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HRP20100284T1 - Derivati piperazinila korisni u liječenju bolesti posredovanih receptorom gpr38 - Google Patents

Derivati piperazinila korisni u liječenju bolesti posredovanih receptorom gpr38 Download PDF

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Publication number
HRP20100284T1
HRP20100284T1 HR20100284T HRP20100284T HRP20100284T1 HR P20100284 T1 HRP20100284 T1 HR P20100284T1 HR 20100284 T HR20100284 T HR 20100284T HR P20100284 T HRP20100284 T HR P20100284T HR P20100284 T1 HRP20100284 T1 HR P20100284T1
Authority
HR
Croatia
Prior art keywords
methyl
phenyl
piperazinyl
pyridinecarboxamide
fluorophenyl
Prior art date
Application number
HR20100284T
Other languages
English (en)
Croatian (hr)
Inventor
Jason Mitchell Darren
Thomas Seal Jonathan
Thompson Mervyn
Marie Westaway Susan
Louisa Brown Samantha
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38476358&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20100284(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0612844A external-priority patent/GB0612844D0/en
Priority claimed from GB0711525A external-priority patent/GB0711525D0/en
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of HRP20100284T1 publication Critical patent/HRP20100284T1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HR20100284T 2006-06-28 2007-06-26 Derivati piperazinila korisni u liječenju bolesti posredovanih receptorom gpr38 HRP20100284T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0612844A GB0612844D0 (en) 2006-06-28 2006-06-28 Compounds
GB0711525A GB0711525D0 (en) 2007-06-14 2007-06-14 Compounds
PCT/EP2007/056342 WO2008000729A1 (en) 2006-06-28 2007-06-26 Piperazinyl derivatives useful in the treatment of gpr38 receptor mediated diseases

Publications (1)

Publication Number Publication Date
HRP20100284T1 true HRP20100284T1 (hr) 2010-06-30

Family

ID=38476358

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20100284T HRP20100284T1 (hr) 2006-06-28 2007-06-26 Derivati piperazinila korisni u liječenju bolesti posredovanih receptorom gpr38

Country Status (29)

Country Link
US (2) US7700599B2 (ru)
EP (1) EP2041093B1 (ru)
JP (1) JP5028484B2 (ru)
KR (1) KR20090031688A (ru)
AR (1) AR061656A1 (ru)
AT (1) ATE465150T1 (ru)
AU (1) AU2007263712B2 (ru)
BR (1) BRPI0713443A2 (ru)
CA (1) CA2655540A1 (ru)
CR (1) CR10497A (ru)
CY (1) CY1110190T1 (ru)
DE (1) DE602007006019D1 (ru)
DK (1) DK2041093T3 (ru)
EA (1) EA015820B1 (ru)
ES (1) ES2344484T3 (ru)
HR (1) HRP20100284T1 (ru)
IL (1) IL195900A0 (ru)
JO (1) JO2645B1 (ru)
MA (1) MA30539B1 (ru)
MX (1) MX2009000110A (ru)
MY (1) MY147677A (ru)
NO (1) NO20090266L (ru)
NZ (1) NZ573450A (ru)
PE (1) PE20080345A1 (ru)
PL (1) PL2041093T3 (ru)
PT (1) PT2041093E (ru)
SI (1) SI2041093T1 (ru)
TW (1) TWI391386B (ru)
WO (1) WO2008000729A1 (ru)

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GB0611907D0 (en) 2006-06-15 2006-07-26 Glaxo Group Ltd Compounds
PL1907374T3 (pl) * 2005-07-26 2012-12-31 Glaxo Group Ltd Pochodne benzylopiperazyny użyteczne do leczenia zaburzeń układu pokarmowego
GB0524814D0 (en) * 2005-12-05 2006-01-11 Glaxo Group Ltd Compounds
TWI391386B (zh) * 2006-06-28 2013-04-01 Glaxo Group Ltd 化合物
GB0723317D0 (en) * 2007-11-28 2008-01-09 Glaxo Group Ltd Compounds
BRPI1007962A2 (pt) 2009-02-27 2016-02-23 Raqualia Pharma Inc composto de fórmula (i), composição farmacêutica contendo o mesmo, uso do mesmo ou de seu sal farmaceuticamente aceitável e método para o tratamento de uma doença mediada pela atividade agonística de receptor de motilina, em um indíviduo mamífero, incluindo um ser humano.
US9452980B2 (en) * 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
EP2531510B1 (en) 2010-02-01 2014-07-23 Novartis AG Pyrazolo[5,1b]oxazole derivatives as crf-1 receptor antagonists
AR080056A1 (es) 2010-02-01 2012-03-07 Novartis Ag Derivados de ciclohexil-amida como antagonistas de los receptores de crf
WO2011095450A1 (en) 2010-02-02 2011-08-11 Novartis Ag Cyclohexyl amide derivatives as crf receptor antagonists
KR20130109124A (ko) * 2010-09-27 2013-10-07 다이이찌 산쿄 가부시키가이샤 시클로헥산 유도체 화합물
US9321727B2 (en) 2011-06-10 2016-04-26 Hoffmann-La Roche Inc. Pyridine derivatives as agonists of the CB2 receptor
KR102537050B1 (ko) 2016-03-17 2023-05-26 에프. 호프만-라 로슈 아게 Taar의 작용제로서 활성을 갖는 5-에틸-4-메틸-피라졸-3-카복스아미드 유도체
TWI794994B (zh) * 2020-09-25 2023-03-01 大陸商上海美悅生物科技發展有限公司 嘧啶甲醯胺類化合物及其應用

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TWI391386B (zh) * 2006-06-28 2013-04-01 Glaxo Group Ltd 化合物

Also Published As

Publication number Publication date
PL2041093T3 (pl) 2010-09-30
PE20080345A1 (es) 2008-05-29
CY1110190T1 (el) 2015-01-14
DK2041093T3 (da) 2010-08-02
US20090192160A1 (en) 2009-07-30
BRPI0713443A2 (pt) 2012-03-06
TWI391386B (zh) 2013-04-01
SI2041093T1 (sl) 2010-07-30
MX2009000110A (es) 2009-01-23
CA2655540A1 (en) 2008-01-03
PT2041093E (pt) 2010-06-28
EP2041093A1 (en) 2009-04-01
KR20090031688A (ko) 2009-03-27
ATE465150T1 (de) 2010-05-15
MY147677A (en) 2012-12-31
WO2008000729A1 (en) 2008-01-03
AU2007263712B2 (en) 2012-08-30
DE602007006019D1 (de) 2010-06-02
EP2041093B1 (en) 2010-04-21
NZ573450A (en) 2011-11-25
US20080027065A1 (en) 2008-01-31
JP2009541432A (ja) 2009-11-26
HK1127608A1 (en) 2009-10-02
JP5028484B2 (ja) 2012-09-19
TW200817352A (en) 2008-04-16
US8853218B2 (en) 2014-10-07
AU2007263712A1 (en) 2008-01-03
MA30539B1 (fr) 2009-06-01
AR061656A1 (es) 2008-09-10
CR10497A (es) 2009-03-20
NO20090266L (no) 2009-03-17
JO2645B1 (en) 2012-06-17
ES2344484T3 (es) 2010-08-27
EA015820B1 (ru) 2011-12-30
IL195900A0 (en) 2009-09-01
EA200970065A1 (ru) 2009-06-30
US7700599B2 (en) 2010-04-20

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