HK25483A - 2-aryl-propionic acid precursors - Google Patents
2-aryl-propionic acid precursorsInfo
- Publication number
- HK25483A HK25483A HK254/83A HK25483A HK25483A HK 25483 A HK25483 A HK 25483A HK 254/83 A HK254/83 A HK 254/83A HK 25483 A HK25483 A HK 25483A HK 25483 A HK25483 A HK 25483A
- Authority
- HK
- Hong Kong
- Prior art keywords
- aryl
- propionic acid
- acid precursors
- coomgx
- compounds
- Prior art date
Links
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Substances CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 title 1
- 239000002243 precursor Substances 0.000 title 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- UUFQTNFCRMXOAE-UHFFFAOYSA-N 1-methylmethylene Chemical compound C[CH] UUFQTNFCRMXOAE-UHFFFAOYSA-N 0.000 abstract 1
- -1 6-methoxy-2-naphthyl Chemical group 0.000 abstract 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000000010 aprotic solvent Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
- C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
- C07C53/19—Acids containing three or more carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
- C07C63/14—Monocyclic dicarboxylic acids
- C07C63/15—Monocyclic dicarboxylic acids all carboxyl groups bound to carbon atoms of the six-membered aromatic ring
- C07C63/24—1,3 - Benzenedicarboxylic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compounds of the formula aryl CH(CH3)COOMgX, in which aryl denotes 6-methoxy-2-naphthyl, 4-alkylphenyl or 4'-fluoro-4-biphenyl, and X denotes chlorine or bromine, and their etherates, are described. They are prepared by treating a solution of the corresponding arylmagnesium bromide with the solution of a complex of the formula CH3CH(Br)COOMgX in an aprotic solvent containing an ether. The compounds are important intermediates in the synthesis of known 2-arylpropionic acids of therapeutic importance.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76907077A | 1977-02-16 | 1977-02-16 | |
| US05/863,290 US4144397A (en) | 1977-02-16 | 1977-12-19 | Preparation of 2-aryl-propionic acids by direct coupling utilizing a mixed magnesium halide complex |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK25483A true HK25483A (en) | 1983-08-12 |
Family
ID=27118118
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK253/83A HK25383A (en) | 1977-02-16 | 1983-08-04 | Preparation of 2-aryl-propionic acids by direct coupling utilizing a mixed magnesium halide complex |
| HK254/83A HK25483A (en) | 1977-02-16 | 1983-08-04 | 2-aryl-propionic acid precursors |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK253/83A HK25383A (en) | 1977-02-16 | 1983-08-04 | Preparation of 2-aryl-propionic acids by direct coupling utilizing a mixed magnesium halide complex |
Country Status (18)
| Country | Link |
|---|---|
| CH (3) | CH640499A5 (en) |
| DD (3) | DD137099A5 (en) |
| DK (1) | DK156898C (en) |
| ES (1) | ES467037A1 (en) |
| FI (1) | FI64571C (en) |
| HK (2) | HK25383A (en) |
| HU (2) | HU179309B (en) |
| IE (1) | IE46614B1 (en) |
| IL (1) | IL54019A (en) |
| IT (1) | IT1107880B (en) |
| MY (2) | MY8400039A (en) |
| NO (1) | NO145435C (en) |
| NZ (1) | NZ186472A (en) |
| PL (1) | PL108144B1 (en) |
| PT (1) | PT67654B (en) |
| SE (3) | SE430155B (en) |
| SU (2) | SU1003749A3 (en) |
| YU (3) | YU41427B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8915531D0 (en) * | 1989-07-06 | 1989-08-23 | Ass Octel | Alkaline earth,transition and lanthanide metal inorganic salt complexes |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1459084A (en) * | 1973-05-24 | 1976-12-22 | Boots Co Ltd | Preparation of arylalkanoic acid |
-
1978
- 1978-02-09 HU HU78SI1618A patent/HU179309B/en unknown
- 1978-02-09 HU HU802271A patent/HU183210B/en unknown
- 1978-02-09 FI FI780417A patent/FI64571C/en not_active IP Right Cessation
- 1978-02-10 IL IL54019A patent/IL54019A/en unknown
- 1978-02-10 IT IT67279/78A patent/IT1107880B/en active
