (zh) | 2011-08-29 | 2013-03-16 | Infinity Pharmaceuticals Inc | 雜環化合物及其用途 |
| JP2014532057A (ja) * | 2011-09-30 | 2014-12-04 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | 粘表皮癌を治療する方法 |
| CN103467482B (zh) | 2012-04-10 | 2017-05-10 | 上海璎黎药业有限公司 | 稠合嘧啶类化合物，其制备方法，中间体，组合物和应用 |
| US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
| AU2013203714B2 (en) | 2012-10-18 | 2015-12-03 | Signal Pharmaceuticals, Llc | Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity |
| EP2914296B2 (en) | 2012-11-01 | 2021-09-29 | Infinity Pharmaceuticals, Inc. | Treatment of cancers using pi3 kinase isoform modulators |
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| NZ631082A (en) | 2013-04-17 | 2017-06-30 | Signal Pharm Llc | Methods for treating cancer using tor kinase inhibitor combination therapy |
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| HK1221168A1 (zh) | 2013-04-17 | 2017-05-26 | 西格诺药品有限公司 | 用於治療癌症的包括tor激酶抑制劑和n-(3-(5-氟-2-(4-(2-甲氧基乙氧基)苯基氨基)嘧啶-4-基氨基)苯基)丙烯醯胺的組合療法 |
| KR102221029B1 (ko) | 2013-04-17 | 2021-02-26 | 시그날 파마소티칼 엘엘씨 | 디하이드로피라지노-피라진을 사용한 암의 치료 |
| US9604939B2 (en) | 2013-05-29 | 2017-03-28 | Signal Pharmaceuticals, Llc | Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-YL)pyridin-3-YL)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino [2,3-B]pyrazin-2(1H)-one, a solid form thereof and methods of their use |
| CN104513254B (zh) | 2013-09-30 | 2019-07-26 | 上海璎黎药业有限公司 | 稠合嘧啶类化合物、中间体、其制备方法、组合物和应用 |
| WO2015051241A1 (en) | 2013-10-04 | 2015-04-09 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
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| US9656996B2 (en) | 2013-10-16 | 2017-05-23 | Shanghai Yingli Pharmaceutical Co., Ltd. | Fused heterocyclic compound, preparation method therefor, pharmaceutical composition, and uses thereof |
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| US10919914B2 (en) | 2016-06-08 | 2021-02-16 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| RU2754507C2 (ru) | 2016-06-24 | 2021-09-02 | Инфинити Фармасьютикалз, Инк. | Комбинированная терапия |
| MX2019006090A (es) | 2016-11-23 | 2019-08-21 | Novartis Ag | Metodos para mejorar la respuesta inmune con everolimus, dactolisib o ambos. |
| KR102795129B1 (ko) | 2017-06-22 | 2025-04-15 | 셀진 코포레이션 | B형 간염 바이러스 감염을 특징으로 하는 간세포 암종의 치료 |
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| US4929624A (en) * | 1989-03-23 | 1990-05-29 | Minnesota Mining And Manufacturing Company | Olefinic 1H-imidazo(4,5-c)quinolin-4-amines |
| US5268376A (en) * | 1991-09-04 | 1993-12-07 | Minnesota Mining And Manufacturing Company | 1-substituted 1H-imidazo[4,5-c]quinolin-4-amines |
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-
2007
- 2007-11-16 EP EP07864492.9A patent/EP2094700B1/en active Active
- 2007-11-16 AU AU2007323820A patent/AU2007323820B2/en not_active Ceased
- 2007-11-16 MY MYPI20091920A patent/MY150216A/en unknown
- 2007-11-16 NZ NZ576357A patent/NZ576357A/en not_active IP Right Cessation
- 2007-11-16 EP EP10176298A patent/EP2364981A1/en not_active Withdrawn
- 2007-11-16 BR BRPI0719112-0A patent/BRPI0719112A2/pt not_active IP Right Cessation
- 2007-11-16 CN CN201610405653.7A patent/CN106045993A/zh active Pending
- 2007-11-16 KR KR1020147014039A patent/KR20140091718A/ko not_active Ceased
- 2007-11-16 CA CA2669199A patent/CA2669199C/en not_active Expired - Fee Related
- 2007-11-16 UA UAA200905006A patent/UA98473C2/ru unknown
- 2007-11-16 JP JP2009537381A patent/JP5562033B2/ja not_active Expired - Fee Related
- 2007-11-16 CN CN201910073048.8A patent/CN109970735A/zh active Pending
- 2007-11-16 CN CNA2007800420773A patent/CN101541793A/zh active Pending
- 2007-11-16 GE GEAP200711260A patent/GEP20125436B/en unknown
- 2007-11-16 AR ARP070105114A patent/AR064256A1/es unknown
- 2007-11-16 CN CN2012102686473A patent/CN102993202A/zh active Pending
- 2007-11-16 RS RS20140278A patent/RS53335B/en unknown
- 2007-11-16 KR KR1020097010203A patent/KR20090080530A/ko not_active Ceased
- 2007-11-16 US US12/514,976 patent/US8436177B2/en not_active Expired - Fee Related
- 2007-11-16 KR KR1020147029446A patent/KR20140129396A/ko not_active Ceased
- 2007-11-16 HR HRP20140627TT patent/HRP20140627T1/hr unknown
- 2007-11-16 WO PCT/US2007/084893 patent/WO2008064093A2/en active Application Filing
- 2007-11-16 MX MX2009005360A patent/MX2009005360A/es active IP Right Grant
- 2007-11-16 EA EA200900638A patent/EA015677B1/ru not_active IP Right Cessation
- 2007-11-16 CN CN2011103337901A patent/CN102336752A/zh active Pending
- 2007-11-19 TW TW096143742A patent/TWI417292B/zh not_active IP Right Cessation
- 2007-11-19 PE PE2011001508A patent/PE20120083A1/es not_active Application Discontinuation
- 2007-11-19 PE PE2007001607A patent/PE20081780A1/es not_active Application Discontinuation
- 2007-11-19 CL CL200703316A patent/CL2007003316A1/es unknown
- 2007-11-19 TW TW102134663A patent/TW201402567A/zh unknown
- 2007-11-19 JO JO2007482A patent/JO2903B1/en active
- 2007-11-20 UY UY30728A patent/UY30728A1/es not_active Application Discontinuation
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2009
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- 2009-04-30 IL IL198467A patent/IL198467A/en not_active IP Right Cessation
- 2009-05-15 TN TNP2009000191A patent/TN2009000191A1/fr unknown
- 2009-05-18 CO CO09050683A patent/CO6382134A2/es active IP Right Grant
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- 2009-05-18 EC EC2009009340A patent/ECSP099340A/es unknown
- 2009-05-19 DO DO2009000116A patent/DOP2009000116A/es unknown
- 2009-05-28 SM SM200900041T patent/SMP200900041B/it unknown
- 2009-06-03 MA MA31947A patent/MA30967B1/fr unknown
- 2009-06-09 NO NO20092227A patent/NO20092227L/no not_active Application Discontinuation
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2012
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2013
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- 2013-05-13 JP JP2013101604A patent/JP2013173788A/ja active Pending
- 2013-10-10 PH PH12013502100A patent/PH12013502100A1/en unknown
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