SG11201407625WA - Process for making amino acid compounds - Google Patents
Process for making amino acid compoundsInfo
- Publication number
- SG11201407625WA SG11201407625WA SG11201407625WA SG11201407625WA SG11201407625WA SG 11201407625W A SG11201407625W A SG 11201407625WA SG 11201407625W A SG11201407625W A SG 11201407625WA SG 11201407625W A SG11201407625W A SG 11201407625WA SG 11201407625W A SG11201407625W A SG 11201407625WA
- Authority
- SG
- Singapore
- Prior art keywords
- lllll
- international
- llll
- amino acid
- acid compounds
- Prior art date
Links
- -1 amino acid compounds Chemical class 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 101000582929 Homo sapiens Plasmolipin Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102100030265 Plasmolipin Human genes 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 239000003197 protein kinase B inhibitor Substances 0.000 abstract 1
- 125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/313—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of doubly bound oxygen containing functional groups, e.g. carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
- C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/32—Preparation of optical isomers by stereospecific synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Peptides Or Proteins (AREA)
Abstract
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 21 November 2013 (21.11.2013) WIPOIPCT (10) International Publication Number WO 2013/173779 A1 (51) International Patent Classification: C07C 67/313 (2006.01) C07C 271/22 (2006.01) C07C 269/06 (2006.01) (21) International Application Number: PCT/US2013/041687 (22) International Filing Date: 17 May 2013 (17.05.2013) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 61/648,534 17 May 2012 (17.05.2012) US (71) Applicant: GENENTECH, INC. [US/US]; 1 DNA Way, South San Francisco, California 94080-4990 (US). (72) Inventor: REMARCHUK, Travis; c/o Genentech, Inc., 1 DNA Way, South San Francisco, California 94080-4990 (US). (74) Agents: MALEN, Peter L. et al.; Viksnins Harris & Padys PLLP, 7900 International Drive, Suite 670, Bloomington, Minnesota 55425 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, [Continued on next page] (54) Title: PROCESS FOR MAKING AMINO ACID COMPOUNDS (57) Abstract: The invention provides new processes for making and purifying amino acid compounds, which are use ful in the preparation of AKT inhibitors used in the treatment of diseases such as cancer, including the compound (S)-2- (4-chlorophenyl)-1 -(4-((5R,7R)-7-hy- droxy- -methyl- 6,7 -dihydro 5 - 5 H-cyclo - penta[d]pyrimidin-4-yl)piperazin-1 -yl)- 3-(isopropylamino)propan-1 -one. 0\ m i> FIG. 1 WO 2013/173779 AI I lllll llllllll II llllll III lllll lllll lllll III III III lllll llll llll lllll lllll lllll lllllll llll llll EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, Published: LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, ~ Wlth mternat ™ nal search re P° rt ( Art - 2l ( » 3 GW, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — ofinventorship (Rule 4.17(iv))
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261648534P | 2012-05-17 | 2012-05-17 | |
| PCT/US2013/041687 WO2013173779A1 (en) | 2012-05-17 | 2013-05-17 | Process for making amino acid compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201407625WA true SG11201407625WA (en) | 2014-12-30 |
Family
ID=48483247
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201407625WA SG11201407625WA (en) | 2012-05-17 | 2013-05-17 | Process for making amino acid compounds |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9278917B2 (en) |
| EP (1) | EP2850054B1 (en) |
| JP (1) | JP6196294B2 (en) |
| KR (1) | KR102074535B1 (en) |
| CN (1) | CN104520263B (en) |
| AU (1) | AU2013262516B2 (en) |
| BR (1) | BR112014028585B1 (en) |
| CA (1) | CA2873658C (en) |
| ES (1) | ES2668477T3 (en) |
| HR (1) | HRP20180948T1 (en) |
| IL (1) | IL235630A (en) |
| MA (1) | MA37751B1 (en) |
| MX (1) | MX350443B (en) |
| MY (1) | MY171538A (en) |
| NZ (1) | NZ702939A (en) |
| PL (1) | PL2850054T3 (en) |
| RU (1) | RU2643146C2 (en) |
| SG (1) | SG11201407625WA (en) |
| SI (1) | SI2850054T1 (en) |
| TR (1) | TR201807444T4 (en) |
| WO (1) | WO2013173779A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013173811A1 (en) | 2012-05-17 | 2013-11-21 | Genentech, Inc. | Amorphous form of an akt inhibiting pyrimidinyl - cyclopentane compound, compositions and methods thereof |
| RU2642311C2 (en) | 2012-05-17 | 2018-01-24 | Дженентек, Инк. | Method for production of hydroxylated cyclopentapyrimidine compounds and their salts |
| SI2861582T1 (en) | 2012-05-17 | 2016-09-30 | Array Biopharma, Inc. | Process for making hydroxylated cyclopentylpyrimidine compounds |
| DK2861583T3 (en) | 2012-05-17 | 2016-10-03 | Array Biopharma Inc | METHOD OF PRODUCING hydroxylated CYCLOPENTYLPYRIMIDINFORBINDELSER |
| PL3656764T3 (en) * | 2013-11-15 | 2024-01-22 | F. Hoffmann-La Roche Ag | Processes for the preparation of pyrimidinylcyclopentane compounds |
| AR102088A1 (en) * | 2014-09-26 | 2017-02-01 | Genentech Inc | PROCESSES TO PREPARE COMPOUNDS OF (CYCLOPENTIL [D] PIRIMIDIN-4-IL) PIPERAZINE |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4663327A (en) * | 1984-05-23 | 1987-05-05 | Bayer Aktiengesellschaft | 1-heteroaryl-4-aryl-pyrazolin-5-ones |
| EP0732874A4 (en) | 1993-12-12 | 1998-10-07 | Agrogene Ltd | A novel method to protect plants from fungal infection |
| AU724216B2 (en) | 1997-04-07 | 2000-09-14 | Merck & Co., Inc. | A method of treating cancer |
| US6201023B1 (en) | 1997-06-10 | 2001-03-13 | Agrogene Ltd. | Methods and compositions to protect crops against plant parasitic nematodes |
| EP0982300A3 (en) | 1998-07-29 | 2000-03-08 | Societe Civile Bioprojet | Non-imidazole alkylamines as histamine H3 - receptor ligands and their therapeutic applications |
| AU3386600A (en) | 1999-03-03 | 2000-09-21 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| WO2001022963A1 (en) | 1999-09-27 | 2001-04-05 | Merck & Co., Inc. | Method of preventing osteoporosis |
| CA2526506A1 (en) | 2003-06-09 | 2004-12-16 | Boehringer Ingelheim International Gmbh | Inhibitors of papilloma virus |
| FR2892416B1 (en) * | 2005-10-20 | 2008-06-27 | Sanofi Aventis Sa | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF |
| US8927546B2 (en) | 2006-02-28 | 2015-01-06 | Dart Neuroscience (Cayman) Ltd. | Therapeutic piperazines |
| UA95641C2 (en) | 2006-07-06 | 2011-08-25 | Эррей Биофарма Инк. | HYDROXYLATED PYRIMIDYL CYCLOPENTANE AS AKT PROTEIN KINASE INHIBITORS |
| US8063050B2 (en) | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
| US20100298289A1 (en) | 2007-10-09 | 2010-11-25 | Ucb Pharma, S.A. | Heterobicyclic compounds as histamine h4-receptor antagonists |
| CN102459165B (en) | 2009-04-15 | 2015-09-02 | Abbvie公司 | Antiviral compound |
| MX2012004780A (en) | 2009-10-23 | 2012-08-23 | Lilly Co Eli | Akt inhibitors. |
| EP2592933B1 (en) | 2010-07-16 | 2017-04-05 | Anderson Gaweco | Mif inhibitors and their uses |
| WO2012177925A1 (en) | 2011-06-21 | 2012-12-27 | The Board Institute, Inc. | Akt inhibitors for treating cancer expressing a magi3 - akt3 fusion gene |
| RU2642311C2 (en) | 2012-05-17 | 2018-01-24 | Дженентек, Инк. | Method for production of hydroxylated cyclopentapyrimidine compounds and their salts |
| DK2861583T3 (en) | 2012-05-17 | 2016-10-03 | Array Biopharma Inc | METHOD OF PRODUCING hydroxylated CYCLOPENTYLPYRIMIDINFORBINDELSER |
| CA2889855A1 (en) | 2012-11-01 | 2014-05-08 | Robert S. Katz | Methods for treating fibromyalgia |
| US20150376198A1 (en) | 2013-02-18 | 2015-12-31 | The Scripps Research Institute | Modulators of vasopressin receptors with therapeutic potential |
| BR112015023193A2 (en) | 2013-03-15 | 2017-07-18 | Shifa Biomedical Corp | uses of a compound and a modulator, and, compound |
-
2013
- 2013-05-17 CA CA2873658A patent/CA2873658C/en active Active
- 2013-05-17 TR TR2018/07444T patent/TR201807444T4/en unknown
- 2013-05-17 MX MX2014013863A patent/MX350443B/en active IP Right Grant
- 2013-05-17 HR HRP20180948TT patent/HRP20180948T1/en unknown
- 2013-05-17 PL PL13724711T patent/PL2850054T3/en unknown
- 2013-05-17 CN CN201380037572.0A patent/CN104520263B/en active Active
- 2013-05-17 KR KR1020147035263A patent/KR102074535B1/en active Active
- 2013-05-17 EP EP13724711.0A patent/EP2850054B1/en active Active
- 2013-05-17 RU RU2014150991A patent/RU2643146C2/en active
- 2013-05-17 JP JP2015512903A patent/JP6196294B2/en active Active
- 2013-05-17 ES ES13724711.0T patent/ES2668477T3/en active Active
- 2013-05-17 MY MYPI2014703417A patent/MY171538A/en unknown
- 2013-05-17 SG SG11201407625WA patent/SG11201407625WA/en unknown
- 2013-05-17 US US14/401,095 patent/US9278917B2/en active Active
- 2013-05-17 AU AU2013262516A patent/AU2013262516B2/en active Active
- 2013-05-17 BR BR112014028585-3A patent/BR112014028585B1/en active IP Right Grant
- 2013-05-17 NZ NZ702939A patent/NZ702939A/en not_active IP Right Cessation
- 2013-05-17 MA MA37751A patent/MA37751B1/en unknown
- 2013-05-17 SI SI201331043T patent/SI2850054T1/en unknown
- 2013-05-17 WO PCT/US2013/041687 patent/WO2013173779A1/en active Application Filing
-
2014
- 2014-11-11 IL IL235630A patent/IL235630A/en active IP Right Grant
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SG11201909955XA (en) | Formulations of anti-lag3 antibodies and co-formulations of anti-lag3 antibodies and anti-pd-1 antibodies | |
| SG11201805044WA (en) | Compounds useful as kinase inhibitors | |
| SG11201809344QA (en) | Process for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde | |
| SG11201805300QA (en) | Heterocyclic compounds as immunomodulators | |
| SG11201407591PA (en) | Process of making hydroxylated cyclopentapyrimidine compounds and salts thereof | |
| SG11201811431VA (en) | Multispecific antibodies against cd40 and cd137 | |
| SG11201809912UA (en) | Hybrid carriers for nucleic acid cargo | |
| SG11201810600WA (en) | Fxr (nr1h4) modulating compounds | |
| SG11201407580YA (en) | Composition comprising two antibodies engineered to have reduced and increased effector function | |
| SG11201804398XA (en) | Method for producing rna molecule compositions | |
| SG11201900163PA (en) | Macrocycle kinase inhibitors | |
| SG11201908326YA (en) | Methods of treating neurodegenerative diseases | |
| SG11201804510PA (en) | Biparatopic polypeptides antagonizing wnt signaling in tumor cells | |
| SG11201810371XA (en) | ANTI-N3pGlu AMYLOID BETA PEPTIDE ANTIBODIES AND USES THEREOF | |
| SG11201900349VA (en) | Somatostatin modulators and uses thereof | |
| SG11201406973PA (en) | Complement pathway modulators and uses thereof | |
| SG11201807827VA (en) | Process for the preparation of pegylated drug-linkers and intermediates thereof | |
| SG11201408133TA (en) | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases | |
| SG11202000333UA (en) | Bicyclic ketone compounds and methods of use thereof | |
| SG11201407613RA (en) | Process for making hydroxylated cyclopentylpyrimidine compounds | |
| SG11201407625WA (en) | Process for making amino acid compounds | |
| SG11201908512YA (en) | Somatostatin modulators and uses thereof | |
| SG11201407546QA (en) | Novel ring-substituted n-pyridinyl amides as kinase inhibitors | |
| SG11201408037SA (en) | Humanized anti-trka antibodies with amino acid substitutions | |
| SG11201804704PA (en) | Compositions and methods for decreasing tau expression |