SG11201810371XA - ANTI-N3pGlu AMYLOID BETA PEPTIDE ANTIBODIES AND USES THEREOF - Google Patents
ANTI-N3pGlu AMYLOID BETA PEPTIDE ANTIBODIES AND USES THEREOFInfo
- Publication number
- SG11201810371XA SG11201810371XA SG11201810371XA SG11201810371XA SG11201810371XA SG 11201810371X A SG11201810371X A SG 11201810371XA SG 11201810371X A SG11201810371X A SG 11201810371XA SG 11201810371X A SG11201810371X A SG 11201810371XA SG 11201810371X A SG11201810371X A SG 11201810371XA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- indianapolis
- rule
- n3pglu
- pct
- Prior art date
Links
- 208000024827 Alzheimer disease Diseases 0.000 abstract 2
- 208000005145 Cerebral amyloid angiopathy Diseases 0.000 abstract 2
- 102000013455 Amyloid beta-Peptides Human genes 0.000 abstract 1
- 108010090849 Amyloid beta-Peptides Proteins 0.000 abstract 1
- 201000010374 Down Syndrome Diseases 0.000 abstract 1
- 206010044688 Trisomy 21 Diseases 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 230000008021 deposition Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000006698 induction Effects 0.000 abstract 1
- 238000011419 induction treatment Methods 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 102220240796 rs553605556 Human genes 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property MD 1101111 0 DOI HIM 011101 0 011111111111111111111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\"\" WO 2018/005282 Al 04 January 2018 (04.01.2018) W I PO I PCT (51) International Patent Classification: Declarations under Rule 4.17: C07K 16/18 (2006.01) A61P 25/28 (2006.01) A61K 39/395 (2006.01) — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) (21) International Application Number: — as to the applicant's entitlement to claim the priority of the PCT/US2017/038999 earlier application (Rule 4.17(iii)) (22) International Filing Date: Published: 23 June 2017 (23.06.2017) — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a)) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/357,579 01 July 2016 (01.07.2016) US (71) Applicant: ELI LILLY AND COMPANY [US/US]; Lilly Corporate Center, Indianapolis, Indiana 46285 (US). (72) Inventors: DEMATTOS, Ronald Bradley; c/o ELI LIL- LY AND COMPANY, P.O. Box 6288, Indianapolis, Indi- ana 46206-6288 (US). IRIZARRY, Michael Carl; c/o ELI LILLY AND COMPANY, P.O. Box 6288, Indianapolis, In- diana 46206-6288 (US). — = Agent: JIVRAJ, Sanjay M. et al.; ELI LILLY AND COM- (74) _ PANY, P.O. Box 6288, Indianapolis, Indiana 46206-6288 = (US). Designated States (unless otherwise indicated, for every = (81) kind of national protection available): AE, AG, AL, AM, = _ AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, = CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, = = KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, = = SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = = Designated States (unless otherwise indicated, for every (84) = kind of regional protection available): ARIPO (BW, GH, = GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, = UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, = TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, — EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). = — 1-1 ei GC N kr) 0 C:::: ) (54) Title: ANTI-N3pGlu AMYLOID BETA PEPTIDE ANTIBODIES AND USES THEREOF --.... ,-1 (57) : The invention is directed to a short term induction treatment with anti-N3pGlu AO antibodies of a disease characterized 0 by deposition of AO in the brain, that include Alzheimer's disease (AD), Down's syndrome, and cerebral amyloid angiopathy (CAA). \" In certain embodiments, patients are administered an induction dose of 10 to 60 mg/kg of an anti-N3pGlu AO antibody for a period 0 of 6 months or less.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662357579P | 2016-07-01 | 2016-07-01 | |
