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HK1048484B - 中性脂質聚合物以及含中性脂質聚合物的脂質體組合物 - Google Patents

中性脂質聚合物以及含中性脂質聚合物的脂質體組合物

Info

Publication number
HK1048484B
HK1048484B HK03100630.3A HK03100630A HK1048484B HK 1048484 B HK1048484 B HK 1048484B HK 03100630 A HK03100630 A HK 03100630A HK 1048484 B HK1048484 B HK 1048484B
Authority
HK
Hong Kong
Prior art keywords
lipopolymers
liposomes
alkyl
compositions containing
group
Prior art date
Application number
HK03100630.3A
Other languages
English (en)
Other versions
HK1048484A1 (en
Inventor
S‧扎裡普斯基
Original Assignee
阿爾薩公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 阿爾薩公司 filed Critical 阿爾薩公司
Publication of HK1048484A1 publication Critical patent/HK1048484A1/xx
Publication of HK1048484B publication Critical patent/HK1048484B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Polyethers (AREA)
HK03100630.3A 1999-07-14 2003-01-24 中性脂質聚合物以及含中性脂質聚合物的脂質體組合物 HK1048484B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14381099P 1999-07-14 1999-07-14
PCT/US2000/018949 WO2001005873A1 (en) 1999-07-14 2000-07-12 Neutral lipopolymer and liposomal compositions containing same

Publications (2)

Publication Number Publication Date
HK1048484A1 HK1048484A1 (en) 2003-04-04
HK1048484B true HK1048484B (zh) 2005-10-14

Family

ID=22505748

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03100630.3A HK1048484B (zh) 1999-07-14 2003-01-24 中性脂質聚合物以及含中性脂質聚合物的脂質體組合物

Country Status (24)

Country Link
US (1) US6586001B1 (zh)
EP (1) EP1198490B1 (zh)
JP (1) JP2003505401A (zh)
KR (2) KR100758158B1 (zh)
CN (1) CN1193059C (zh)
AT (1) ATE317869T1 (zh)
AU (1) AU769517B2 (zh)
BR (1) BR0012443A (zh)
CA (1) CA2379060A1 (zh)
CY (1) CY1105466T1 (zh)
CZ (1) CZ2002140A3 (zh)
DE (1) DE60026030T2 (zh)
DK (1) DK1198490T3 (zh)
ES (1) ES2255501T3 (zh)
HK (1) HK1048484B (zh)
HU (1) HUP0202177A3 (zh)
IL (2) IL147564A0 (zh)
MX (1) MXPA02000402A (zh)
NO (1) NO20020175L (zh)
PL (1) PL352711A1 (zh)
PT (1) PT1198490E (zh)
RU (1) RU2250911C2 (zh)
WO (1) WO2001005873A1 (zh)
ZA (1) ZA200200303B (zh)

