HRP20010126B1 - Pyrroloindoles, pyridoindoles and azepinoindoles as 5-ht2c agonists - Google Patents

Pyrroloindoles, pyridoindoles and azepinoindoles as 5-ht2c agonists

Info

Publication number: HRP20010126B1
Authority: HR; Croatia
Prior art keywords: alkyl; disorders; hydrogen; independently selected; treatment
Prior art date: 1998-09-01

Application number

HR20010126A

Other languages

English (en)

Inventor

David Reginald Adams

Mark Bentley Jonathan

Richard Anthony Roffey Jonathan

John Hamlyn Richard

Gaur Suneel

Alexander James Duncton Matthew

Edward Paul Davidson James

John Bickerdike Michael

Anthony Cliffe Ian

Langham Mansell Howard

Original Assignee

Vernalis Research Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-09-01

Filing date

1999-09-01

Publication date

2005-06-30

1999-09-01 Application filed by Vernalis Research Limited filed Critical Vernalis Research Limited

2002-02-28 Publication of HRP20010126A2 publication Critical patent/HRP20010126A2/hr

2005-06-30 Publication of HRP20010126B1 publication Critical patent/HRP20010126B1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Addiction (AREA)
Endocrinology (AREA)
Obesity (AREA)
Reproductive Health (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Child & Adolescent Psychology (AREA)
Gynecology & Obstetrics (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Cardiology (AREA)
Psychology (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

HR20010126A 1998-09-01 1999-09-01 Pyrroloindoles, pyridoindoles and azepinoindoles as 5-ht2c agonists HRP20010126B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9819035.8A GB9819035D0 (en)	1998-09-01	1998-09-01	Chemical compounds VII
PCT/GB1999/002884 WO2000012510A1 (en)	1998-09-01	1999-09-01	Pyrroloindoles, pyridoindoles and azepinoindoles as 5-ht2c agonists

Publications (2)

Publication Number	Publication Date
HRP20010126A2 HRP20010126A2 (en)	2002-02-28
HRP20010126B1 true HRP20010126B1 (en)	2005-06-30

Family

ID=10838167

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20010126A HRP20010126B1 (en)	1998-09-01	1999-09-01	Pyrroloindoles, pyridoindoles and azepinoindoles as 5-ht2c agonists

Country Status (29)

Country	Link
US (1)	US6433175B1 (zh)
EP (1)	EP1109813B1 (zh)
JP (1)	JP2002523508A (zh)
KR (2)	KR100768595B1 (zh)
CN (1)	CN1165537C (zh)
AT (1)	ATE273308T1 (zh)
AU (1)	AU758084B2 (zh)
BR (1)	BR9913477A (zh)
CA (1)	CA2341991C (zh)
CZ (1)	CZ296275B6 (zh)
DE (1)	DE69919364T2 (zh)
DK (1)	DK1109813T3 (zh)
ES (1)	ES2226430T3 (zh)
GB (1)	GB9819035D0 (zh)
HR (1)	HRP20010126B1 (zh)
HU (1)	HUP0103333A3 (zh)
ID (1)	ID28842A (zh)
IL (2)	IL141659A0 (zh)
MX (1)	MXPA01002101A (zh)
NO (1)	NO321527B1 (zh)
NZ (1)	NZ510097A (zh)
PL (1)	PL346427A1 (zh)
PT (1)	PT1109813E (zh)
RU (1)	RU2232162C2 (zh)
SI (1)	SI1109813T1 (zh)
TR (2)	TR200501110T2 (zh)
WO (1)	WO2000012510A1 (zh)
YU (1)	YU16001A (zh)
ZA (1)	ZA200101457B (zh)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6960579B1 (en)	1998-05-19	2005-11-01	Alcon Manufacturing, Ltd.	Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders
GB9902047D0 (en) *	1999-01-29	1999-03-17	Cerebrus Ltd	Chemical compounds XI
US6465467B1 (en)	1999-05-21	2002-10-15	Biovitrum Ab	Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases
GB9918965D0 (en)	1999-08-11	1999-10-13	Cerebrus Ltd	Chemical compounds xxi
US6818639B2 (en)	2000-07-21	2004-11-16	Biovitrum Ab	Pharmaceutical combination formulation and method of treatment with the combination
SE0002754D0 (sv) *	2000-07-21	2000-07-21	Pharmacia & Upjohn Ab	New pharmaceutical combination formulation and method of treatment with the combination
JP4204315B2 (ja)	2000-11-20	2009-01-07	ビオヴィトルム・アクチボラゲット（プブリクト）	セロトニン５−ｈｔ２レセプターのアンタゴニストとしてのピペラジニルピラジン化合物
SE0004245D0 (sv)	2000-11-20	2000-11-20	Pharmacia Ab	Novel compounds and their use
WO2002059082A2 (en)	2000-12-20	2002-08-01	Bristol-Myers Squibb Pharma Company	Aryl and aminoaryl substituted serotonin receptor agonist and antagonist ligands
CN1250549C (zh) *	2000-12-27	2006-04-12	霍夫曼-拉罗奇有限公司	吲哚衍生物及其作为5－ht2b和5－ht2c受体配体的应用
EP1392658A4 (en)	2001-06-01	2004-10-13	Alcon Inc	NOVEL FUSED INDAZOLES AND INDOLES AND THEIR USE IN THE TREATMENT OF GLAUCOMES
CN100384417C (zh)	2001-06-01	2008-04-30	艾尔科公司	吡喃并吲唑类化合物及其用于制备治疗青光眼药物的用途
WO2002098400A1 (en)	2001-06-01	2002-12-12	Alcon, Inc.	Novel arylaminopropane analogues and their use for the treatment of glaucoma
TW593302B (en)	2001-12-20	2004-06-21	Alcon Inc	Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma
AU2003243089B2 (en)	2002-06-19	2010-01-07	Biovitrum Ab (Publ)	Novel compounds, their use and preparation
CN1678302A (zh) *	2002-08-30	2005-10-05	爱尔康公司	取代的5－苯并二氢吡喃－5－基－乙胺化合物及其在治疗青光眼中的用途
EP1581209A4 (en)	2002-12-13	2009-03-11	Alcon Inc	NEW BENZOPYRAN ANALOGUE AND ITS USE FOR THE TREATMENT OF GLAUKOM
CL2004000826A1 (es)	2003-04-25	2005-03-04	Pfizer	Uso de un agonista para el receptor 5-ht2c para preparar un medicamento util en el tratamiento de la incontinencia urinaria provocada por estres, con la condicion de que el agonista no sea 1-[6-cloro-5-(trifluorometil)-2-piridinil]piperazina (org-129
GB0314967D0 (en)	2003-06-26	2003-07-30	Hoffmann La Roche	Piperazine derivatives
US7435837B2 (en) *	2003-10-24	2008-10-14	Wyeth	Dihydrobenzofuranyl alkanamine derivatives and methods for using same
US7476687B2 (en)	2003-11-26	2009-01-13	Alcon, Inc.	Substituted furo[2,3-g]indazoles for the treatment of glaucoma
US7338972B1 (en)	2003-12-15	2008-03-04	Alcon, Inc.	Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma
US7129257B1 (en)	2003-12-15	2006-10-31	Alcon, Inc.	Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma
AR046890A1 (es)	2003-12-15	2005-12-28	Alcon Inc	[1,4] oxazino [2,3-g] indazoles sustituidos para el tratamiento del glaucoma.
EP2248524A3 (en)	2004-08-25	2011-03-09	Takeda Pharmaceutical Company Limited	Preventives/remedies for stress urinary incontinence and method of screening the same
AU2005302559A1 (en)	2004-11-01	2006-05-11	Wyeth	Substituted indolizines and derivatives as CNS agents
WO2006062839A1 (en)	2004-12-08	2006-06-15	Alcon, Inc.	Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma
WO2006103511A1 (en)	2005-03-31	2006-10-05	Pfizer Products Inc.	Cyclopentapyridine and tetrahydroquinoline derivatives
FR2884252B1 (fr) *	2005-04-08	2007-05-18	Aventis Pharma Sa	Nouveaux derives d'isoindoles, compositions les contenant, leur preparation et leurs utilisations pharmaceutiques notamment en tant qu'inhibiteurs d'activites de la proteine chaperone hsp90
US20060252825A1 (en) *	2005-04-22	2006-11-09	Wyeth	Crystal forms of {[(2r)-7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}amine hydrochloride
AU2006243243B2 (en) *	2005-05-03	2009-05-14	F. Hoffmann-La Roche Ag	Tetracyclic azapyrazinoindolines as 5-HT2 ligands
US8158617B2 (en)	2006-05-16	2012-04-17	Takeda Pharmaceutical Company Limited	Fused heterocyclic compound and use thereof
ATE496894T1 (de) *	2006-07-14	2011-02-15	Pfizer Prod Inc	Tartratsalz von (7s)-7-ä(5-fluor-2-
JP5520051B2 (ja)	2007-11-15	2014-06-11	武田薬品工業株式会社	縮合ピリジン誘導体およびその用途
KR101062376B1 (ko)	2008-04-10	2011-09-06	한국화학연구원	신규 인돌 카르복실산 비스피리딜 카르복사마이드 유도체,이의 제조방법 및 이를 유효성분으로 함유하는 조성물
US20120253036A1 (en)	2009-12-11	2012-10-04	Yukinori Nagakura	Agent for treating fibromyalgia
US20130267500A1 (en)	2010-09-01	2013-10-10	Arena Pharmaceuticals, Inc.	5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level
CN102964352B (zh) *	2012-11-23	2015-04-08	华中师范大学	具有生物活性的手性2,3-二氢吡咯[1,2-a]吲哚衍生物及其不对称合成方法
WO2015066344A1 (en)	2013-11-01	2015-05-07	Arena Pharmaceuticals, Inc.	5-ht2c receptor agonists and compositions and methods of use
WO2019131902A1 (ja)	2017-12-27	2019-07-04	武田薬品工業株式会社	腹圧性尿失禁および便失禁の治療薬
EP3860996A4 (en)	2018-10-02	2022-08-31	Northwestern University	BETA-CARBOLINES AS POSITIVE ALLOSTERIC MODULATORS OF HUMAN SEROTONIN RECEPTOR 2C (5-HT2C)