| PCT/US2017/038999 WO2018005282A1 (en) | 2016-07-01 | 2017-06-23 | ANTI-N3pGlu AMYLOID BETA PEPTIDE ANTIBODIES AND USES THEREOF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201810371XA true SG11201810371XA (en) | 2018-12-28 |
Family
ID=59295341
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201810371XA SG11201810371XA (en) | 2016-07-01 | 2017-06-23 | ANTI-N3pGlu AMYLOID BETA PEPTIDE ANTIBODIES AND USES THEREOF |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US11312763B2 (en) |
| EP (2) | EP4272828A3 (en) |
| JP (4) | JP7165588B2 (en) |
| KR (3) | KR20210024213A (en) |
| CN (3) | CN114887054A (en) |
| AU (1) | AU2017291414B2 (en) |
| BR (1) | BR112018073843A2 (en) |
| CA (1) | CA3029550C (en) |
| DK (1) | DK3478712T5 (en) |
| EA (1) | EA201892690A1 (en) |
| ES (1) | ES2958508T3 (en) |
| FI (1) | FI3478712T3 (en) |
| HR (1) | HRP20230861T1 (en) |
| HU (1) | HUE062980T2 (en) |
| IL (1) | IL263788B2 (en) |
| LT (1) | LT3478712T (en) |
| MA (1) | MA45543B1 (en) |
| MD (1) | MD3478712T2 (en) |
| MX (2) | MX2018016066A (en) |
| NZ (1) | NZ772768A (en) |
| PL (1) | PL3478712T3 (en) |
| PT (1) | PT3478712T (en) |
| RS (1) | RS64386B1 (en) |
| SG (1) | SG11201810371XA (en) |
| SI (1) | SI3478712T1 (en) |
| TW (2) | TWI735600B (en) |
| UA (2) | UA127101C2 (en) |
| WO (1) | WO2018005282A1 (en) |
| ZA (1) | ZA201807633B (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI735600B (en) | 2016-07-01 | 2021-08-11 | 美商美國禮來大藥廠 | ANTI-N3pGlu AMYLOID BETA PEPTIDE ANTIBODIES AND USES THEREOF |
| JOP20190247A1 (en) | 2017-04-20 | 2019-10-20 | Lilly Co Eli | ANTI-N3pGlu AMYLOID BETA PEPTIDE ANTIBODIES AND USES THEREOF |
| EP3521308B1 (en) * | 2018-01-31 | 2024-03-13 | Vivoryon Therapeutics N.V. | Humanized and de-immunized antibodies |
| WO2019169448A1 (en) * | 2018-03-09 | 2019-09-12 | St Vincent's Institute Of Medical Research | Multi-specific antibodies |
| MX2021000778A (en) * | 2018-07-24 | 2021-03-31 | Eisai R&D Man Co Ltd | METHODS OF TREATMENT AND PREVENTION OF ALZHEIMER'S DISEASE. |
| CN111184725B (en) * | 2020-02-27 | 2020-12-01 | 慈溪市人民医院医疗健康集团(慈溪市人民医院) | Medicinal preparation for preventing and treating cerebral infarction and preparation method thereof |
| TWI843040B (en) * | 2021-01-11 | 2024-05-21 | 美商美國禮來大藥廠 | ANTI-N3pGlu AMYLOID BETA ANTIBODIES AND USES THEREOF |
| WO2022251048A1 (en) | 2021-05-24 | 2022-12-01 | Eli Lilly And Company | Anti-amyloid beta antibodies and uses thereof |
| MX2024005146A (en) * | 2021-10-29 | 2024-05-13 | Lilly Co Eli | Compounds and methods targeting interleukin-34. |
| AU2022376940A1 (en) * | 2021-10-29 | 2024-05-02 | Eli Lilly And Company | Compounds and methods targeting interleukin-34 |
| WO2023146818A2 (en) * | 2022-01-26 | 2023-08-03 | T3D Therapeutics, Inc. | Methods of treating amyloid related brain disorders using novel compounds and antibodies |
| US20250064417A1 (en) * | 2022-02-03 | 2025-02-27 | Eli Lilly And Company | Regional tau imaging for diagnosing and treating alzheimer's disease |
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| US1397539A (en) * | 1920-01-14 | 1921-11-22 | Odell Risdon Moore | Egg-carton |
| MXPA02008145A (en) | 2000-02-24 | 2004-04-05 | Univ Washington | HUMANIZED ANTIBODIES THAT SEQUESTER Abeta PEPTIDE. |