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ES2260321T3 (es) * 2000-12-07 2006-11-01 Universiteit Utrecht Holding B.V. Composicion para el tratamiento de transtornos inflamatorios.
WO2002087541A1 (en) * 2001-04-30 2002-11-07 Protiva Biotherapeutics Inc. Lipid-based formulations for gene transfer
CA2488121C (en) 2002-06-07 2012-07-24 Rutgers, The State University Micelle assemblies
DK1519714T3 (da) 2002-06-28 2011-01-31 Protiva Biotherapeutics Inc Fremgangsmåde og apparat til fremstilling af liposomer
CN100379404C (zh) * 2003-02-28 2008-04-09 阿尔扎公司 用于减少脂质体诱导的补体激活的脂质体组合物
AU2004218489A1 (en) * 2003-02-28 2004-09-16 Alza Corporation Liposome composition for reduction of liposome-induced complement activation
EP1610763A2 (en) * 2003-03-31 2006-01-04 Yissum Research Development Company Of The Hebrew University Of Jerusalem Stable liposomes or micelles comprising a sphingolipid and a peg-lipopolymer
CA2522179C (en) * 2003-04-15 2012-02-14 Opperbas Holding B.V. Pharmaceutical composition comprising proteins and/or polypeptides and colloidal particles
US7947261B2 (en) 2003-05-23 2011-05-24 Nektar Therapeutics Conjugates formed from polymer derivatives having particular atom arrangements
JP5048332B2 (ja) * 2003-05-23 2012-10-17 ネクター セラピューティクス 特定の原子配置を有するポリマー誘導体
KR20060015265A (ko) * 2003-05-30 2006-02-16 알자 코포레이션 제제의 폐 투여 방법
EP2567693B1 (en) * 2003-07-16 2015-10-21 Protiva Biotherapeutics Inc. Lipid encapsulated interfering RNA
EP1664316B1 (en) 2003-09-15 2012-08-29 Protiva Biotherapeutics Inc. Polyethyleneglycol-modified lipid compounds and uses thereof
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JP2007520481A (ja) * 2004-01-15 2007-07-26 アルザ・コーポレーシヨン 治療薬を送達するためのリポソーム組成物
EP1766035B1 (en) 2004-06-07 2011-12-07 Protiva Biotherapeutics Inc. Lipid encapsulated interfering rna
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US8998881B2 (en) 2005-08-10 2015-04-07 Alza Corporation Method for delivering drugs to tissue under microjet propulsion
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JP5277417B2 (ja) * 2006-11-30 2013-08-28 ネクター セラピューティクス ポリマー複合体を調製する方法
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PL2279254T3 (pl) 2008-04-15 2017-11-30 Protiva Biotherapeutics Inc. Nowe preparaty lipidowe do dostarczania kwasów nukleinowych
KR100967833B1 (ko) 2008-05-20 2010-07-05 아이디비켐(주) 고순도의 폴리에틸렌글리콜 알데하이드 유도체의 제조방법
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JP2012521763A (ja) 2009-03-27 2012-09-20 メルク・シャープ・エンド・ドーム・コーポレイション 低分子干渉核酸（ｓｉＮＡ）を用いたシグナル伝達性転写因子１（ＳＴＡＴ１）遺伝子発現のＲＮＡ干渉媒介性阻害
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CN102439152A (zh) 2009-03-27 2012-05-02 默沙东公司 使用短干扰核酸（siNA）的RNA干扰介导的细胞间粘附分子1（ICAM-1）基因表达的抑制
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GB202111758D0 (en) 2021-08-17 2021-09-29 Cantab Biopharmaceuticals Patents Ltd Modified colloidal particles for use in the treatment of haemophilia A
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Also Published As

Publication number Publication date
BR0012443A (pt) 2002-04-02
ATE317869T1 (de) 2006-03-15
MXPA02000402A (es) 2002-07-30
DE60026030T2 (de) 2006-08-10
KR20070086708A (ko) 2007-08-27
HUP0202177A2 (hu) 2002-12-28
EP1198490A1 (en) 2002-04-24
NO20020175D0 (no) 2002-01-14
PL352711A1 (en) 2003-09-08
WO2001005873A1 (en) 2001-01-25
AU769517B2 (en) 2004-01-29
NO20020175L (no) 2002-01-14
AU5930300A (en) 2001-02-05
RU2250911C2 (ru) 2005-04-27
ES2255501T3 (es) 2006-07-01
IL147564A (en) 2007-03-08
KR100758158B1 (ko) 2007-09-12
HK1048484A1 (en) 2003-04-04
CY1105466T1 (el) 2010-04-28
CN1193059C (zh) 2005-03-16
CZ2002140A3 (cs) 2002-05-15
KR20020012008A (ko) 2002-02-09
ZA200200303B (en) 2003-03-26
US6586001B1 (en) 2003-07-01
PT1198490E (pt) 2006-06-30
DE60026030D1 (de) 2006-04-20
CN1360611A (zh) 2002-07-24
HUP0202177A3 (en) 2004-05-28
IL147564A0 (en) 2002-08-14
JP2003505401A (ja) 2003-02-12
CA2379060A1 (en) 2001-01-25
DK1198490T3 (da) 2006-06-19
EP1198490B1 (en) 2006-02-15

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20090712