AR045517A1 - Procedimiento para la sintesis de perindopril y de sus sales farmaceuticamente aceptables - Google Patents
Procedimiento para la sintesis de perindopril y de sus sales farmaceuticamente aceptablesInfo
- Publication number
- AR045517A1 AR045517A1 ARP040103080A ARP040103080A AR045517A1 AR 045517 A1 AR045517 A1 AR 045517A1 AR P040103080 A ARP040103080 A AR P040103080A AR P040103080 A ARP040103080 A AR P040103080A AR 045517 A1 AR045517 A1 AR 045517A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- compound
- synthesis
- pharmaceutically acceptable
- acceptable salts
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Reivindicación 1: Procedimiento para la síntesis de los compuestos de fórmula (1) y de sus sales farmacéuticamente aceptables, caracterizado porque se hace reaccionar el compuesto de fórmula (2) en la cual R1 representa un grupo alquilo C1-6 lineal o ramificado o un grupo bencilo, con un compuesto de fórmula (3) de configuración S; en la cual X representa un átomo de halógeno y R2 representa un grupo de protección para la función amino, en presencia de una base, para obtener, después de la desprotección de la función amino, un compuesto de fórmula (4) en la cual R1 es tal como se ha definido anteriormente, que se somete a reacción con 2-oxopentanoato de etilo bajo presión de H, en presencia de platino sobre C, para obtener el compuesto de fórmula (5), en la cual R1 es tal como se ha definido anteriormente, que se desprotege para obtener el compuesto de la fórmula (1).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03292133A EP1371659B1 (fr) | 2003-08-29 | 2003-08-29 | Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR045517A1 true AR045517A1 (es) | 2005-11-02 |
Family
ID=29558494
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040103080A AR045517A1 (es) | 2003-08-29 | 2004-08-27 | Procedimiento para la sintesis de perindopril y de sus sales farmaceuticamente aceptables |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7223872B2 (es) |
| EP (1) | EP1371659B1 (es) |
| JP (1) | JP4331207B2 (es) |
| CN (1) | CN100374459C (es) |
| AR (1) | AR045517A1 (es) |
| AT (1) | ATE306496T1 (es) |
| AU (1) | AU2004270429B2 (es) |
| DE (1) | DE60301820T2 (es) |
| DK (1) | DK1371659T3 (es) |
| EA (1) | EA008626B1 (es) |
| ES (1) | ES2250853T3 (es) |
| HK (1) | HK1097852A1 (es) |
| MY (1) | MY136288A (es) |
| NZ (1) | NZ545338A (es) |
| PL (1) | PL211507B1 (es) |
| SI (1) | SI1371659T1 (es) |
| WO (1) | WO2005023843A1 (es) |
| ZA (1) | ZA200601426B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1380590B1 (fr) * | 2003-08-29 | 2006-09-06 | Les Laboratoires Servier | Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables |
| DK1380591T3 (da) * | 2003-08-29 | 2006-01-23 | Servier Lab | Fremgangsmåde til syntese af perindopril og farmaceutiske acceptable salte heraf |
| DK1675827T3 (da) * | 2003-10-21 | 2010-04-19 | Servier Lab | Ny fremgangsmåde til fremstilling af krystallint perindopril erbumin |
| SI21704A (en) * | 2004-01-14 | 2005-08-31 | Lek Farmacevtska Druzba Dd | New crystal form of perindopril, procedure of its preparation, pharmaceutical preparations containing this form and their application in treatment of hypertensia |
