HRP20110085T1 - Fotostabilni farmaceutski pripravci za tretman herpesnog keratitisa koji sadrže brivudin - Google Patents
Fotostabilni farmaceutski pripravci za tretman herpesnog keratitisa koji sadrže brivudin Download PDFInfo
- Publication number
- HRP20110085T1 HRP20110085T1 HR20110085T HRP20110085T HRP20110085T1 HR P20110085 T1 HRP20110085 T1 HR P20110085T1 HR 20110085 T HR20110085 T HR 20110085T HR P20110085 T HRP20110085 T HR P20110085T HR P20110085 T1 HRP20110085 T1 HR P20110085T1
- Authority
- HR
- Croatia
- Prior art keywords
- preparation according
- preparation
- amount
- film
- coating agent
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Oftalmički pripravak naznačen time da sadrži od 0.05 do 0.3% w/w brivudina kao aktivni sastojak i sredstvo za tvorbu film-ovojnice odabrano iz sljedeće skupine: polivinil pirolidon (PVP), polivinil alkohol (PVA) i poliakrilat (PA). Patent sadrži još 13 patentnih zahtjeva.
Claims (14)
1. Oftalmički pripravak naznačen time da sadrži od 0.05 do 0.3% w/w brivudina kao aktivni sastojak i sredstvo za tvorbu film-ovojnice odabrano iz sljedeće skupine: polivinil pirolidon (PVP), polivinil alkohol (PVA) i poliakrilat (PA).
2. Pripravak prema patentnom zahtjevu 1, naznačen time da je količina sredstva za tvorbu film-ovojnice u rasponu od 0.5 do 10% w/w.
3. Pripravak prema patentnom zahtjevu 2, naznačen time da je količina rečenog reagensa u rasponu od 1 do 5% w/w.
4. Pripravak prema patentnom zahtjevu 1, naznačen time da nadalje sadrži konzervans u količini do 2% w/w.
5. Pripravak prema patentnom zahtjevu 4, naznačen time da je rečena količina u rasponu od 0.01 do 1.5% w/w.
6. Pripravak prema patentnom zahtjevu 1, naznačen time da nadalje sadrži antioksidans u količini od 0.001 do 12 masenih %.
7. Pripravak prema patentnom zahtjevu 6, naznačen time da rečena količina jest od 0.001 do 0.1% w/w.
8. Pripravak prema patentnom zahtjevu 1, naznačen time da se nalazi u sljedećem obliku: kapi za oči, otopina, gel, mast.
9. Pripravak prema patentnom zahtjevu 8, naznačen time da je pakiran u jedinici doze ili u spremniku u višestrukoj dozi.
10. Pripravak prema patentnom zahtjevu 1, naznačen time da sadrži 0.1-0.3% w/w brivudina, 1-7% w/w sredstva za tvorbu film-ovojnice, 0-2% w/w konzervansa, 0-2% pufera, 0-0.9% NaCl, 0-4% 0.1M NaOH čime nastaje pH u rasponu od 5.5 do 6.5, 0-25% površinski aktivne tvari,0-0.003% antioksidansa, 0.01-0.05% natrij-EDTA te 100% vode.
11. Kombinirani pripravak, naznačen time da sadrži oftalmički pripravak u skladu s patentnim zahtjevima 1-10 i steroidni ili nesteroidni antiupalni lijek za istovremenu, uzastopnu ili odvojenu primjenu za tretman očnih bolesti.
12. Kombinirani pripravak prema patentnom zahtjevu 11, naznačen time da steroid jest prednisolon-acetat ili fluormetolon te da nesteroidno antiupalno sredstvo jest flurbiprofen.
13. Primjena oftalmičkog pripravka prema patentnim zahtjevima 1-10, naznačena time da je za pripravu lijeka za tretman sljedećih: HSV-epitelni keratitis, HSV-stromalni keratitis, okularne komplikacije od herpes zoster ophthalmicus.
