HK1115131A1 - Pharmaceutical salts and polymorphs of n-(5-chloro-2-pyridinyl)-2-[[4- [(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxy-benzamide , a factor xa inhibitor - Google Patents

Pharmaceutical salts and polymorphs of n-(5-chloro-2-pyridinyl)-2-[[4- [(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxy-benzamide , a factor xa inhibitor

Info

Publication number: HK1115131A1
Authority: HK; Hong Kong
Prior art keywords: iminomethyl; polymorphs; benzamide; pyridinyl; dimethylamino
Prior art date: 2005-11-08

Application number

HK08110550.3A

Other languages

English (en)

Inventor

Craig Grant

James P Kanter

Graeme Langlands

Original Assignee

Millennium Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-11-08

Filing date

2008-09-23

Publication date

2008-11-21

2008-09-23 Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc

2008-11-21 Publication of HK1115131A1 publication Critical patent/HK1115131A1/xx

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Hematology (AREA)
Diabetes (AREA)
Vascular Medicine (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

HK08110550.3A 2005-11-08 2008-09-23 Pharmaceutical salts and polymorphs of n-(5-chloro-2-pyridinyl)-2-[[4- [(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxy-benzamide , a factor xa inhibitor HK1115131A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US73522405P	2005-11-08	2005-11-08
PCT/US2006/043635 WO2007056517A2 (en)	2005-11-08	2006-11-07	Pharmaceutical salts and polymorphs of n- (5-chl0r0-2-pyridinyl) -2- [ [4- [ (dimethylamino) iminomethyl] benzoyl] amino] -5-meth oxy-benzamide, a factor xa inhibitor

Publications (1)

Publication Number	Publication Date
HK1115131A1 true HK1115131A1 (en)	2008-11-21

Family

ID=38023988

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK08110550.3A HK1115131A1 (en)	2005-11-08	2008-09-23	Pharmaceutical salts and polymorphs of n-(5-chloro-2-pyridinyl)-2-[[4- [(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxy-benzamide , a factor xa inhibitor

Country Status (21)

Country	Link
US (7)	US7598276B2 (xx)
EP (2)	EP2431358A1 (xx)
JP (2)	JP5227178B2 (xx)
KR (1)	KR101358574B1 (xx)
CN (2)	CN102336702B (xx)
AR (2)	AR056787A1 (xx)
AT (1)	ATE549317T1 (xx)
AU (1)	AU2006311544B2 (xx)
BR (1)	BRPI0618362A2 (xx)
CA (1)	CA2627086C (xx)
DK (1)	DK1948608T3 (xx)
ES (1)	ES2384116T3 (xx)
HK (1)	HK1115131A1 (xx)
IL (2)	IL190524A (xx)
NZ (2)	NZ567992A (xx)
PE (2)	PE20110070A1 (xx)
PT (1)	PT1948608E (xx)
RU (1)	RU2440986C2 (xx)
TW (1)	TWI443088B (xx)
WO (1)	WO2007056517A2 (xx)
ZA (1)	ZA200803820B (xx)