| ATE409036T1 (de) | 2005-01-06 | 2008-10-15 | Ipca Lab Ltd | Verfahren zur synthese von (2s,3as,7as)-1-(s)- alanyl-octahydro-1h-2-carbonsäurederivaten und verwendung in der synthese von perindopril |
| WO2016178591A2 (en) | 2015-05-05 | 2016-11-10 | Gene Predit, Sa | Genetic markers and treatment of male obesity |
| PH12018502155B1 (en) | 2016-04-20 | 2024-03-27 | Servier Lab | Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid |
| CN113980096A (zh) * | 2021-11-29 | 2022-01-28 | 绍兴市上虞区武汉理工大学高等研究院 | 一种吨级培哚普利叔丁胺的合成工艺方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60300106T2 (de) * | 2003-03-12 | 2005-10-13 | Les Laboratoires Servier | Verfahren zur Synthese von (2S,3aS,7aS)-1-((S)-Alanyl)-octahydro-1H-indol-2-carbonsäurederivaten und Verwendung in der Synthese von Perindopril |
| DK1380591T3 (da) * | 2003-08-29 | 2006-01-23 | Servier Lab | Fremgangsmåde til syntese af perindopril og farmaceutiske acceptable salte heraf |
-
2003
- 2003-08-29 SI SI200330103T patent/SI1371659T1/sl unknown
- 2003-08-29 ES ES03292133T patent/ES2250853T3/es not_active Expired - Lifetime
- 2003-08-29 DK DK03292133T patent/DK1371659T3/da active
- 2003-08-29 DE DE60301820T patent/DE60301820T2/de not_active Expired - Lifetime
- 2003-08-29 EP EP03292133A patent/EP1371659B1/fr not_active Expired - Lifetime
- 2003-08-29 AT AT03292133T patent/ATE306496T1/de active
-
2004
- 2004-08-26 MY MYPI20043494A patent/MY136288A/en unknown
- 2004-08-27 AR ARP040103080A patent/AR045517A1/es not_active Application Discontinuation
- 2004-08-27 ZA ZA200601426A patent/ZA200601426B/xx unknown
- 2004-08-27 US US10/570,565 patent/US7223872B2/en not_active Expired - Fee Related
- 2004-08-27 JP JP2006524396A patent/JP4331207B2/ja not_active Expired - Fee Related
- 2004-08-27 WO PCT/FR2004/002198 patent/WO2005023843A1/fr active IP Right Grant
- 2004-08-27 EA EA200600455A patent/EA008626B1/ru not_active IP Right Cessation
- 2004-08-27 NZ NZ545338A patent/NZ545338A/en not_active IP Right Cessation
- 2004-08-27 AU AU2004270429A patent/AU2004270429B2/en not_active Ceased
- 2004-08-27 CN CNB2004800235321A patent/CN100374459C/zh not_active Expired - Fee Related
- 2004-08-27 PL PL379627A patent/PL211507B1/pl unknown
-
2007
- 2007-02-01 HK HK07101189A patent/HK1097852A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE60301820T2 (de) | 2006-07-13 |
| CN100374459C (zh) | 2008-03-12 |
| JP4331207B2 (ja) | 2009-09-16 |
| EP1371659A1 (fr) | 2003-12-17 |
| ATE306496T1 (de) | 2005-10-15 |
| EA200600455A1 (ru) | 2006-08-25 |
| US20070088168A1 (en) | 2007-04-19 |
| SI1371659T1 (sl) | 2006-02-28 |
| AU2004270429A1 (en) | 2005-03-17 |
| JP2007536202A (ja) | 2007-12-13 |
| DK1371659T3 (da) | 2005-11-21 |
| EA008626B1 (ru) | 2007-06-29 |
| ZA200601426B (en) | 2007-05-30 |
| WO2005023843A1 (fr) | 2005-03-17 |
| DE60301820D1 (de) | 2006-02-23 |
| US7223872B2 (en) | 2007-05-29 |
| PL379627A1 (pl) | 2006-10-30 |
| HK1097852A1 (en) | 2007-07-06 |
| NZ545338A (en) | 2009-03-31 |
| AU2004270429B2 (en) | 2007-05-24 |
| MY136288A (en) | 2008-09-30 |
| CN1835965A (zh) | 2006-09-20 |
| PL211507B1 (pl) | 2012-05-31 |
| ES2250853T3 (es) | 2006-04-16 |
| EP1371659B1 (fr) | 2005-10-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |