HK1034523A1 - Hemiasterlin analogs - Google Patents

Hemiasterlin analogs

Info

Publication number: HK1034523A1
Authority: HK; Hong Kong
Prior art keywords: analogs; hemiasterlin; hemiasterlin analogs; synthesis; methods
Prior art date: 1997-12-19

Application number

HK01105313.8A

Other languages

English (en)

Inventor

Raymond Andersen

Edward Piers

John Coleman

Michel Reberge

Original Assignee

Univ British Columbia Industry

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-12-19

Filing date

2001-07-31

Publication date

2001-10-26

2001-07-31 Application filed by Univ British Columbia Industry filed Critical Univ British Columbia Industry

2001-10-26 Publication of HK1034523A1 publication Critical patent/HK1034523A1/xx

Links

KQODQNJLJQHFQV-MKWZWQCGSA-N (e,4s)-4-[[(2s)-3,3-dimethyl-2-[[(2s)-3-methyl-2-(methylamino)-3-(1-methylindol-3-yl)butanoyl]amino]butanoyl]-methylamino]-2,5-dimethylhex-2-enoic acid Chemical class C1=CC=C2C(C(C)(C)[C@@H](C(=O)N[C@H](C(=O)N(C)[C@H](\C=C(/C)C(O)=O)C(C)C)C(C)(C)C)NC)=CN(C)C2=C1 KQODQNJLJQHFQV-MKWZWQCGSA-N 0.000 title abstract 2
KQODQNJLJQHFQV-UHFFFAOYSA-N (-)-hemiasterlin Natural products C1=CC=C2C(C(C)(C)C(C(=O)NC(C(=O)N(C)C(C=C(C)C(O)=O)C(C)C)C(C)(C)C)NC)=CN(C)C2=C1 KQODQNJLJQHFQV-UHFFFAOYSA-N 0.000 abstract 1
239000003080 antimitotic agent Substances 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
231100000433 cytotoxic Toxicity 0.000 abstract 1
230000001472 cytotoxic effect Effects 0.000 abstract 1
229930187626 hemiasterlin Natural products 0.000 abstract 1
108010057806 hemiasterlin Proteins 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Crystallography & Structural Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Junction Field-Effect Transistors (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Amplifiers (AREA)
Steroid Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pyrrole Compounds (AREA)

HK01105313.8A 1997-12-19 2001-07-31 Hemiasterlin analogs HK1034523A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CA002225325A CA2225325A1 (fr)	1997-12-19	1997-12-19	Substances hemiasterlines analogues
PCT/CA1998/001184 WO1999032509A2 (fr)	1997-12-19	1998-12-18	Analogues d'hemiasterline

Publications (1)

Publication Number	Publication Date
HK1034523A1 true HK1034523A1 (en)	2001-10-26

Family

ID=4161925

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK01105313.8A HK1034523A1 (en)	1997-12-19	2001-07-31	Hemiasterlin analogs

Country Status (17)

Country	Link
US (2)	US7579323B1 (fr)
EP (1)	EP1040119B1 (fr)
JP (1)	JP4417551B2 (fr)
KR (1)	KR100937756B1 (fr)
CN (1)	CN100422208C (fr)
AT (1)	ATE419268T1 (fr)
AU (1)	AU762691C (fr)
BR (1)	BR9813817A (fr)
CA (2)	CA2225325A1 (fr)
DE (1)	DE69840415D1 (fr)
DK (1)	DK1040119T3 (fr)
ES (1)	ES2320499T3 (fr)
HK (1)	HK1034523A1 (fr)
HU (1)	HUP0105460A3 (fr)
IL (1)	IL136654A0 (fr)
NZ (1)	NZ505086A (fr)
WO (1)	WO1999032509A2 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2003072754A2 (fr) *	2002-02-27	2003-09-04	The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services	Conjugues de ligand, adaptateur et agent cytotoxique, compositions associees et procedes d'utilisation relatifs
MXPA04009209A (es) *	2002-03-22	2004-11-26	Eisai Co Ltd	Derivados de hemiasterlina y usos de los mismos.
US7064211B2 (en)	2002-03-22	2006-06-20	Eisai Co., Ltd.	Hemiasterlin derivatives and uses thereof
WO2004026814A2 (fr) *	2002-09-20	2004-04-01	Wyeth Holdings Corporation	Procede de synthese d'intermediaires utiles dans la synthese d'inhibiteurs de tubuline
US20040121965A1 (en) *	2002-09-20	2004-06-24	Wyeth Holdings Corporation	Method of treating resistant tumors
AU2003295808A1 (en) *	2002-11-21	2004-06-18	Wyeth	Hemiasterlin affinity probes and their uses
US7390910B2 (en)	2003-08-08	2008-06-24	Wyeth	Compounds for treating tumors
GB201001070D0 (en)	2010-01-22	2010-03-10	St George's Hospital Medical School	Theraputic compounds and their use
TR201911139T4 (tr)	2013-03-15	2019-08-21	Zymeworks Inc	Sitotoksik ve anti-mitotik bileşikler ve bunları kullanmanın yöntemleri.
KR20160125361A (ko) *	2013-12-27	2016-10-31	자임워크스 인코포레이티드	Ｖａｒ２ｃｓａ－약물 접합체
KR102384740B1 (ko) *	2013-12-27	2022-04-07	자임워크스 인코포레이티드	약물 접합체를 위한 설폰아마이드-함유 연결 시스템
CN113416229B (zh)	2014-09-17	2024-12-13	酵活英属哥伦比亚有限公司	细胞毒性和抗有丝分裂化合物、及其使用方法
SG11201704976VA (en) *	2015-01-30	2017-07-28	Sutro Biopharma Inc	Hemiasterlin derivatives for conjugation and therapy
RS63143B1 (sr)	2016-06-01	2022-05-31	Athira Pharma Inc	Jedinjenja
US10517958B2 (en)	2016-10-04	2019-12-31	Zymeworks Inc.	Compositions and methods for the treatment of platinum-drug resistant cancer
WO2018128745A1 (fr)	2017-01-06	2018-07-12	The Board Of Trustees Of The Leland Stanford Junior University	Ligands du récepteur du facteur neurotrophique ciliaire et leurs méthodes d'utilisation
EP4321523A3 (fr)	2017-08-10	2024-04-24	Sumitomo Pharma Co., Ltd.	Dérivés d'hémiasterline et conjugués anticorps-médicament les comprenant
DK3666787T3 (da)	2017-08-10	2024-03-11	Sumitomo Pharma Co Ltd	Antistoflægemiddelkonjugater som inkluderer hemiasterlinderivat
US20220144889A1 (en)	2019-02-13	2022-05-12	Sumitomo Dainippon Pharma Co., Ltd.	Hemiasterlin Derivative Having Cysteine Residue
WO2020166592A1 (fr)	2019-02-13	2020-08-20	大日本住友製薬株式会社	Dérivé d'hémiastérline et conjugué anticorps-médicament associé

