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HK1223102A1 - 用於製備嘧啶基環戊烷化合物的方法 - Google Patents

用於製備嘧啶基環戊烷化合物的方法

Info

Publication number
HK1223102A1
HK1223102A1 HK16111431.6A HK16111431A HK1223102A1 HK 1223102 A1 HK1223102 A1 HK 1223102A1 HK 16111431 A HK16111431 A HK 16111431A HK 1223102 A1 HK1223102 A1 HK 1223102A1
Authority
HK
Hong Kong
Prior art keywords
processes
preparation
pyrimidinylcyclopentane
compounds
pyrimidinylcyclopentane compounds
Prior art date
Application number
HK16111431.6A
Other languages
English (en)
Inventor
Hans Iding
Reinhard Reents
Michelangelo Scalone
Francis Gosselin
Original Assignee
Hoffmann La Roche
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche, Genentech Inc filed Critical Hoffmann La Roche
Publication of HK1223102A1 publication Critical patent/HK1223102A1/zh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • A61K31/497Non-condensed pyrazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/02Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from isocyanates with formation of carbamate groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/165Heterorings having nitrogen atoms as the only ring heteroatoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
HK16111431.6A 2013-11-15 2016-09-30 用於製備嘧啶基環戊烷化合物的方法 HK1223102A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13193030 2013-11-15
PCT/US2014/065567 WO2015073739A1 (en) 2013-11-15 2014-11-13 Processes for the preparation of pyrimidinylcyclopentane compounds

Publications (1)

Publication Number Publication Date
HK1223102A1 true HK1223102A1 (zh) 2017-07-21

Family

ID=49582648

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16111431.6A HK1223102A1 (zh) 2013-11-15 2016-09-30 用於製備嘧啶基環戊烷化合物的方法

Country Status (22)

Country Link
US (3) US9862689B2 (zh)
EP (3) EP3068770B1 (zh)
JP (4) JP6374503B2 (zh)
KR (2) KR102493603B1 (zh)
CN (3) CN110590606B (zh)
AR (1) AR098427A1 (zh)
AU (5) AU2014348570B2 (zh)
CA (2) CA2930870C (zh)
ES (2) ES2765511T3 (zh)
HK (1) HK1223102A1 (zh)
HR (2) HRP20231100T1 (zh)
HU (1) HUE063095T2 (zh)
IL (3) IL245636B (zh)
MX (3) MX2020009462A (zh)
MY (2) MY174153A (zh)
NZ (1) NZ720805A (zh)
PL (2) PL3068770T3 (zh)
RU (1) RU2702355C1 (zh)
SG (1) SG10201901578UA (zh)
SI (1) SI3068770T1 (zh)
WO (1) WO2015073739A1 (zh)
ZA (2) ZA201603434B (zh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2020009462A (es) * 2013-11-15 2021-08-31 Hoffmann La Roche Procesos para la preparación de compuestos de pirimidinilciclopentano.
SI3197875T1 (sl) 2014-09-26 2019-12-31 F. Hoffmann-La Roche Ag Postopki za pripravo (ciklopentil(D)pirimidin-4-IL)piperazinskih spojin
KR20250023595A (ko) 2016-08-10 2025-02-18 에프. 호프만-라 로슈 아게 Akt 단백질 키나아제 저해제를 포함하는 약학 조성물
GB201802383D0 (en) * 2018-02-14 2018-03-28 Givaudan Sa Process

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US6545165B1 (en) 2000-02-04 2003-04-08 Roche Colorado Corporation Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one
ATE407126T1 (de) * 2005-05-24 2008-09-15 Hoffmann La Roche Herstellung von (s)-4-fluormethyl-dihydro-furan-2-on
CN101198594A (zh) * 2005-06-22 2008-06-11 尼科梅德有限责任公司 用于制备生产三环苯并咪唑类的中间体的方法
UA95641C2 (xx) * 2006-07-06 2011-08-25 Эррей Биофарма Инк. Гідроксильовані піримідильні циклопентани як інгібітори акт протеїнкінази$гидроксилированные пиримидильные циклопентаны как ингибиторы акт протеинкиназы
AU2007269052B2 (en) * 2006-07-06 2014-10-23 Array Biopharma Inc. Cyclopenta [D] pyrimidines as AKT protein kinase inhibitors
US8063050B2 (en) 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
WO2009029554A2 (en) 2007-08-24 2009-03-05 Codexis, Inc. Improved ketoreductase polypeptides for the stereoselective production of (r)-3-hydroxythiolane
KR101624752B1 (ko) * 2008-01-09 2016-05-26 어레이 바이오파마 인크. Akt 단백질 키나제 저해물질로써의 수산화된 피리미딜 시클로펜탄
CA2711699A1 (en) 2008-01-09 2009-07-16 Array Biopharma Inc. Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors
PE20091364A1 (es) * 2008-01-17 2009-10-13 Novartis Ag Proceso para la preparacion de inhibidores de nep
EP2329013B1 (en) 2008-08-27 2015-10-28 Codexis, Inc. Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
WO2010025085A2 (en) 2008-08-29 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the stereoselective production of (4s)-3[(5s)-5(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one
US20110054174A1 (en) * 2009-08-28 2011-03-03 Stephan Bachmann Process for the preparation of a glucokinase activator compound
EP2558864A1 (en) * 2010-04-16 2013-02-20 Genentech, Inc. Fox03a as predictive biomarker for pi3k/akt kinase pathway inhibitor efficacy
MX2013011329A (es) * 2011-04-01 2014-03-12 Genentech Inc Combinaciones de compuestos inhibidores de akt y erlotinib y metodos de uso.
SG11201407625WA (en) * 2012-05-17 2014-12-30 Genentech Inc Process for making amino acid compounds
RU2650511C2 (ru) * 2012-05-17 2018-04-16 Дженентек, Инк. Формы и составы пиримидинилциклопентанового соединения, композиции и способы, относящиеся к ним
CN104487430B (zh) 2012-05-17 2016-08-24 阵列生物制药公司 用于制造羟基化的环戊基嘧啶化合物的方法
MY169028A (en) * 2012-05-17 2019-02-04 Genentech Inc Process for making hydroxylated cyclopentylpyrimidine compounds
CA2873661C (en) * 2012-05-17 2020-07-21 Genentech, Inc. Process of making hydroxylated cyclopentapyrimidine compounds and salts thereof
MX2020009462A (es) * 2013-11-15 2021-08-31 Hoffmann La Roche Procesos para la preparación de compuestos de pirimidinilciclopentano.
SI3197875T1 (sl) 2014-09-26 2019-12-31 F. Hoffmann-La Roche Ag Postopki za pripravo (ciklopentil(D)pirimidin-4-IL)piperazinskih spojin