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3250783A (en)	1964-09-21	1966-05-10	American Cyanamid Co	Novel pyrrolo (1, 2-alpha) indoles
US4134894A (en) *	1978-05-04	1979-01-16	Warner-Lambert Company	Pyrrolo[1,2-a]indole compounds
GB8416724D0 (en)	1984-06-30	1984-08-01	Sorbio Sa Lab	Active compounds
US4778812A (en) *	1987-06-12	1988-10-18	American Home Products Corporation	2,3-dihydro-9-methyl-1H-pyrrolo[1,2-a]indol-1-amines and derivatives thereof
GB8802127D0 (en)	1988-02-01	1988-03-02	Glaxo Group Ltd	Chemical compounds
MC2096A1 (fr) *	1989-02-23	1991-02-15	Hoffmann La Roche	Pyrroles substitues
ES2132223T3 (es) *	1992-03-12	1999-08-16	Smithkline Beecham Plc	Derivados de indol condensados en calidad de antagonistas del receptor 5-ht4.
EP0572863A1 (de) *	1992-06-05	1993-12-08	F. Hoffmann-La Roche Ag	ZNS Pyrazinoindole
TW251284B (zh) *	1992-11-02	1995-07-11	Pfizer
CN1118990A (zh) *	1993-03-08	1996-03-20	藤泽药品工业株式会社	治疗或预防脑血管疾病药物
US5629427A (en) *	1993-08-26	1997-05-13	Peterson; Dwight M.	2,7-diaminomitosene analogues

1998
- 1998-09-01 GB GBGB9819035.8A patent/GB9819035D0/en not_active Ceased
1999
- 1999-09-01 TR TR2005/01110T patent/TR200501110T2/xx unknown
- 1999-09-01 US US09/763,889 patent/US6433175B1/en not_active Expired - Fee Related
- 1999-09-01 EP EP99943091A patent/EP1109813B1/en not_active Expired - Lifetime
- 1999-09-01 CN CNB998128341A patent/CN1165537C/zh not_active Expired - Fee Related
- 1999-09-01 HU HU0103333A patent/HUP0103333A3/hu unknown
- 1999-09-01 ES ES99943091T patent/ES2226430T3/es not_active Expired - Lifetime
- 1999-09-01 DK DK99943091T patent/DK1109813T3/da active
- 1999-09-01 HR HR20010126A patent/HRP20010126B1/xx not_active IP Right Cessation
- 1999-09-01 SI SI9930677T patent/SI1109813T1/xx unknown
- 1999-09-01 YU YU16001A patent/YU16001A/sh unknown
- 1999-09-01 ID IDW20010677A patent/ID28842A/id unknown
- 1999-09-01 IL IL14165999A patent/IL141659A0/xx active IP Right Grant
- 1999-09-01 NZ NZ510097A patent/NZ510097A/xx unknown
- 1999-09-01 CZ CZ20010772A patent/CZ296275B6/cs not_active IP Right Cessation
- 1999-09-01 PT PT99943091T patent/PT1109813E/pt unknown
- 1999-09-01 TR TR2001/00659T patent/TR200100659T2/xx unknown
- 1999-09-01 MX MXPA01002101A patent/MXPA01002101A/es not_active IP Right Cessation
- 1999-09-01 BR BR9913477-2A patent/BR9913477A/pt not_active Application Discontinuation
- 1999-09-01 KR KR1020017002608A patent/KR100768595B1/ko not_active Expired - Fee Related
- 1999-09-01 KR KR1020077011961A patent/KR20070062609A/ko not_active Abandoned
- 1999-09-01 AU AU56375/99A patent/AU758084B2/en not_active Ceased
- 1999-09-01 CA CA002341991A patent/CA2341991C/en not_active Expired - Fee Related
- 1999-09-01 PL PL99346427A patent/PL346427A1/xx not_active IP Right Cessation
- 1999-09-01 RU RU2001108570/04A patent/RU2232162C2/ru not_active IP Right Cessation
- 1999-09-01 JP JP2000567532A patent/JP2002523508A/ja active Pending
- 1999-09-01 DE DE69919364T patent/DE69919364T2/de not_active Expired - Fee Related
- 1999-09-01 AT AT99943091T patent/ATE273308T1/de not_active IP Right Cessation
- 1999-09-01 WO PCT/GB1999/002884 patent/WO2000012510A1/en not_active Application Discontinuation
2001
- 2001-02-21 ZA ZA200101457A patent/ZA200101457B/xx unknown
- 2001-02-26 IL IL141659A patent/IL141659A/en not_active IP Right Cessation
- 2001-02-27 NO NO20010991A patent/NO321527B1/no not_active IP Right Cessation