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1049404B (it)	1975-04-09	1981-01-20	Zambeletti Spa L	Tripeptidi loro esteri ed amidi ad attivita antiulcera
EP0150227A1 (fr)	1983-12-23	1985-08-07	FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC.	Dérivés de dipeptides et leur utilisation pour déterminer l'activité de la carboxypeptidase A
IT1209644B (it) *	1985-06-21	1989-08-30	Isf Spa	Composti farmacologicamente attivi.
US4820691A (en) *	1987-06-24	1989-04-11	E. R. Squibb & Sons, Inc.	Amino acid 1,2-diketo derivatives as renin inhibitors
CA2042027A1 (fr)	1989-09-15	1991-03-16	Arthur E. Bogden	Traitemenet du cancer du colon
GB9508195D0 (en)	1995-04-20	1995-06-07	Univ British Columbia	Novel biologically active compounds and compositions,their use and derivation
US5811515A (en) *	1995-06-12	1998-09-22	California Institute Of Technology	Synthesis of conformationally restricted amino acids, peptides, and peptidomimetics by catalytic ring closing metathesis
US5661175A (en)	1995-06-20	1997-08-26	Kashman; Yoel	Hemiasterlin and geodiamolide TA
AU716716B2 (en) *	1995-07-17	2000-03-02	Medivir Uk Ltd	Cysteine protease inhibitors for use in treatment of IgE mediated allergic diseases
US6214799B1 (en) *	1996-05-14	2001-04-10	Agouron Pharmaceuticals, Inc.	Antipicornaviral compounds and methods for their use and preparation
US6126939A (en) *	1996-09-03	2000-10-03	Yeda Research And Development Co. Ltd.	Anti-inflammatory dipeptide and pharmaceutical composition thereof
US6331554B1 (en) *	1997-03-28	2001-12-18	Agouron Pharmaceuticals, Inc.	Antipicornaviral compounds, compositions containing them, and methods for their use
US6194578B1 (en)	1998-11-20	2001-02-27	Pfizer Inc.	Dipeptide derivatives