- 1978-02-13 DK DK064578A patent/DK156898C/en not_active IP Right Cessation
- 1978-02-13 YU YU329/78A patent/YU41427B/en unknown
- 1978-02-13 SE SE7801648A patent/SE430155B/en not_active IP Right Cessation
- 1978-02-14 NZ NZ186472A patent/NZ186472A/en unknown
- 1978-02-14 IE IE320/78A patent/IE46614B1/en not_active IP Right Cessation
- 1978-02-14 PT PT67654A patent/PT67654B/en unknown
- 1978-02-15 DD DD78203717A patent/DD137099A5/en not_active IP Right Cessation
- 1978-02-15 DD DD78214578A patent/DD148212A5/en not_active IP Right Cessation
- 1978-02-15 DD DD78214577A patent/DD145107A5/en not_active IP Right Cessation
- 1978-02-15 SU SU782580499A patent/SU1003749A3/en active
- 1978-02-15 NO NO780524A patent/NO145435C/en unknown
- 1978-02-15 CH CH167578A patent/CH640499A5/en not_active IP Right Cessation
- 1978-02-16 ES ES467037A patent/ES467037A1/en not_active Expired
- 1978-02-16 PL PL1978204667A patent/PL108144B1/en unknown
- 1978-10-11 SU SU782672198A patent/SU963462A3/en active
-
1982
- 1982-03-09 SE SE8201459A patent/SE453094B/en not_active IP Right Cessation
- 1982-03-09 SE SE8201458A patent/SE453093B/en not_active IP Right Cessation
- 1982-09-07 CH CH531782A patent/CH640498A5/en not_active IP Right Cessation
- 1982-09-07 CH CH531882A patent/CH640500A5/en not_active IP Right Cessation
-
1983
- 1983-03-10 YU YU588/83A patent/YU42843B/en unknown
- 1983-03-10 YU YU587/83A patent/YU43302B/en unknown
- 1983-08-04 HK HK253/83A patent/HK25383A/en not_active IP Right Cessation
- 1983-08-04 HK HK254/83A patent/HK25483A/en not_active IP Right Cessation
-
1984
- 1984-12-30 MY MY39/84A patent/MY8400039A/en unknown
- 1984-12-30 MY MY40/84A patent/MY8400040A/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SE8406138D0 (en) | NEW RETINOIDE | |
| MY8400039A (en) | 2-aryl-propionic acid precursors | |
| JPS55162763A (en) | Perfluoroalkyl compound and its preparation | |
| IL64662A (en) | Preparation of monochloromethyl ketones and the novel 1-chloro-3,3-dimethylpent-4-en-2-one produced thereby | |
| ES445263A1 (en) | Dimercaptoethyl ether sulfonium compounds and use as antiinflammatory and antirheumatic agents | |
| ES450369A1 (en) | Process for preparing 22*33benzoylphenyl** propionate | |
| DE3173145D1 (en) | Cyclopropane derivatives, processes for their preparation and their use in the preparation of dihalovinylcyclopropane carboxylic acids | |
| SU790614A1 (en) | ETHYL ETHER 6- / 2-CHLORO-PHENOXY / -SORBIC ACID, MANIFESTING HERBICIDAL ACTIVITY AND METHOD FOR ITS OBTAINING | |
| Srivastava et al. | Synthesis and reactivity of diorganotellurium (IV) β-diketonates | |
| JPS5473772A (en) | Isoxazoline-3-one derivative | |
| JPS5690035A (en) | Cyclohexylidene acetic acid derivative | |
| JPS57106645A (en) | Preparation of 4-bromo-3-methylchrotonic acid ester | |
| JPS51146442A (en) | Process for preparing cyclopropanecarboxylic acid derivatives | |
| JPS54100398A (en) | Meso-tetra(p-sulfophenyl)porphine derivative | |
| ES477098A2 (en) | Improvements in the object of the main patent no. 414366, by: procedure for the preparation of mono and diesters of the 2,5-dihydroxybenenosulphonic acid. (Machine-translation by Google Translate, not legally binding) | |
| GB2004865A (en) | Methyl-2-picolymercaptan and derivatives thereof which are useful as flavouring agents | |
| JPS5481253A (en) | 2-methyl-2-hydroxyperhydrotriquinacene | |
| JPS57146732A (en) | Preparation of perfluoroalkyl-substituted keto compound | |
| JPS56118068A (en) | 3,8,9-trialkoxyphenanthridinium salt | |
| ES474440A1 (en) | Procedure for the preparation of acid 6 (d (-) a-amino-p-hydroxypenylacetamide) penicilanoic. (Machine-translation by Google Translate, not legally binding) | |
| ES478504A1 (en) | A procedure for the preparation of trans-2,8-dibencilciclocanonan. (Machine-translation by Google Translate, not legally binding) | |
| JPS5444636A (en) | Production of tetrabromobisphenol-s |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PE | Patent expired |