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Publication number	Publication date
DE69919364T2 (de)	2005-08-04
IL141659A0 (en)	2002-03-10
AU5637599A (en)	2000-03-21
WO2000012510A1 (en)	2000-03-09
HUP0103333A2 (hu)	2002-01-28
ATE273308T1 (de)	2004-08-15
NO20010991D0 (no)	2001-02-27
HRP20010126A2 (en)	2002-02-28
CA2341991C (en)	2009-04-07
NO20010991L (no)	2001-04-23
TR200501110T2 (tr)	2005-07-21
KR20010079715A (ko)	2001-08-22
CA2341991A1 (en)	2000-03-09
PL346427A1 (en)	2002-02-11
KR100768595B1 (ko)	2007-10-18
CZ296275B6 (cs)	2006-02-15
HK1034967A1 (zh)	2001-11-09
JP2002523508A (ja)	2002-07-30
ES2226430T3 (es)	2005-03-16
ID28842A (id)	2001-07-05
DE69919364D1 (de)	2004-09-16
ZA200101457B (en)	2002-02-21
CN1165537C (zh)	2004-09-08
CZ2001772A3 (cs)	2001-07-11
RU2232162C2 (ru)	2004-07-10
US6433175B1 (en)	2002-08-13
EP1109813B1 (en)	2004-08-11
EP1109813A1 (en)	2001-06-27
TR200100659T2 (tr)	2001-10-22
NO321527B1 (no)	2006-05-15
BR9913477A (pt)	2001-10-09
GB9819035D0 (en)	1998-10-28
PT1109813E (pt)	2004-11-30
CN1325399A (zh)	2001-12-05
YU16001A (sh)	2003-10-31
MXPA01002101A (es)	2002-08-20
KR20070062609A (ko)	2007-06-15
HUP0103333A3 (en)	2002-07-29
IL141659A (en)	2007-10-31
NZ510097A (en)	2003-06-30
SI1109813T1 (en)	2005-02-28
DK1109813T3 (da)	2004-12-20
AU758084B2 (en)	2003-03-13

Publication	Publication Date	Title
HRP20010126B1 (en)	2005-06-30	Pyrroloindoles, pyridoindoles and azepinoindoles as 5-ht2c agonists
GB9819019D0 (en)	1998-10-28	Chemical compounds II
GB9819032D0 (en)	1998-10-28	Chemical compounds IV
WO2000017170A3 (en)	2000-08-03	N1-substituted benzopyrazoles as inhibitors of 5-ht2 receptors
HUP0301201A2 (hu)	2003-12-29	Kinazolinonok és kinazolinonokat tartalmazó készítmények
AR029815A1 (es)	2003-07-16	Derivados aza-indolicos, un proceso para su preparacion, composicion farmaceutica, un metodo para su elaboracion y el uso de dichos derivados para la manufactura de un medicamento
IL158269A0 (en)	2004-05-12	Utilization of pyrazoline derivatives in the preparation of a medicament for the prevention and/or treatment of proliferative cell diseases
WO2000012482A3 (en)	2000-05-25	Indazole derivatives with 5-ht2 receptor activity
GEP19970661B (en)	1997-01-04	Process for preparing arylcyclobutyl alkylamine derivatives
PT1147110E (pt)	2003-09-30	Derivados de pirazino (aza)-indol
WO2001012602A8 (en)	2001-04-05	Condensed indoline derivatives and their use as 5ht, in particular 5ht2c, receptor ligands
NZ336754A (en)	2001-03-30	Aminobenzophenones as inhibitors of interleukin and TNF
TW200508221A (en)	2005-03-01	New azetidine compounds
MXPA04003278A (es)	2004-07-23	Derivados de 5-metoxi-8-aril-?1,2,4?triazolo?1,5-a?piridina como antagonistas del receptor de adenosina.
DK1049672T3 (da)	2004-01-19	Azetidincarboxamid-derivater til behandling af CNS-lidelser
JO1815B1 (en)	1995-07-05	Therapeutic agents
MY108027A (en)	1996-07-30	Substitute tetrahydroisoquinolines and use as therepuetic agents

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