Also Published As

Publication number Publication date
JP6374503B2 (ja) 2018-08-15
US10435378B2 (en) 2019-10-08
US20180086722A1 (en) 2018-03-29
IL271331B (en) 2021-03-25
JP6634428B2 (ja) 2020-01-22
IL281072B (en) 2022-05-01
US20160297773A1 (en) 2016-10-13
CN110590606B (zh) 2023-02-17
NZ720805A (en) 2022-01-28
CA2930870A1 (en) 2015-05-21
AR098427A1 (es) 2016-05-26
KR20220139440A (ko) 2022-10-14
EP4282973A3 (en) 2024-03-27
CA2930870C (en) 2023-09-19
MY191759A (en) 2022-07-14
MY174153A (en) 2020-03-11
JP2016539939A (ja) 2016-12-22
CN105899492A (zh) 2016-08-24
AU2014348570A1 (en) 2016-06-09
JP2018052966A (ja) 2018-04-05
MX2016006299A (es) 2017-02-22
CN112898210A (zh) 2021-06-04
EP4282973A2 (en) 2023-11-29
EP3656764C0 (en) 2023-07-05
AU2014348570B2 (en) 2019-02-28
MX374852B (es) 2025-03-06
RU2702355C1 (ru) 2019-10-08
SG10201901578UA (en) 2019-03-28
MX367620B (es) 2019-08-28
CN110590606A (zh) 2019-12-20
EP3068770A1 (en) 2016-09-21
HUE063095T2 (hu) 2023-12-28
IL271331A (en) 2020-01-30
SI3068770T1 (sl) 2020-02-28
ES2765511T3 (es) 2020-06-09
AU2019202461B2 (en) 2021-01-14
MX2019006959A (es) 2019-08-01
KR102698200B1 (ko) 2024-08-26
CN105899492B (zh) 2021-08-24
AU2022275477A1 (en) 2023-01-05
US9862689B2 (en) 2018-01-09
CA3207199A1 (en) 2015-05-21
PL3068770T3 (pl) 2020-04-30
HRP20231100T1 (hr) 2023-12-22
JP2019218384A (ja) 2019-12-26
KR102493603B1 (ko) 2023-01-31
US20200062717A1 (en) 2020-02-27
WO2015073739A1 (en) 2015-05-21
BR112016011048A2 (pt) 2017-08-08
IL245636B (en) 2019-12-31
EP3656764A1 (en) 2020-05-27
RU2019130505A (ru) 2020-02-18
US10858324B2 (en) 2020-12-08
ZA201603434B (en) 2020-08-26
IL245636A0 (en) 2016-06-30
JP2021100953A (ja) 2021-07-08
ZA202002611B (en) 2023-10-25
JP7377828B2 (ja) 2023-11-10
PL3656764T3 (pl) 2024-01-22
KR20160075816A (ko) 2016-06-29
AU2019202461A1 (en) 2019-05-02
HRP20192340T1 (hr) 2020-04-03
EP3068770B1 (en) 2019-10-23
IL281072A (en) 2021-04-29
AU2021202196A1 (en) 2021-05-06
JP6857219B2 (ja) 2021-04-14
BR112016011048A8 (pt) 2020-04-22
ES2957314T3 (es) 2024-01-17
EP3656764B1 (en) 2023-07-05
RU2016123365A (ru) 2017-12-18
EP3068770A4 (en) 2017-04-19
MX2020009462A (es) 2021-08-31
CN112898210B (zh) 2025-02-21
AU2024205845A1 (en) 2024-09-05

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