| US7122374B1 (en) | 2002-04-09 | 2006-10-17 | Takaomi Saido | Amyloid beta-protein 3(pE)-42 antibodies and uses thereof |
| JP2006513259A (en) | 2002-07-24 | 2006-04-20 | イノジェネティックス・ナムローゼ・フェンノートシャップ | Prevention, treatment and diagnosis of diseases associated with beta-amyloid production and / or aggregation |
| US20070031416A1 (en) | 2003-09-09 | 2007-02-08 | Takeda Pharmaceutical Company Limited | Use of antibody |
| KR20070040824A (en) | 2004-07-30 | 2007-04-17 | 리나트 뉴로사이언스 코퍼레이션 | Antibodies directed against amyloid-beta peptides and methods of use thereof |
| RS52004B (en) | 2005-12-12 | 2012-04-30 | F. Hoffmann-La Roche Ag | Antiboides against amyloid beta with glycosylation in the variable region |
| CA2630344C (en) | 2006-03-23 | 2015-04-28 | Bioarctic Neuroscience Ab | Improved protofibril selective antibodies and the use thereof |
| KR101605207B1 (en) | 2006-07-14 | 2016-03-22 | 에이씨 이뮨 에스.에이. | Humanized antibody against amyloid beta |
| KR101414847B1 (en) | 2007-01-18 | 2014-07-03 | 일라이 릴리 앤드 캄파니 | Pegylated A [beta] FAB |
| PT2182983E (en) * | 2007-07-27 | 2014-09-01 | Janssen Alzheimer Immunotherap | Treatment of amyloidogenic diseases with humanised anti-abeta antibodies |
| EP2310032A2 (en) | 2008-06-12 | 2011-04-20 | Affiris AG | Compounds for treating symptoms associated with parkinson's disease |
| CA2730073A1 (en) | 2008-07-09 | 2010-01-14 | University Of Zurich | Method of promoting neurogenesis |
| NZ590563A (en) | 2008-07-21 | 2012-06-29 | Probiodrug Ag | Diagnostic antibody assay |
| CN101397539B (en) * | 2008-10-14 | 2011-10-05 | 中国人民解放军第三军医大学 | Force application apparatus simulating human physiological stress of tissue bionic culture for tissue engineering |
| UA108363C2 (en) | 2009-10-08 | 2015-04-27 | IMINOTIADIASIADIOXIDE OXIDES AS BACE INHIBITORS, COMPOSITIONS THEREOF AND THEIR APPLICATIONS | |
| EP2576617B1 (en) | 2010-06-04 | 2016-04-27 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts Universitätsmedizin | MONOCLONAL ANTIBODIES TARGETING Aß OLIGOMERS |
| WO2012021475A2 (en) | 2010-08-12 | 2012-02-16 | Eli Lilly And Company | ANTI-N3pGlu AMYLOID BETA PEPTIDE ANTIBODIES AND USES THEREOF |
| EP2603523B1 (en) * | 2010-08-12 | 2016-01-27 | Eli Lilly and Company | ANTI-N3pGlu AMYLOID BETA PEPTIDE ANTIBODIES AND USES THEREOF |
| WO2012136552A1 (en) | 2011-04-08 | 2012-10-11 | H. Lundbeck A/S | ANTIBODIES SPECIFIC TO PYROGLUTAMATED Αβ |
| JP2016501247A (en) | 2012-12-07 | 2016-01-18 | バイオジェン インターナショナル ニューロサイエンス ゲーエムベーハー | Method for reducing brain amyloid plaques using anti-Aβ antibody |
| TWI593692B (en) | 2013-03-12 | 2017-08-01 | 美國禮來大藥廠 | Tetrahydropyrrolothiazine compounds |
| EP3102230B1 (en) | 2014-02-08 | 2021-04-28 | F. Hoffmann-La Roche AG | Methods of treating alzheimer's disease |
| WO2015175769A1 (en) * | 2014-05-15 | 2015-11-19 | Biogen Ma Inc. | Methods for the detection of amyloid beta oligomers in biological samples |
| WO2015191825A1 (en) * | 2014-06-13 | 2015-12-17 | Biogen Ma Inc. | Methods for the detection and measurement of amyloid beta in biological samples |
| JP6201928B2 (en) * | 2014-08-04 | 2017-09-27 | トヨタ自動車株式会社 | Vehicle control device |
| TWI570127B (en) | 2014-09-15 | 2017-02-11 | 美國禮來大藥廠 | Crystalline n-[3- [(4ar,7as)-2-amino-6-(5-fluoropyrimidin-2-yl)-4,4a,5,7- tetrahydropyrrolo [3,4-d] [ 1 ,3]thiazin-7a-yl] -4-fluoro-phenyl] -5 -methoxy- pyrazine-2-carboxamide, and use and pharmaceutical composition thereof |