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US7598276B2 (en)	2005-11-08	2009-10-06	Millenium Pharmaceuticals, Inc.	Pharmaceutical salts and polymorphs of a factor Xa inhibitor
US20090186810A1 (en) *	2006-03-27	2009-07-23	Portola Pharmaceuticals, Inc.	Potassium channel modulators and platelet procoagulant activity
US7763608B2 (en) *	2006-05-05	2010-07-27	Millennium Pharmaceuticals, Inc.	Factor Xa inhibitors
ES2382055T3 (es)	2006-11-02	2012-06-04	Millennium Pharmaceuticals, Inc.	Métodos para sintetizar sales farmacéuticas de un inhibidor del factor Xa
AU2007333377B2 (en)	2006-12-08	2014-01-16	Millennium Pharmaceuticals, Inc.	Unit dose formulations and methods of treating thrombosis with an oral factor Xa inhibitor
CA2674924A1 (en) *	2007-01-05	2008-07-17	Millennium Pharmaceuticals, Inc.	Factor xa inhibitors
TWI384986B (zh) *	2007-01-17	2013-02-11	Lg Life Sciences Ltd	抗病毒劑之順丁烯二酸單鹽以及含有該單鹽之醫藥組成物
CN103071154A (zh) *	2007-04-13	2013-05-01	千年药品公司	用起因子xa抑制剂作用的化合物的组合抗凝治疗
CN101686959B (zh)	2007-05-02	2014-05-07	波托拉医药品公司	作为血小板adp受体抑制剂的化合物的组合疗法
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CN102625712B (zh)	2009-07-15	2017-07-25	博尔托拉制药公司	用于因子xa抑制剂的解毒剂的单位剂量制剂及其使用方法
AR079491A1 (es)	2009-12-17	2012-02-01	Millennium Pharm Inc	Metodos de sintesis de inhibidores del factor xa tal como el betrixaban y composiciones farmaceuticas que contienen la base libre de betrixaban o su sal sustancialmente pura.
WO2011075602A1 (en) *	2009-12-17	2011-06-23	Millennium Pharmaceuticals, Inc.	Methods of preparing factor xa inhibitors and salts thereof
JP5796872B2 (ja) *	2009-12-17	2015-10-21	ミレニアムファーマシューティカルズ，インコーポレイテッドＭｉｌｌｅｎｎｉｕｍＰｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ．	第Ｘａ因子阻害剤の結晶性塩
EA015918B1 (ru) *	2010-03-03	2011-12-30	Дмитрий Геннадьевич ТОВБИН	УРЕТАНЫ, МОЧЕВИНЫ, АМИДЫ И РОДСТВЕННЫЕ ИНГИБИТОРЫ ФАКТОРА Xa
AR082803A1 (es)	2010-09-01	2013-01-09	Portola Pharm Inc	Metodos y formulaciones para el tratamiento de la trombosis con betrixaban y un inhibidor de la glicoproteina p
AR082804A1 (es) *	2010-09-01	2013-01-09	Portola Pharm Inc	Formas cristalinas de un inhibidor del factor xa
CN102952138B (zh) *	2011-08-17	2016-07-06	上海特化医药科技有限公司	一种吡唑并嘧啶酮化合物的盐、多晶型物及其药物组合物、制备方法和应用
US20150224091A1 (en) *	2011-08-31	2015-08-13	Portola Pharmaceuticals, Inc.	Prevention and treatment of thrombosis in medically ill patients
US20140346397A1 (en)	2012-12-27	2014-11-27	Portola Pharmaceuticals, Inc.	Compounds and methods for purification of serine proteases
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CN104341343B (zh) *	2013-07-24	2018-09-28	四川海思科制药有限公司	贝曲西班的晶型及其制备方法和用途
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CN108883160B (zh)	2016-02-24	2022-06-28	博尔托拉制药公司	因子xa解毒剂的冻干制剂
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2006
- 2006-11-07 US US11/594,280 patent/US7598276B2/en active Active
- 2006-11-07 ES ES06837238T patent/ES2384116T3/es active Active
- 2006-11-07 CN CN201110197429.0A patent/CN102336702B/zh active Active
- 2006-11-07 PT PT06837238T patent/PT1948608E/pt unknown
- 2006-11-07 PE PE2010000471A patent/PE20110070A1/es not_active Application Discontinuation
- 2006-11-07 EP EP11187927A patent/EP2431358A1/en not_active Withdrawn
- 2006-11-07 BR BRPI0618362-0A patent/BRPI0618362A2/pt not_active Application Discontinuation
- 2006-11-07 NZ NZ567992A patent/NZ567992A/en not_active IP Right Cessation
- 2006-11-07 AU AU2006311544A patent/AU2006311544B2/en not_active Ceased
- 2006-11-07 CA CA2627086A patent/CA2627086C/en not_active Expired - Fee Related
- 2006-11-07 JP JP2008540190A patent/JP5227178B2/ja not_active Expired - Fee Related
- 2006-11-07 PE PE2006001368A patent/PE20070717A1/es active IP Right Grant
- 2006-11-07 RU RU2008123055/04A patent/RU2440986C2/ru not_active Application Discontinuation
- 2006-11-07 NZ NZ592533A patent/NZ592533A/xx not_active IP Right Cessation
- 2006-11-07 KR KR1020087011799A patent/KR101358574B1/ko not_active Expired - Fee Related
- 2006-11-07 CN CN2006800415554A patent/CN101304971B/zh active Active
- 2006-11-07 DK DK06837238.2T patent/DK1948608T3/da active
- 2006-11-07 AT AT06837238T patent/ATE549317T1/de active
- 2006-11-07 EP EP06837238A patent/EP1948608B1/en active Active
- 2006-11-07 WO PCT/US2006/043635 patent/WO2007056517A2/en active Application Filing
- 2006-11-08 TW TW095141382A patent/TWI443088B/zh not_active IP Right Cessation
- 2006-11-08 AR ARP060104900A patent/AR056787A1/es not_active Application Discontinuation
2008
- 2008-03-31 IL IL190524A patent/IL190524A/en active IP Right Grant
- 2008-05-05 ZA ZA200803820A patent/ZA200803820B/xx unknown
- 2008-09-23 HK HK08110550.3A patent/HK1115131A1/xx not_active IP Right Cessation
2009
- 2009-08-28 US US12/550,291 patent/US8557852B2/en not_active Expired - Fee Related
2011
- 2011-06-12 IL IL213487A patent/IL213487A0/en unknown
2012
- 2012-09-12 US US13/612,476 patent/US20130064806A1/en not_active Abandoned
- 2012-09-18 JP JP2012204757A patent/JP5662980B2/ja active Active
2014
- 2014-02-17 US US14/182,209 patent/US9061019B2/en not_active Expired - Fee Related
2015
- 2015-05-18 US US14/715,507 patent/US9555023B2/en not_active Expired - Fee Related
2016
- 2016-12-12 AR ARP160103799A patent/AR106960A2/es unknown
- 2016-12-20 US US15/385,651 patent/US20170326119A1/en not_active Abandoned
2018
- 2018-03-08 US US15/915,940 patent/US20190046510A1/en not_active Abandoned