14. Primjena sredstva za tvorbu film-ovojnice, naznačeno time da je odabrano iz sljedeće skupine: polivinil pirolidon (PVP), polivinil alkohol (PVA) i poliakrilat (PA), a za pripravu oftalmičkog pripravka prema patentnom zahtjevu 1.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005046769A DE102005046769A1 (de) | 2005-09-29 | 2005-09-29 | Lichtstabile, brivudinhaltige pharmazeutische Formulierung zur Behandlung von Augenherpes (Herpes Ophthalmicus) |
| PCT/EP2006/009383 WO2007039201A2 (en) | 2005-09-29 | 2006-09-27 | Photostable pharmaceutical composition containing brivudine for the treatment of herpetic keratitis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110085T1 true HRP20110085T1 (hr) | 2011-03-31 |
Family
ID=37561306
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110085T HRP20110085T1 (hr) | 2005-09-29 | 2011-02-03 | Fotostabilni farmaceutski pripravci za tretman herpesnog keratitisa koji sadrže brivudin |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US20080249061A1 (hr) |
| EP (1) | EP1940353B1 (hr) |
| JP (1) | JP2009509993A (hr) |
| KR (1) | KR20080053319A (hr) |
| CN (1) | CN101272765A (hr) |
| AP (1) | AP2008004394A0 (hr) |
| AR (1) | AR056551A1 (hr) |
| AT (1) | ATE489076T1 (hr) |
| AU (1) | AU2006299115A1 (hr) |
| BR (1) | BRPI0616449A2 (hr) |
| CA (1) | CA2624111A1 (hr) |
| CR (1) | CR9839A (hr) |
| CY (1) | CY1111059T1 (hr) |
| DE (2) | DE102005046769A1 (hr) |
| DK (1) | DK1940353T3 (hr) |
| EA (1) | EA012975B1 (hr) |
| EC (1) | ECSP088310A (hr) |
| ES (1) | ES2356774T3 (hr) |
| HN (1) | HN2008000497A (hr) |
| HR (1) | HRP20110085T1 (hr) |
| IL (1) | IL190466A0 (hr) |
| MA (1) | MA29887B1 (hr) |
| NO (1) | NO20081488L (hr) |
| PE (1) | PE20070767A1 (hr) |
| PL (1) | PL1940353T3 (hr) |
| PT (1) | PT1940353E (hr) |
| RS (1) | RS51615B (hr) |
| SI (1) | SI1940353T1 (hr) |
| TN (1) | TNSN08094A1 (hr) |
| TW (1) | TW200744664A (hr) |
| UA (1) | UA90911C2 (hr) |
| WO (1) | WO2007039201A2 (hr) |
| ZA (1) | ZA200802729B (hr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009006130A2 (en) * | 2007-06-28 | 2009-01-08 | Bausch & Lomb Incorporated | Salt free hyaluronate ophthalmic solution |
| US20090196833A1 (en) * | 2008-02-06 | 2009-08-06 | Adherex Technologies Inc. | Compositions comprising topical dpd inhibitors and methods of using same in the treatment of hand-foot syndrome |
| DE102009003942A1 (de) * | 2009-01-07 | 2010-07-08 | D2O Biosience Group Ltd., Hamilton | Verwendung von Deuteriumoxid zur Behandlung Virus-basierter Erkrankungen des Auges |
| PT2898888T (pt) | 2014-01-22 | 2019-07-16 | Visufarma B V | Composição que compreende iota-carragenina contra conjuntivite viral |
| AU2017261303B9 (en) * | 2016-05-06 | 2021-09-23 | Sacsh, Inc. | Ophthalmic compositions |
| CN113712928A (zh) * | 2021-09-29 | 2021-11-30 | 重庆市力扬医药开发有限公司 | 经口腔粘膜吸收的溴夫定药物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY136633A (en) * | 2001-01-17 | 2008-11-28 | Berlin Chemie Ag | Stabilized brivudine topical formulations |
| DE10162593A1 (de) * | 2001-12-19 | 2003-07-03 | Menarini Ricerche Spa | Stabilisierte topische Brivudin-Formulierungen |
-
2005
- 2005-09-29 DE DE102005046769A patent/DE102005046769A1/de not_active Withdrawn
-
2006
- 2006-09-27 US US12/088,397 patent/US20080249061A1/en not_active Abandoned
- 2006-09-27 BR BRPI0616449-8A patent/BRPI0616449A2/pt not_active IP Right Cessation
- 2006-09-27 CA CA002624111A patent/CA2624111A1/en not_active Abandoned
- 2006-09-27 ZA ZA200802729A patent/ZA200802729B/xx unknown
- 2006-09-27 CN CNA2006800356965A patent/CN101272765A/zh active Pending