| TWI599358B (en) * | 2014-09-16 | 2017-09-21 | 美國禮來大藥廠 | Combination therapy |
| US10017505B2 (en) | 2014-09-30 | 2018-07-10 | Merck Sharp & Dohme Corp. | Crystalline forms of a BACE inhibitor, compositions, and their use |
| MA41115A (en) * | 2014-12-02 | 2017-10-10 | Biogen Int Neuroscience Gmbh | ALZHEIMER'S DISEASE TREATMENT PROCESS |
| JOP20170004B1 (en) | 2016-01-15 | 2022-09-15 | Lilly Co Eli | Anti-N3pGlu anti-amyloid beta-peptide antibody and its uses |
| TWI735600B (en) | 2016-07-01 | 2021-08-11 | 美商美國禮來大藥廠 | ANTI-N3pGlu AMYLOID BETA PEPTIDE ANTIBODIES AND USES THEREOF |
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2017
- 2017-06-16 TW TW106120115A patent/TWI735600B/en active
- 2017-06-16 TW TW110125726A patent/TWI798751B/en active
- 2017-06-23 CN CN202210683585.6A patent/CN114887054A/en active Pending
- 2017-06-23 CN CN202210683554.0A patent/CN114917338A/en active Pending
- 2017-06-23 BR BR112018073843-3A patent/BR112018073843A2/en unknown
- 2017-06-23 EP EP23176986.0A patent/EP4272828A3/en active Pending
- 2017-06-23 UA UAA201811726A patent/UA127101C2/en unknown
- 2017-06-23 CN CN201780040635.6A patent/CN109415433A/en active Pending
- 2017-06-23 MD MDE20190551T patent/MD3478712T2/en unknown
- 2017-06-23 MA MA45543A patent/MA45543B1/en unknown
- 2017-06-23 SI SI201731389T patent/SI3478712T1/en unknown
- 2017-06-23 WO PCT/US2017/038999 patent/WO2018005282A1/en unknown
- 2017-06-23 HR HRP20230861TT patent/HRP20230861T1/en unknown
- 2017-06-23 CA CA3029550A patent/CA3029550C/en active Active
- 2017-06-23 LT LTEPPCT/US2017/038999T patent/LT3478712T/en unknown
- 2017-06-23 IL IL263788A patent/IL263788B2/en unknown
- 2017-06-23 AU AU2017291414A patent/AU2017291414B2/en active Active
- 2017-06-23 FI FIEP17736841.2T patent/FI3478712T3/en active
- 2017-06-23 SG SG11201810371XA patent/SG11201810371XA/en unknown
- 2017-06-23 HU HUE17736841A patent/HUE062980T2/en unknown
- 2017-06-23 UA UAA202202998A patent/UA129392C2/en unknown
- 2017-06-23 US US16/310,629 patent/US11312763B2/en active Active
- 2017-06-23 MX MX2018016066A patent/MX2018016066A/en unknown
- 2017-06-23 PL PL17736841.2T patent/PL3478712T3/en unknown
- 2017-06-23 ES ES17736841T patent/ES2958508T3/en active Active
- 2017-06-23 KR KR1020217005333A patent/KR20210024213A/en not_active Ceased
- 2017-06-23 JP JP2018567740A patent/JP7165588B2/en active Active
- 2017-06-23 KR KR1020237004025A patent/KR20230021773A/en not_active Withdrawn
- 2017-06-23 EP EP17736841.2A patent/EP3478712B1/en active Active
- 2017-06-23 RS RS20230595A patent/RS64386B1/en unknown
- 2017-06-23 PT PT177368412T patent/PT3478712T/en unknown
- 2017-06-23 DK DK17736841.2T patent/DK3478712T5/en active
- 2017-06-23 NZ NZ772768A patent/NZ772768A/en unknown
- 2017-06-23 EA EA201892690A patent/EA201892690A1/en unknown
- 2017-06-23 KR KR1020187037757A patent/KR102221402B1/en active Active
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2018
- 2018-11-13 ZA ZA2018/07633A patent/ZA201807633B/en unknown
- 2018-12-18 MX MX2023001299A patent/MX2023001299A/en unknown
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2020
- 2020-12-03 JP JP2020201051A patent/JP2021059547A/en active Pending
- 2020-12-03 JP JP2020201050A patent/JP7241058B2/en active Active
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2022
- 2022-04-01 US US17/711,099 patent/US20220235122A1/en active Pending
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2023
- 2023-06-06 JP JP2023093033A patent/JP2023123503A/en active Pending
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