Also Published As

Publication number	Publication date
JP2009514976A (ja)	2009-04-09
US9061019B2 (en)	2015-06-23
IL213487A0 (en)	2011-07-31
ZA200803820B (en)	2009-03-25
CA2627086A1 (en)	2007-05-18
US9555023B2 (en)	2017-01-31
CN102336702A (zh)	2012-02-01
NZ592533A (en)	2012-08-31
DK1948608T3 (da)	2012-07-02
RU2440986C2 (ru)	2012-01-27
CN101304971A (zh)	2008-11-12
US20100063113A1 (en)	2010-03-11
IL190524A (en)	2013-02-28
BRPI0618362A2 (pt)	2011-08-30
WO2007056517A3 (en)	2008-04-17
US20130064806A1 (en)	2013-03-14
PE20110070A1 (es)	2011-03-04
IL190524A0 (en)	2008-12-29
AR056787A1 (es)	2007-10-24
WO2007056517A2 (en)	2007-05-18
RU2008123055A (ru)	2009-12-20
JP5227178B2 (ja)	2013-07-03
US20140288028A1 (en)	2014-09-25
TW200736221A (en)	2007-10-01
EP1948608A2 (en)	2008-07-30
NZ567992A (en)	2011-05-27
US20190046510A1 (en)	2019-02-14
TWI443088B (zh)	2014-07-01
US8557852B2 (en)	2013-10-15
US7598276B2 (en)	2009-10-06
KR20080065662A (ko)	2008-07-14
JP2012246323A (ja)	2012-12-13
US20160101089A1 (en)	2016-04-14
AU2006311544B2 (en)	2012-03-08
ATE549317T1 (de)	2012-03-15
US20170326119A1 (en)	2017-11-16
US20070112039A1 (en)	2007-05-17
ES2384116T3 (es)	2012-06-29
EP2431358A1 (en)	2012-03-21
JP5662980B2 (ja)	2015-02-04
PE20070717A1 (es)	2007-08-17
AU2006311544A1 (en)	2007-05-18
CA2627086C (en)	2016-04-05
KR101358574B1 (ko)	2014-02-04
CN101304971B (zh)	2011-09-07
CN102336702B (zh)	2015-02-11
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EP1948608B1 (en)	2012-03-14
PT1948608E (pt)	2012-05-24

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