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HK1256417A1 - 氰基噻吩並三唑並二氮雜環庚三烯及其用途 - Google Patents

氰基噻吩並三唑並二氮雜環庚三烯及其用途

Info

Publication number
HK1256417A1
HK1256417A1 HK18115549.4A HK18115549A HK1256417A1 HK 1256417 A1 HK1256417 A1 HK 1256417A1 HK 18115549 A HK18115549 A HK 18115549A HK 1256417 A1 HK1256417 A1 HK 1256417A1
Authority
HK
Hong Kong
Prior art keywords
thienotriazolodiazepines
cyano
cyano thienotriazolodiazepines
Prior art date
Application number
HK18115549.4A
Other languages
English (en)
Inventor
James E Bradner
Jun Qi
Minoru Tanaka
Dennis Buckley
Original Assignee
達納-法伯癌症研究所股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 達納-法伯癌症研究所股份有限公司 filed Critical 達納-法伯癌症研究所股份有限公司
Publication of HK1256417A1 publication Critical patent/HK1256417A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
HK18115549.4A 2015-09-11 2018-12-05 氰基噻吩並三唑並二氮雜環庚三烯及其用途 HK1256417A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562217521P 2015-09-11 2015-09-11
PCT/US2016/051107 WO2017044849A1 (en) 2015-09-11 2016-09-09 Cyano thienotriazolodiazepines and uses thereof

Publications (1)

Publication Number Publication Date
HK1256417A1 true HK1256417A1 (zh) 2019-09-20

Family

ID=58240288

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18115549.4A HK1256417A1 (zh) 2015-09-11 2018-12-05 氰基噻吩並三唑並二氮雜環庚三烯及其用途

Country Status (20)

Country Link
US (1) US11306105B2 (zh)
EP (1) EP3347021A4 (zh)
JP (1) JP2018526421A (zh)
KR (1) KR20180049058A (zh)
CN (1) CN108472300A (zh)
AU (1) AU2016319116B2 (zh)
BR (1) BR112018004618A2 (zh)
CA (1) CA2996974A1 (zh)
CL (2) CL2018000621A1 (zh)
CO (1) CO2018002483A2 (zh)
CR (1) CR20180200A (zh)
HK (1) HK1256417A1 (zh)
IL (1) IL257594A (zh)
MX (1) MX2018003031A (zh)
PE (1) PE20181287A1 (zh)
PH (1) PH12018550027A1 (zh)
RU (1) RU2750164C2 (zh)
SG (1) SG10202007090UA (zh)
WO (1) WO2017044849A1 (zh)
ZA (1) ZA201801548B (zh)

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WO2015117087A1 (en) 2014-01-31 2015-08-06 Dana-Farber Cancer Institute, Inc. Uses of diazepane derivatives
EP3347021A4 (en) 2015-09-11 2019-07-24 Dana-Farber Cancer Institute, Inc. CYANO-THIENOTRIAZOLOAZEPINES AND THEIR USES
SG10202007099TA (en) * 2015-09-11 2020-08-28 Dana Farber Cancer Inst Inc Acetamide thienotriazoldiazepines and uses thereof
SG11201803210YA (en) 2015-11-25 2018-05-30 Dana Farber Cancer Inst Inc Bivalent bromodomain inhibitors and uses thereof
EP3686204A4 (en) * 2017-09-22 2021-05-19 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. THIENODIAZEPIN DERIVATIVES AND THEIR USES
CN108084193A (zh) * 2017-12-19 2018-05-29 郭守东 一种brd4蛋白抑制剂
EP4342543A3 (en) * 2018-09-11 2024-06-19 F. Hoffmann-La Roche AG Tert-butyl (s)-2-(4-(phenyl)-6h-thieno[3,2-f][1,2,4]triazolo[4,3-a] [1,4]diazepin-6-yl) acetate derivatives and related compounds as bromodomain brd4 inhibitors for treating cancer
WO2021175432A1 (en) 2020-03-04 2021-09-10 Boehringer Ingelheim International Gmbh Method for administration of an anti cancer agent
WO2022221786A2 (en) * 2022-06-22 2022-10-20 Plexium, Inc. Compounds and pharmaceutical compositions that modulate brd4

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