- 2006-09-27 AT AT06805904T patent/ATE489076T1/de active
- 2006-09-27 EA EA200800646A patent/EA012975B1/ru not_active IP Right Cessation
- 2006-09-27 UA UAA200802782A patent/UA90911C2/ru unknown
- 2006-09-27 AP AP2008004394A patent/AP2008004394A0/xx unknown
- 2006-09-27 EP EP06805904A patent/EP1940353B1/en active Active
- 2006-09-27 SI SI200630913T patent/SI1940353T1/sl unknown
- 2006-09-27 DK DK06805904.7T patent/DK1940353T3/da active
- 2006-09-27 DE DE602006018505T patent/DE602006018505D1/de active Active
- 2006-09-27 JP JP2008532659A patent/JP2009509993A/ja not_active Withdrawn
- 2006-09-27 WO PCT/EP2006/009383 patent/WO2007039201A2/en active Application Filing
- 2006-09-27 PT PT06805904T patent/PT1940353E/pt unknown
- 2006-09-27 AU AU2006299115A patent/AU2006299115A1/en not_active Abandoned
- 2006-09-27 KR KR1020087007483A patent/KR20080053319A/ko not_active Application Discontinuation
- 2006-09-27 ES ES06805904T patent/ES2356774T3/es active Active
- 2006-09-27 PL PL06805904T patent/PL1940353T3/pl unknown
- 2006-09-27 TW TW095135667A patent/TW200744664A/zh unknown
- 2006-09-27 RS RS20110016A patent/RS51615B/en unknown
- 2006-09-28 PE PE2006001181A patent/PE20070767A1/es not_active Application Discontinuation
- 2006-09-28 AR ARP060104294A patent/AR056551A1/es unknown
-
2008
- 2008-02-28 TN TNP2008000094A patent/TNSN08094A1/en unknown
- 2008-03-25 EC EC2008008310A patent/ECSP088310A/es unknown
- 2008-03-26 NO NO20081488A patent/NO20081488L/no not_active Application Discontinuation
- 2008-03-27 IL IL190466A patent/IL190466A0/en unknown
- 2008-03-27 HN HN2008000497A patent/HN2008000497A/es unknown
- 2008-03-27 CR CR9839A patent/CR9839A/es not_active Application Discontinuation
- 2008-04-24 MA MA30877A patent/MA29887B1/fr unknown
-
2010
- 2010-12-23 CY CY20101101189T patent/CY1111059T1/el unknown
-
2011
- 2011-02-03 HR HR20110085T patent/HRP20110085T1/hr unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2550500T3 (es) | Uso de prostaglandinas F2alfa y análogos para la curación de lesiones de la córnea y la conjuntiva | |
| HRP20110085T1 (hr) | Fotostabilni farmaceutski pripravci za tretman herpesnog keratitisa koji sadrže brivudin | |
| US7399790B2 (en) | Virucidal compositions | |
| CN101405009B (zh) | 包含黄原胶和葡萄糖的眼科组合物 | |
| JP3090125B2 (ja) | ソフトコンタクトレンズ用の眼科用組成物、ソフトコンタクトレンズの濡れ増強方法およびテルペノイドの吸着抑制方法 | |
| CA2798069C (en) | Stabilized ophthalmic galactomannan formulations | |
| PL188470B1 (pl) | Kompozycja stosowana przeciw mikroorganizmom w zakażeniach wirusem opryszczki i innych chorobach infekcyjnych | |
| JP2019094356A (ja) | 眼科用水性組成物 | |
| AR061166A1 (es) | Composiciones farmaceuticas para la liberacion sostenida de fenilferina | |
| MX2014013444A (es) | Composiciones oftalmicas con retención y proteccion de desecación mejoradas. | |
| JP2003206241A (ja) | 眼科用剤 | |
| WO2012100109A2 (en) | Therapeutic eye drop comprising doxycycline and a stabilizer | |
| JP2011098961A (ja) | 非イオン性シリコーンハイドロゲルコンタクトレンズ用眼科組成物 | |
| JP5258329B2 (ja) | プラノプロフェン含有水性医薬組成物 | |
| US20080268022A1 (en) | Mehtods for treating and preventing ailments caused by human papillomavirus | |
| JPWO2015041193A1 (ja) | 両性イオン性ソフトコンタクトレンズ用眼科用組成物 | |
| JP5019923B2 (ja) | プラノプロフェン含有医薬組成物 | |
| JP2010043068A (ja) | 眼科用組成物及びなみだ目改善剤 | |
| US20140296348A1 (en) | Ophthalmological aqueous composition | |
| JP2019094300A (ja) | 点眼剤組成物 | |
| JP4508628B2 (ja) | 眼科用組成物 | |
| JP2008156268A (ja) | 眼科用組成物 | |
| JP6366583B2 (ja) | 両性イオン性ソフトコンタクトレンズ用眼科用組成物 | |
| GR1010664B (el) | Υδατικο διαλυμα πολλαπλων χρησεων για φακους επαφης που περιεχει εκτοϊνη και μιγμα φυτικων παρασκευασματων | |
| JP2022100796A (ja) | 眼科用組成物 |