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HK1097852A1 - Novel method for the synthesis of peridopril and the pharmaceutically-acceptable salts thereof - Google Patents

Novel method for the synthesis of peridopril and the pharmaceutically-acceptable salts thereof

Info

Publication number
HK1097852A1
HK1097852A1 HK07101189A HK07101189A HK1097852A1 HK 1097852 A1 HK1097852 A1 HK 1097852A1 HK 07101189 A HK07101189 A HK 07101189A HK 07101189 A HK07101189 A HK 07101189A HK 1097852 A1 HK1097852 A1 HK 1097852A1
Authority
HK
Hong Kong
Prior art keywords
formula
ester
perindopril
hexahydroindole
synthesis
Prior art date
Application number
HK07101189A
Other languages
English (en)
Inventor
Dubuffet Thierry
Lecouve Jean-Pierre
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of HK1097852A1 publication Critical patent/HK1097852A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HK07101189A 2003-08-29 2007-02-01 Novel method for the synthesis of peridopril and the pharmaceutically-acceptable salts thereof HK1097852A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03292133A EP1371659B1 (fr) 2003-08-29 2003-08-29 Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables
PCT/FR2004/002198 WO2005023843A1 (fr) 2003-08-29 2004-08-27 Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables

Publications (1)

Publication Number Publication Date
HK1097852A1 true HK1097852A1 (en) 2007-07-06

Family

ID=29558494

Family Applications (1)

Application Number Title Priority Date Filing Date
HK07101189A HK1097852A1 (en) 2003-08-29 2007-02-01 Novel method for the synthesis of peridopril and the pharmaceutically-acceptable salts thereof

Country Status (18)

Country Link
US (1) US7223872B2 (es)
EP (1) EP1371659B1 (es)
JP (1) JP4331207B2 (es)
CN (1) CN100374459C (es)
AR (1) AR045517A1 (es)
AT (1) ATE306496T1 (es)
AU (1) AU2004270429B2 (es)
DE (1) DE60301820T2 (es)
DK (1) DK1371659T3 (es)
EA (1) EA008626B1 (es)
ES (1) ES2250853T3 (es)
HK (1) HK1097852A1 (es)
MY (1) MY136288A (es)
NZ (1) NZ545338A (es)
PL (1) PL211507B1 (es)
SI (1) SI1371659T1 (es)
WO (1) WO2005023843A1 (es)
ZA (1) ZA200601426B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60302287T2 (de) * 2003-08-29 2006-08-10 Les Laboratoires Servier Verfahren für die Synthese von Perindopril und seiner pharmazeutisch annehmbaren Salzen
DK1380590T3 (da) * 2003-08-29 2007-01-08 Servier Lab Ny fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
ES2336554T3 (es) * 2003-10-21 2010-04-14 Les Laboratoires Servier Nuevo metodo para la preparacion de perindopril erbumina cristalina.
SI21704A (en) * 2004-01-14 2005-08-31 Lek Farmacevtska Druzba Dd New crystal form of perindopril, procedure of its preparation, pharmaceutical preparations containing this form and their application in treatment of hypertensia
SI1679072T1 (sl) 2005-01-06 2009-02-28 Ipca Lab Ltd Postopek za sintezo derivatov (2S,3aS,7aS)-1-(S)-alanil-oktahidro-1H-indol-2-karboksilne kisline inuporaba v sintezi perindoprila
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
PH12018502155B1 (en) 2016-04-20 2024-03-27 Servier Lab Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid
CN113980096A (zh) * 2021-11-29 2022-01-28 绍兴市上虞区武汉理工大学高等研究院 一种吨级培哚普利叔丁胺的合成工艺方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1323729T1 (en) * 2003-03-12 2005-02-28 Les Laboratoires Servier Method for synthesis of (2S,3aS,7aS)-perhydroindole-2-carboxylic acid and esters thereof derivatives; and use in the synthesis of perindopril
DE60302287T2 (de) * 2003-08-29 2006-08-10 Les Laboratoires Servier Verfahren für die Synthese von Perindopril und seiner pharmazeutisch annehmbaren Salzen

Also Published As

Publication number Publication date
WO2005023843A1 (fr) 2005-03-17
CN100374459C (zh) 2008-03-12
CN1835965A (zh) 2006-09-20
JP4331207B2 (ja) 2009-09-16
EP1371659B1 (fr) 2005-10-12
DK1371659T3 (da) 2005-11-21
US7223872B2 (en) 2007-05-29
DE60301820T2 (de) 2006-07-13
MY136288A (en) 2008-09-30
PL379627A1 (pl) 2006-10-30
AR045517A1 (es) 2005-11-02
ES2250853T3 (es) 2006-04-16
SI1371659T1 (sl) 2006-02-28
PL211507B1 (pl) 2012-05-31
AU2004270429A1 (en) 2005-03-17
JP2007536202A (ja) 2007-12-13
ZA200601426B (en) 2007-05-30
NZ545338A (en) 2009-03-31
EA200600455A1 (ru) 2006-08-25
US20070088168A1 (en) 2007-04-19
ATE306496T1 (de) 2005-10-15
EA008626B1 (ru) 2007-06-29
DE60301820D1 (de) 2006-02-23
EP1371659A1 (fr) 2003-12-17
AU2004270429B2 (en) 2007-05-24

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20180825