1997
- 1997-12-19 CA CA002225325A patent/CA2225325A1/fr not_active Abandoned
1998
- 1998-12-13 US US09/581,511 patent/US7579323B1/en not_active Expired - Fee Related
- 1998-12-18 NZ NZ505086A patent/NZ505086A/en unknown
- 1998-12-18 JP JP2000525446A patent/JP4417551B2/ja not_active Expired - Fee Related
- 1998-12-18 CN CNB988124343A patent/CN100422208C/zh not_active Expired - Fee Related
- 1998-12-18 ES ES98962157T patent/ES2320499T3/es not_active Expired - Lifetime
- 1998-12-18 DK DK98962157T patent/DK1040119T3/da active
- 1998-12-18 WO PCT/CA1998/001184 patent/WO1999032509A2/fr active IP Right Grant
- 1998-12-18 AU AU17459/99A patent/AU762691C/en not_active Ceased
- 1998-12-18 KR KR1020007006814A patent/KR100937756B1/ko not_active IP Right Cessation
- 1998-12-18 EP EP98962157A patent/EP1040119B1/fr not_active Expired - Lifetime
- 1998-12-18 BR BR9813817-0A patent/BR9813817A/pt not_active Application Discontinuation
- 1998-12-18 AT AT98962157T patent/ATE419268T1/de not_active IP Right Cessation
- 1998-12-18 DE DE69840415T patent/DE69840415D1/de not_active Expired - Lifetime
- 1998-12-18 HU HU0105460A patent/HUP0105460A3/hu unknown
- 1998-12-18 CA CA2312826A patent/CA2312826C/fr not_active Expired - Fee Related
- 1998-12-18 IL IL13665498A patent/IL136654A0/xx unknown
2001
- 2001-07-31 HK HK01105313.8A patent/HK1034523A1/xx not_active IP Right Cessation
2009
- 2009-06-25 US US12/491,839 patent/US20090264487A1/en not_active Abandoned

Also Published As

Publication number	Publication date
HUP0105460A3 (en)	2002-08-28
AU762691B2 (en)	2003-07-03
BR9813817A (pt)	2000-10-10
DK1040119T3 (da)	2009-04-14
EP1040119B1 (fr)	2008-12-31
CA2312826A1 (fr)	1999-07-01
CN100422208C (zh)	2008-10-01
KR100937756B1 (ko)	2010-01-20
ATE419268T1 (de)	2009-01-15
JP2001526294A (ja)	2001-12-18
WO1999032509A2 (fr)	1999-07-01
CA2225325A1 (fr)	1999-06-19
NZ505086A (en)	2003-05-30
HUP0105460A2 (en)	2002-06-29
DE69840415D1 (de)	2009-02-12
US20090264487A1 (en)	2009-10-22
CA2312826C (fr)	2013-06-11
IL136654A0 (en)	2001-06-14
AU1745999A (en)	1999-07-12
EP1040119A2 (fr)	2000-10-04
US7579323B1 (en)	2009-08-25
ES2320499T3 (es)	2009-05-22
WO1999032509A3 (fr)	1999-10-07
KR20010024783A (ko)	2001-03-26
AU762691C (en)	2004-07-08
CN1282336A (zh)	2001-01-31
JP4417551B2 (ja)	2010-02-17

Publication	Publication Date	Title
HK1034523A1 (en)	2001-10-26	Hemiasterlin analogs
SI0797439T1 (en)	2003-12-31	Use of pramipexole as a neuroprotective agent
MX9800625A (es)	1998-04-30	Marcfortinas y paraherquamidas antiparasitarias.
IL147803A0 (en)	2002-08-14	28-epirapalogs
YU15299A (sh)	2002-06-19	Farmaceutski sastavi
HK1032759A1 (en)	2001-08-03	Apparatus for restoring the balance of the human body.
AP9901534A0 (en)	1999-06-30	Pharmaceutical formulations.
DE69905170D1 (en)	2003-03-06	Thiazolopyrimidinderivate
AU5186799A (en)	2000-02-07	Peptides of il-2 and derivatives thereof and their use as therapeutic agents
CY2261B1 (en)	2003-07-04	Cytotoxic amino sugar and relatd sugar derivativesof indolopyrrolocarbazoles
ZA976242B (en)	1998-03-18	Illudin analogs useful as antitumor agents.
MX9601994A (es)	1997-08-30	Profarmacos de derivados de paclitaxel.
BG104038A (en)	2001-04-30	Use of specific antagonist of 5ht2 receptors for preparing medicines useful for treating sleep-disordered breathing
ZA9811276B (en)	2000-06-09	Non-whitening underarm compositions.
BG105539A (en)	2001-12-29	Eletriptan hydrobromide monohydrate
BG101401A (en)	1997-12-30	Cisaspide extended release oral compositions
HK1043058A1 (zh)	2002-09-06	異環磷酰胺芥子類似物及其用途
MY127474A (en)	2006-12-29	Naphthyl compounds, intermediates, compositions, and methods of use
IL139604A0 (en)	2002-02-10	Novel peptides
BG103649A (en)	2000-06-30	Method for the preparation of eprosartan
BG103650A (en)	2000-06-30	Method for the preparation of eprosartan
IL139144A0 (en)	2001-11-25	Mycobacterial inhibitors
DE69818492D1 (en)	2003-10-30	7-methylthiooxomethyl- und 7-methylthiodioxomethyl-paclitaxele
RS47804A (en)	2006-12-15	1,3-diarylprop-2-en-1-ones, compositions containing same and use thereof
ZA978233B (en)	1998-04-01	The use of protein as anti-retroviral agents.

Legal Events

Date	Code	Title	Description
2009-09-18	CHRG	Changes in the register	Free format text: CORRECTION OF THE CHINESE NAME OF INVENTOR FROM ?A ?R
2013-07-12	PC	Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)	Effective date: 20121218